Health‐beneficial effects of probiotics: Its mode of action

OHASHI, Yuji; USHIDA, Kazunari

doi:10.1111/j.1740-0929.2009.00645.x

Cited by 209Probiotics and Fermented FoodsAnimal Nutrition and PhysiologyGut microbiota and health

Health‐beneficial effects of probiotics: Its mode of action

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OHASHI, Yuji, USHIDA, Kazunari·2009·Animal Science Journal

DOI 10.1111/j.1740-0929.2009.00645.x

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Abstract

It is now widely recognized that probiotics have health‐beneficial effects on humans and animals. Probiotics should survive in the intestinal tract to exert beneficial effects on the host's health. To keep a sufficient level of probiotic bacteria in the gastrointestinal tract, a shorter interval between doses may be required. Although adherence to the intestinal epithelial cell and mucus is not a universal property of probiotics, high ability to adhere to the intestinal surface might strongly interfere with infection of pathogenic bacteria and regulate the immune system. The administration of probiotic Lactobacillus stimulated indigenous Lactobacilli and the production of short‐chain fatty acids. This alteration of the intestinal environment should contribute to maintain the host's health. The immunomodulatory effects of probiotics are related to important parts of their beneficial effects. Probiotics may modulate the intestinal immune response through the stimulation of certain cytokine and IgA secretion in intestinal mucosa. The health‐beneficial effects, in particular the immunomodulation effect, of probiotics depend on the strain used. Differences in indigenous intestinal microflora significantly alter the magnitude of the effects of a probiotic. Specific probiotic strains suitable for each animal species and their life stage as well as each individual should be found.

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Several reports have documented the ability of probiotic lactobacilli and bifidobacteria to inhibit mucosa colonisation and invasion by pathogenic strains.
“Several reports have already documented the ability of probiotic lactobacilli and bifidobacteria to inhibit mucosa colonisation and invasion by pathogenic strains (Gopal et al. 2001; Ohashi and Ushida 2009).”
From Adhesion and aggregation properties of Lactobacillaceae strains as protection ways against enteropathogenic bacteria (2022) · cites this paper as Ohashi and Ushida 2009
The PROBIOTICS section says that probiotics that adhere to the intestinal surface are expected to interfere with pathogenic bacteria’s adhesion, and ROLE OF INTESTINAL MICROFLORA describes competitive exclusion from intestinal mucus. A cited study’s title in the References reports inhibited attachment and invasion by a Lactobacillus strain, but the review does not establish the claimed inhibition of invasion by both lactobacilli and bifidobacteria. Page numbers are not supplied for these passages. (LLM, conf=0.84)
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Authors: OHASHI, Y., & USHIDA, K.
Affiliations: Nippon Veterinary and Life Science University (JP)
Kyoto Prefectural University (JP)
Corresponding author: OHASHI, Yuji
ORCID: USHIDA, Kazunari
Venue: Animal Science Journal
Publisher: Wiley
Published: 2009-07-24
Volume: 80
Issue: 4
Pages: 361-371
ISSN: 1344-3941 (ISSN-L)
1740-0929
DOI: 10.1111/j.1740-0929.2009.00645.x
OpenAlex: W2031748680
Cited by: 209
References: 123
Citations by year: 2026: 7 · 2025: 5 · 2024: 13 · 2023: 18 · 2022: 17 · 2021: 23 · 2020: 11 · 2019: 15 · 2018: 7 · 2017: 8 · 2016: 15 · 2015: 15 · 2014: 8 · 2013: 18 · 2012: 9
FWCI: 1.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Animal Science Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: probiotics, mechanism of action, intestinal colonization, Lactobacillus, short-chain fatty acids, immunomodulation, intestinal immune response, cytokines, IgA secretion, strain specificity
MeSH terms: Animals, Gastrointestinal Motility, Humans, Intestinal Mucosa, Swine, Probiotics, Gastrointestinal Tract, Immunomodulation

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Health‐beneficial effects of probiotics: Its mode of action

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