The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
How Palatable Food Disrupts Appetite Regulation
Open accessAbstract
Abstract: Appetite regulation is part of a feedback system that controls the energy balance, involving a complex interplay of hunger and satiety signals, produced in the hypothalamus as well as in peripheral organs. Hunger signals may be generated in peripheral organs (e.g. ghrelin) but most of them are expressed in the hypothalamus (neuropeptide Y, orexins, agouti‐related peptide, melanin concentrating hormone, endogenous opiates and dopamine) and are expressed during situations of energy deficiency. Some satiety signals, such as cholecystokinin, glucagon‐like peptide 1, peptide YY and enterostatin are released from the digestive tract in response to food intake. Others, such as leptin and insulin, are mobilized in response to perturbations in the nutritional state. Still others are generated in neurones of the hypothalamus (α‐melanocyte‐stimulating hormone and serotonin). Satiety signals act by inhibiting the expression of hunger signals and/or by blunting their effect. Palatable food, i.e. food rich in fat and sugar, up‐regulates the expression of hunger signals and satiety signals, at the same time blunting the response to satiety signals and activating the reward system. Hence, palatable food offsets normal appetite regulation, which may explain the increasing problem of obesity worldwide.
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“It is largely recognized that the hedonic system is implicated in overeating, particularly in the current environment of unlimited access to a high variety of highly palatable and energy dense foods [114].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [114]
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Metadata
- Authors
- Erlanson‐Albertsson, C.
- Affiliations
- Lund University (SE)
- Corresponding author
- Erlanson‐Albertsson, Charlotte
- Venue
- Basic & Clinical Pharmacology & Toxicology
- Publisher
- Wiley
- Published
- 2005-07
- Volume
- 97
- Issue
- 2
- Pages
- 61-73
- ISSN
- 1742-7835 (ISSN-L)
- 1742-7843
- OpenAlex
- W2161715455
- Cited by
- 330
- References
- 158
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 18 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 23 · 2019: 11 · 2018: 15 · 2017: 17 · 2016: 20 · 2015: 23 · 2014: 25 · 2013: 18 · 2012: 20
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Basic & Clinical Pharmacology & Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- appetite regulation, palatable food, energy balance, hunger signals, satiety signals, hypothalamus, ghrelin, leptin, insulin, neuropeptide Y, orexin, cholecystokinin, glucagon-like peptide-1, peptide YY, enterostatin, melanin-concentrating hormone, serotonin, reward systems, obesity
- MeSH terms
- Animals, Appetite Regulation, Food Preferences, Humans, Hunger, Reward, Satiety Response, Behavior, Addictive
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