The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Multiple bacterial species reside in chronic wounds: a longitudinal study
Open accessAbstract
The aim of the study was to investigate the bacterial profile of chronic venous leg ulcers and the importance of the profile to ulcer development. Patients with persisting venous leg ulcers were included and followed for 8 weeks. Every second week, ulcer samples were collected and the bacterial species present were identified. More than one bacterial species were detected in all the ulcers. The most common bacteria found were Staphylococcus aureus (found in 93·5% of the ulcers), Enterococcus faecalis (71·7%), Pseudomonas aeruginosa (52·2%), coagulase‐negative staphylococci (45·7%), Proteus species (41·3%) and anaerobic bacteria (39·1%). Resident bacterial species were present in all the ulcers. In 76% of the ulcers, two or more (up to five) resident bacterial species were found. The most common resident bacterial species were S. aureus and P. aeruginosa. Furthermore, ulcers with P. aeruginosa were found to be significantly larger than ulcers without the presence of P. aeruginosa (P < 0·005). Our study demonstrated that the chronic wound is colonised by multiple bacterial species and that once they are established many of them persist in the wound. Our results suggest that the presence of P. aeruginosa in venous leg ulcers can induce ulcer enlargement and/or cause delayed healing.
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Cites
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099
Bacterial colonization and healing of venous leg ulcers
Madsen, S. M., Westh, H., Danielsen, L., & Rosdahl, V. T. (1996) · APMIS · doi:10.1111/j.1699-0463.1996.tb04955.x · Cited by 164
Cited by
James, G. A., Swogger, E., Wolcott, R., Pulcini, E. D., Secor, P., Sestrich, J., Costerton, J. W., & Stewart, P. S. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00321.x · Cited by 1,543
The role of bacterial biofilms in chronic infections
Bjarnsholt, T. (2013) · APMIS · doi:10.1111/apm.12099 · Cited by 1,080
Biofilm, pathogenesis and prevention—a journey to break the wall: a review
Gupta, P., Sarkar, S., Das, B., Bhattacharjee, S., & Tribedi, P. (2016) · Archives of Microbiology · doi:10.1007/s00203-015-1148-6 · Cited by 493
Biofilms and Inflammation in Chronic Wounds
Zhao, G., Usui, M. L., Lippman, S. I., James, G. A., Stewart, P. S., Fleckman, P., & Olerud, J. E. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0381 · Cited by 448
Pastar, I., Nusbaum, A. G., Gil, J., Patel, S. B., Chen, J., Valdes, J., Stojadinovic, O., Plano, L. R., Tomic-Canic, M., & Davis, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056846 · Cited by 391
Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection
Korgaonkar, A., Trivedi, U., Rumbaugh, K. P., & Whiteley, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214550110 · Cited by 315
Zhao, G., Hochwalt, P. C., Usui, M. L., Underwood, R. A., Singh, P. K., James, G. A., Stewart, P. S., Fleckman, P., & Olerud, J. E. (2010) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00608.x · Cited by 275
The Extracellular Matrix in Wound Healing: A Closer Look at Therapeutics for Chronic Wounds
Agren, M. S., & Werthen, M. (2007) · The International Journal of Lower Extremity Wounds · doi:10.1177/1534734607301394 · Cited by 136
Time course study of delayed wound healing in a biofilm-challenged diabetic mouse model
Zhao, G., Usui, M. L., Underwood, R. A., Singh, P. K., James, G. A., Stewart, P. S., Fleckman, P., & Olerud, J. E. (2012) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2012.00793.x · Cited by 127
Effect of Human Burn Wound Exudate on Pseudomonas aeruginosa Virulence
Gonzalez, M. R., Fleuchot, B., Lauciello, L., Jafari, P., Applegate, L. A., Raffoul, W., Que, Y.-A., & Perron, K. (2016) · mSphere · doi:10.1128/msphere.00111-15 · Cited by 109
Seth, A. K., Geringer, M. R., Galiano, R. D., Leung, K. P., Mustoe, T. A., & Hong, S. J. (2012) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2012.05.028 · Cited by 65
Arunachalam, K., Pandurangan, P., Shi, C., & Lagoa, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020310 · Cited by 48
Jafari-Sabet, M., & Baratian, A. (2017) · Journal of Archives in Military Medicine · doi:10.5812/jamm.45046 · Cited by 3
Anderson, C. M., Mattenberger, Y., Parga, A., Portalier, H., Tan, C. A. Z., Esteban Henao, M., Viollier, P. H., & Kline, K. A. (2026) · Journal of Bacteriology · doi:10.1128/jb.00548-25 · Cited by 2
Metadata
- Authors
- Gjødsbøl, K., Christensen, J. J., Karlsmark, T., Jørgensen, B., Klein, B. M., & Krogfelt, K. A.
- Venue
- International Wound Journal
- Publisher
- Wiley
- Published
- 2006-09
- Volume
- 3
- Issue
- 3
- Pages
- 225-231
- ISSN
- 1742-4801 (ISSN-L)
- 1742-481X
- OpenAlex
- W1965006954
- Cited by
- 622
- References
- 2
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
