The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer
Open accessAbstract
Abstract: Histone deacetylases (HDAC) have been under intense scientific investigation for a number of years. However, only recently the unique class III HDAC, sirtuins, have gained increasing investigational momentum. Originally linked to longevity in yeast, sirtuins and more specifically, SIRT1 have been implicated in numerous biological processes having both protective and/or detrimental effects. SIRT1 appears to play a critical role in the process of carcinogenesis, especially in age‐related neoplasms. Similarly, alterations in circadian rhythms as well as production of the pineal hormone melatonin have been linked to aging and cancer risk. Melatonin has been found act as a differentiating agent in some cancer cells and to lower their invasive and metastatic status. In addition, melatonin synthesis and release occurs in a circadian rhythm fashion and it has been linked to the core circadian machinery genes (Clock, Bmal1, Periods, and Cryptochromes). Melatonin has also been associated with chronotherapy, the timely administration of chemotherapy agents to optimize trends in biological cycles. Interestingly, a recent set of studies have linked SIRT1 to the circadian rhythm machinery through direct deacetylation activity as well as through the nicotinamide adenine dinucleotide (NAD+) salvage pathway. In this review, we provide evidence for a possible connection between sirtuins, melatonin, and the circadian rhythm circuitry and their implications in aging, chronomodulation, and cancer.
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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
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Melatonin: Nature’s most versatile biological signal?
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The circadian clock: pacemaker and tumour suppressor
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Sirtuins in aging and age-related disease
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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
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Cross‐Talk between Aging and Cancer: The Epigenetic Language
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Cited by
Melatonin—A pleiotropic, orchestrating regulator molecule
Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843
Melatonin membrane receptors in peripheral tissues: Distribution and functions
Slominski, R. M., Reiter, R. J., Schlabritz-Loutsevitch, N., Ostrom, R. S., & Slominski, A. T. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.01.004 · Cited by 675
Self-citationWang, P., Yin, L., Liang, D., Li, C., Ma, F., & Yue, Z. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00966.x · Cited by 458
Melatonin and inflammation-Story of a double-edged blade
Hardeland, R. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12525 · Cited by 455
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
Galano, A., & Reiter, R. J. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12514 · Cited by 353
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Metadata
- Authors
- Jung‐Hynes, B., Reiter, R. J., & Ahmad, N.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2009-12-04
- Volume
- 48
- Issue
- 1
- Pages
- 9-19
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2083784822
- Cited by
- 233
- References
- 12
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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