Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles
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The present study examines the developmental consequences of neonatal exposure to oxytocin on adult social behaviors in female prairie voles (Microtus ochrogaster). Female neonates were injected within 24 h of birth with isotonic saline or one of four dosages of oxytocin (OT). As adults, females were tested in an elevated plus-maze paradigm (a measure of anxiety and exploratory behavior), and for alloparental behavior and partner preferences. At 2 mg/kg OT, females took longer to approach pups, but were the only group to form a statistically significant within-group partner preference. At 4 mg/kg OT, females retrieved pups significantly more frequently but no longer displayed a partner preference; while females treated developmentally with 8 mg/kg spent significantly more time in side-to-side contact with a male stranger than any other treatment group. OT may have broad developmental consequences, but these effects are not linear and may both increase and decrease the propensity to display behaviors such as pair-bonding.
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Oxytocin injected into the cerebral ventricles of a virgin rat can produce nurturing behavior towards pups within two hours.
“OT injected into the cerebral ventricles (ICV) of a virgin rat could produce nurturing behavior towards pups within two hours [7].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [7]
A single shot of oxytocin in pups shortly after birth was associated with increased participation in allo-parental care when they became adults.
“In addition, a single shot of oxytocin in pups shortly after birth was associated with increased participation in allo-parental care when they became adults (Bales et al., 2007).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Bales et al., 2007
Oxytocin can produce opposing effects at different dosages.
“OT (like other peptides) can produce opposing effects at different dosages (19–22).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [19]
Female prairie voles seem more resilient to developmental manipulations of the oxytocin system, typically responding only at higher doses of oxytocin.
“Females seem more resilient to developmental manipulations, typically responding only at higher dose of OT (19,39).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [19]
A single intraperitoneal oxytocin administration on postnatal day 1 led to long-term effects on partner preference in both male and female prairie voles, which differed depending on dose.
“In voles, we found a single intraperitoneal OT administration postnatal day 1, led to long-term effects on partner preference in both male and female prairie voles, which differed depending on dose (19, 20).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [19]
Dose-dependent oxytocin efficacy has been shown in animal and human studies on diseases other than autism spectrum disorder.
“Previous animal14, 15 and human studies on diseases other than ASD16, 17, 18 have shown dose-dependent oxytocin efficacy.”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [14]
Studies in numerous species provide converging evidence that oxytocin during development can have permanent effects on the brain and behavior.
“Yet, in the last 12 years, there has been a resurgence of research in this area, with studies in numerous species providing converging evidence that Oxt during development can have permanent effects on the brain and behavior (3, 13–29) (see Table 1).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [16]
Oxytocin treatment increases the responsiveness of female mice to pups, as measured by approach times, in a dose-dependent manner, with the lowest dose resulting in longer approach times compared to saline controls.
“Oxt treatment also increases the responsiveness of females to pups, as measured by approach times, although this effect is dose dependent, with the lowest dose of Oxt resulting in longer approach times compared to saline controls (16).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [16]
Animal research has shown the potential for long-term adverse effects after large oxytocin doses.
“Animal research has shown the potential for long-term adverse effects after large oxytocin doses.67, 68”
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- Authors
- Bales, K. L., van Westerhuyzen, J. A., Lewis-Reese, A. D., Grotte, N. D., Lanter, J. A., & Carter, C. S.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Bales, Karen L.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 52
- Issue
- 2
- Pages
- 274-279
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC1978481
- OpenAlex
- W2017104298
- Cited by
- 192
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 25 · 2019: 9 · 2018: 12 · 2017: 18 · 2016: 17 · 2015: 17 · 2014: 14 · 2013: 18 · 2012: 8
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- U.S. Public Health Service (R01 073022)
- National Institute of Mental Health (R01MH073022)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 38490, P01HD038490, F32 HD08702, F32HD008702)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- oxytocin, Microtus ochrogaster, pair bonding, mate preferences, alloparental care, pup retrieval, female social behavior, anxiety, exploratory behavior, dose-dependent effects, developmental programming
- MeSH terms
- Animals, Animals, Newborn, Arvicolinae, Dose-Response Relationship, Drug, Female, Nesting Behavior, Oxytocin, Pair Bond, Maze Learning
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