Oxytocin Receptor Distribution Reflects Social Organization in Monogamous and Polygamous Voles
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In voles, monogamous versus polygamous behavior is associated with higher density of dopamine D2 receptors in medial prefrontal cortex and oxytocin receptors in medial prefrontal cortex, NAcc, and caudate putamen.
“Furthermore, in different species of voles, a monogamous, as opposed to polygamous, pattern of behavior is associated with a higher density of dopamine D2 receptors (D2R) in the medial prefrontal cortex (mPFC) (3) and of OXT receptors (OXTR) in mPFC, NAcc, and caudate putamen (4,5).”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [4]
Brain distribution of the oxytocin receptor significantly differs between monogamous prairie voles and polygamous montane voles, with high oxytocin receptor density in prelimbic cortex and nucleus accumbens being crucial for monogamous behavior.
“While the expression of OXT is similar among both species (11), brain distribution of the OXTR significantly differs between them, with high OXTR density in the prelimbic cortex and nucleus accumbens (NAcc) being crucial for the expression of monogamous behavior (12,13).”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [12]
Cites
Comparison between the behavioural effects of septal and hippocampal lesions: A review
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125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT: a selective oxytocin receptor ligand
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Rat pup ultrasonic isolation calls: Possible mediation by the benzodiazepine receptor complex
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Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487 · see citing works
Self-citationInsel, T., Wang, Z., & Ferris, C. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05381.1994 · Cited by 454 · see citing works
Self-citationInfant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse
Winslow, J. T., Hearn, E. F., Ferguson, J., Young, L. J., Matzuk, M. M., & Insel, T. R. (2000) · Hormones and Behavior · doi:10.1006/hbeh.1999.1566 · Cited by 348 · see citing works
Self-citationOxytocin enhances brain reward system responses in men viewing the face of their female partner
Scheele, D., Wille, A., Kendrick, K. M., Stoffel-Wagner, B., Becker, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314190110 · Cited by 345 · see citing works
Bales, K. L., van Westerhuyzen, J. A., Lewis-Reese, A. D., Grotte, N. D., Lanter, J. A., & Carter, C. S. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.004 · Cited by 192 · see citing works
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Self-citationDevelopmental experiences and the oxytocin receptor system
Bales, K. L., & Perkeybile, A. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.013 · Cited by 142 · see citing works
Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships
Hurlemann, R., & Scheele, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.013 · Cited by 136 · see citing works
Dopamine regulation of social choice in a monogamous rodent species
Aragona, B. J. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.015.2009 · Cited by 119 · see citing works
“As pair bonding involves a myriad of cognitive and psychological processes, it is not surprising that a wide range of neural systems are important for its regulation including: oxytocin (Bales et al., 2007; Bamshad et al., 1993; Insel and Shapiro, 1992; Liu and Wang, 2003; Witt et al., 1990), vasopressin (Bamshad et a…”
BackgroundHormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face
Scheele, D., Plota, J., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv157 · Cited by 116 · see citing works
“For instance, monogamous prairie voles exhibit higher OXT receptor (OXTR) densities in the medial prefrontal cortex and nucleus accumbens (NAcc) compared with polygamous montane voles (Shapiro and Insel, 1992) and exogenous admin-”
BackgroundPeptide therapeutics for CNS indications
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- Authors
- SHAPIRO, L. E., & INSEL, T. R.
- Affiliations
- National Institute of Mental Health (US)
- ORCID
- INSEL, T. R.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1992-06
- Volume
- 652
- Issue
- 1
- Pages
- 448-451
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1984047095
- Cited by
- 84
- References
- 5
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 21 · 2019: 2 · 2017: 7 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin receptor, social organization, monogamy, polygamy, voles, social behavior, neuropeptide receptors
- MeSH terms
- Animals, Arvicolinae, Female, Maternal Behavior, Receptors, Angiotensin, Receptors, Opioid, Receptors, GABA-A, Sexual Behavior, Animal, Social Behavior, Species Specificity, Receptors, Oxytocin
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