Cited by 173Regulation of Appetite and ObesityDiabetes Treatment and ManagementNeuropeptides and Animal Physiology

Role of the glucagon-like-peptide-1 receptor in the control of energy balance

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Hayes, Matthew R., De Jonghe, Bart C., Kanoski, Scott E.·2010·Physiology & Behavior

Abstract

The peripheral and central glucagon-like-peptide-1 (GLP-1) systems play an essential role in glycemic and energy balance regulation. Thus, pharmacological targeting of peripheral and/or central GLP-1 receptors (GLP-1R) may represent a potential long-term treatment option for both obesity and type-II diabetes mellitus (T2DM). Uncovering and understanding the neural pathways, physiological mechanisms, specific GLP-1R populations, and intracellular signaling cascades that mediate the food intake inhibitory and incretin effects produced by GLP-1R activation are vital to the development of these potential successful therapeutics. Particular focus will be given to the essential role of the nucleus tractus solitarius (NTS) in the caudal brainstem, as well as the gut-to-brain communication by vagal afferent fibers in mediating the physiological and behavioral responses following GLP-1R activation. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.

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Crossref · 10.1016/j.physbeh.2010.02.029

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Research works printed but not linked: 5

  1. [16]Hayes MR Skibicka KP Grill HJ Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation Endocrinology 2008 149 8 4059 68 18420740 PMC2488211
  2. [53]Ruttimann EB Intrameal Hepatic-Portal and Intraperitoneal Infusions of Glucagon-Like Peptide-1 (GLP-1) Reduce Spontaneous Meal Size in the Rat via Different Mechanisms Endocrinology 2008 PMC2654737 18948395
  3. [61]Sarwer DB The Management of Mood Disorders with Anti-depressant Medications After Bariatric Surgery Current Psychiatry 2010 In Press
  4. [87]Hayes MR Bradley L Grill HJ Endogenous hindbrain GLP-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling Endocrinology 2009 In Press PMC2689794 19264875
  5. [111]Grill HJ Hayes MR The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake Int J Obes (Lond) 2009 33 Suppl 1 S11 5 19363500

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Authors
Hayes, M. R., De Jonghe, B. C., & Kanoski, S. E.
Affiliations
University of Pennsylvania (US)
Corresponding author
Hayes, Matthew R.
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2010-07
Volume
100
Issue
5
Pages
503-510
ISSN
0031-9384 (ISSN-L)
OpenAlex
W2058747032
Cited by
173
References
121
Citations by year
2026: 6 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 17 · 2014: 13 · 2013: 16 · 2012: 14
FWCI
1.64
Type
journal article
Language
en
Open access
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH-NIDDK (077484)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
GLP-1 receptor, energy balance, obesity, type 2 diabetes, nucleus tractus solitarius, vagal afferents, gut-brain signaling, food intake regulation, incretin effect, GLP-1 receptor signaling
MeSH terms
Glucagon-Like Peptide-1 Receptor, Animals, Drug Administration Routes, Eating, Energy Metabolism, Humans, Signal Transduction, Receptors, Glucagon, Glucagon-Like Peptide 1, Incretins

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