Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder
Open accessAbstract
Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, communication, and behavioral flexibility. Several lines of evidence indicate that oxytocin, signaling through its receptor (OXTR), is important in a wide range of social behaviors. In attempts to determine whether genetic variations in the oxytocin signaling system contribute to ASD susceptibility, seven recent reports indicated association of common genetic polymorphisms in the OXTR gene with ASD. Each involved relatively small sample sizes (57 to 436 families) and, where it was examined, failed to identify association of OXTR polymorphisms with measures of social behavior in individuals with ASD. We report genetic association analysis of 25 markers spanning the OXTR locus in 1,238 pedigrees including 2,333 individuals with ASD. Association of three markers previously implicated in ASD susceptibility, rs2268493 (P = 0.043), rs1042778 (P = 0.037), and rs7632287 (P = 0.016), was observed. Further, these genetic markers were associated with multiple core ASD phenotypes, including social domain dysfunction, measured by standardized instruments used to diagnose and describe ASD. The data suggest association of OXTR genetic polymorphisms with ASD, although the results should be interpreted with caution because none of the significant associations would survive appropriate correction for multiple comparisons. However, the current findings of association in a large independent cohort are consistent with previous results, and the biological plausibility of participation of the oxytocin signaling system in modulating social disruptions characteristic of ASD, suggest that functional polymorphisms of OXTR may contribute to ASD risk in a subset of families.
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Polymorphisms in the human OXTR gene are significantly associated with an ASD diagnosis and/or predict the severity of ASD.
“many of these genetic studies have found that polymorphisms in the human OXT receptor (OXTR) gene are significantly associated with an ASD diagnosis and/or predict the severity of ASD4–12.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [9]
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Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Glessner, J. T., Wang, K., Cai, G., Korvatska, O., Kim, C. E., Wood, S., Zhang, H., Estes, A., Brune, C. W., Bradfield, J. P., et al. (2009) · Nature · doi:10.1038/nature07953 · Cited by 1,421 · see citing works
Self-citationOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989 · see citing works
Self-citationIntranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841 · see citing works
Oxytocin increases generosity in humans
Zak, P. J., Stanton, A. A., & Ahmadi, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001128 · Cited by 831 · see citing works
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 1× · see citing works
“…enhanced functions relevant to social behavior following oxytocin application in healthy adults (Heinrichs et al. 2003; Kosfeld et al. 2005; Rimmele et al. 2009; Zak et al. 2007; Domes et al. 2007a; Domes et al. 2007b; Guastella et al. 2008a; Guastella et al. 2008b; Hurlemann et al. 2010).”
BackgroundInfluentialOxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771 · see citing works
Horvath, S., Xu, X. P., & Laird, N. M. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200625 · Cited by 739 · see citing works
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
A Genomic Screen of Autism: Evidence for a Multilocus Etiology
Risch, N., Spiker, D., Lotspeich, L., Nouri, N., Hinds, D., Hallmayer, J., Kalaydjieva, L., McCague, P., Dimiceli, S., Pitts, T., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302497 · Cited by 684 · see citing works
A genome-wide linkage and association scan reveals novel loci for autism
The Gene Discovery Project of Johns Hopkins & the Autism Consortium, Weiss, L. A., & Arking, D. E. (2009) · Nature · doi:10.1038/nature08490 · Cited by 619 · see citing works
A genome-wide scan for common alleles affecting risk for autism
Anney, R., Klei, L., Pinto, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., Sykes, N., Pagnamenta, A. T., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq307 · Cited by 593 · see citing works
Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
Gregory, S. G., Connelly, J. J., Towers, A. J., Johnson, J., Biscocho, D., Markunas, C. A., Lintas, C., Abramson, R. K., Wright, H. H., Ellis, P., et al. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-62 · Cited by 576 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Bailey, A. J., Amaia Hervas, G., Matthews, N., Palferman, S., Wallace, S., Aubin, A., Michelotti, J., Wainhouse, C., Papanikolaou, Κ., Rutter, M. L., et al. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.3.571 · Cited by 537 · see citing works
Characteristics and Concordance of Autism Spectrum Disorders Among 277 Twin Pairs
Rosenberg, R. E., Law, J. K., Yenokyan, G., McGready, J., Kaufmann, W. E., & Law, P. A. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.98 · Cited by 495 · see citing works
Williams, J. R., Insel, T. R., Harbaugh, C. R., & Carter, C. S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00579.x · Cited by 483 · see citing works
Genome-Wide Scan for Autism Susceptibility Genes
Philippe, A., Martinez, M., Guilloud-Bataille, M., Gillberg, C., Rastam, M., Sponheim, E., Coleman, M., Zappella, M., Aschauer, H., Van Maldergem, L., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.805 · Cited by 471 · see citing works
A Genomewide Screen for Autism: Strong Evidence for Linkage to Chromosomes 2q, 7q, and 16p
(2001) · The American Journal of Human Genetics · doi:10.1086/323264 · Cited by 453 · see citing works
A Broader Phenotype of Autism: The Clinical Spectrum in Twins
Couteur, A. S. L., Bailey, A. J., Goode, S., Pickles, A. R., Gottesman, I. I., Robertson, S., & Rutter, M. L. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01475.x · Cited by 442 · see citing works
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425 · see citing works
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · see citing works
Oxytocin Makes a Face in Memory Familiar
Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4260-08.2009 · Cited by 402 · see citing works
A genetic variant that disrupts <i>MET</i> transcription is associated with autism
Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., Elia, M., Schneider, C., Melmed, R., Sacco, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605296103 · Cited by 401 · see citing works
Self-citationGenetic influences and infantile autism
FOLSTEIN, S., & RUTTER, M. (1977) · Nature · doi:10.1038/265726a0 · Cited by 400 · see citing works
Horvath, S., Xu, X. P., Lake, S. L., Silverman, E. K., Weiss, S. T., & Laird, N. M. (2003) · Genetic Epidemiology · doi:10.1002/gepi.10295 · Cited by 391 · see citing works
Concordance for the syndrome of autism in 40 pairs of afflicted twins
(1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.1.74 · Cited by 378 · see citing works
Intracerebroventricular oxytocin stimulates maternal behaviour in the sheep
Kendrick, K. M., Keverne, E. B., & Baldwin, B. A. (2008) · Neuroendocrinology · doi:10.1159/000124796 · Cited by 373 · see citing works
Oxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352 · see citing works
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349 · see citing works
Sullivan, P. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.010 · Cited by 335 · see citing works
Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., Herrmann, F. H., Kroemer, H., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.004 · Cited by 271 · see citing works
A Genomewide Screen of 345 Families for Autism-Susceptibility Loci
Yonan, A. L., Alarcón, M., Cheng, R., Magnusson, P. K. E., Spence, S. J., Palmer, A. A., Grunn, A., Juo, S. H., Terwilliger, J. D., Liu, J., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/378778 · Cited by 266 · see citing works
Liu, X., Kawamura, Y., Shimada, T., Otowa, T., Koishi, S., Sugiyama, T., Nishida, H., Hashimoto, O., Nakagami, R., Tochigi, M., et al. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2009.140 · Cited by 195 · see citing works
Arginine Vasopressin and Oxytocin Modulate Human Social Behavior
Ebstein, R. P., Israel, S., Lerer, E., Uzefovsky, F., Shalev, I., Gritsenko, I., Riebold, M., Salomon, S., & Yirmiya, N. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04541.x · Cited by 194 · see citing works
Jansen, L. M. C., Gispen-de Wied, C. C., Wiegant, V. M., Westenberg, H. G. M., Lahuis, B. E., & van Engeland, H. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0124-z · Cited by 177 · see citing works
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172 · see citing works
Wermter, A., Kamp‐Becker, I., Hesse, P., Schulte‐Körne, G., Strauch, K., & Remschmidt, H. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31032 · Cited by 163 · see citing works
Campbell, D. B., Li, C., Sutcliffe, J. S., Persico, A. M., & Levitt, P. (2008) · Autism Research · doi:10.1002/aur.27 · Cited by 154 · see citing works
Self-citationWILLIAMS, J. R., CARTER, C. S., & INSEL, T. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34393.x · Cited by 147 · see citing works
Early speech and language development in children with velocardiofacial syndrome
Scherer, N. J., DʼAntonio, L. L., & Kalbfleisch, J. H. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19991215)88:6 · Cited by 145 · see citing works
Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families
Ylisaukko‐oja, T., Alarcón, M., Cantor, R. M., Auranen, M., Vanhala, R., Kempas, E., von Wendt, L., Järvelä, I. E., Geschwind, D. H., & Peltonen, L. (2005) · Annals of Neurology · doi:10.1002/ana.20722 · Cited by 136 · see citing works
Ontogeny of oxytocin receptors in rat forebrain: A quantitative study
Shapiro, L. E., & Insel, T. R. (1989) · Synapse · doi:10.1002/syn.890040312 · Cited by 131 · see citing works
Developmental course of autistic social impairment in males
Constantino, J. N., Abbacchi, A. M., LaVesser, P., Reed, H., Givens, L., Chiang, L., Gray, T., Gross, M. M., Zhang, Y., & Todd, R. D. (2009) · Development and Psychopathology · doi:10.1017/s095457940900008x · Cited by 121 · see citing works
Exploratory and confirmatory factor analysis of the Autism Diagnostic Interview—revised
Frazier, T. W., Youngstrom, E. A., Kubu, C. S., Sinclair, L., & Rezai, A. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0415-z · Cited by 116 · see citing works
Genetic influences on the broad spectrum of autism: Study of proband‐ascertained twins
Taniai, H., Nishiyama, T., Miyachi, T., Imaeda, M., & Sumi, S. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30740 · Cited by 110 · see citing works
Tansey, K. E., Brookes, K. J., Hill, M., Cochrane, L. E., Gill, M., Skuse, D., Correia, C., Vicente, A. M., Kent, L., Gallagher, L., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.035 · Cited by 102 · see citing works
Snijdewint, F. G. M., van Leeuwen, F. W. B., & Gj, B. (1989) · PubMed · Cited by 56 · see citing works
Campbell, D. B., Warren, D. E., Sutcliffe, J. S., Lee, E. B., & Levitt, P. R. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30998 · Cited by 48 · see citing works
Self-citationHammock, E. A. D., & Levitt, P. R. (2006) · Human Development · doi:10.1159/000095581 · Cited by 46 · see citing works
Self-citationThompson, B. L., & Levitt, P. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.010 · Cited by 27 · see citing works
Self-citationWang (1997) · doi:10.1002/(sici)1098-2396(199709)27:1
Flagged first, then by citations
1 of the 62 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“VP and OT systems have been implicated in sex-biased psychiatric disorders of social dysfunction, such as autism spectrum disorder and schizophrenia(Green et al., 2001; Wu et al., 2005; Jacob et al., 2007; Campbell et al., 2011; Miller et al., 2013; Di Napoli et al., 2014; Golimbet et al., 2014; Jobst et al., 2014).”
BackgroundThe impact of atypical sensory processing on social impairments in autism spectrum disorder
Thye, M. D., Bednarz, H. M., Herringshaw, A. J., Sartin, E. B., & Kana, R. K. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.04.010 · Cited by 513 · see citing works
“…and alterations in: the gene that encodes the oxytocin receptor, OXTR, (Ebstein et al., 2009; Hammock and Levitt, 2006), in oxytocin receptors (Campbell et al., 2011; Liu et al., 2010; Skuse et al., 2014; Wermter et al., 2010; Wu et al., 2005), and in epigenetic mechanisms (Gregory et al.,…”
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis
LoParo, D., & Waldman, I. D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.77 · Cited by 343 · see citing works
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283 · see citing works
Cochran, D. M., Fallon, D., Hill, M., & Frazier, J. A. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0b013e3182a75b7d · Cited by 267 · see citing works
Oxytocin receptor gene ( <i>OXTR</i> ) is related to psychological resources
Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K., & Taylor, S. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113137108 · Cited by 262 · see citing works
Nasal oxytocin for social deficits in childhood autism: A randomized controlled trial
Dadds, M. R., MacDonald, E., Cauchi, A., Williams, K., Levy, F., & Brennan, J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1899-3 · Cited by 250 · see citing works
Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223 · see citing works
Multi-Scale molecular deconstruction of the serotonin neuron system
Okaty, B. W., Freret, M. E., Rood, B. D., Brust, R. D., Hennessy, M. L., deBairos, D., Kim, J. C., Cook, M. N., & Dymecki, S. M. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.007 · Cited by 217 · see citing works
The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218 · see citing works
A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans
Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283643684 · Cited by 217 · see citing works
Variation in the Oxytocin Receptor Gene Is Associated with Pair-Bonding and Social Behavior
Walum, H., Lichtenstein, P., Neiderhiser, J. M., Reiss, D., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Anckarsäter, H., Larsson, H., & Westberg, L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.002 · Cited by 211 · see citing works
Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications
Kohls, G., Chevallier, C., Troiani, V., & Schultz, R. T. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-10 · Cited by 197 · see citing works
Developmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 177 · see citing works
Self-citationSocial attention: a possible early indicator of efficacy in autism clinical trials
Dawson, G., Bernier, R., & Ring, R. H. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-11 · Cited by 181 · see citing works
Smearman, E. L., Almli, L. M., Conneely, K. N., Brody, G. H., Sales, J. M., Bradley, B., Ressler, K. J., & Smith, A. K. (2016) · Child Development · doi:10.1111/cdev.12493 · Cited by 173 · see citing works
Balasco, L., Provenzano, G., & Bozzi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01016 · Cited by 183 · see citing works
Keebaugh, A. C., Barrett, C. E., Laprairie, J. L., Jenkins, J. J., & Young, L. J. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1040893 · Cited by 150 · see citing works
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149 · see citing works
Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Young, W. S., Lee, H., Blanchard, D. C., & Blanchard, R. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.010 · Cited by 139 · see citing works
Intranasal oxytocin increases covert attention to positive social cues
Domes, G., Sibold, M., Schulze, L., Lischke, A., Herpertz, S. C., & Heinrichs, M. (2013) · Psychological Medicine · doi:10.1017/s0033291712002565 · Cited by 130 · see citing works
The role of oxytocin and oxytocin receptor gene variants in childhood‐onset aggression
Malik, A. I., Zai, C. C., Abu, Z., Nowrouzi, B., & Beitchman, J. H. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00776.x · Cited by 128 · see citing works
Montag, C., Brockmann, E.-M., Lehmann, A. I., Müller, D. J., Rujescu, D., & Gallinat, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051882 · Cited by 123 · see citing works
Oxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 122 · see citing works
Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy
Dadds, M. R., Moul, C., Cauchi, A., Dobson‐Stone, C., Hawes, D. J., Brennan, J., Urwin, R., & Ebstein, R. P. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000485 · Cited by 108 · see citing works
Childhood aggression, callous-unemotional traits and oxytocin genes
Beitchman, J. H., Zai, C. C. H., Muir, K. E., Berall, L. E., Nowrouzi‐Kia, B., Choi, E., & Kennedy, J. L. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0240-6 · Cited by 103 · see citing works
Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study
Montag, C., Brockmann, E.-M., Bayerl, M., Rujescu, D., Müller, D. J., & Gallinat, J. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.677547 · Cited by 104 · see citing works
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Francis, S. M., Sagar, A., Levin-Decanini, T., Liu, W., Carter, C. S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.021 · Cited by 101 · see citing works
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 102 · see citing works
Cataldo, I., Azhari, A., & Esposito, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00027 · Cited by 95 · see citing works
Freeman, S. M., Palumbo, M. C., Lawrence, R. H., Smith, A. L., Goodman, M. M., & Bales, K. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0315-3 · Cited by 82 · see citing works
Stavropoulos, K. K. M., & Carver, L. J. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12061 · Cited by 95 · see citing works
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91 · see citing works
“Autism-plus” Spectrum Disorders
Cochran, D., Dvir, Y., & Frazier, J. A. (2013) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2013.04.005 · Cited by 82 · see citing works
Examining Autism Spectrum Disorders by Biomarkers: Example From the Oxytocin and Serotonin Systems
Hammock, E. A. D., Veenstra-VanderWeele, J. M., Yan, Z., Kerr, T. M., Morris, M., Anderson, G. M., Carter, C. S., Cook, E. H., & Jacob, S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.04.010 · Cited by 79 · see citing works
Self-citationZhang, R., Zhang, H.-F., Han, J., & Han, S. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0120-7 · Cited by 78 · see citing works
Is oxytocin a maternal-foetal signalling molecule at birth? Implications for development
Kenkel, W. M., Yee, J. R., & Carter, C. S. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12186 · Cited by 70 · see citing works
Taurines, R., Schwenck, C., Lyttwin, B., Schecklmann, M., Jans, T., Reefschläger, L., Geissler, J. M., Gerlach, M., & Romanos, M. (2014) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0145-y · Cited by 61 · see citing works
ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin—AVPR1A, AVPR1B, and OXTR
Francis, S. M., Kim, S., Kistner‐Griffin, E., Guter, S. J., Cook, E. H., & Jacob, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00516 · Cited by 62 · see citing works
Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome
Di Napoli, A., Warrier, V., Baron-Cohen, S., & Chakrabarti, B. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-48 · Cited by 59 · see citing works
Yamasue, H. (2012) · Brain and Development · doi:10.1016/j.braindev.2012.08.010 · Cited by 57 · see citing works
Butovskaya, P. R., Lazebny, O. E., Sukhodolskaya, E. M., Vasiliev, V. A., Dronova, D. A., Fedenok, J. N., Rosa, A., Peletskaya, E. N., Рысков, А. П., & Butovskaya, M. (2016) · BMC Genetics · doi:10.1186/s12863-015-0323-8 · Cited by 59 · see citing works
Kraaijenvanger, E. J., He, Y., Spencer, H., Smith, A. K., Bos, P. A., & Boks, M. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.016 · Cited by 57 · see citing works
Laursen, H. R., Siebner, H. R., Haren, T., Madsen, K., Grønlund, R., Hulme, O., & Henningsson, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00423 · Cited by 56 · see citing works
Higashida, H., Munesue, T., Kosaka, H., Yamasue, H., Yokoyama, S., & Kikuchi, M. (2019) · Diseases · doi:10.3390/diseases7010024 · Cited by 64 · see citing works
Gemmer, A., Mirkes, K., Anneser, L., Eilers, T., Kibat, C., Mathuru, A., Ryu, S., & Schuman, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-07990-y · Cited by 56 · see citing works
Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez, L. M., Lawrence, K. E., Padgaonkar, N. T., Inada, M., Hoekstra, J. N., Lowe, J. K., Eilbott, J., Jack, A., Aylward, E., Gaab, N., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0750-9 · Cited by 54 · see citing works
Johansson, A., Bergman, H., Corander, J., Waldman, I. D., Karrani, N., Salo, B., Jern, P., Ålgars, M., Sandnabba, K. N., Santtila, P. O., et al. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00744.x · Cited by 54 · see citing works
Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards
Damiano, C. R., Aloi, J. M., Dunlap, K., Burrus, C. J., Mosner, M. G., Kozink, R. V., McLaurin, R. E., Mullette-Gillman, O. A., Carter, R., Huettel, S. A., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-7 · Cited by 54 · see citing works
Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder
Bjørklund, G., Meguid, N. A., El-Ansary, A. K., El‐Bana, M. A., Dadar, M., Aaseth, J., Hemimi, M., Osredkar, J., & Chirumbolo, S. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1192-1 · Cited by 51 · see citing works
Mutant Mouse Models of Autism Spectrum Disorders
Provenzano, G., Zunino, G., Genovesi, S., Sgadó, P., & Bozzi, Y. (2012) · Disease Markers · doi:10.1155/2012/916082 · Cited by 49 · see citing works
The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism
Uzefovsky, F., Bethlehem, R. A. I., Shamay-Tsoory, S., Ruigrok, A., Holt, R., Spencer, M., Chura, L., Warrier, V., Chakrabarti, B., Bullmore, E., et al. (2019) · Molecular Autism · doi:10.1186/s13229-019-0258-4 · Cited by 49 · see citing works
Association between the oxytocin receptor ( OXTR ) gene and children's social cognition at 18 months
Wade, M., Hoffmann, T. J., Wigg, K., & Jenkins, J. M. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12148 · Cited by 47 · see citing works
Kranz, T. M., Kopp, M., Waltes, R., Sachse, M., Duketis, E., Jarczok, T. A., Degenhardt, F., Görgen, K., Meyer, J., Freitag, C. M., et al. (2016) · Autism Research · doi:10.1002/aur.1597 · Cited by 46 · see citing works
Muscatelli, F., Desarménien, M. G., Matarazzo, V. A., & Grinevich, V. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_16 · Cited by 46 · see citing works
Aebi, M., van Donkelaar, M. M. J., Poelmans, G., Buitelaar, J. K., Sonuga-Barke, E. J. S., Stringaris, A. K., Faraone, S. V., Franke, B., Steinhausen, H., & van Hulzen, K. J. E. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32346 · Cited by 45 · see citing works
Hovey, D., Lindstedt, M., Zettergren, A., Jönsson, L., Johansson, A., Melke, J., Kerekes, N., Anckarsäter, H. S., Lichtenstein, P., Lundström, S., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.144 · Cited by 46 · see citing works
Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism
Hernandez, L. M., Krasileva, K., Green, S. A., Sherman, L. E., Ponting, C., McCarron, R., Lowe, J. K., Geschwind, D. H., Bookheimer, S. Y., & Dapretto, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.209 · Cited by 43 · see citing works
Relationship between oxytocin receptor genotype and recognition of facial emotion.
Melchers, M., Montag, C., Markett, S. A., & Reuter, M. (2013) · Behavioral Neuroscience · doi:10.1037/a0033748 · Cited by 41 · see citing works
Davis, M. C., Horan, W. P., Nurmi, E. L., Rizzo, S., Li, W. W., Sugar, C. A., & Green, M. F. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.006 · Cited by 40 · see citing works
Pobbe, R. L. H., Pearson, B. L., Blanchard, D. C., & Blanchard, R. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.024 · Cited by 40 · see citing works
Ma, W.-J., Hashii, M., Munesue, T., Hayashi, K., Yagi, K., Yamagishi, M., Higashida, H., & Yokoyama, S. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-22 · Cited by 42 · see citing works
Nyffeler, J., Walitza, S., Bobrowski, E., Gundelfinger, R., & Grünblatt, E. (2014) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-2-1 · Cited by 40 · see citing works
Tops, S., Habel, U., & Radke, S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.03.002 · Cited by 39 · see citing works
Guoynes, C. D., Simmons, T. C., Downing, G., Jacob, S., Solomon, M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.037 · Cited by 38 · see citing works
Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment
Bernhard, R. M., Chaponis, J., Siburian, R., Gallagher, P., Ransohoff, K. J., Wikler, D. I., Perlis, R. H., & Greene, J. D. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw103 · Cited by 38 · see citing works
DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders
Siu, M. T., Goodman, S. J., Yellan, I., Butcher, D. T., Jangjoo, M., Grafodatskaya, D., Rajendram, R., Lou, Y., Zhang, R., Zhao, C., et al. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04792-x · Cited by 36 · see citing works
Ceroni, F., Sagar, A., Simpson, N. H., Gawthrope, A. J. T., Newbury, D. F., Pinto, D., Francis, S. M., Tessman, D. C., Cook, E. H., Monaco, A. P., et al. (2014) · Autism Research · doi:10.1002/aur.1365 · Cited by 34 · see citing works
Slane, M. M., Lusk, L. G., Boomer, K. B., Hare, A., King, M. K., & Evans, D. W. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.04.001 · Cited by 34 · see citing works
The association between the oxytocin receptor gene (OXTR) and hypnotizability
Bryant, R. A., Hung, L., Dobson‐Stone, C., & Schofield, P. R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.002 · Cited by 33 · see citing works
Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based?
Lee, S. Y., Lee, A. R., Hwangbo, R., Han, J., Hong, M., & Bahn, G. H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.312 · Cited by 32 · see citing works
Glenn, A. L., Lochman, J. E., Dishion, T., Powell, N. P., Boxmeyer, C., & Qu, L. (2018) · Prevention Science · doi:10.1007/s11121-017-0777-1 · Cited by 30 · see citing works
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease
Aulinas, A., & Lawson, E. A. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf008 · Cited by 30 · see citing works
Schaschl, H., Huber, S., Schæfer, K., Windhager, S., Wallner, B., & Fieder, M. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0372-7 · Cited by 27 · see citing works
Harrison, A. J., Gamsiz, E. D., Berkowitz, I. C., Nagpal, S., & Jerskey, B. A. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32377 · Cited by 26 · see citing works
Davis, C. A., Patte, K. A., Zai, C. C. H., & Kennedy, J. L. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.24 · Cited by 26 · see citing works
Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes
Ribeiro, L. D. O. P., Vargas‐Pinilla, P., Kappel, D. B., Longo, D., Ranzan, J., Becker, M. M., Riesgo, R. D. S., Schüler‐Faccini, L., Roman, T., & Schuch, J. B. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1088-0 · Cited by 25 · see citing works
Advanced Pharmacotherapy Evidenced by Pathogenesis of Autism Spectrum Disorder
Lee, Y. J., Oh, S. H., Park, C., Hong, M., Lee, A. R., Yoo, H. J., Shin, C. Y., Cheon, K.-A. A., & Bahn, G. H. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.1.19 · Cited by 25 · see citing works
Holdman, R., Vigil, D., Robinson, K. J., Shah, P., & Contreras, A. E. (2021) · Cannabis and Cannabinoid Research · doi:10.1089/can.2020.0154 · Cited by 31 · see citing works
Szczepanska‐Sadowska, E. K., Wsół, A., Cudnoch‐Jędrzejewska, A., Czarzasta, K., & Żera, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11040908 · Cited by 26 · see citing works
Imaging genetics in neurodevelopmental psychopathology
Klein, M., van Donkelaar, M. M. J., Verhoef, E., & Franke, B. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32542 · Cited by 25 · see citing works
Kryski, K. R., Smith, H. J., Sheikh, H. I., Singh, S. M., & Hayden, E. P. (2014) · Personality and Individual Differences · doi:10.1016/j.paid.2014.02.028 · Cited by 24 · see citing works
Vanya, M., Szücs, S., Vetró, Á., & Bártfai, G. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.12.007 · Cited by 24 · see citing works
Ocakoğlu, F. T., Köse, S., Özbaran, B., & Onay, H. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2018.01.002 · Cited by 23 · see citing works
OXTRpolymorphism predicts social relationships through its effects on social temperament
Creswell, K. G., Wright, A. G. C., Troxel, W., Ferrell, R. E., Flory, J. D., & Manuck, S. B. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu132 · Cited by 23 · see citing works
Oxytocin treatment in pediatric populations
Taylor, A. E., Lee, H.-E., & Buisman‐Pijlman, F. T. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00360 · Cited by 23 · see citing works
Haas, B. W., Anderson, I. W., & Smith, J. M. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00801 · Cited by 23 · see citing works
Westberg, L., Henningsson, S., Zettergren, A., Svärd, J., Hovey, D., Lin, T., Ebner, N. C., & Fischer, H. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00178 · Cited by 22 · see citing works
Wilczyński, K. M., Siwiec, A., & Janas-Kozik, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00380 · Cited by 21 · see citing works
The non-coding genome in Autism Spectrum Disorders
Dominguez-Alonso, S., Carracedo, Á., & Rodriguez‐Fontenla, C. (2023) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2023.104752 · Cited by 20 · see citing works
Fakhoury, M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.026 · Cited by 20 · see citing works
Antonucci, L. A., Taurisano, P., Coppola, G., & Cassibba, R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.002 · Cited by 20 · see citing works
Kang, J. I., Kim, H. W., Kim, C. H., Hwang, E. H., & Kim, S. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.09.011 · Cited by 19 · see citing works
Hirayama, T., Hiraoka, Y., Kitamura, E., Miyazaki, S., Horie, K., Fukuda, T., Hidema, S., Koike, M., Itakura, A., Takeda, S., et al. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14149 · Cited by 17 · see citing works
Spanos, M., Chandrasekhar, T., Kim, S., Hamer, R. M., King, B. H., McDougle, C. J., Sanders, K. B., Gregory, S. G., Kolevzon, A. L., Veenstra-VanderWeele, J. M., et al. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106103 · Cited by 22 · see citing works
Oxytocin system social function impacts in children with attention‐deficit/hyperactivity disorder
Ayaz, A. B., Karkucak, M., Ayaz, M., Gökçe, S., Kayan, E., Güler, E. E., Güngen, B. D., Kuşçu, T. D., Ocakoğlu, G., & Yakut, T. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32343 · Cited by 18 · see citing works
Sanathara, N. M., Alhassen, L., Marmouzi, I., Khoudari, M., Phan, J., Alhassen, W., Civelli, O., & Alachkar, A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108423 · Cited by 16 · see citing works
Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors
Shen, L.-P., Li, W., Pei, L.-Z., Yin, J., Xie, S.-T., Li, H.-Z., Yan, C., Wang, J., Zhang, Q., Zhang, X., et al. (2022) · The Cerebellum · doi:10.1007/s12311-022-01466-5 · Cited by 16 · see citing works
The Role of the Oxytocin/Arginine Vasopressin System in Animal Models of Autism Spectrum Disorder
Zhang, R., Xu, X., Zhang, H.-F., Han, S., & Han, J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_8 · Cited by 16 · see citing works
- Authors
- Campbell, D. B., Datta, D., Jones, S. T., Batey Lee, E., Sutcliffe, J. S., Hammock, E. A. D., & Levitt, P.
- Affiliations
- University of Southern California (US)
- Vanderbilt University (US)
- Corresponding author
- Campbell, Daniel B.
- Venue
- Journal of Neurodevelopmental Disorders
- Published
- 2011-01-06
- Volume
- 3
- Issue
- 2
- Pages
- 101-112
- ISSN
- 1866-1947 (ISSN-L)
- 1866-1955
- PMC
- PMC3113442
- OpenAlex
- W2016290219
- Cited by
- 170
- References
- 62
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 22 · 2013: 15 · 2012: 22
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neurodevelopmental Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vanderbilt University
- National Institute of Mental Health (R01MH080759, T32MH065215)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, oxytocin receptor, genetic association, social behavior, oxytocin signaling, family-based association
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