Differential gene expression in periportal and perivenous mouse hepatocytes
Open accessAbstract
Hepatocytes located in the periportal and perivenous zones of the liver lobule show remarkable differences in the levels and activities of various enzymes and other proteins. To analyze global gene expression patterns of periportal and perivenous hepatocytes, enriched populations of the two cell types were isolated by combined collagenase/digitonin perfusion from mouse liver and used for microarray analysis. In total, 198 genes and expressed sequences were identified that demonstrated a ≥ 2‐fold difference in expression between hepatocytes from the two different zones of the liver. A subset of 20 genes was additionally analyzed by real‐time RT‐PCR, validating the results obtained by the microarray analysis. Several of the differentially expressed genes encoded key enzymes of intermediary metabolism, including those involved in glycolysis and gluconeogenesis, fatty acid degradation, cholesterol and bile acid metabolism, amino acid degradation and ammonia utilization. In addition, several enzymes of phase I and phase II of xenobiotic metabolism were differentially expressed in periportal and perivenous hepatocytes. Our results confirm previous findings on metabolic zonation in liver, and extend our knowledge of the regulatory mechanisms at the transcriptional level.
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These observations are consistent with the classic zonation described in human and mouse liver, supporting the MERFISH measurements.
“Collectively, these observations are consistent with the classic zonation described in human and mouse liver4,24–26, supporting our MERFISH measurements.”
From Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution (2025) · cites this paper as [24]
SDS was enriched in zone 1 (periportal), while CYP2E1 expression increased in zone 3 (pericentral), as previously described in mouse.
“SDS was enriched in zone 1 (periportal), while CYP2E1 expression increased in zone 3 (pericentral), as previously described in mouse24–27 (Fig. 1c, e, f; Supplementary Fig. 5a).”
From Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution (2025) · cites this paper as [24]
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Self-citationSignal integration by the CYP1A1 promoter -- a quantitative study
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Self-citation
- Authors
- Braeuning, A., Ittrich, C., Köhle, C., Hailfinger, S., Bonin, M., Buchmann, A., & Schwarz, M.
- Affiliations
- University of Tübingen (DE)
- German Cancer Research Center (DE)
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2006-10-20
- Volume
- 273
- Issue
- 22
- Pages
- 5051-5061
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2031402631
- Cited by
- 240
- References
- 27
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 13 · 2021: 15 · 2020: 28 · 2019: 14 · 2018: 16 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 12 · 2013: 11 · 2012: 3
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Krebshilfe
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- periportal hepatocytes, perivenous hepatocytes, differential gene expression, hepatocyte isolation, xenobiotic metabolism, transcriptional regulation, mouse liver
- MeSH terms
- Amino Acids, Ammonia, Animals, Cholesterol, Fatty Acids, Gene Expression Regulation, Gluconeogenesis, Glycolysis, Hepatic Veins, Liver, Male, Mice, Inbred C3H, Models, Biological, Portal Vein, Protein Denaturation, Xenobiotics, Gene Expression Regulation, Enzymologic, Gene Expression Profiling, Hepatocytes, Mice
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