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Cited by 100Sexual function and dysfunction studiesSexuality, Behavior, and TechnologyUrinary Bladder and Prostate Research

Phosphodiesterase type 5 inhibitors and female sexual response: faulty protocols or paradigms?

Chivers, Meredith L., Rosen, Raymond C.·2010·The Journal of Sexual Medicine
DOI 10.1111/j.1743-6109.2009.01599.x
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Abstract

INTRODUCTION: Phosphodiesterase type 5 inhibitors (PDE5), such as sildenafil, tadalafil, and vardenafil, have revolutionized the treatment of erectile dysfunction. Few successes, in contrast, have been reported for the use of these agents in treatment of sexual arousal problems in women. AIM: To review research examining efficacy of PDE5 in women, critique the methods and models employed, and integrate the findings within a broader, gender-specific understanding of female sexual response. METHODS: A conceptual and methodological review of all published studies examining PDE5 efficacy in female samples. MAIN OUTCOME MEASURES: Study methods, populations, outcome measures, study results. RESULTS: A total of 16 studies were reviewed. Studies using self-reported measures of sexual functioning showed mixed results whereas studies examining physiological effects of PDE5 on genital vasocongestion consistently report significant effects on genital sexual response. CONCLUSIONS: The lack of efficacy of PDE5 treatment in women is likely attributable to gender differences in the concordance between physiological and psychological components of sexual response. Discordance between genital and subjective measures of sexual response in women may be augmented by PDE5 effects on genital vasocongestion in some populations, rendering successful treatment unlikely via pharmacological treatment alone.

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Crossref · 10.1111/j.1743-6109.2009.01599.x

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72 of 72 references verified0 citation errors · 0 not checkable

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  • Physiologically based treatments (Viagra) only heighten the discordance between physiological arousal and subjective experience because the level of physiological arousal is irrelevant if psychological barriers are not addressed.

    “Physiologically based treatments (Viagra) only heighten this discordance: the level of physiological arousal is irrelevant if psychological barriers are not addressed (8).”

    From Effects of Mindfulness Training on Body Awareness to Sexual Stimuli: Implications for Female Sexual Dysfunction (2011) · cites this paper as [8]

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Authors
Chivers, M. L., & Rosen, R. C.
Affiliations
  • Queen's University (CA)
  • New England Research Institutes (US)
Corresponding author
Chivers, Meredith L.
ORCID
Chivers, Meredith L.
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2010-02-01
Volume
7
Issue
2_Part_2
Pages
858-872
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1111/j.1743-6109.2009.01599.x
OpenAlex
W1967671557
Cited by
100
References
72
Citations by year
2026: 2 · 2025: 2 · 2024: 9 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 12 · 2016: 9 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 12
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Solar Energy Technologies Office
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
phosphodiesterase-5 inhibitors, female sexual dysfunction, female sexual response, sildenafil, tadalafil, vardenafil
MeSH terms
Tadalafil, Sildenafil Citrate, Vardenafil Dihydrochloride, Animals, Carbolines, Clitoris, Female, Humans, Imidazoles, Phosphodiesterase Inhibitors, Piperazines, Purines, Sexual Dysfunction, Physiological, Sex Factors, Sulfones, Triazines, Vagina, Women's Health, Sexual Dysfunctions, Psychological, Phosphodiesterase 5 Inhibitors

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