Differential gene expression in periportal and perivenous mouse hepatocytes

Functional specialization of different hepatocyte populations

Jungermann, K. A., & Katz, N. R. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.3.708 · Cited by 655

Metabolic zonation of the liver: Regulation and implications for liver function

Gebhardt, R. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90055-5 · Cited by 607

Zonation of parenchymal and nonparenchymal metabolism in liver.

Jungermann, K., & Keitzmann, T. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.001143 · Cited by 589

Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver

Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., Moinard, C., Vasseur-Cognet, M., Kuo, C. J., Kahn, A., Perret, C., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.015 · Cited by 543

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

Rider, M. H., Bertrand, L., Vertommen, D., Michels, P. A. M., Rousseau, G. G., & Hue, L. (2004) · Biochemical Journal · doi:10.1042/bj20040752 · Cited by 435

New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

Cadoret, A., Ovejero, C., Terris, B., Souil, E., Lévy, L., Lamers, W. H., Kitajewski, J., Kahn, A., & Perret, C. (2002) · Oncogene · doi:10.1038/sj.onc.1206118 · Cited by 412

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.

Gebhardt, R., & Mecke, D. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01464.x · Cited by 377

Zonation of hepatic cytochrome P-450 expression and regulation

Oinonen, T., & LINDROS, O. K. (1998) · Biochemical Journal · doi:10.1042/bj3290017 · Cited by 227

Zonal gene expression in murine liver: Lessons from tumors

Hailfinger, S., Jaworski, M., Braeuning, A., Buchmann, A., & Schwarz, M. (2006) · Hepatology · doi:10.1002/hep.21082 · Cited by 149

Localization of the ammonium transporters, Rh B glycoprotein and Rh C glycoprotein, in the mouse liver

Weiner, I. D., Miller, R. T., & Verlander, J. W. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00277-4 · Cited by 121

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674

Metabolic zonation of the liver: The oxygen gradient revisited

Kietzmann, T. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.012 · Cited by 499

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

Cairo, S., Armengol, C., de Reyniès, A., Yu, W., Thomas, E., Renard, C.-A., Goga, A., Balakrishnan, A., Semeraro, M., Gresh, L., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.11.002 · Cited by 530

Spatial heterogeneity in the mammalian liver

Ben-Moshe, S., & Itzkovitz, S. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0134-x · Cited by 485

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

Halpern, K. B., Shenhav, R., Massalha, H., Toth, B., Egozi, A., Massasa, E. E., Medgalia, C., David, E., Giladi, A., Moor, A. E., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4231 · Cited by 368

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

Marro, S. G., Pang, Z. P., Yang, N., Tsai, M.-C., Qu, K., Chang, H. Y., Südhof, T. C., & Wernig, M. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.09.002 · Cited by 343

Commensal-driven immune zonation of the liver promotes host defence

Gola, A., Dorrington, M. G., Speranza, E. E., Sala, C., Shih, R. M., Radtke, A. J., Wong, H. S., Baptista, A. P., Hernandez, J. M., Castellani, G., et al. (2020) · Nature · doi:10.1038/s41586-020-2977-2 · Cited by 286

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

Gebhardt, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8491 · Cited by 275

Bursty Gene Expression in the Intact Mammalian Liver

Halpern, K. B., Tanami, S., Landen, S., Chapal, M., Szlak, L., Hutzler, A., Nizhberg, A., & Itzkovitz, S. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.027 · Cited by 251

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

Fitamant, J., Kottakis, F., Benhamouche, S., Tian, H. S., Chuvin, N., Parachoniak, C. A., Nagle, J. M., Perera, R. M., Lapouge, M., Deshpande, V., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.027 · Cited by 248

Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions

Wilson, G. K., Tennant, D. A., & McKeating, J. A. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.025 · Cited by 205

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation

Rocha, A. S., Vidal, V., Mertz, M., Kendall, T. J., Charlet, A., Okamoto, H., & Schedl, A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.049 · Cited by 194

Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme

Diggle, C. P., Shires, M., Leitch, D., Brooke, D., Carr, I., MARKHAM, A. F., Hayward, B. E., Asipu, A., & Bonthron, D. T. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953190 · Cited by 197

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

Hildebrandt, F., Andersson, A., Saarenpää, S., Larsson, L., Hul, N. V., Kanatani, S., Masek, J., Ellis, E. C. S., Barragán, A., Mollbrink, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27354-w · Cited by 191

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

Gougelet, A., Torre, C., Veber, P., Sartor, C., Bachelot, L., Denechaud, P.-D., Godard, C., Moldes, M., Burnol, A.-F., Dubuquoy, C., et al. (2014) · Hepatology · doi:10.1002/hep.26924 · Cited by 190

Amino acid metabolism, transport and signalling in the liver revisited

Paulusma, C. C., Lamers, W. H., Bröer, S., & van de Graaf, S. F. J. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115074 · Cited by 185

In Situ Lipidomic Analysis of Nonalcoholic Fatty Liver by Cluster TOF-SIMS Imaging

Debois, D., Bralet, M., Naour, F. L., Brunelle, A., & Laprévôte, O. (2009) · Analytical Chemistry · doi:10.1021/ac900045m · Cited by 168

Liver zonation, revisited

Paris, J., & Henderson, N. C. (2022) · Hepatology · doi:10.1002/hep.32408 · Cited by 177

Liver Zonation – Revisiting Old Questions With New Technologies

Cunningham, R. P., & Porat‐Shliom, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.732929 · Cited by 181

Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity

Payen, V. L., Lavergne, A., Alevra Sarika, N., Colonval, M., Karim, L., Deckers, M., Najimi, M., Coppieters, W., Charloteaux, B., Sokal, E. M., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100278 · Cited by 160

Liver tissue engineering in the evaluation of drug safety

Dash, A., Inman, W., Hoffmaster, K. A., Sevidal, S., Kelly, J., Obach, R. S., Griffith, L. G., & Tannenbaum, S. R. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903160664 · Cited by 157

The Liver–α-Cell Axis and Type 2 Diabetes

Albrechtsen, N. J. W., Pedersen, J., Galsgaard, K. D., Winther‐Sørensen, M., Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, F. K., & Holst, J. J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00251 · Cited by 154

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

Kubota, N., Kubota, T., Kajiwara, E., Iwamura, T., Kumagai, H., Watanabe, T., Inoue, M., Takamoto, I., Sasako, T., Kumagai, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms12977 · Cited by 143

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

McCommis, K. S., Hodges, W. T., Brunt, E. M., Nalbantoglu, I., McDonald, W. G., Holley, C. L., Fujiwara, H., Schaffer, J. E., Colca, J. R., & Finck, B. N. (2016) · Hepatology · doi:10.1002/hep.29025 · Cited by 139

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

Pu, W., Zhang, H., Huang, X., Tian, X., He, L., Wang, Y., Zhang, L., Liu, Q., Li, Y., Li, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms13369 · Cited by 136

Human hepatocellular carcinomas with a periportal phenotype have the lowest potential for early recurrence after curative resection

Désert, R., Rohart, F., Canal, F., Sicard, M., Desille, M., Renaud, S., Turlin, B., Bellaud, P., Perret, C., Clément, B., et al. (2017) · Hepatology · doi:10.1002/hep.29254 · Cited by 148

Wnt signaling and hepatocarcinogenesis: The hepatoblastoma model

Armengol, C., Cairo, S., Fabrè, M., & Buendia, M. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.07.012 · Cited by 137

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution

Watson, B. R., Paul, B., Rahman, R. U., Amir-Zilberstein, L., Segerstolpe, Å., Epstein, E. T., Murphy, S., Geistlinger, L., Lee, T., Shih, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55325-4 · Cited by 123

Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma

Garrido, A., & Djouder, N. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.08.005 · Cited by 123

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

Leibing, T., Géraud, C., Augustin, I., Boutros, M., Augustin, H. G., Okun, J. G., Langhans, C., Zierow, J., Wohlfeil, S. A., Olsavszky, V., et al. (2018) · Hepatology · doi:10.1002/hep.29613 · Cited by 116

Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology

Martini, T., Naef, F., & Tchorz, J. S. (2023) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-024831 · Cited by 113

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin

Lefebvre, P., Lalloyer, F., Baugé, E., Pawlak, M., Gheeraert, C., Dehondt, H., Vanhoutte, J., Woitrain, E., Hennuyer, N., Mazuy, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92264 · Cited by 117

Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics

Liang, Y., Kaneko, K., Xin, B., Lee, J., Sun, X., Zhang, K., & Feng, G.-S. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.01.004 · Cited by 116

Important Considerations for Sample Collection in Metabolomics Studies with a Special Focus on Applications to Liver Functions

Smith, L., Villaret, J., Claus, S. P., Canlet, C., Guillou, H., Cabaton, N. J., & Ellero‐Simatos, S. (2020) · Metabolites · doi:10.3390/metabo10030104 · Cited by 121

Intersection of AHR and Wnt Signaling in Development, Health, and Disease

Schneider, A. J., Branam, A. M., & Peterson, R. E. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151017852 · Cited by 109

Lgr5 + pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

Ang, C. H., Hsu, S. H., Guo, F., Tan, C. T., Yu, V. C., Visvader, J. E., Chow, P. K. H., & Fu, N. Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908099116 · Cited by 102

Transcription dynamics in a physiological process: β-Catenin signaling directs liver metabolic zonation

Torre, C., Perret, C., & Colnot, S. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.004 · Cited by 106

Rosiglitazone Attenuates Age- and Diet-Associated Nonalcoholic Steatohepatitis in Male Low-Density Lipoprotein Receptor Knockout Mice

Gupte, A. A., Liu, J. Z., Ren, Y., Minze, L. J., Wiles, J. R., Collins, A. R., Lyon, C. J., Praticò, D., Finegold, M. J., Wong, S. T. C., et al. (2010) · Hepatology · doi:10.1002/hep.23941 · Cited by 98

Molecular Determinants of Liver Zonation

Torre, C., Perret, C., & Colnot, S. (2010) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-385233-5.00005-2 · Cited by 97

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

Norton, L., Fourcaudot, M. J., Abdul-Ghani, M. A., Winnier, D. A., Mehta, F. F., Jenkinson, C. P., & DeFronzo, R. A. (2011) · Diabetologia · doi:10.1007/s00125-011-2289-z · Cited by 93

Dynamic zonation of liver polyploidy

Tanami, S., Ben-Moshe, S., Elkayam, A., Mayo, A., Bahar Halpern, K., & Itzkovitz, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2427-5 · Cited by 77

Glucagon contributes to liver zonation

Cheng, X., Kim, S. Y., Okamoto, H., Xin, Y., Yancopoulos, G. D., Murphy, A. J., & Gromada, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721403115 · Cited by 90

Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis

Wattacheril, J. J., Seeley, E. H., Angel, P. M., Chen, H., Bowen, B. P., Lanciault, C., Caprioli, R. M., Abumrad, N. N., & Flynn, C. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057165 · Cited by 88

Regulation of CAR and PXR Expression in Health and Disease

Daujat‐Chavanieu, M., & Gerbal‐Chaloin, S. (2020) · Cells · doi:10.3390/cells9112395 · Cited by 87

Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

Budinsky, R. A., Schrenk, D., Simon, T. W., van den Berg, M., Reichard, J. F., Silkworth, J. B., Aylward, L. L., Brix, A., Gasiewicz, T. A., Kaminski, N. E., et al. (2013) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.835787 · Cited by 87

Dicer is required for proper liver zonation

Sekine, S., Ogawa, R., McManus, M. T., Kanai, Y., & Hebrok, M. (2009) · The Journal of Pathology · doi:10.1002/path.2606 · Cited by 85

Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications

Truong, X. T., & Lee, D. H. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0644 · Cited by 84

Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1

Braeuning, A., Sanna, R., Huelsken, J., & Schwarz, M. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.026179 · Cited by 82

Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways

McEnerney, L., Duncan, K., Bang, B.-R., Elmasry, S., Li, M., Miki, T., Ramakrishnan, S. K., Shah, Y. M., & Saito, T. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.226 · Cited by 81

Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling

Lan, T., Hu, Y., Hu, F., Li, H., Chen, Y., Zhang, J., Yu, Y., Jiang, S., Weng, Q., Tian, S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.040 · Cited by 75

Novel aspects of glutamine synthetase in ammonia homeostasis

Zhou, Y., Eid, T., Hassel, B., & Danbolt, N. C. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104809 · Cited by 80

Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations

Comar, J. F., Suzuki‐Kemmelmeier, F., Constantin, J., & Bracht, A. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-1 · Cited by 71

Influence of Liver Fibrosis on Lobular Zonation

Ghallab, A., Myllys, M., Holland, C. H., Zaza, A., Murad, W., Hassan, R. A. R. A., Ahmed, Y. A., Abbas, T., Abdelrahim, E. A., Schneider, K. M., et al. (2019) · Cells · doi:10.3390/cells8121556 · Cited by 74

Selective Insulin Resistance in the Kidney

Horita, S., Nakamura, M., Suzuki, M., Satoh, N., Suzuki, A., & Seki, G. (2016) · BioMed Research International · doi:10.1155/2016/5825170 · Cited by 71

Zonation of hepatic fatty acid metabolism — The diversity of its regulation and the benefit of modeling

Schleicher, J., Tokarski, C., Marbach, E., Matz‐Soja, M., Zellmer, S., Gebhardt, R., & Schuster, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.004 · Cited by 75

Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations

Gougèlet, A., Sartor, C., Bachelot, L., Godard, C., Marchiol, C., Renault, G., Torès, F., Nitschké, P., Cavard, C., Terris, B., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308969 · Cited by 75

The WNT/β-Catenin Pathway Is a Transcriptional Regulator of CYP2E1, CYP1A2, and Aryl Hydrocarbon Receptor Gene Expression in Primary Human Hepatocytes

Gerbal‐Chaloin, S., Dumé, A., Briolotti, P., Klieber, S., Raulet, E., Duret, C., Fabre, J., Ramos, J., Maurel, P., & Daujat‐Chavanieu, M. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.094797 · Cited by 71

Liver regeneration: Cellular origin and molecular mechanisms

Huang, R. C. C., Zhang, X., Gracia‐Sancho, J., & Xie, W. (2022) · Liver International · doi:10.1111/liv.15174 · Cited by 69

Transcriptional switch of hepatocytes initiates macrophage recruitment and T-cell suppression in endotoxemia

Sun, X., Wu, J., Liu, L., Chen, Y., Tang, Y., Liu, S., Chen, H., Jiang, Y., Liu, Y., Yuan, H., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.02.028 · Cited by 68

Cellular and molecular basis of liver regeneration

Bangru, S., & Kalsotra, A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.004 · Cited by 67

Molecular mechanisms of liver and bile duct development

Zong, Y., & Stanger, B. Z. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.47 · Cited by 65

The transforming growth factor-α and cyclin D1 genes are direct targets of β-catenin signaling in hepatocyte proliferation

Torre, C., Benhamouche, S., Mitchell, C., Godard, C., Veber, P., Letourneur, F., Cagnard, N., Jacques, S., Finzi, L., Perret, C., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.021 · Cited by 60

A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

Yang, S., Liu, C., Jiang, M., Liu, X., Geng, L., Zhang, Y., Sun, S., Wang, K., Yin, J. B., Ma, S., et al. (2023) · Protein & Cell · doi:10.1093/procel/pwad039 · Cited by 65

Wnt/β-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver

Giera, S., Braeuning, A., Köhle, C., Bursch, W., Metzger, U., Buchmann, A., & Schwarz, M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq033 · Cited by 66

13N as a tracer for studying glutamate metabolism

Cooper, A. J. L. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.11.011 · Cited by 62

Regulation of hepatocyte identity and quiescence

Berasain, C., & Avila, M. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1970-7 · Cited by 64

Cell-type diversity and regionalized gene expression in the planarian intestine

Forsthoefel, D. J., Cejda, N. I., Khan, U. W., & Newmark, P. A. (2020) · eLife · doi:10.7554/elife.52613 · Cited by 54

Functional Consequences of Metabolic Zonation in Murine Livers: Insights for an Old Story

Berndt, N., Kolbe, E., Gajowski, R., Eckstein, J., Ott, F., Meierhofer, D., Holzhütter, H., & Matz‐Soja, M. (2020) · Hepatology · doi:10.1002/hep.31274 · Cited by 55

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity

Marx‐Stoelting, P., Knebel, C., & Braeuning, A. (2020) · Cells · doi:10.3390/cells9051192 · Cited by 54

Role and Regulation of Wnt/β-Catenin in Hepatic Perivenous Zonation and Physiological Homeostasis

Goel, C., Monga, S. P., & Nejak-Bowen, K. (2022) · The American Journal of Pathology · doi:10.1016/j.ajpath.2021.09.007 · Cited by 53

Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas

Nault, J., Couchy, G., Caruso, S., Meunier, L., Caruana, L., Letouzé, É., Rebouissou, S., Paradis, V., Caldéraro, J., & Zucman‐Rossi, J. (2018) · Hepatology · doi:10.1002/hep.29884 · Cited by 52

Liver Zonation

Colnot, S., & Perret, C. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_2 · Cited by 58

Serum components and activated Ha‐ras antagonize expression of perivenous marker genes stimulated by β‐catenin signaling in mouse hepatocytes

Braeuning, A., Menzel, M., Kleinschnitz, E., Harada, N., Tamai, Y., Köhle, C., Buchmann, A., & Schwarz, M. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06002.x · Cited by 50

Organismal complexity, cell differentiation and gene expression: human over mouse

Vinogradov, A. E., & Anatskaya, O. V. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm723 · Cited by 50

Single-cell and spatially resolved transcriptomics for liver biology

Lin, P., Yan, X., Jing, S., Wu, Y., Shan, Y., Guo, W., Gu, J., Li, Y., Zhang, H., & Li, H. (2023) · Hepatology · doi:10.1097/hep.0000000000000387 · Cited by 56

Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin

Rojas, I. Y., Moyer, B. J., Ringelberg, C. S., & Tomlinson, C. R. (2020) · International Journal of Obesity · doi:10.1038/s41366-019-0512-z · Cited by 51

The liver as an immunological barrier redefined by single‐cell analysis

Stamataki, Z., & Swadling, L. (2020) · Immunology · doi:10.1111/imm.13193 · Cited by 48

MASLD in children: integrating epidemiological trends with mechanistic and translational advances

Schwimmer, J. B., Biddinger, S. B., & Ibrahim, S. H. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186422 · Cited by 49

Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats

Pridans, C., Sauter, K. A. D., Irvine, K. M., Davis, G. M., Lefèvre, L., Raper, A., Rojo, R., Nirmal, A. J., Beard, P. M., Cheeseman, M. T., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00343.2017 · Cited by 46

The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease

Annunziato, S., Sun, T., & Tchorz, J. S. (2022) · Hepatology · doi:10.1002/hep.32328 · Cited by 45

Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation

Trinh, V. Q.-H., Lee, T.-F., Lemoinne, S., Ray, K. C., Ybanez, M. D., Tsuchida, T., Carter, J. K., Agudo, J., Brown, B. D., Akat, K. M., et al. (2023) · Science Signaling · doi:10.1126/scisignal.adf6696 · Cited by 45

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

Walenbergh, S. M. A., Houben, T., Rensen, S. S., Bieghs, V., Hendrikx, T., van Gorp, P. J., Oligschlaeger, Y., Jeurissen, M. L. J., Gijbels, M. J., Buurman, W. A., et al. (2016) · Scientific Reports · doi:10.1038/srep38278 · Cited by 44

Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) in disease diagnosis: an overview

Kumar, B. S. (2023) · Analytical Methods · doi:10.1039/d3ay00867c · Cited by 45

Zonal Gene Expression in Mouse Liver Resembles Expression Patterns of Ha-ras and β-Catenin Mutated Hepatomas

Braeuning, A., Ittrich, C., Köhle, C., Buchmann, A., & Schwarz, M. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.013656 · Cited by 42

Sex-related variations in liver homeostasis and disease: From zonation dynamics to clinical implications

Matz‐Soja, M., Berg, T., & Kietzmann, T. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.08.007 · Cited by 54

Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing

Umbaugh, D. S., Ramachandran, A., & Jaeschke, H. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab052 · Cited by 42

Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.

Wang, S., Wang, X., Shan, Y., Tan, Z., Su, Y., Cao, Y., Wang, S., Dong, J., Gu, J., & Wang, Y. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.01.013 · Cited by 40

Spatial metabolic gradients in the liver and small intestine

Samarah, L. Z., Zheng, C., Xing, X., Lee, W. D., Afriat, A., Chitra, U., MacArthur, M. R., Lu, W., Jankowski, C. S. R., Ma, C., et al. (2025) · Nature · doi:10.1038/s41586-025-09616-5 · Cited by 53

Mechanisms of RAS/β-catenin interactions

Zeller, E., Hammer, K., Kirschnick, M., & Braeuning, A. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1035-3 · Cited by 40

β-Catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver

Braeuning, A., & Schwarz, M. (2009) · Biological Chemistry · doi:10.1515/bc.2010.012 · Cited by 39

Sexual dimorphisms in zonal gene expression in mouse liver

Saito, K., Negishi, M., & James Squires, E. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.025 · Cited by 36

Transcriptomic Dissection of Hepatocyte Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell Characteristics

Katsuda, T., Hosaka, K., Matsuzaki, J., Usuba, W., Prieto‐Vila, M., Yamaguchi, T., Tsuchiya, A., Terai, S., & Ochiya, T. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.08.011 · Cited by 37

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon

Li, L., Zhang, P., Bao, Z., Wang, T., Liu, S., & Huang, F. (2016) · Scientific Reports · doi:10.1038/srep24156 · Cited by 38

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

Campos, G., Schmidt‐Heck, W., Smedt, J. D., Widera, A., Ghallab, A., Pütter, L., González, D., Edlund, K., Cadenas, C., Marchan, R., et al. (2020) · Archives of Toxicology · doi:10.1007/s00204-019-02630-3 · Cited by 37

Induction of in vitro Metabolic Zonation in Primary Hepatocytes Requires Both Near-Physiological Oxygen Concentration and Flux

Scheidecker, B., Shinohara, M., Sugimoto, M., Danoy, M., Nishikawa, M., & Sakai, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00524 · Cited by 38

Spatial lipidomics reveals zone-specific hepatic lipid alteration and remodeling in metabolic dysfunction-associated steatohepatitis

Seubnooch, P., Montani, M., Dufour, J., & Masoodi, M. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100599 · Cited by 39

Ha‐ras and β‐catenin oncoproteins orchestrate metabolic programs in mouse liver tumors

Unterberger, E. B., Eichner, J., Wrzodek, C., Lempiäinen, H., Luisier, R., Terranova, R., Metzger, U., Plummer, S. M., Knorpp, T., Braeuning, A., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28798 · Cited by 37

Signal integration by the CYP1A1 promoter -- a quantitative study

Schulthess, P., Loffler, A., Vetter, S., Kreft, L., Schwarz, M., Braeuning, A., & Blüthgen, N. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv423 · Cited by 35

Metabolic Zonation of Liver Parenchyma

Jungermann, K. A. (1988) · Seminars in Liver Disease · doi:10.1055/s-2008-1040554 · Cited by 151

Preparation of Isolated Periportal or Perivenous Hepatocytes from Rat Liver

Quistorff, B. (2003) · Humana Press eBooks · doi:10.1385/0-89603-150-0:177 · Cited by 5

Functional Hepatocellular Heterogeneity

Jungermann, K., & Katz, N. (1982) · Hepatology · doi:10.1002/hep.1840020316 · Cited by 370

Role of intralobular compartmentation in hepatic metabolism.

Jungermann, K. A. (1992) · PubMed · Cited by 19

Functional Heterogeneity of Periportal and Perivenous Hepatocytes

Jungermann, K. (2017) · Enzyme · doi:10.1159/000469338 · Cited by 139