A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity
Open accessAbstract
A great body of experimental evidence collected over many years indicates that calcium has a central role in a variety of neuronal functions. In particular, calcium participates in synaptic plasticity, a neuronal process presumably correlated with cognitive brain functions such as learning and memory. In contrast, only recently, evidence has begun to emerge supporting a physiological role of reactive oxygen (ROS) and nitrogen (RNS) species in synaptic plasticity. This subject will be the central topic of this review. The authors also present recent results showing that, in hippocampal neurons, ROS/RNS, including ROS generated by iron through the Fenton reaction, stimulate ryanodine receptor-mediated calcium release, and how the resulting calcium signals activate the signaling cascades that lead to the transcription of genes known to participate in synaptic plasticity. They discuss the possible participation of ryanodine receptors jointly stimulated by calcium and ROS/RNS in the normal signaling cascades needed for synaptic plasticity, and how too much ROS production may contribute to neurodegeneration via excessive calcium release. In addition, the dual role of iron as a necessary, but potentially toxic, element for normal neuronal function is discussed.
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Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory
Massaad, C. A., & Klann, E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3208 · Cited by 635 · see citing works
Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works
Uranga, R. M., & Salvador, G. A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2850341 · Cited by 48 · see citing works
- Authors
- Hidalgo, C., Carrasco, M. A., Muñoz, P., & Núñez, M. T.
- Affiliations
- University of Chile (CL)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2007-02
- Volume
- 9
- Issue
- 2
- Pages
- 245-255
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1994493541
- Cited by
- 81
- References
- 127
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 6 · 2014: 4 · 2013: 3 · 2012: 6
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- reactive oxygen species, reactive nitrogen species, iron, synaptic plasticity, calcium signaling, ryanodine receptor, calcium release, Fenton reaction, hippocampal neurons, gene transcription, neurodegeneration, oxidative stress, learning and memory
- MeSH terms
- Animals, Brain, Calcium, Cells, Cultured, Hippocampus, Humans, Iron, Neuronal Plasticity, Neurons, Phosphorylation, Synapses, Signal Transduction, Reactive Oxygen Species, Ryanodine Receptor Calcium Release Channel, Reactive Nitrogen Species
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