The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Periodontitis: a host‐mediated disruption of microbial homeostasis. Unlearning learned concepts
Open accessAbstract
New concepts evolve when existing ones fail to address known factors adequately or are invalidated by new evidence. For decades periodontitis has been considered to be caused by specific bacteria or groups of bacteria and, accordingly, treatment protocols have largely been based on anti‐infective therapies. However, close inspection of current data leads one to question whether these bacteria are the cause or the result of periodontitis. Good evidence is emerging to suggest that it is indeed the host response to oral bacteria that leads to the tissue changes noted in gingivitis. These changes lead to an altered subgingival environment that favors the emergence of ‘periodontal pathogens’ and the subsequent development of periodontitis if the genetic and external environmental conditions are favorable for disease development. Thus, it seems that it is indeed the initial early host‐inflammatory and immune responses occurring during the development of gingivitis, and not specific bacteria or their so‐called virulence factors, which determine whether periodontitis develops and progresses. In this review we consider these concepts and their potential to change the way in which we view and manage the inflammatory periodontal diseases.
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Citations
Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · cited 2×
“After the landmark studies of Löe and colleagues implicating bacteria in the pathogenesis of periodontal diseases (50), the nonspecific plaque hypothesis was an early concept put forward to explain the nature of periodontal disease (51, 94).”
BackgroundPeriodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
Dental biofilms: difficult therapeutic targets
SOCRANSKY, S. S., & HAFFAJEE, A. D. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.280102.x · Cited by 1,273
Are dental diseases examples of ecological catastrophes?
Marsh, P. D. (2003) · Microbiology · doi:10.1099/mic.0.26082-0 · Cited by 1,256
Resolution of in flammation: state of the art, definitions and terms
Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045 · cited 1×
“This process leads to the release of cytokines, which stop neutrophil migration to the inflammatory site, attract monocytes that do not release proinflammatory mediators, enhance phagocytosis of bacteria and apoptotic cells by macrophages, direct the movement of phagocytes away from the site via the lymphatics and sti…”
BackgroundResolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996
Campbell, E. L., Louis, N. A., Tomassetti, S. E., Canny, G. O., Arita, M., Serhan, C. N., & Colgan, S. P. (2007) · The FASEB Journal · doi:10.1096/fj.07-8473com · Cited by 205
Cited by
D'Aiuto, F., Gkranias, N., Bhowruth, D., Khan, T., Orlandi, M., Suvan, J., Masi, S., Tsakos, G., Hurel, S., Hingorani, A. D., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30038-x · Cited by 473
Kocher, T., König, J., Borgnakke, W. S., Pink, C., & Meisel, P. (2018) · Periodontology 2000 · doi:10.1111/prd.12235 · Cited by 293
Monje, A., Catena, A., & Borgnakke, W. S. (2017) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12724 · Cited by 282
Microbiota, cirrhosis, and the emerging oral-gut-liver axis
Acharya, C., Sahingur, S. E., & Bajaj, J. S. (2017) · JCI Insight · doi:10.1172/jci.insight.94416 · Cited by 256
Integrated hypothesis of dental caries and periodontal diseases
Nyvad, B., & Takahashi, N. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2019.1710953 · Cited by 194
Metadata
- Authors
- Bartold, P. M., & Van Dyke, T. E.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2013-04-11
- Volume
- 62
- Issue
- 1
- Pages
- 203-217
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W1747197150
- Cited by
- 540
- References
- 9
- FWCI
- 32.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Bartold, P. M., & Van Dyke, T. E. (2013). Periodontitis: a host‐mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontology 2000. https://doi.org/10.1111/j.1600-0757.2012.00450.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
