The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Metabolic switching and fuel choice during T‐cell differentiation and memory development
Open accessAbstract
Summary: Clearance or control of pathogens or tumors usually requires T‐cell‐mediated immunity. As such, understanding the mechanisms that govern the function, maintenance, and persistence of T cells will likely lead to new treatments for controlling disease. During an immune response, T‐cell development is marked by striking changes in metabolism. There is a growing appreciation that these metabolic changes underlie the capacity of T cells to perform particular functions, and this has led to a recent focus on the idea that the manipulation of cellular metabolism can be used to shape adaptive immune responses. Although interest in this area has grown in the last few years, a full understanding of the metabolic control of T‐cell functions, particularly during an immune response in vivo , is still lacking. In this review, we first provide a basic overview of metabolism in T cells, and then we focus on recent studies providing new or updated insights into the regulation of metabolic pathways and how they underpin T‐cell differentiation and memory T‐cell development.
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“signalling pathways involving the T cell receptor (TCR), CD28 and the PI3K–Akt–mTOR axis upregulate the expression of glucose transporter 1 (GLUT1), increasing the rate of aerobic glycolysis71,72”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [71]
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Self-citationMetabolic Pathways in Immune Cell Activation and Quiescence
Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692
Self-citationThommen, D. S., & Schumacher, T. N. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.012 · Cited by 1,351
Patsoukis, N., Bardhan, K., Chatterjee, P., Sari, D., Liu, B., Bell, L. N., Karoly, E. D., Freeman, G. J., Petkova, V., Seth, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms7692 · Cited by 1,249
T cell metabolism drives immunity
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Metadata
- Authors
- van der Windt, G. J. W., & Pearce, E. L.
- Affiliations
- Department of Pathology & Immunology Washington University School of Medicine St. Louis MO USA
- Washington University in St. Louis (US)
- Corresponding author
- Pearce, Erika L.
- ORCID
- Pearce, Erika L.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2012-08-14
- Volume
- 249
- Issue
- 1
- Pages
- 27-42
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC3645891
- OpenAlex
- W1999195849
- Cited by
- 563
- References
- 157
- Citations by year
- 2026: 38 · 2025: 52 · 2024: 44 · 2023: 55 · 2022: 58 · 2021: 53 · 2020: 54 · 2019: 44 · 2018: 41 · 2017: 35 · 2016: 22 · 2015: 26 · 2014: 23 · 2013: 14 · 2012: 3
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Emerald Foundation
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
- National Cancer Institute (R21CA158823)
- National Institute of Allergy and Infectious Diseases (R01AI091965)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- T cell metabolism, metabolic switch, fuel selection, T cell differentiation, memory T cells, metabolic reprogramming, adaptive immune response, T cell immunity
- MeSH terms
- Animals, Cell Differentiation, Energy Metabolism, Humans, Immunity, Cellular, Immunologic Memory, Lymphocyte Activation, Mitochondria, T-Lymphocytes, Cell Proliferation
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