Intramuscular substrate utilization during prolonged exercise
Abstract
Large stores of intramuscular substrates are found in the different fiber types of human skeletal muscle, and with prolonged exercise both glycogen and triglyceride stores are utilized. The contribution from intramuscular glycogen stores is greatest at higher work intensities while triglyceride stores are utilized at moderate intensities. In man all fiber types have a similar glycogen content whereas the highest lipid content is found in the more oxidative fibers. The muscle metabolism is well adapted to the supply of substrate as well as to the demand for energy. Among several regulatory mechanisms, changes in citrate concentration seems to be an important factor in the interplay between carbohydrate and lipid metabolism.
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Under normal conditions, glycogen content in the muscle ranges between 300-400 mmol glucosyl units·kg dry mass−1.
“Under normal conditions, glycogen content in the muscle ranges between 300–400 mmol glucosyl units·kg dry mass−1 [34].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [34]
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- Authors
- Esséen, B.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1977-10
- Volume
- 301
- Issue
- 1
- Pages
- 30-44
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2137382230
- Cited by
- 133
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2016: 3 · 2015: 5 · 2013: 3 · 2012: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- prolonged exercise, skeletal muscle glycogen, intramuscular triglycerides, muscle fiber type, work intensity, citrate, lipid and carbohydrate metabolism, energy metabolism
- MeSH terms
- Diet, Dietary Carbohydrates, Physical Exertion, Glycogen, Glycolysis, Histocytochemistry, Humans, Muscles, Oxygen Consumption, Sports Medicine, Triglycerides
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