The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer
Abstract
BACKGROUNDS: Oral squamous cell carcinoma (OSCC) is a worldwide disease. MicroRNAs are endogenously expressed non-coding RNAs that have important biological and pathological functions. miR-31 was found markedly up-regulated in OSCC and several other malignancies. However, miR-31 expression was also down-regulated in the metastasis process of breast carcinoma. MATERIALS AND METHODS: Using quantitative RT-PCR analysis, we identified plasma miR-31 in OSCC patients (n = 43) and case controlled individuals (n = 21). Nine OSCC patients saliva were also analyzed. The Mann-Whitney test and Wilcoxon matched pairs test were used to compare the differences among the various clinical variants. RESULTS: miR-31 in plasma was significantly elevated in OSCC patients relative to age and sex-matched control individuals. This marker yielded a receiver operating characteristic curve area of 0.82 and an accuracy of 0.72 defined by leave-one-out cross-validation. In addition, the plasma miR-31 in patients was remarkably reduced after tumor resection suggesting that this marker is tumor associated. Our preliminary analysis also demonstrated the feasibility of detecting the increase of miR-31 in patient's saliva. CONCLUSION: This study concluded that plasma miR-31 could be validated a marker of OSCC for diagnostic uses.
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1 retracted
RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
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MicroRNAs: Target Recognition and Regulatory Functions
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Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
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Serum MicroRNAs Are Promising Novel Biomarkers
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Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection
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Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
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Cited by
Oral squamous cell carcinomas: state of the field and emerging directions
Tan, Y., Wang, Z., Xu, M., Li, B., Huang, Z., Qin, S., Nice, E. C., Tang, J., & Huang, C. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00249-w · Cited by 831
Extracellular microRNA: A new source of biomarkers
Etheridge, A., Lee, I., Hood, L., Galas, D., & Wang, K. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.03.004 · Cited by 659
Plasma HULC as a Promising Novel Biomarker for the Detection of Hepatocellular Carcinoma
Xie, H., Ma, H., & Zhou, D. (2013) · BioMed Research International · doi:10.1155/2013/136106 · Cited by 290
Metadata
- Authors
- Liu, C.-J., Kao, S.-Y., Tu, H.-F., Tsai, M.-M., Chang, K.-W., & Lin, S.-C.
- Venue
- Oral Diseases
- Publisher
- Wiley
- Published
- 2010-05
- Volume
- 16
- Issue
- 4
- Pages
- 360-364
- ISSN
- 1354-523X (ISSN-L)
- 1601-0825
- OpenAlex
- W1997870435
- Cited by
- 268
- References
- 28
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, C.-J., Kao, S.-Y., Tu, H.-F., Tsai, M.-M., Chang, K.-W., & Lin, S.-C. (2010). Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. Oral Diseases. https://doi.org/10.1111/j.1601-0825.2009.01646.x
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