The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
A role of miR‐27 in the regulation of adipogenesis
Open accessAbstract
MicroRNAs (miRNAs) are involved in a plethora of important biological processes, from embryonic development to homeostasis in adult tissues. Recently, miRNAs have emerged as a class of epigenetic regulators of metabolism and energy homeostasis. We have investigated the role of miRNAs in the regulation of adipogenic differentiation. In this article, we demonstrate that the miR‐27 gene family is downregulated during adipogenic differentiation. Overexpression of miR‐27 specifically inhibited adipocyte formation, without affecting myogenic differentiation. We also found that expression of miR‐27 resulted in blockade of expression of PPAR γ and C/EBP α, the two master regulators of adipogenesis. Importantly, expression of miR‐27 was increased in fat tissue of obese mice and was regulated by hypoxia, an important extracellular stress associated with obesity. Our data strongly suggest that miR‐27 represents a new class of adipogenic inhibitors and may play a role in the pathological development of obesity.
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Cites
Inflammation and metabolic disorders
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The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
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Transcriptional regulation of adipogenesis
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Molecular Regulation of Adipogenesis
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Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
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A MicroRNA Signature of Hypoxia
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MicroRNA-143 Regulates Adipocyte Differentiation
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Cited by
MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156
microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ
Karbiener, M., Fischer, C., Nowitsch, S., Opriessnig, P., Papak, C., Ailhaud, G., Dani, C., Amri, E.-Z., & Scheideler, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.098 · Cited by 409
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MicroRNAs in Metabolic Disease
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Metadata
- Authors
- Lin, Q., Gao, Z., Alarcon, R. M., Ye, J., & Yun, Z.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2009-03-23
- Volume
- 276
- Issue
- 8
- Pages
- 2348-2358
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1997386949
- Cited by
- 437
- References
- 33
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- green
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