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IL-6 and NF-IL6 in acute-phase response and viral infection

Akira, Shizuo, Kishimoto†, Tadamitsu·1992·Immunological Reviews
DOI 10.1111/j.1600-065x.1992.tb01407.x
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Abstract

NF-IL6 was originally identified as a DNA-binding protein responsible for IL-1-stimulated IL-6 induction. Direct cloning of NF-IL6 revealed its homology with C/EBP. C/EBP is expressed in liver and adipose tissues and is supposed to regulate several hepatocyte- and adipocyte-specific genes. In contrast, NF-IL6 is suppressed in normal tissues, but is rapidly and drastically induced by LPS or inflammatory cytokines such as IL-1, TNF, and IL-6. NF-IL6 can also bind to the regulatory region of various genes including IL-8, G-CSF, IL-1 and immunoglobulin genes. Furthermore, NF-IL6 is shown to be identical to IL-6DBP, a DNA-binding protein responsible for IL-6-mediated induction in acute-phase proteins, demonstrating that NF-IL6 is responsible for the genes regulated by IL-6. These results indicate that NF-IL6 may be a pleiotropic mediator of many inducible genes involved in acute, immune, and inflammatory responses, like NFkB. In this regard, it is noteworthy that both an NF-IL6 binding site and an NFkB binding site are present in the inducible genes such as IL-6, IL-8, and several acute-phase genes. On the other hand, accumulating evidence has revealed that overproduction of IL-6 may be responsible for the pathogenesis and/or several symptoms of a variety of diseases, including autoimmune diseases, malignancies, and viral diseases. At present, the molecular mechanisms of abnormal expression of the IL-6 gene are not known. Recently it has become evident that interplays between vira…

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Metadata

Authors
Akira, S., & Kishimoto†, T.
Venue
Immunological Reviews
Publisher
Wiley
Published
1992-06
Volume
127
Issue
1
Pages
25-50
ISSN
  • 0105-2896
  • 1600-065X
DOI
10.1111/j.1600-065x.1992.tb01407.x
Cited by
411
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5079 d)

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