CoChat
Sign Up
Cited by 27Coffee research and impactsCarcinogens and Genotoxicity AssessmentPlant Toxicity and Pharmacological Properties

The pharmacology and toxicology of caffeine

LACHANCE, MICHAEL P.·1982·Journal of Food Safety
DOI 10.1111/j.1745-4565.1982.tb00435.x
Open this paper in CoChat — free account

Abstract

The widespread use of caffeine is most commonly linked to the stimulatory action it has on the central nervous system. Generally, adverse effects include gastrorrhea, insomnia, and diuresis. Tolerance and withdrawal symptoms have been observed and excessive consumption can lead to an anxiety neurosis condition (caffeinism). The actions of caffeine may involve its effects on neurotransmitter turnover and metabolism; its promotion of the cellular messenger, cAMP; its sensitization of the calcium releasing mechanisms of cellular reticulum; or its antagonism of the autacoid, adenosine. Caffeine lethality is rare in man but caffeine poisoning with its gastrointestinal, CNS, and cardiovascular stimulation could especially be hazardous to children. Most of the mutagenicity work has been performed in organisms whose cellular DNA synthesis and repair mechanism vary significantly from those found in man. The work in human cell lines suggests that caffeine‐induced chromosomal breakage, with its lack of chromatid exchange would promote cell lethality, not muta‐genticity. Nothing but circumstantial evidence implicates caffeine as a human carcinogen or teratogen. Involvement of caffeine as a cocarcinogen or a coteratogen (which includes effects on gamete production or fetal development) appears far more likely, but neither has even begun to be truly evaluated. Basic metabolism of caffeine involves the processes of N‐demethylation, hydration, and oxidation; and most likely requires the cytochrome P1‐450 system. Though various metabolites of caffeine are pharmacologically active, the extent of involvement of individual metabolites in the pharmacological or toxicological responses of caffeine in man is still unknown.

Integrity signals

Registry

Crossref · 10.1111/j.1745-4565.1982.tb00435.x

Cites

250 of 250 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Additive caffeine reduced the dose of acetaminophen necessary to achieve the target of a 40% reduction in pain scores.

    “However, its pain-reduction effects were not properly studied until 1984, when Lachance (96) documented that additive caffeine reduced the dose of acetaminophen necessary to achieve the target of a 40% reduction in pain scores (96).”

    From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [96]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
LACHANCE, M. P.
Affiliations
University of Louisville (US)
Corresponding author
LACHANCE, MICHAEL P.
Venue
Journal of Food Safety
Publisher
Wiley
Published
1982-06
Volume
4
Issue
2
Pages
71-112
ISSN
  • 0149-6085 (ISSN-L)
  • 1745-4565
DOI
10.1111/j.1745-4565.1982.tb00435.x
OpenAlex
W2058152412
Cited by
27
References
250
Citations by year
2022: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2012: 1
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9072 d)
Locations
Journal of Food Safety (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
Keywords
caffeine, caffeine toxicity, caffeine pharmacology, central nervous system stimulation, caffeine withdrawal, adenosine antagonism, cyclic AMP, chromosomal damage, carcinogenesis, teratogenicity, caffeine metabolism, cytochrome P450, caffeine metabolites

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review