Oxidative stress of the newborn in the pre‐ and postnatal period and the clinical utility of melatonin
Open accessAbstract
Abstract: Newborns, and especially those delivered preterm, are probably more prone to oxidative stress than individuals later in life. Also during pregnancy, increased oxygen demand augments the rate of production of reactive oxygen species (ROS) and women, even with normal pregnancies, experience elevated oxidative stress and lipid peroxidation compared with nonpregnant women. Also, there appears to be an increase in ROS generation in the placenta of pre‐eclamptic women. In comparison with healthy adults, newborn infants have lower levels of plasma antioxidants such as vitamin E, β‐carotene, and sulphydryl groups, lower levels of plasma metal binding proteins including ceruloplasmin and transferrin, and reduced activity of erythrocyte superoxide dismutase. This review summarizes conditions of newborns where there is elevated oxidative stress. Included in this group of conditions is asphyxia, respiratory distress syndrome and sepsis and the review also summarizes the literature related to clinical trials of antioxidant therapies and of melatonin, a highly effective antioxidant and free radical scavenger. The authors document there is general agreement that short‐term melatonin therapy may be highly effective and that it has a remarkably benign safety profile, even when neonates are treated with pharmacological doses. Significant complications with long‐term melatonin therapy in children and adults also have not been reported. None of the animal studies of maternal melatonin treatment or in postnatal life have shown any treatment‐related side effects. The authors conclude that treatment with melatonin might result in a wide range of health benefits, improved quality of life and reduced healthcare costs and may help reduce complications in the neonatal period.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Administration of melatonin reduces oxidative stress in newborn infants exposed to infection or fetal distress.
“it was shown that the administration of melatonin reduces oxidative stress in newborn infants exposed to infection or fetal distress,104”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994 · see citing works
Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?
Halliwell, B. B. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92211-x · Cited by 2,926 · see citing works
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742 · see citing works
Regulation of antioxidant enzymes: a significant role for melatonin
Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990 · see citing works
Self-citationMelatonin : a potent, endogenous hydroxyl radical scavenger
Tan, D. (1993) · Endocrine Journal · Cited by 1,659 · see citing works
Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601 · see citing works
Self-citationActions of Melatonin in the Reduction of Oxidative Stress
Reiter, R. J., Tan, D. X., Osuna, C., & Gitto, E. (2000) · Journal of Biomedical Science · doi:10.1007/bf02253360 · Cited by 1,182 · see citing works
Self-citationOxygen Toxicity: A Radical Explanation
Fridovich, I. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1203 · Cited by 850 · see citing works
Vitamin C exhibits pro-oxidant properties
Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J. (1998) · Nature · doi:10.1038/33308 · Cited by 800 · see citing works
Novel strategies for the treatment of sepsis
Riedemann, N. C., Guo, R., & Ward, P. A. (2003) · Nature Medicine · doi:10.1038/nm0503-517 · Cited by 774 · see citing works
NF-κB activation as a pathological mechanism of septic shock and inflammation
Liu, S. F., & Malik, A. B. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00477.2005 · Cited by 760 · see citing works
Melatonin: A peroxyl radical scavenger more effective than vitamin E
Pieri, C., Marra, M., Moroni, F., Recchioni, R., & Marcheselli, F. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00666-0 · Cited by 735 · see citing works
The chemistry of melatonin's interaction with reactive species
Allegra, M., Reiter, R. J., Tan, D. ‐., Gentile, C., Tesoriere, L., & Livrea, M. A. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02112.x · Cited by 718 · see citing works
Self-citationReiter, R. J., Tan, D., Manchester, L. C., & Qi, W. (2001) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:34:2:237 · Cited by 697 · see citing works
Self-citationOxidative Stress in the Pathogenesis of Preeclampsia
Hubel, C. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-139.x · Cited by 673 · see citing works
Crapo, J. D., Barry, B. E., Foscue, H. A., & Shelburne, J. D. (1980) · PubMed · doi:10.1164/arrd.1980.122.1.123 · Cited by 669 · see citing works
Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb
Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666 · see citing works
A Review of the Multiple Actions of Melatonin on the Immune System
Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 664 · see citing works
Self-citationSignificance of Melatonin in Antioxidative Defense System: Reactions and Products
Tan, D., Manchester, L. C., Reiter, R. J., Qi, W., Karbownik‐Lewińska, M., & Calvo, J. R. (2000) · Neurosignals · doi:10.1159/000014635 · Cited by 566 · see citing works
Self-citationVitamin A Supplementation for Extremely-Low-Birth-Weight Infants
Tyson, J. E., Wright, L. L., Oh, W., Kennedy, K. A., Mele, L., Ehrenkranz, R. A., Stoll, B. J., Lemons, J. A., Stevenson, D. K., Bauer, C. R., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906243402505 · Cited by 557 · see citing works
Melatonin mitigates mitochondrial malfunction
León, J., Acuña-Castroviejo, D., Escames, G., Tan, D. X., & Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00181.x · Cited by 515 · see citing works
Self-citationEffects of Melatonin Treatment in Septic Newborns
Gitto, E., Karbownik‐Lewińska, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G. R., & Barberi, I. (2001) · Pediatric Research · doi:10.1203/00006450-200112000-00021 · Cited by 507 · see citing works
Self-citationRegulation of antioxidant enzymes 1
Harris, E. D. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.9.1612291 · Cited by 462 · see citing works
Nitrosative and Oxidative Injury to Premyelinating Oligodendrocytes in Periventricular Leukomalacia
Haynes, R. L., Folkerth, R. D., Keefe, R. J., Sung, I., Swzeda, L. I., Rosenberg, P. A., Volpe, J. J., & Kinney, H. C. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.5.441 · Cited by 454 · see citing works
DNA Damage Induced by Peroxynitrite: Subsequent Biological Effects
Szabó, C., & Ohshima, H. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0143 · Cited by 444 · see citing works
Mechanisms of sepsis-induced organ dysfunction
Abraham, E. H., & Singer, M. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000282072.56245.91 · Cited by 442 · see citing works
Saugstad, O. D. (1988) · Pediatric Research · doi:10.1203/00006450-198802000-00001 · Cited by 418 · see citing works
Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall
Rao, R. M., Yang, L., García‐Cardeña, G., & Luscinskas, F. W. (2007) · Circulation Research · doi:10.1161/circresaha.107.151860b · Cited by 391 · see citing works
Panacek, E. A., Marshall, J. C., Albertson, T. E., Johnson, D. H., Johnson, S. B., MacArthur, R. D., Miller, M. J., Barchuk, W., Fischkoff, S. A., Kaul, M., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000145229.59014.6c · Cited by 385 · see citing works
Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
Inoue, S., & Kawanishi, S. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00873-8 · Cited by 366 · see citing works
Oxidative Stress in the Newborn – A 30-Year Perspective
Saugstad, O. D. (2005) · Neonatology · doi:10.1159/000087586 · Cited by 356 · see citing works
Szabó, C., Cuzzocrea, S., Zingarelli, B., O’Connor, M. P., & Salzman, A. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119585 · Cited by 354 · see citing works
Bronchopulmonary dysplasia—oxidative stress and antioxidants
Saugstad, O. D. (2003) · Seminars in Neonatology · doi:10.1016/s1084-2756(02)00194-x · Cited by 339 · see citing works
Cardiovascular diseases: protective effects of melatonin
Tengattini, S., Reiter, R. J., Tan, D., Terrón, M. P., Rodella, L. F., & Rezzani, R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00518.x · Cited by 337 · see citing works
Self-citationDarlow, B. A., Graham, P. J., & Rojas, M. X. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000501.pub4 · Cited by 334 · see citing works
Melatonin and mitochondrial function
León, J., Acuña-Castroviejo, D., Sainz, R. M., Mayo, J. C., Tan, D., & Reiter, R. J. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.03.003 · Cited by 331 · see citing works
Self-citationTan, D., Manchester, L. C., Reiter, R. J., Plummer, B. F., Hardies, L. J., Weintraub, S. T., Vijayalaxmi, V., & Shepherd, A. M. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9826 · Cited by 319 · see citing works
Self-citationMelatonin, endocrine pancreas and diabetes
Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00519.x · Cited by 309 · see citing works
Melatonin: Lowering the High Price of Free Radicals
Reiter, R. J. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.5.246 · Cited by 305 · see citing works
Self-citationVitamin E supplementation for prevention of morbidity and mortality in preterm infants
Brion, L. P., Bell, E. F., & Raghuveer, T. S. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003665 · Cited by 304 · see citing works
The Effect of Maternal Milk on Neonatal Morbidity of Very Low-Birth-Weight Infants
Furman, L., Taylor, G. H., Minich, N. M., & Hack, M. (2003) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.157.1.66 · Cited by 301 · see citing works
Invasive Cytotrophoblasts Manifest Evidence of Oxidative Stress in Preeclampsia
Many, A., Hubel, C. A., Fisher, S. J., Roberts, J. M., & Zhou, Y. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64733-5 · Cited by 278 · see citing works
Causes of Oxidative Stress in the Pre- and Perinatal Period
Gitto, E., Reiter, R. J., Karbownik‐Lewińska, M., Tan, D., Gitto, P., Barberi, S., & Barberi, I. (2002) · Neonatology · doi:10.1159/000051527 · Cited by 272 · see citing works
Self-citationDNA Damage and Oxidation of Thiols Peroxynitrite Causes in Rat Thymocytes
Salgo, M. G., Bermúdez, E., Squadrito, G. L., & PRYOR, W. A. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1493 · Cited by 268 · see citing works
Jahnke, G. D. (1999) · Toxicological Sciences · doi:10.1093/toxsci/50.2.271 · Cited by 266 · see citing works
Davis, J. M., Parad, R. B., Michele, T. M., Allred, E. N., Price, A. P., Rosenfeld, W., & for the North American Recombinant Human CuZnSOD Study Group (2003) · PEDIATRICS · doi:10.1542/peds.111.3.469 · Cited by 265 · see citing works
Antioxidant status in patients with acute respiratory distress syndrome
Metnitz, P., Bartens, C., Fischer, M., Fridrich, P., Steltzer, H., & Druml, W. (1999) · Intensive Care Medicine · doi:10.1007/s001340050813 · Cited by 263 · see citing works
Fulia, F., Gitto, E., Cuzzocrea, S., Reiter, R. J., Dugo, L., Gitto, P., Barberi, S., Cordaro, S., & Barberi, I. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.310409.x · Cited by 261 · see citing works
Self-citationJou, M., Peng, T.-I., Yu, P., Jou, S., Reiter, R. J., Chen, J., WU, H., Chen, C., & Hsu, L. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00490.x · Cited by 258 · see citing works
Self-citationWang, Y., & Walsh, S. W. (1996) · Journal of the Society for Gynecologic Investigation · doi:10.1177/107155769600300404 · Cited by 253 · see citing works
Tan, D. X., Manchester, L. C., Burkhardt, S., Sainz, R. M., Mayo, J. C., Kohen, R., Shohami, E., Huo, Y., Hardeland, R., & Reiter, R. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0309fje · Cited by 253 · see citing works
Self-citationNuclear Factor–κB and Its Role in Sepsis‐Associated Organ Failure
Abraham, E. H. (2003) · The Journal of Infectious Diseases · doi:10.1086/374750 · Cited by 235 · see citing works
Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease
Saugstad, O. D. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb13880.x · Cited by 234 · see citing works
Placental isoprostane is significantly increased in preeclampsia
Walsh, S. W. (2000) · The FASEB Journal · doi:10.1096/fj.14.10.1289 · Cited by 234 · see citing works
Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension
Wisdom, S., Wilson, R., McKillop, J. H., & Walker, J. J. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90018-m · Cited by 228 · see citing works
Darlow, B. A., & Graham, P. J. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000501.pub2 · Cited by 228 · see citing works
Development of melatonin production in infants and the impact of prematurity.
Kennaway, D. J., Stamp, G. E., & Goble, F. C. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.2.1639937 · Cited by 223 · see citing works
Manda, K., Ueno, M., & Anzai, K. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00432.x · Cited by 222 · see citing works
The Role of Peroxynitrite in Nitric Oxide-Mediated Toxicity
Crow, J. P., & Beckman, J. S. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79130-7_7 · Cited by 221 · see citing works
Scavenging of reactive oxygen species by melatonin
Zang, L., Cosma, G., Gardner, H. S., et al. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00099-3 · Cited by 217 · see citing works
Mao, G. D., Thomas, P. D., Lopaschuk, G. D., & Poznansky, M. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54167-3 · Cited by 205 · see citing works
Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae
Vanderlelie, J. J., Venardos, K. M., Clifton, V. L., Gude, N. M., Clarke, F. M., & Perkins, A. V. (2004) · Placenta · doi:10.1016/j.placenta.2004.04.002 · Cited by 202 · see citing works
The potential of melatonin in reducing morbidity–mortality after craniocerebral trauma
y Aibar, M. D. M., Murillo-Cabezas, F., Terrón, M. P., Flores, L. J., Tan, D. X., Manchester, L. C., & Reiter, R. J. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00376.x · Cited by 191 · see citing works
Self-citationLipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia
Atamer, Y., Koçyiğit, Y., Yokuş, B., et al. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.06.033 · Cited by 189 · see citing works
Melatonin rhythm in human milk
Illnerová, H., Buresová, M., & Presl, J. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.3.8370707 · Cited by 188 · see citing works
Oxygen radicals as key mediators in neurological disease: Fact or fiction?
Halliwell, B. B. (1992) · Annals of Neurology · doi:10.1002/ana.410320704 · Cited by 186 · see citing works
Vitamin A supplementation for preventing morbidity and mortality in very low birthweight infants
Darlow, B., & Graham, P. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000501 · Cited by 185 · see citing works
Johnson, L. H., Bowen, F. W., Abbasi, S., Herrmann, N., Weston, M., Sacks, L. M., Porat, R., Stahl, G. E., Peckham, G. J., Delivoria‐Papadopoulos, M., et al. (1985) · PEDIATRICS · doi:10.1542/peds.75.4.619 · Cited by 183 · see citing works
The Role of Placental Oxidative Stress and Lipid Peroxidation in Preeclampsia
Gupta, S., Agarwal, A. K., & Sharma, R. K. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000193879.79268.59 · Cited by 176 · see citing works
Ferrali, M., Signorini, C., Ciccoli, L., et al. (1992) · Biochemical Journal · doi:10.1042/bj2850295 · Cited by 175 · see citing works
Melatonin reduces oxidative stress in surgical neonates
Gitto, E., Romeo, C., Reiter, R. J., Impellizzeri, P., Pesce, S., Basile, M., Antonuccio, P., Trimarchi, G. R., Gentile, C., Barberi, I., et al. (2004) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2003.10.003 · Cited by 172 · see citing works
Self-citationLamb, N. J., Gutteridge, J. M. C., Baker, C., Evans, T. W., & Quinlan, G. J. (1999) · Critical Care Medicine · doi:10.1097/00003246-199909000-00007 · Cited by 168 · see citing works
Microvascular Dysfunction in Sepsis
Lush, C. W., & Kvietys, P. R. (2000) · Microcirculation · doi:10.1038/sj.mn.7300096 · Cited by 166 · see citing works
Gitto, E., Reiter, R. J., Cordaro, S., et al. (2004) · American Journal of Perinatology · doi:10.1055/s-2004-828610 · Cited by 163 · see citing works
Self-citationLipid peroxidation and antioxidants in normal and pre-eclamptic pregnancies
Poranena, A.-K., Ekblad, U., Uotila, P. J., & Ahotupa, M. O. (1996) · Placenta · doi:10.1016/s0143-4004(96)90021-1 · Cited by 162 · see citing works
Walsh, S. W., & Wang, Y. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90418-i · Cited by 162 · see citing works
Melatonin as a hydroxyl radical scavenger
Stasica, P., Ulański, P., & Rosiak, J. M. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00387.x · Cited by 161 · see citing works
Selenium supplementation to prevent short-term morbidity in preterm neonates
Darlow, B. A., & Austin, N. C. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003312 · Cited by 150 · see citing works
Miller, S., Yan, E. B., Castillo-Meléndez, M., Jenkin, G., & Walker, D. W. (2005) · Developmental Neuroscience · doi:10.1159/000085993 · Cited by 149 · see citing works
Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis
Kurt, A. N. Ç., Aygün, A. D., Gödekmerdan, A., Kurt, A., Doğan, Y., & Yılmaz, E. (2007) · Mediators of Inflammation · doi:10.1155/2007/31397 · Cited by 146 · see citing works
Secretion of lipid peroxides by the human placenta
Walsh, S. W., & Wang, Y. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90419-j · Cited by 144 · see citing works
Gitto, E., Reiter, R. J., Sabatino, G., et al. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00251.x · Cited by 144 · see citing works
Self-citationRosenfeld, W., Evans, H. E., Concepcion, L., Jhaveri, R., Schaeffer, H. A., & Friedman, A. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80307-8 · Cited by 143 · see citing works
Plasma 3-Nitrotyrosine Is Elevated in Premature Infants Who Develop Bronchopulmonary Dysplasia
Banks, B. A., Ischiropoulos, H., McClelland, M., Ballard, P. L., & Ballard, R. A. (1998) · PEDIATRICS · doi:10.1542/peds.101.5.870 · Cited by 142 · see citing works
Gitto, E., Reiter, R. J., Amodio, A., Romeo, C., Cuzzocrea, E., Sabatino, G., Buonocore, G., Cordaro, V., Trimarchi, G. R., & Barberi, I. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00124.x · Cited by 139 · see citing works
Self-citationWalsh, S. W., & Wang, Y. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.6.7775637 · Cited by 136 · see citing works
ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space
Basit, A., Reutershan, J., Morris, M. A., Solga, M. D., Rose, C. E., & Ley, K. F. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00346.2005 · Cited by 134 · see citing works
Wardle, S. P., Hughes, A., Chen, S., & Shaw, N. J. (2001) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.84.1.f9 · Cited by 130 · see citing works
Davis, J. M., Rosenfeld, W., Richter, S. E., Parad, R. B., Gewolb, I. H., Spitzer, A. R., Carlo, W. A., Couser, R. J., Price, A. P., Flaster, E. R., et al. (1997) · PEDIATRICS · doi:10.1542/peds.100.1.24 · Cited by 129 · see citing works
Lung growth: implications for the newborn infant
Kotecha, S. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.82.1.f69 · Cited by 129 · see citing works
Factors influencing the development of melatonin rhythmicity in humans.
Kennaway, D. J., Goble, F. C., & Stamp, G. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636362 · Cited by 128 · see citing works
Rodríguez, M. I., Escames, G., López, L. C., López, A., García, J. A. G., Ortiz, F., & Acuña-Castroviejo, D. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00416.x · Cited by 127 · see citing works
Berger, R. E., & Garnier, Y. (2000) · Journal of Perinatal Medicine · doi:10.1515/jpm.2000.034 · Cited by 124 · see citing works
The development of circadian rhythms in the fetus and neonate
Serón‐Ferré, M., Torres‐Farfan, C., Forcelledo, M. L., & Valenzuela, G. J. (2001) · Seminars in Perinatology · doi:10.1053/sper.2001.29037 · Cited by 121 · see citing works
Phelps, D. T., Ferro, T. J., Higgins, P. J., et al. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.269.4.l551 · Cited by 116 · see citing works
Melatonin is an efficient antioxidant
Pieri, C., Moroni, F., Marra, M., et al. (1995) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(94)00593-v · Cited by 115 · see citing works
Placental isoprostane is significantly increased in preeclampsia
Walsh, S. W., Vaughan, J. E., Wang, Y., et al. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1289 · Cited by 114 · see citing works
Antioxidants as Therapy in the Newborn: Some Words of Caution
Jankov, R. P., Negus, A., & Tanswell, A. K. (2001) · Pediatric Research · doi:10.1203/00006450-200112000-00009 · Cited by 109 · see citing works
OXIDATIVE STRESS AND PULMONARY INFLAMMATION: PHARMACOLOGICAL INTERVENTION WITH ANTIOXIDANTS
Morcillo, E. J., Estrela, J. M., & Cortijo, J. (1999) · Pharmacological Research · doi:10.1006/phrs.1999.0549 · Cited by 108 · see citing works
Cerebral energy metabolism during hypoxia-ischemia and early recovery in immature rats
Yager, J. Y., Brucklacher, R. M., & Vannucci, R. C. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.3.h672 · Cited by 108 · see citing works
Juánez, J. C., Valero, V., Sánchez, J. C., Rivero, M., Parvez, H. S., Rodríguez, A. B., & Barriga, C. (2005) · PubMed · Cited by 107 · see citing works
Breastfeeding of Very Low Birth Weight Infants
Furman, L., Minich, N. M., & Hack, M. (1998) · Journal of Human Lactation · doi:10.1177/089033449801400112 · Cited by 106 · see citing works
The Importance of Superoxide in Nitric Oxide-Dependent Toxicity
Crow, J. P., & Beckman, J. S. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-9480-9_21 · Cited by 105 · see citing works
Oxidative stress and antioxidant protection in the perinatal period
Shoji, H., & Koletzko, B. V. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3280a94f6d · Cited by 105 · see citing works
Molecular mechanisms of leukocyte recruitment: organ-specific mechanisms of action
Kubes, P., & Liu, L. (2003) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613434 · Cited by 104 · see citing works
The effect of vitamin E prophylaxis on the incidence and severity of bronchopulmonary dysplasia
Behrman, R. E., Saldanha, R. L., Cepeda, E. E., et al. (1982) · The Journal of Pediatrics · doi:10.1016/s0022-3476(82)80193-5 · Cited by 104 · see citing works
Leucocyte-Endothelial Interactions in Health and Disease
Ley, K. F., & Reutershan, J. (2006) · Springer eBooks · doi:10.1007/3-540-36028-x_4 · Cited by 100 · see citing works
Hardeland, R., Backhaus, C., & Fadavi, A. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00489.x · Cited by 100 · see citing works
Characterization of antioxidant activities of pulmonary surfactant mixtures
Matalon, S., Holm, B. A., Baker, R. R., et al. (1990) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(90)90105-6 · Cited by 98 · see citing works
Palmer, C., Brucklacher, R. M., Christensen, M. A., & Vannucci, R. C. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.39 · Cited by 97 · see citing works
Alterations in antioxidant status during neonatal sepsis
Batra, S., Kumar, R., Seema, et al. (2000) · Annals of Tropical Paediatrics · doi:10.1080/02724930092039 · Cited by 96 · see citing works
Nitric oxide, inflammation and acute burn injury
Rawlingson, A. (2003) · Burns · doi:10.1016/s0305-4179(03)00079-2 · Cited by 96 · see citing works
Melatonin involvement in oxidative processes.
Ianăş, O., Olinescu, R. M., & Bădescu, I. (1991) · PubMed · Cited by 95 · see citing works
Chaudhari, T., & McGuire, W. L. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006817.pub2 · Cited by 94 · see citing works
Randomised controlled trial of allopurinol prophylaxis in very preterm infants.
Russell, G. A., & Cooke, R. W. I. (1995) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.73.1.f27 · Cited by 94 · see citing works
Argüelles, S., Machado, M. J., Ayala, A., Machado, A., & Hervías, B. (2006) · Free Radical Research · doi:10.1080/10715760500519834 · Cited by 93 · see citing works
Darlow, B. A., Winterbourn, C. C., Inder, T. E., et al. (2000) · The Journal of Pediatrics · doi:10.1016/s0022-3476(00)90010-6 · Cited by 92 · see citing works
Melatonin and ischemia–reperfusion injury of the brain
Cervantes, M., Moralı́, G., & Letechipía‐Vallejo, G. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00551.x · Cited by 90 · see citing works
Vento, M., Asensi, M. A., Sastre, J., Lloret, A., Garcia-Sala, F., Miñana, J. B., & Viña, J. (2002) · Seminars in Perinatology · doi:10.1053/sper.2002.37312 · Cited by 88 · see citing works
Nature, time-course, and extent of cerebral edema in perinatal hypoxic-ischemic brain damage
Vannucci, R. C., Christensen, M. A., & Yager, J. Y. (1993) · Pediatric Neurology · doi:10.1016/0887-8994(93)90006-x · Cited by 85 · see citing works
Development of melatonin production in infants and the impact of prematurity
Kennaway, D. J. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.2.367 · Cited by 85 · see citing works
Peroxide induces vasoconstriction in the human placenta by stimulating thromboxane
Walsh, S. W., Wang, Y., & Jesse, R. L. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90044-j · Cited by 84 · see citing works
Winterbourn, C. C., Chan, T., Buss, I. H., et al. (2000) · Pediatric Research · doi:10.1203/00006450-200007000-00015 · Cited by 81 · see citing works
Emergence and Evolution of the Circadian Rhythm of Melatonin in Children
Ardura, J., Gutierrez, R., Andrés, J., & Agapito, T. (2003) · Hormone Research in Paediatrics · doi:10.1159/000068571 · Cited by 81 · see citing works
Ogihara, T., Hirano, K., Morinobu, T., et al. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.80.1.f21 · Cited by 81 · see citing works
Clyman, R. I., Saugstad, O. D., & Mauray, F. (1989) · Circulation Research · doi:10.1161/01.res.64.1.1 · Cited by 79 · see citing works
Superoxide dismutase for preventing chronic lung disease in mechanically ventilated preterm infants
Suresh, G., Davis, J. M., & Soll, R. F. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001968 · Cited by 75 · see citing works
Breast-feeding of very low birth weight infants
Bier, J. B., Ferguson, A. E., Anderson, L., Solomon, E., Voltas, C., Oh, W. K., & Vohr, B. R. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80858-3 · Cited by 73 · see citing works
Activated Protein C for Severe Sepsis
Ely, E. W., Bernard, G. R., & Vincent, J. (2002) · New England Journal of Medicine · doi:10.1056/nejm200209263471315 · Cited by 69 · see citing works
Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung
Archer, S. L., PETERSON, D. F., Nelson, D. P., et al. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.1.102 · Cited by 68 · see citing works
Frosali, S., Simplicio, P. D., Perrone, S., et al. (2003) · Neonatology · doi:10.1159/000075814 · Cited by 66 · see citing works
Oxidative stress in the fetal circulation does not depend on mode of delivery
Fogel, I., Pinchuk, I., Kupferminc, M. J., et al. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.10.637 · Cited by 66 · see citing works
Walsh, S. W. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.6.1888 · Cited by 63 · see citing works
Melatonin Production in Healthy Infants: Evidence for Seasonal Variations
Sivan, Y., Laudon, M., Tauman, R., et al. (2001) · Pediatric Research · doi:10.1203/00006450-200101000-00015 · Cited by 61 · see citing works
The injury response in the term newborn brain: can we neuroprotect?
Hamrick, S. E. G., & Ferriero, D. M. (2003) · Current Opinion in Neurology · doi:10.1097/01.wco.0000063775.81810.79 · Cited by 60 · see citing works
Pulmonary oxidant stress in murine sepsis is due to inflammatory cell nitric oxide*
Razavi, H. M., Wang, L., Weicker, S., et al. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000165445.48350.4f · Cited by 60 · see citing works
Lipid peroxidation and antioxidants in erythrocyte membranes of full term and preterm newborns
Huertas, J. R., Palomino, N., Ochoa, J. J., et al. (1998) · BioFactors · doi:10.1002/biof.5520080122 · Cited by 59 · see citing works
Hypoxia-induced free iron release in the red cells of newborn infants
Buonocore, G., Zani, S., Sargentini, I., et al. (1998) · Acta Paediatrica · doi:10.1080/08035259850157912 · Cited by 57 · see citing works
Oxygen radical-induced single-strand DNA breaks and repair of the damage in a cell-free system
Sarker, A. H., Watanabe, S., Seki, S., et al. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(95)00012-9 · Cited by 56 · see citing works
Lung Injury and Surfactant Metabolism after Hyperventilation of Premature Lambs
Ikegami, M., Kallapur, S. G., Michna, J., et al. (2000) · Pediatric Research · doi:10.1203/00006450-200003000-00019 · Cited by 55 · see citing works
Tan, D., Manchester, L. C., Sainz, R. M., Mayo, J. C., León, J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:149 · Cited by 53 · see citing works
Self-citationMuñoz‐Hoyos, A., Bonillo-Perales, A., Ávila-Villegas, R., et al. (2007) · Neonatology · doi:10.1159/000102957 · Cited by 50 · see citing works
Absence of plasma melatonin circadian rhythm during the first 72 hours of life in human infants.
Muñoz‐Hoyos, A., Jaldo-Alba, F., Molina‐Carballo, A., et al. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.3.8370692 · Cited by 48 · see citing works
Buonocore, G., Gioia, D., Filippo, M. D., et al. (1994) · Pediatric Research · doi:10.1203/00006450-199411000-00015 · Cited by 48 · see citing works
Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion.
Li, X., Zhang, L. M., Gu, J., et al. (1997) · PubMed · Cited by 48 · see citing works
PMN transendothelial migration decreases nuclear NFκB in IL-1β–activated endothelial cells
Cepinskas, G., Savickienė, J., Ionescu, C. V., & Kvietys, P. R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212048 · Cited by 47 · see citing works
Factors influencing the development of melatonin rhythmicity in humans
Kennaway, D. J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.4.1525 · Cited by 47 · see citing works
Different Degrees of Fetal Oxidative Stress in Elective and Emergent Cesarean Section
Lurie, S., Matas, Z., Boaz, M., et al. (2007) · Neonatology · doi:10.1159/000100965 · Cited by 45 · see citing works
Melatonin production in infants
Tauman, R., Zisapel, N., Laudon, M., Nehama, H., & Sivan, Y. (2002) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00417-9 · Cited by 45 · see citing works
Janssen-Heininger, Y. M. W., Soultanakis, R. P., Steece, K., Heerdt, E., Singh, R., Joseph, J., & Kalyanaraman, B. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.6.l1100 · Cited by 45 · see citing works
Bhandari, V., Maulik, N., & Kresch, M. J. (2000) · Lung · doi:10.1007/s004080000006 · Cited by 44 · see citing works
The failure of aerosolized superoxide dismutase to modify pulmonary oxygen toxicity.
Crapo, J. D., DeLong, D. M., Sjostrom, K., Hasler, G. R., & Drew, R. T. (1977) · PubMed · doi:10.1164/arrd.1977.115.6.1027 · Cited by 44 · see citing works
Perinatal asphyxia: Timing and mechanisms of injury in neonatal encephalopathy
Scher, M. S. (2001) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-001-0014-x · Cited by 43 · see citing works
Inhaled nitric oxide in acute lung injury and acute respiratory distress syndrome
Dellinger, R. P. (1999) · Intensive Care Medicine · doi:10.1007/s001340050973 · Cited by 40 · see citing works
Muñoz‐Hoyos, A., Rodríguez‐Cabezas, T., Molina‐Carballo, A., et al. (1992) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1992.tb00074.x · Cited by 38 · see citing works
Novel Approaches to the Prevention and Therapy of Neonatal Bacterial Sepsis
Pérez, E. M. R., & Weisman, L. E. (1997) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30193-3 · Cited by 37 · see citing works
Sepsis and Septic Shock: Pro-Inflammatory or Anti-Inflammatory State?
Antonelli, M. M. (1999) · Journal of Chemotherapy · doi:10.1179/joc.1999.11.6.536 · Cited by 36 · see citing works
Serum TNF-alpha and free radical scavengers in neonatal septicemia
Seema, Kumar, R., Mandal, R. N., et al. (1999) · The Indian Journal of Pediatrics · doi:10.1007/bf02727159 · Cited by 35 · see citing works
Sanderud, J., Bjøro, K., & Saugstad, O. D. (1993) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519309092539 · Cited by 35 · see citing works
The impact of fetal size and length of gestation on 6‐sulphatoxymelatonin excretion in adult life
Kennaway, D. J., Flanagan, D., Moore, V., et al. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.300308.x · Cited by 35 · see citing works
Effects of Recombinant Human Activated Protein C in Human Models of Endotoxin Administration
Abraham, E. H. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200501-004ac · Cited by 34 · see citing works
BODA, D., Németh, I., & Pintér, S. (1998) · Neonatology · doi:10.1159/000014035 · Cited by 32 · see citing works
Marro, P. J., Baumgart, S., Delivoria‐Papadopoulos, M., Zirin, S., Corcoran, L., McGaurn, S. P., Davis, L. E., & Clancy, R. R. (1997) · Pediatric Research · doi:10.1203/00006450-199704000-00010 · Cited by 32 · see citing works
Gordon, J. B., Rehorst-Paea, L. A., Hoffman, G. M., et al. (1999) · Pediatric Research · doi:10.1203/00006450-199912000-00013 · Cited by 32 · see citing works
Block, E. R., & Fisher, A. B. (1977) · American Review of Respiratory Disease · doi:10.1164/arrd.1977.116.3.441 · Cited by 29 · see citing works
Development of pre-implantation, mouse embryos under the influence of pineal indoles
Chan, W. Y., & Ng, T. B. (1994) · Journal of Neural Transmission · doi:10.1007/bf01277925 · Cited by 28 · see citing works
Increase in Extracellular Glutathione Peroxidase in Plasma and Lungs of Mice Exposed to Hyperoxia
Kim, K. K., Whitin, J. C., Sukhova, N. M., et al. (1999) · Pediatric Research · doi:10.1203/00006450-199912000-00016 · Cited by 25 · see citing works
Vento, G., Mele, M. C., Mordente, A., et al. (2000) · Acta Paediatrica · doi:10.1111/j.1651-2227.2000.tb01336.x · Cited by 24 · see citing works
Serum malondialdehyde concentration as a measure of oxygen free radical damage in preterm infants
Yiğit, Ş., Yurdakök, M., Kılınç, K., et al. (1998) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.1998.3298 · Cited by 24 · see citing works
Evaluation of oxidative stress markers after vaginal delivery or Caesarean section.
Hracskó, Z., Sáfár, Z., Orvos, H., et al. (2007) · PubMed · Cited by 23 · see citing works
Karp, W. B., & ROBERTSON, A. F. (1986) · Advances in Pediatrics · doi:10.1016/s0065-3101(24)00303-7 · Cited by 22 · see citing works
Mochida, S., Matsura, T., Yamashita, A., Horie, S., Ohata, S., Kusumoto, C., Nishida, T., Minami, Y., Inagaki, Y., Ishibe, Y., et al. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2007016 · Cited by 20 · see citing works
Berger, R. E., GJEDDE, A. H., Heck, J., et al. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63010271.x · Cited by 20 · see citing works
Furman, L., & Minich, N. M. (2004) · Journal of Perinatology · doi:10.1038/sj.jp.7211175 · Cited by 19 · see citing works
Absence of plasma melatonin circadian rhythm during the first 72 hours of life in human infants
Muñoz‐Hoyos, A. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.3.699 · Cited by 19 · see citing works
Enzymatic Activity in Rat Lungs. Some Changes with Exposure to 1 ATM Oxygen
Tierney, D. F., Yang, J., & Ayers, L. N. (1975) · CHEST Journal · doi:10.1378/chest.67.2_supplement.40s · Cited by 17 · see citing works
Superoxide Dismutase and Tolerance to Pulmonary Oxygen Toxicity
Crapo, J. D. (1975) · CHEST Journal · doi:10.1378/chest.67.2_supplement.39s · Cited by 12 · see citing works
Griefahn, B., Blaszkewicz, M., Bröde, P., et al. (2004) · Hormone Research in Paediatrics · doi:10.1159/000080072 · Cited by 8 · see citing works
Intermittent Exposure to 40 Percent Oxygen Prolongs Rat Survival in 100 Percent Oxygen
Paegle, R. D., Bernhard, W., & Turndorf, H. (1977) · Anesthesia & Analgesia · doi:10.1213/00000539-197711000-00020 · Cited by 7 · see citing works
Glucose-6-phosphate dehydrogenase and sepsis: The jury is still out*
Abraham, E. H. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000251493.55098.f5 · Cited by 6 · see citing works
Hypoxia‐induced free iron release in the red cells of newborn infants*
Buonocore, G., Zani, S., Sargentini, I., et al. (1998) · Acta Paediatrica · doi:10.1111/j.1651-2227.1998.tb01390.x · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Wisdom SJ, Wilson R, Mckillop JH, Walker JJ. Antiox- idant systems in normal pregnancy and in pregnancy hyper- tension. Am J Obstet Gynecol 1991; 6:1701-1705.
- Vanderlelie J, Venardos K, Clifton VL et al. Increased biological oxidation and reduced antioxidant enzyme activity in preeclamptic placentae. Placenta 2005; 26:53-58.
- Walsh SW, Wang Y. Trophoblast and placental villous coreproduction of lipid peroxides, thromboxane, and pros- tacyclin in preeclampsia. J Clin Endocrinol Metab 1995; 80:1888-1893.
- Harris ED. Regulation of antioxidant enzymes. FASEB J 1992; 6:2675-2683.
- Huertas JR, Palomino N, Ochoa JJ et al. Lipid peroxida- tion and antioxidant erythrocyte membranes of full-term and preterm newborns. Biofactors 1998; 8:133-137.
- Mao GD, Thomas PD, Lopaschuk GD et al. Superoxide dismutase (SOD)-catalase conjugates. J Biol Chem 1993; 268:416-620.
- Simon L. Protection against toxic effect of sustained hyper- oxia on lung macrophages by superoxide dismutase. Clin Res 1980; 28:432A.
Cited by
Sorted by citations
Autism risk factors: genes, environment, and gene-environment interactions
Chaste, P., & Leboyer, M. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/pchaste · Cited by 807 · see citing works
Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease
Chitimus, D. M., Popescu, M. R., Voiculescu, S. E., Panaitescu, A. M., Pavel, B., Zagrean, L., & Zagrean, A.-M. (2020) · Biomolecules · doi:10.3390/biom10091211 · Cited by 354 · see citing works
Natural and synthetic antioxidants: An updated overview
Augustyniak, A., Bartosz, G., Čipak, A., Duburs, G., Horáková, L., Łuczaj, W., Majekova, M., Odysseos, A. D., Rackova, L., Skrzydlewska, E., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.508495 · Cited by 319 · see citing works
Koziróg, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., & Broncel, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00835.x · Cited by 299 · see citing works
Neurotoxins: Free radical mechanisms and melatonin protection
J. Reiter, R., C. Manchester, L., & Tan, D.-X. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246236 · Cited by 179 · see citing works
Schwertner, A., Conceição dos Santos, C. C., Costa, G. D., Deitos, A., de Souza, A., de Souza, I. C. C., Torres, I. L. S., da Cunha Filho, J. S. L., & Caumo, W. (2013) · Pain · doi:10.1016/j.pain.2013.02.025 · Cited by 155 · see citing works
Parlapani, E., Agakidis, C., Karagiozoglou-Lampoudi, T., Sarafidis, K., Agakidou, E., Athanasiadis, A., & Diamanti, E. (2019) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1399120 · Cited by 45 · see citing works
Rezzani, R., Rodella, L. F., Favero, G., Damiani, G., Paganelli, C., & Reiter, R. J. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12622 · Cited by 31 · see citing works
Self-citation
- Authors
- Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., & Reiter, R. J.
- Affiliations
- University of Messina (IT)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Reiter, Russel J.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2009-01-29
- Volume
- 46
- Issue
- 2
- Pages
- 128-139
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2069866574
- Cited by
- 291
- References
- 183
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 5 · 2020: 12 · 2019: 11 · 2018: 12 · 2017: 16 · 2016: 13 · 2015: 21 · 2014: 24 · 2013: 36 · 2012: 22
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- oxidative stress, neonates, preterm birth, melatonin, reactive oxygen species, lipid peroxidation, antioxidant therapy, neonatal asphyxia, respiratory distress syndrome, neonatal sepsis, superoxide dismutase, ceruloplasmin, vitamin E, pregnancy, preeclampsia, placenta
- MeSH terms
- Animals, Asphyxia Neonatorum, Clinical Trials as Topic, Female, Humans, Infant, Newborn, Infant, Premature, Melatonin, Placenta, Pre-Eclampsia, Pregnancy, Respiratory Distress Syndrome, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress, Sepsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
