Cited by 81Neuroscience and Neuropharmacology ResearchRedox biology and oxidative stressNitric Oxide and Endothelin Effects

A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity

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Hidalgo, Cecilia, Carrasco, M. Angélica, Muñoz, Pablo, Núñez, Marco T.·2007·Antioxidants & Redox Signaling

Abstract

A great body of experimental evidence collected over many years indicates that calcium has a central role in a variety of neuronal functions. In particular, calcium participates in synaptic plasticity, a neuronal process presumably correlated with cognitive brain functions such as learning and memory. In contrast, only recently, evidence has begun to emerge supporting a physiological role of reactive oxygen (ROS) and nitrogen (RNS) species in synaptic plasticity. This subject will be the central topic of this review. The authors also present recent results showing that, in hippocampal neurons, ROS/RNS, including ROS generated by iron through the Fenton reaction, stimulate ryanodine receptor-mediated calcium release, and how the resulting calcium signals activate the signaling cascades that lead to the transcription of genes known to participate in synaptic plasticity. They discuss the possible participation of ryanodine receptors jointly stimulated by calcium and ROS/RNS in the normal signaling cascades needed for synaptic plasticity, and how too much ROS production may contribute to neurodegeneration via excessive calcium release. In addition, the dual role of iron as a necessary, but potentially toxic, element for normal neuronal function is discussed.

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Crossref · 10.1089/ars.2007.9.245

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Authors
Hidalgo, C., Carrasco, M. A., Muñoz, P., & Núñez, M. T.
Affiliations
University of Chile (CL)
Venue
Antioxidants & Redox Signaling
Published
2007-02
Volume
9
Issue
2
Pages
245-255
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
OpenAlex
W1994493541
Cited by
81
References
127
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 6 · 2014: 4 · 2013: 3 · 2012: 6
FWCI
0.48
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
reactive oxygen species, reactive nitrogen species, iron, synaptic plasticity, calcium signaling, ryanodine receptor, calcium release, Fenton reaction, hippocampal neurons, gene transcription, neurodegeneration, oxidative stress, learning and memory
MeSH terms
Animals, Brain, Calcium, Cells, Cultured, Hippocampus, Humans, Iron, Neuronal Plasticity, Neurons, Phosphorylation, Synapses, Signal Transduction, Reactive Oxygen Species, Ryanodine Receptor Calcium Release Channel, Reactive Nitrogen Species

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