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Cited by 84Body Composition Measurement TechniquesNutrition and Health in AgingClinical Nutrition and Gastroenterology

Smaller Organ Tissue Mass in the Elderly Fails to Explain Lower Resting Metabolic Rate

GALLAGHER, DYMPNA, ALLEN, AARON, WANG, ZIMIAN, HEYMSFIELD, STEVEN B., KRASNOW, NORMAN·2000·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.2000.tb06499.x
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Abstract

A bstract: We previously reported our in vivo prediction of whole body resting energy expenditure (REE) using magnetic resonance imaging and echocardiography‐derived organ volumes combined with published organ tissue metabolic rates.1 The models, developed in young healthy persons from predicted and measured variables, were highly correlated (e.g., calculated vs. measured REE, r= 0.92, p < 0.001), with no significant differences (p= NS) between them. This study employed the same approach to determine whether possible age‐related decreases in organ tissue mass may account for the lower REE commonly reported in elderly persons. Measurements of REE (REE m) were acquired by indirect calorimetry. Calculated REE (REE c) models were developed from measured tissues and organs, and energy flux rates were assigned for each of the seven tissue/organ components, as reported by Elia.2 Older men (n= 6) and women (n= 7) had significantly lower REE m compared to REE c (p= 0.001). The magnitude of the differences were 13% and 9.5%, respectively, for men and women. These preliminary data suggest that factors other than organ atrophy may contribute to the lower metabolic rate of older persons. Further studies are required to investigate whether there is a reduction in the oxidative capacity of individual organs and tissues.

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  • This pattern agrees with prior work reporting elevated tissue-specific metabolic rates in children and adolescents and reduced rates in older adults.

    “consistent with previous work indicating that tissue-specific metabolic rates are elevated in children and adolescents (22, 24) and reduced in older adults (21, 23, 25).”

    From Daily energy expenditure through the human life course (2021) · cites this paper as [21]

  • At rest, the heart, liver, brain, and kidneys have much higher tissue-specific metabolic rates than muscles, other lean tissue, or fat.

    “At rest, the tissue-specific metabolic rates (Watts/gram) of the heart, liver, brain, and kidneys are much greater than those of the muscles and other lean tissue or fat (21–25).”

    From Daily energy expenditure through the human life course (2021) · cites this paper as [21]

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Authors
GALLAGHER, D., ALLEN, A., WANG, Z., HEYMSFIELD, S. B., & KRASNOW, N.
Affiliations
St. Luke's-Roosevelt Hospital Center (US)
Corresponding author
GALLAGHER, DYMPNA
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2000-05
Volume
904
Issue
1
Pages
449-455
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.2000.tb06499.x
OpenAlex
W2004507170
Cited by
84
References
13
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 4 · 2012: 4
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2095 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (R29-AG 14715, R29AG014715)
Topics
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
resting energy expenditure, aging, organ atrophy, resting metabolic rate, organ volume, older adults, sex differences
MeSH terms
Aged, Aged, 80 and over, Basal Metabolism, Body Composition, Body Height, Body Weight, Calorimetry, Echocardiography, Female, Humans, Magnetic Resonance Imaging, Male, Models, Biological, Organ Size, Potassium, Sex Characteristics, Absorptiometry, Photon, Body Mass Index

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