The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
Open accessAbstract
Summary: Patients with cancer have an impaired T‐cell response that can decrease the potential therapeutic benefit of cancer vaccines and other forms of immunotherapy. l‐arginine (l‐Arg) is a conditionally essential amino acid that is fundamental for the function of T lymphocytes. Recent findings in tumor‐bearing mice and cancer patients indicate that increased metabolism of l‐Arg by myeloid derived suppressor cells (MDSCs) producing arginase I inhibits T‐lymphocyte responses. Here we discuss some of the most recent concepts how MDSC expressing arginase I may regulate T‐cell function in cancer and other chronic inflammatory diseases and suggest possible therapeutic interventions to overcome this inhibitory effect.
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Cites
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Cited by
The blockade of immune checkpoints in cancer immunotherapy
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Myeloid-derived-suppressor cells as regulators of the immune system
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“MDSCs express high levels of both arginase 1 and iNOS, and a direct role for both of these enzymes in the inhibition of T-cell function is well established; this has been reviewed recentl”
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
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Metadata
- Authors
- Rodríguez, P. C., & Ochoa, A. C.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2008-03-19
- Volume
- 222
- Issue
- 1
- Pages
- 180-191
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2077508806
- Cited by
- 719
- References
- 119
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Rodríguez, P. C., & Ochoa, A. C. (2008). Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunological Reviews. https://doi.org/10.1111/j.1600-065x.2008.00608.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
