Developmental experiences and the oxytocin receptor system

Bales, Karen L.; Perkeybile, Allison M.

doi:10.1016/j.yhbeh.2011.12.013

Cited by 142Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

Developmental experiences and the oxytocin receptor system

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Bales, Karen L., Perkeybile, Allison M.·2012·Hormones and Behavior

DOI 10.1016/j.yhbeh.2011.12.013

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Abstract

The long-term effects of developmental experiences on social behavior, and the neuropeptide systems such as oxytocin which subserve the behavior, are still little understood. In this article, we review various types of early experience, including normal development, knockout models, pharmacological exposures, and early social experiences. We consider the processes by which experience can affect oxytocin receptor binding, and what is known about the directionality of experience effects on oxytocin receptors. Finally, we attempt to synthesize the literature into a predictive model as to the direction of early experience effects on oxytocin receptor binding potential, and whether these changes have functional significance. These predictions are relevant to current human health practice, given proposals to use chronic intranasal oxytocin to treat developmental disorders including autism and schizophrenia. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

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Developmental treatments can have particular ramifications to receptor binding and up- or down-regulation of peptide production.
“Developmental treatments can have particular ramifications to receptor binding and up- or down-regulation of peptide production (38,54,74,75).”
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Ancellin, N., Preisser, L., Maout, S. L., Barbado, M., Créminon, C., Corman, B., & Morel, A. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00035-2 · Cited by 30 · see citing works
Neonatal oxytocin alters subsequent estrogen receptor alpha protein expression and estrogen sensitivity in the female rat
Perry, A. N., Paramadilok, A., & Cushing, B. S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.021 · Cited by 26 · see citing works
Oxytocin selectively increases ERα mRNA in the neonatal hypothalamus and hippocampus of female prairie voles
Pournajafi-Nazarloo, H., Carr, M. S., Papademeteriou, E., Schmidt, J. V., & Cushing, B. S. (2007) · Neuropeptides · doi:10.1016/j.npep.2006.10.002 · Cited by 23 · see citing works
Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development
Chen, Q., Schreiber, S. S., & Brinton, R. D. (2000) · Neuropeptides · doi:10.1054/npep.2000.0809 · Cited by 23 · see citing works
Developmental Changes in Forebrain Vasopressin Receptor Binding in Prairie Voles (Microtus ochrogaster) and Montane Voles (Microtus montanus)
Wang, Z., LIU, Y., Young, L. J., & Insel, T. R. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51954.x · Cited by 19 · see citing works
The neuroendocrinology of the social brain
Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.06.002 · Cited by 19 · see citing works
Early experience and the developmental programming of oxytocin and vasopressin
Sue carter, C., Boone, E. M., & Bales, K. L. (2008) · Neurobiology of the Parental Brain · doi:10.1016/b978-012374285-8.00027-5 · Cited by 14 · see citing works
Oxytocin Receptor-Mediated Activation of Phosphoinositidase C and Elevation of Cytosolic Calcium in the Gonadotrope-Derived T3-1 Cell Line
Evans, J. J. (1997) · Endocrinology · doi:10.1210/en.138.5.2049 · Cited by 14 · see citing works

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Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development
Hostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0032671 · Cited by 739 · see citing works
The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions
Sheng, J. A., Bales, N. J., Myers, S. A., Bautista, A. I., Roueinfar, M., Hale, T. M., & Handa, R. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601939 · Cited by 418 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Chen, X., Gautam, P., Stair, S., Haroon, E., Thompson, R., Ditzen, B., Patel, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.022 · Cited by 343 · see citing works
“Such effects may be attributable to developmental influences on OTreceptor expression (Bales and Perkeybile, 2012), which in turn should affect responsiveness to intranasal OT.”
Background
Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265 · see citing works
Empathy as a “risky strength”: A multilevel examination of empathy and risk for internalizing disorders
Tone, E. B., & Tully, E. C. (2014) · Development and Psychopathology · doi:10.1017/s0954579414001199 · Cited by 231 · see citing works
Developmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 177 · see citing works
Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works
Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network
Smith, C. J. W., Poehlmann, M. L., Li, S., Ratnaseelan, A. M., Bredewold, R., & Veenema, A. H. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1260-7 · Cited by 143 · see citing works
Social stimuli induce activation of oxytocin neurons within the paraventricular nucleus of the hypothalamus to promote social behavior in male mice
Resendez, S. L., Namboodiri, V. M. K., Otis, J. M., Eckman, L. E. H., Rodriguez-Romaguera, J., Ung, R. L., Basiri, M. L., Kosyk, O., Rossi, M. A., Dichter, G. S., et al. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1515-18.2020 · Cited by 142 · see citing works
Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system
Buisman‐Pijlman, F. T. A., Sumracki, N. M., Gordon, J. J., Hull, P. R., Carter, C. S., & Mattie Tops, A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.005 · Cited by 143 · see citing works
Social support can buffer against stress and shape brain activity
Hostinar, C. E., & Gunnar, M. R. (2015) · AJOB Neuroscience · doi:10.1080/21507740.2015.1047054 · Cited by 131 · see citing works
Long-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131 · see citing works
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 121 · see citing works
Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin
MacDonald, K. S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00194 · Cited by 119 · see citing works
Natural variation in early parental care correlates with social behaviors in adolescent prairie voles (Microtus ochrogaster)
Perkeybile, A. M., Griffin, L. L., & Bales, K. L. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00021 · Cited by 114 · see citing works
Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care
Buckley, S. J. (2015) · Issue Lab (Candid) · Cited by 113 · see citing works
Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains
Newmaster, K. T., Nolan, Z. T., Chon, U., Vanselow, D. J., Weit, A. R., Tabbaa, M., Hidema, S., Nishimori, K., Hammock, E. A. D., & Kim, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-15659-1 · Cited by 109 · see citing works
Repeated intranasal oxytocin administration in early life dysregulates the HPA axis and alters social behavior
Rault, J.-L., Carter, C. S., Garner, J. P., Marchant, J. N., Richert, B. T., & Lay, D. C. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.007 · Cited by 94 · see citing works
Research Review: Social motivation and oxytocin in autism – implications for joint attention development and intervention
Stavropoulos, K. K. M., & Carver, L. J. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12061 · Cited by 95 · see citing works
Transgenerational effects of social stress on social behavior, corticosterone, oxytocin, and prolactin in rats
Babb, J. A., Carini, L. M., Spears, S. L., & Nephew, B. C. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.005 · Cited by 95 · see citing works
Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways
Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13140 · Cited by 85 · see citing works
Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats
Beery, A. K., McEwen, L. M., MacIsaac, J. L., Francis, D. D., & Kobor, M. S. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.022 · Cited by 81 · see citing works
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 82 · see citing works
Editorial comment: Oxytocin, vasopressin and social behavior
Young, L. J., & Flanagan-Cato, L. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.019 · Cited by 81 · see citing works
Systematic review and meta‐analysis of reported adverse events of long‐term intranasal oxytocin treatment for autism spectrum disorder
Cai, Q., Feng, L., & Yap, K. Z. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12627 · Cited by 77 · see citing works
Epigenetics of childhood trauma: Long term sequelae and potential for treatment
Thumfart, K. M., Jawaid, A., Bright, K., Flachsmann, M., & Mansuy, I. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.042 · Cited by 78 · see citing works
Intergenerational transmission of alloparental behavior and oxytocin and vasopressin receptor distribution in the prairie vole
Perkeybile, A. M., Delaney-Busch, N., Hartman, S., Grimm, K. J., & Bales, K. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00191 · Cited by 76 · see citing works
Self-citation
Advances in nonhuman primate models of autism: Integrating neuroscience and behavior
Bauman, M. D., & Schumann, C. M. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.07.021 · Cited by 71 · see citing works
The Parental Brain
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 101 · see citing works
Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing
Schneider-Hassloff, H., Straube, B., Jansen, A., Nuscheler, B., Wemken, G., Witt, S. H., Rietschel, M., & Kircher, T. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.009 · Cited by 71 · see citing works
Lifespan oxytocin signaling: Maturation, flexibility, and stability in newborn, adolescent, and aged brain
Sannino, S., Chini, B., & Grinevich, V. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22450 · Cited by 70 · see citing works
Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders
Cataldo, I., Azhari, A., Lepri, B., & Esposito, G. (2017) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2017.10.007 · Cited by 70 · see citing works
Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study
Arambula, S. E., Jima, D. D., & Patisaul, H. B. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.10.005 · Cited by 69 · see citing works
Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Developmental stress and social phenotypes: integrating neuroendocrine, behavioural and evolutionary perspectives
Spencer, K. A. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0242 · Cited by 56 · see citing works
A Neuroscientist’s Guide to the Vole
Kenkel, W. M., Gustison, M. L., & Beery, A. K. (2021) · Current Protocols · doi:10.1002/cpz1.175 · Cited by 52 · see citing works
Early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators
Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00143 · Cited by 53 · see citing works
The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy
Baracz, S. J., Everett, N. A., & Cornish, J. L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.014 · Cited by 52 · see citing works
Early Social Environment Affects the Endogenous Oxytocin System: A Review and Future Directions
Alves, E., Fielder, A. L., Ghabriel, N., Sawyer, M., & Buisman‐Pijlman, F. T. A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00032 · Cited by 48 · see citing works
How do hypothalamic nonapeptides shape youth’s sociality? A systematic review on oxytocin, vasopressin and human socio-emotional development
Torres, N., Martins, D., dos Santos, A. J., Prata, D. P., & Veríssimo, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.004 · Cited by 46 · see citing works
A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children
Shou, X., Xu, X., Zeng, X., Liu, Y., Yuan, H., Xing, Y., Jia, M., Wei, Q.-Y., Han, S., Zhang, R., et al. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0109-2 · Cited by 44 · see citing works
Oxytocin Signaling in the Early Life of Mammals: Link to Neurodevelopmental Disorders Associated with ASD
Muscatelli, F., Desarménien, M. G., Matarazzo, V. A., & Grinevich, V. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_16 · Cited by 46 · see citing works
Birth signalling hormones and the developmental consequences of caesarean delivery
Kenkel, W. M. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12912 · Cited by 45 · see citing works
The two fold role of oxytocin in social developmental disorders: A cause and a remedy?
Lefèvre, A., & Angela Sirigu, B. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.011 · Cited by 45 · see citing works
Perinatal and juvenile social environments interact to shape cognitive behaviour and neural phenotype in prairie voles
Prounis, G. S., Foley, L., Rehman, A., & Ophir, A. G. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.2236 · Cited by 44 · see citing works
Maternal Bonding in Early Infancy Predicts Childrens' Social Competences in Preschool Age
Joas, J., & Möhler, E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.687535 · Cited by 43 · see citing works
An integrated framework for the role of oxytocin in multistage social decision‐making
Piva, M., & Chang, S. W. C. (2018) · American Journal of Primatology · doi:10.1002/ajp.22735 · Cited by 38 · see citing works
“OT may also modulate different stages depending on the social context or even on individual differences in developmental experiences between animals (Bales & Perkeybile, 2012), likely mediating some of the inconsistencies observed in the effects of OT on social behavior (Bartz, Zaki, et al., 2011).”
Background
Comparative and developmental perspectives on oxytocin and vasopressin.
Bales, K. L. (2013) · American Psychological Association eBooks · doi:10.1037/14250-002 · Cited by 40 · see citing works
Developmental trajectories and influences of environmental complexity on oxytocin receptor and vasopressin 1A receptor expression in male and female prairie voles
Prounis, G. S., Thomas, K., & Ophir, A. G. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24450 · Cited by 36 · see citing works
Chronic Intranasal Oxytocin has Dose-dependent Effects on Central Oxytocin and Vasopressin Systems in Prairie Voles (Microtus ochrogaster)
Guoynes, C. D., Simmons, T. C., Downing, G., Jacob, S., Solomon, M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.037 · Cited by 38 · see citing works
Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood
Suraev, A. S., Bowen, M. T., Ali, S. O., Hicks, C., Ramos, L., & McGregor, I. S. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.002 · Cited by 35 · see citing works
Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation
Cimarelli, G., Virányi, Z., Turcsán, B., Rónai, Z., Sasvári‐Székely, M., & Bánlaki, Z. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00549 · Cited by 36 · see citing works
Interplay between the oxytocin and opioid systems in regulating social behaviour
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0050 · Cited by 33 · see citing works
Oxytocin and social salience: a call for gene-environment interaction research
Tabak, B. A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00199 · Cited by 33 · see citing works
Peripartum depression and anxiety as an integrative cross domain target for psychiatric preventative measures
Babb, J. A., Deligiannidis, K. M., Murgatroyd, C., & Nephew, B. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.039 · Cited by 31 · see citing works
Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis
Farshim, P. P., Walton, G., Chakrabarti, B., Givens, D. I., Saddy, D., Kitchen, I., Swann, J. R., & Bailey, A. (2016) · Scientific Reports · doi:10.1038/srep21958 · Cited by 32 · see citing works
Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic‐like behaviours to 20 years of age?
Guastella, A. J., Cooper, M., White, C. R. H., White, M. K., Pennell, C. E., & Whitehouse, A. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12924 · Cited by 29 · see citing works
Early involvement in friendships predicts later plasma concentrations of oxytocin and vasopressin in juvenile rhesus macaques (Macaca mulatta)
Weinstein, T. A. R., Bales, K. L., Maninger, N., Hostetler, C. M., & Capitanio, J. P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00295 · Cited by 26 · see citing works
Prenatal alcohol exposure disrupts male adolescent social behavior and oxytocin receptor binding in rodents
Holman, P. J., Ellis, L. A., Morgan, E., & Weinberg, J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.08.004 · Cited by 26 · see citing works
MAGEL2 (patho‐)physiology and Schaaf–Yang syndrome
Schubert, T., & Schaaf, C. P. (2024) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.16018 · Cited by 25 · see citing works
Exploration in a dispersal task: Effects of early experience and correlation with other behaviors in prairie voles ( Microtus ochrogaster )
Razo, R. A., & Bales, K. L. (2016) · Behavioural Processes · doi:10.1016/j.beproc.2016.10.002 · Cited by 25 · see citing works
Early experience alters developmental trajectory of central oxytocin systems involved in hypothalamic-pituitary-adrenal axis regulation in Long-Evans rats
Lapp, H. E., Bartlett, A. A., Zup, S. L., Hunter, R. G., & Moore, C. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104822 · Cited by 23 · see citing works
Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse
Morais, L. H., Golubeva, A. V., Casey, S., Scott, K. A., Costa, A. P., Moloney, G. M., Dinan, T. G., & Cryan, J. F. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01040-3 · Cited by 22 · see citing works
Long term effects of chronic intranasal oxytocin on adult pair bonding behavior and brain glucose uptake in titi monkeys (Plecturocebus cupreus)
Razo, R. A., Vázquez, M. D. L. V., Turcanu, P., Legrand, M., Floch, M., Weinstein, T. A. R., Goetze, L. R., Freeman, S. M., BAXTER, A. B., Witczak, L. R., et al. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105126 · Cited by 23 · see citing works
Electro-acupuncture improves the social interaction behavior of rats
Zhang, H., Li, H.-X., Dai, Y., Xu, X., Han, S., Zhang, R., & Han, J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.08.014 · Cited by 24 · see citing works
Visual systemizing preference in children with autism: A randomized controlled trial of intranasal oxytocin
Strathearn, L., Kim, S., Bastian, D. A., Jung, J., Iyengar, U., Martinez, S. R., Goin‐Kochel, R. P., & Fonagy, P. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001018 · Cited by 23 · see citing works
Post-weaning A1/A2 β-casein milk intake modulates depressive-like behavior, brain μ-opioid receptors, and the metabolome of rats
Osman, A., Zuffa, S., Walton, G., Fagbodun, E. O., Zanos, P., Georgiou, P., Kitchen, I., Swann, J. R., & Bailey, A. (2021) · iScience · doi:10.1016/j.isci.2021.103048 · Cited by 24 · see citing works
Early life adversity and males: Biology, behavior, and implications for fathers’ parenting
Condon, E. M., Dettmer, A. M., Baker, E., McFaul, C., & Stover, C. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104531 · Cited by 27 · see citing works
Oxytocin treatment in pediatric populations
Taylor, A. E., Lee, H.-E., & Buisman‐Pijlman, F. T. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00360 · Cited by 23 · see citing works
Effects of chronic oxytocin on attention to dynamic facial expressions in infant macaques
Parr, L. A., Brooks, J. M., Jonesteller, T., Moss, S., Jordano, J. O., & Heitz, T. R. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.028 · Cited by 23 · see citing works
When too much of a good thing is bad: chronic oxytocin, development, and social impairments
Young, L. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.015 · Cited by 22 · see citing works
L’ocytocine et la dépression du post-partum
Cardaillac, C., Rua, C., Simon, E. G., & El‐Hage, W. (2016) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2016.05.002 · Cited by 22 · see citing works
Oxytocin receptors in the Magel2 mouse model of autism: Specific region, age, sex and oxytocin treatment effects
Gigliucci, V., Busnelli, M., Santini, F., Paolini, C., Bertoni, A., Schaller, F., Muscatelli, F., & Chini, B. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1026939 · Cited by 20 · see citing works
Adversity impacting on oxytocin and behaviour: timing matters
Johnson, J. L., & Buisman‐Pijlman, F. T. A. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000269 · Cited by 20 · see citing works
Attachment style: The neurobiological substrate, interaction with genetics and role in neurodevelopmental disorders risk pathways
Antonucci, L. A., Taurisano, P., Coppola, G., & Cassibba, R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.002 · Cited by 20 · see citing works
Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex
Duchemin, A., Seelke, A. M. H., Simmons, T. C., Freeman, S. M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.017 · Cited by 19 · see citing works
Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra
Frehner, S. S., Dooley, K. T., Palumbo, M. C., Smith, A. L., Goodman, M. M., Bales, K. L., & Freeman, S. M. (2022) · Philosophical Transactions of the Royal Society B · doi:10.1098/rstb.2021.0118 · Cited by 18 · see citing works
Environmental enrichment and intranasal oxytocin administration reverse maternal separation-induced impairments of prosocial choice behavior
Joushi, S., Taherizadeh, Z., Esmaeilpour, K., & Sheibani, V. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173318 · Cited by 18 · see citing works
Neonatal oxytocin gives the tempo of social and feeding behaviors
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Authors: Bales, K. L., & Perkeybile, A. M.
Affiliations: University of California, Davis (US)
Corresponding author: Bales, Karen L.
ORCID: Bales, Karen L.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2012-03
Volume: 61
Issue: 3
Pages: 313-319
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2011.12.013
OpenAlex: W1964035308
Cited by: 142
References: 92
Citations by year: 2026: 6 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 8 · 2020: 21 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 12 · 2013: 14 · 2012: 3
FWCI: 1.17
Type: journal article
Language: en
Open access: green
escholarship.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: oxytocin receptor, developmental experiences, early social experience, receptor binding potential, knockout models, social behavior, autism spectrum disorder, schizophrenia, intranasal oxytocin, developmental disorders, neuropeptide systems
MeSH terms: Animals, Child, Child Development, Child, Preschool, Humans, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin, Mice, Knockout, Mice

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Developmental experiences and the oxytocin receptor system

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