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The role of oxytocin and oxytocin receptor gene variants in childhood‐onset aggression
Abstract
Aggressive antisocial behaviours are the most common reasons why adolescents are referred to mental health clinics. Antisocial behaviours are costly in social and financial terms. The aetiology of aggressive behaviours is unknown but growing evidence suggests it is heritable, and certain genetic variants have been implicated as contributing factors. The purpose of this study was to determine whether genes regulating the hormone oxytocin (OXT) were associated with aggressive antisocial behaviour. The case‐control study sample consisted of 160 cases of children displaying extreme, persistent and pervasive aggressive behaviour. This case sample was compared with 160 adult controls. We used polymerase chain reaction (PCR) to determine the genotype for three oxytocin gene (OXT) single nucleotide polymorphisms (SNPs): rs3761248, rs4813625 and rs877172; and five oxytocin receptor gene (OXTR) SNPs: rs6770632, rs11476, rs1042778, rs237902 and rs53576. Genotypic analyses were performed using stata, while differences in haplotypic and allelic frequencies were analysed using Unphased. We also performed within‐case analyses (n = 236 aggressive cases) examining genotypic and allelic associations with callous‐unemotional (CU) scores (as measured by the psychopathic screening device). OXTR SNPs rs6770632 and rs1042778 may be associated with extreme, persistent and pervasive aggressive behaviours in females and males, respectively. These and haplotype results suggest gender‐specific effects of SNPs. No significant differences were detected with respect to CU behaviours. These results may help to elucidate the biochemical pathways associated with aggressive behaviours, which may aid in the development of novel medications.
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“C allele for OXTR rs1042778 was over-represented in the male aggressive cases (P = 0.016) compared to male adult controls”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Malik [159]
In the citing paper
“haplotype consisting of OXTR rs1042778 allele C and OXTR rs53576 allele T was over-represented in male aggressive cases vs. controls (window P = 0.036, specific P = 0.016, OR = 2.5)”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Malik [159]
In the citing paper
“haplotype consisting of OXTR rs1042778 allele C and OXTR rs6770632 allele G was over-represented in male aggressive cases vs. controls (window P = 0.032, specific P = 0.0024, OR = 1.9)”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Malik [159]
In the citing paper
“similar findings in Caucasian subsample”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Malik [159]
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Metadata
- Authors
- Malik, A. I., Zai, C. C., Abu, Z., Nowrouzi, B., & Beitchman, J. H.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Beitchman, J. H.
- ORCID
- Zai, C. C.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2012-03-23
- Volume
- 11
- Issue
- 5
- Pages
- 545-551
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W1964979302
- Cited by
- 128
- References
- 45
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 14 · 2019: 5 · 2018: 12 · 2017: 15 · 2016: 10 · 2015: 12 · 2014: 17 · 2013: 17 · 2012: 3
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, oxytocin receptor, antisocial behavior, callous-unemotional traits, single nucleotide polymorphisms, haplotypes, sex differences, genetic susceptibility
- MeSH terms
- Adolescent, Adult, Aggression, Alleles, Child, Child Behavior Disorders, Female, Gene Frequency, Genotype, Haplotypes, Humans, Male, Oxytocin, Sex Characteristics, Case-Control Studies, Receptors, Oxytocin, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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