The Immune–Pineal Axis: Stress as a Modulator of Pineal Gland Function

A Syndrome produced by Diverse Nocuous Agents

Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967 · see citing works

Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs

Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149 · see citing works

From Psychological Stress to the Emotions: A History of Changing Outlooks

Lazarus, R. S. (1993) · Annual Review of Psychology · doi:10.1146/annurev.ps.44.020193.000245 · Cited by 2,596 · see citing works

The role of the amygdala in fear and anxiety

Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357 · see citing works

Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works

Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness

Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740 · see citing works

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works

REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance

Bubenik, G. A. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020107915919 · Cited by 655 · see citing works

Effects of adverse experiences for brain structure and function

McEwen, B. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00964-1 · Cited by 639 · see citing works

Corticosteroids in relation to fear, anxiety and psychopathology

Korte, S. M. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00002-1 · Cited by 607 · see citing works

Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups

Dayas, C. V., Buller, K. M., Crane, J. W., Xu, Y., & Day, T. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01733.x · Cited by 514 · see citing works

Chapter 12 The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress

Sawchenko, P. E., Brown, E. R., Chan, R. K. W., Ericsson, A. B., Li, H.-Y., Roland, B. L., & Kovács, K. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61866-x · Cited by 323 · see citing works

Restraint stress in biomedical research: An update

Glavin, G. B., Paré, W. P., Sandbak, T., Bakke, H.-K., & Murison, R. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90027-2 · Cited by 304 · see citing works

The circumventricular organs: An atlas of comparative anatomy and vascularization

Duvernoy, H. M., & Risold, P. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.002 · Cited by 263 · see citing works

Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFκB activation

Gilad, E., Wong, H. R., Zingarelli, B., Virág, L., O'connor, M., Salzman, A. L., & Szabó, C. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.685 · Cited by 252 · see citing works

Role of melatonin in neurodegenerative diseases

Srinivasan, V. J., Pandi-Perumal, S. R., Maestroni, G. J. M., Esquifino, A. I., Hardeland, R., & Cardinali, D. P. (2005) · Neurotoxicity Research · doi:10.1007/bf03033887 · Cited by 232 · see citing works

The Increase in TNF-α Levels Is Implicated in NF-κB Activation and Inducible Nitric Oxide Synthase Expression in Brain Cortex after Immobilization Stress

Madrigal, J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00292-5 · Cited by 232 · see citing works

Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury

Cuzzocrea, S., & Reiter, R. J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01175-x · Cited by 226 · see citing works

Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro‐/anti‐inflammatory cytokine network, protection against oxidative damage and anti‐apoptotic effects

Carrillo‐Vico, A., Lardone, P. J., Naji, L., Fernández‐Santos, J. M., Martín‐Lacave, I., Guerrero, J. M., & Calvo, J. R. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00265.x · Cited by 204 · see citing works

Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites.

Hotta, C. T., Gazarini, M. L., Beraldo, F. H., Varotti, F. D. P., Lopes, C., Markus, R. P., Pozzan, T., & Garcia, C. R. S. (2000) · Nature Cell Biology · doi:10.1038/35017112 · Cited by 196 · see citing works

Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation

Lotufo, C. M. C., Lopes, C., Dubocovich, M. L., Farsky, S. H. P., & Markus, R. P. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01369-3 · Cited by 183 · see citing works

The Immune-Pineal Axis: A Shuttle between Endocrine and Paracrine Melatonin Sources

Markus, R. P., Ferreira, Z. S., Fernandes, P. A. C. M., & Cecon, E. (2007) · NeuroImmunoModulation · doi:10.1159/000110635 · Cited by 161 · see citing works

Suprachiasmatic nucleus lesion increases corticosterone secretion

Buijs, R. M., Kalsbeek, A., van der Woude, T. P., van Heerikhuize, J. J., & Shinn, S. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.6.r1186 · Cited by 149 · see citing works

The cytokine-HPA axis feed-back circuit

Besedovsky, H. O., & del Rey, A. (2000) · Zeitschrift für Rheumatologie · doi:10.1007/s003930070014 · Cited by 146 · see citing works

Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization stress in rats: an in vivo microdialysis study

Pacák, K., Armando, I., Fukuhara, K., Kvetnatsky, R., Palkovits, M., Kopin, I. J., & Goldstein, D. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91165-b · Cited by 139 · see citing works

Stress as an endogenous adjuvant: augmentation of the immunization phase of cell-mediated immunity

Viswanathan, K., Daugherty, C., & Dhabhar, F. S. (2005) · International Immunology · doi:10.1093/intimm/dxh286 · Cited by 138 · see citing works

Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) – melatonin in human colostrum and colostrum phagocytes

Pontes, G. N., Cardoso, E. C., Carneiro-Sampaio, M. M. S., & Markus, R. P. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00345.x · Cited by 129 · see citing works

Stress and the brain

Heuser, I., & Lammers, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00048-4 · Cited by 126 · see citing works

Pineal melatonin and the innate immune response: the TNF‐α increase after cesarean section suppresses nocturnal melatonin production

Pontes, G. N., Cardoso, E. C., Carneiro-Sampaio, M. M. S., & Markus, R. P. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00487.x · Cited by 120 · see citing works

Bidirectional communication between the pineal gland and the immune system

Skwarło‐Sońta, K., Majewski, P. M., Markowska, M., Obłap, R., & Olszańska, B. (2003) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y03-026 · Cited by 114 · see citing works

Effect of TNF‐α on the melatonin synthetic pathway in the rat pineal gland: basis for a ‘feedback’ of the immune response on circadian timing

Fernandes, P. A. C. M., Cecon, E., Markus, R. P., & Ferreira, Z. S. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00373.x · Cited by 111 · see citing works

Melatonin effect on endothelial cells reduces vascular permeability increase induced by leukotriene B4

Lotufo, C. M. C., Yamashita, C. E., Farsky, S. H. P., & Markus, R. P. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.01.050 · Cited by 96 · see citing works

Corticosterone modulates noradrenaline‐induced melatonin synthesis through inhibition of nuclear factor kappa B

Ferreira, Z., Fernandes, P., Duma, D., Assreuy, J., Avellar, M. C. W., & Markus, R. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00191.x · Cited by 92 · see citing works

Morphological changes of thymus and the thyroid gland after postnatal extirpation of pineal body.

Csaba, G., & Baráth, P. (1975) · PubMed · Cited by 88 · see citing works

Tertian and Quartan Fevers: Temporal Regulation in Malarial Infection

Garcia, C. R. S., Markus, R. P., & da Silva, L. M. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002114 · Cited by 78 · see citing works

Melatonin inhibits endothelial nitric oxide production in vitro

Tamura, E. K., Silva, C. L. M., & Markus, R. P. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00366.x · Cited by 76 · see citing works

Circadian rhythm in experimental granulomatous inflammation is modulated by melatonin

Lopes, C., deLyra, J. L., Markus, R. P., & Mariano, M. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00338.x · Cited by 72 · see citing works

Central/peripheral nervous system and immune responses

Lawrence, D. A. (2000) · Toxicology · doi:10.1016/s0300-483x(99)00144-4 · Cited by 67 · see citing works

Effects of noradrenaline depletion in the brain on response to novelty in isolation-reared rats

Bluhm, M. D. L., Mateo, Y., Parker, T. L., & Marsden, C. A. (2000) · Psychopharmacology · doi:10.1007/s002130000534 · Cited by 64 · see citing works

Stress, the immune system and vulnerability to degenerative disorders of the central nervous system in transgenic mice expressing glucocorticoid receptor antisense RNA

Marchetti, B., Morale, M. C., Testa, N., Tirolo, C., Caniglia, S., Amor, S., Dijkstra, C. D., & Barden, N. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00130-8 · Cited by 62 · see citing works

Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice

Lopes, C., & Mariano, R. P. M. M. (2001) · Inflammation Research · doi:10.1007/s000110050717 · Cited by 60 · see citing works

Melatonin inhibits nitric oxide production by microvascular endothelial cellsin vivoandin vitro

Silva, C. L. M., Tamura, E. K., Macedo, S., Cecon, E., Bueno-Alves, L., Farsky, S. H. P., Ferreira, Z. S., & Markus, R. P. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707225 · Cited by 59 · see citing works

Genetic modification of corticosteroid receptor signalling: Novel insights into pathophysiology and treatment strategies of human affective disorders

Müller, M. B., Holsboer, F., & Keck, M. E. (2002) · Neuropeptides · doi:10.1054/npep.2002.0896 · Cited by 58 · see citing works

Seesaw signal processing in pineal cells: homologous sensitization of adrenergic stimulation of cyclic GMP accompanies homologous desensitization of beta-adrenergic stimulation of cyclic AMP.

Klein, D. C., Auerbach, D. A., & Weller, J. L. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.7.4625 · Cited by 57 · see citing works

Nervous System-Immune System Interactions: An Overview

Dunn, A. J. (1988) · Journal of Receptor Research · doi:10.3109/10799898809049013 · Cited by 55 · see citing works

Purinergic and noradrenergic cotransmission in the rat pineal gland

Barbosa, E. J. M., Ferreira, Z. S., & Markus, R. P. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00416-7 · Cited by 54 · see citing works

Release of [3h]-l-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices

Renó, L. A. C., Zago, W. M., & Markus, R. P. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.023 · Cited by 52 · see citing works

Local Corticosterone Infusion Enhances Nocturnal Pineal Melatonin Production In Vivo

Fernandes, P. A. C. M., Bothorel, B., Clesse, D., Monteiro, A. W. A., Calgari, C., Raison, S., Simonneaux, V., & Markus, R. P. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01817.x · Cited by 46 · see citing works

Relationship between corticotropin‐releasing factor and interleukin‐2: Evolutionary evidence

Ottaviani, E., Franchini, A., Caselgrandi, E., Cossarizza, A., & Franceschi, C. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00802-7 · Cited by 45 · see citing works

Hans Selye and the Field of Stress Research

Neylan, T. C. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.2.230 · Cited by 44 · see citing works

Effects of Mild Hypothermia on Survival and Serum Cytokines in Uncontrolled Hemorrhagic Shock in Rats

Kentner, R., Rollwagen, F. M., Prueckner, S., Behringer, W., Wu, X., Stezoski, J. P., Safar, P. J., & Tisherman, S. A. (2002) · Shock · doi:10.1097/00024382-200206000-00014 · Cited by 36 · see citing works

Presence of P2‐purinoceptors in the rat pineal gland

Ferreira, Z. S., Cipolla‐Neto, J., & Markus, R. P. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13037.x · Cited by 35 · see citing works

Long‐term effects of a single exposure to immobilization stress on the hypothalamic–pituitary–adrenal axis: transcriptional evidence for a progressive desensitization process

Vallès, A., Martı́, O., & Armario, A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02857.x · Cited by 35 · see citing works

Melatonin modulates rat myotube-acetylcholine receptors by inhibiting calmodulin

Almeida-Paula, L. D., Costa-Lotufo, L. V., Ferreira, Z. S., Monteiro, A., Isoldi, M. C., Godinho, R. O., & Markus, R. P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.056 · Cited by 33 · see citing works

Cytokine mRNA levels in brain and peripheral tissues of the rat: relationships with plus-maze behavior

Pawlak, C. R., Schwarting, R. K. W., & Bauhofer, A. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.03.002 · Cited by 31 · see citing works

Melatonin modulation of presynaptic nicotinic acetylcholine receptors in the rat vas deferens.

Markus, R. P., Zago, W. M., & Carneiro, R. C. G. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20931-4 · Cited by 30 · see citing works

Characterisation of P2Y1-like receptor in cultured rat pineal glands

Ferreira, Z. S., & Markus, R. P. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00823-8 · Cited by 28 · see citing works

Presynaptic nicotinic receptors involved in release of noradrenaline and ATP from the prostatic portion of the rat vas deferens.

Carneiro, R. C. G., & Markus, R. P. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12791-2 · Cited by 28 · see citing works

Diurnal variation of the rat vas deferens contraction induced by stimulation of presynaptic nicotinic receptors and pineal function.

Carneiro, R. C. G., Cipolla‐Neto, J., & Markus, R. P. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20376-7 · Cited by 28 · see citing works

Age-related changes in melatonin modulation of sympathetic neurotransmission.

Carneiro, R. C. G., Pereira, E. P., Cipolla‐Neto, J., & Markus, R. P. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39545-5 · Cited by 20 · see citing works

Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells

Sampaio, L. F. S., Hamassaki‐Britto, D. E., & Markus, R. P. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000400015 · Cited by 10 · see citing works

Induction of the c-fos proto-oncogene in the rat pineal gland during stress.

Del-Bel, E. A., Titze‐de‐Almeida, R., Shida, H., Garcia‐Cairasco, N., Corrêa, F. M. D. A., & Guimarães, F. S. (1993) · PubMed · Cited by 8 · see citing works

Ritmos biológicos: entendendo as horas, os dias e as estações do ano

Markus, R. P., Mortani, E. J., Júnior, B., & Ferreira, Z. S. (2003) · Cited by 4 · see citing works

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00118 · Cited by 385 · see citing works

Acute heat stress impairs performance parameters and induces mild intestinal enteritis in broiler chickens: Role of acute hypothalamic-pituitary-adrenal axis activation1

Quinteiro-Filho, W. M., Rodrigues, M. V., Ribeiro, A. B., Ferraz-de-Paula, V., Pinheiro, M. L., de Sá, L. R. M., Ferreira, A. J. P., & Palermo‐Neto, J. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-3949 · Cited by 218 · see citing works

Immune‐pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes

Markus, R. P., Fernandes, P. A. C. M., Kinker, G. S., Cruz‐Machado, S. D. S., & Marçola, M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14083 · Cited by 196 · see citing works

NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene

Muxel, S. M., Lapa, M. A. P. C., Monteiro, A. W. A., Cecon, E., Tamura, E. K., Floeter‐Winter, L. M., & Markus, R. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052010 · Cited by 152 · see citing works

Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)

Leja‐Szpak, A., Jaworek, J. M., Pierzchalski, P., & Reiter, R. J. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00789.x · Cited by 117 · see citing works

Modeling the influence of circadian rhythms on the acute inflammatory response

Scheff, J. D., Calvano, S. E., Lowry, S. F., & Androulakis, I. P. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2010.03.026 · Cited by 111 · see citing works

Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF ‐1 in a mouse tumor model

Kim, K., Choi, J., Kang, I., Kim, K., Jeong, C., & Jeong, J. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01030.x · Cited by 106 · see citing works

MicroRNA and gene expression analysis of melatonin-exposed human breast cancer cell lines indicating involvement of the anticancer effect

Lee, S. E., Kim, S. J., Youn, J.-P., Hwang, S. Y., Park, C., & Park, Y. S. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00896.x · Cited by 105 · see citing works

HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?

Heck, T. G., Schöler, C. M., & de Bittencourt, P. I. H. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1739 · Cited by 101 · see citing works

Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress

Agorastos, A., Nicolaides, N. C., Bozikas, V. P., Chrousos, G. P., & Pervanidou, P. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01003 · Cited by 89 · see citing works

Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system

NaveenKumar, S. K., Hemshekhar, M., Jagadish, S., Manikanta, K., Vishalakshi, G. J., Kemparaju, K., & Girish, K. S. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12676 · Cited by 82 · see citing works

Melatonin inhibits proliferation and invasion via repression of miRNA-155 in glioma cells

Gu, J., Lu, Z., Ji, C., Chen, Y., Liu, Y., Lei, Z., Wang, L., Zhang, H., & Li, X. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.010 · Cited by 81 · see citing works

Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization

Yi, W.-J., & Kim, T. S. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.006 · Cited by 70 · see citing works

Analgesic and Sedative Effects of Melatonin in Temporomandibular Disorders: A Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study

Vidor, L. P., Torres, I. L. D. S., de Souza, I. C. C., Fregni, F., & Caumo, W. (2012) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2012.08.019 · Cited by 69 · see citing works

Expression of Concern: Melatonin potentiates the antiproliferative and pro‐apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways

Wang, J., Guo, W., Chen, W., Yu, W., Tian, Y., Fu, L., Shi, D., Tong, B. T., Xiao, X., Huang, W., et al. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12035 · Cited by 69 · see citing works

Cutaneous wound healing of chronically stressed mice is improved through catecholamines blockade

Romana‐Souza, B., Pôrto, L. C., & Monte‐Alto‐Costa, A. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01113.x · Cited by 66 · see citing works

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

Fernandes, P. A. C. M., Tamura, E. K., D'Argenio-Garcia, L., Muxel, S. M., Cruz‐Machado, S. D. S., Marçola, M., Carvalho‐Sousa, C. E., Cecon, E., Ferreira, Z. S., & Markus, R. P. (2016) · Neuroendocrinology · doi:10.1159/000445189 · Cited by 65 · see citing works

Circadian disruption and cancer- and treatment-related symptoms

Amidi, A., & Wu, L. M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1009064 · Cited by 63 · see citing works

Traumatic stress and the circadian system: neurobiology, timing and treatment of posttraumatic chronodisruption

Agorastos, A., & Olff, M. (2020) · European Journal of Psychotraumatology · doi:10.1080/20008198.2020.1833644 · Cited by 53 · see citing works

Neuroimmune endocrine effects of antidepressants

de Carvalho, L. A. (2012) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s16409 · Cited by 52 · see citing works

Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis

Bang, J., Chang, H. W., Jung, H.-R., Cho, C., Hur, J., Lee, S., Choi, T. H., Kim, S.-H., & Ha, E. (2010) · Rheumatology International · doi:10.1007/s00296-010-1641-9 · Cited by 50 · see citing works

The effects of low levels of light at night upon the endocrine physiology of western scrub‐jays (Aphelocoma californica)

Schoech, S. J., Bowman, R., Hahn, T. P., Goymann, W., Schwabl, I., & Bridge, E. S. (2013) · Journal of Experimental Zoology Part A Ecological Genetics and Physiology · doi:10.1002/jez.1816 · Cited by 48 · see citing works

Dim Light at Night Increases Immune Function in Nile Grass Rats, a Diurnal Rodent

Fonken, L. K., Haim, A., & Nelson, R. J. (2012) · Chronobiology International · doi:10.3109/07420528.2011.635831 · Cited by 48 · see citing works

Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression

Lambrou, G. Ι., Hatziagapiou, K., & Vlahopoulos, S. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05410-w · Cited by 42 · see citing works

Potential pleiotropic beneficial effects of adjuvant melatonergic treatment in posttraumatic stress disorder

Agorastos, A., & Linthorst, A. C. E. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12330 · Cited by 41 · see citing works

Immune‐pineal axis protects rat lungs exposed to polluted air

Carvalho‐Sousa, C. E., Pereira, E. P., Kinker, G. S., Veras, M. M., Ferreira, Z. S., Nunes, F. P. B., Martins, J. O., Saldiva, P. H. N., Reiter, R. J., Fernandes, P. A. C. M., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12636 · Cited by 41 · see citing works

The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis

Giudice, A., Crispo, A., Grimaldi, M., Polo, A., Bimonte, S., Capunzo, M., Amore, A., D'Arena, G. F., Cerino, P., Budillon, A., et al. (2018) · Molecules · doi:10.3390/molecules23061308 · Cited by 39 · see citing works

An antibody-based platform for melatonin quantification

Brazaca, L. C., Bramorski, C. B., Cancino‐Bernardi, J., Cruz‐Machado, S. D. S., Markus, R. P., Janegitz, B. C., & Zucolotto, V. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.07.006 · Cited by 36 · see citing works

Effects of cold stress andSalmonellaHeidelberg infection on bacterial load and immunity of chickens

Borsoi, A., Quinteiro-Filho, W. M., Calefi, A. S., Ferreira, A. J. P., Astolfi‐Ferreira, C. S., Flório, J. C., & Palermo‐Neto, J. (2015) · Avian Pathology · doi:10.1080/03079457.2015.1086976 · Cited by 35 · see citing works

The effect of sunlight exposure on interleukin-6 levels in depressive and non-depressive subjects

Levandovski, R. M., Pfaffenseller, B., Carissimi, A., Gama, C. S., & Hidalgo, M. P. L. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-75 · Cited by 35 · see citing works

Thyroid Hormone Receptor α Modulates Lipopolysaccharide-Induced Changes in Peripheral Thyroid Hormone Metabolism

Kwakkel, J., Chassande, O., van Beeren, H. C., Fliers, E., Wiersinga, W. M., & Boelen, A. (2010) · Endocrinology · doi:10.1210/en.2009-1049 · Cited by 34 · see citing works

When time stands still: an integrative review on the role of chronodisruption in posttraumatic stress disorder

Agorastos, A., Kellner, M., Baker, D. G., & Otte, C. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000079 · Cited by 33 · see citing works

Avian biological clock – Immune system relationship

Markowska, M., Majewski, P. M., & Skwarło‐Sońta, K. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.05.017 · Cited by 32 · see citing works

Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program

Cruz‐Machado, S. D. S., Tamura, E. K., Carvalho‐Sousa, C. E., da Rocha, V. A., Pinato, L., Fernandes, P. A. C. M., & Markus, R. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-02286-y · Cited by 32 · see citing works

The pineal regulation of the immune system: 40 years since the discovery

CSABA, G. (2013) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/amicr.60.2013.2.1 · Cited by 30 · see citing works

Central Interleukin-1βSuppresses the Nocturnal Secretion of Melatonin

Herman, A. P., Bochenek, J., Król, K., Krawczyńska, A., Antushevich, H., Pawlina, B., Herman, A. P., Romanowicz, K., & Tomaszewska-Zaremba, D. (2016) · Mediators of Inflammation · doi:10.1155/2016/2589483 · Cited by 28 · see citing works

Pineal arylalkylamine N-acetyltransferase (Aanat) gene expression as a target of inflammatory mediators in the chicken

Piesiewicz, A., Kędzierska, U., Adamska, I., Usarek, M., Zeman, M., Skwarło‐Sońta, K., & Majewski, P. M. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.08.013 · Cited by 25 · see citing works

Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR

Kim, M.-J., Choi, G. E., Chae, C. W., Lim, J. R., Jung, Y. H., Yoon, J. H., Park, J. Y., & Han, H. J. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05676-5 · Cited by 24 · see citing works

Melatonin in Synaptic Impairments of Alzheimer’s Disease

Shi, Y., Fang, Y., Wei, Y., Jiang, Q., Zeng, P. H., Tang, N., Lu, Y., & Tian, Q. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171178 · Cited by 24 · see citing works

Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies

Beriwal, N., Namgyal, T., Sangay, P., & Quraan, A. M. A. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01190 · Cited by 19 · see citing works

Implication of NOTCH1 gene in susceptibility to anxiety and depression among sexual abuse victims

Steine, I. M., Zayats, T., Stansberg, C. T., Pallesen, S., Mrdalj, J., Håvik, B., Soule, J. D., Haavik, J., Milde, A. M., Skrede, S., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.248 · Cited by 18 · see citing works

Effects of the social environment on vertebrate fitness and health in nature: Moving beyond the stress axis

Lemonnier, C., Bize, P., Boonstra, R., Dobson, F. S., Criscuolo, F., & Viblanc, V. A. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105232 · Cited by 17 · see citing works

Zebrafish Expression Ontology of Gene Sets (ZEOGS): A Tool to Analyze Enrichment of Zebrafish Anatomical Terms in Large Gene Sets

Prykhozhij, S. V., Marsico, A., & Meijsing, S. H. (2013) · Zebrafish · doi:10.1089/zeb.2012.0865 · Cited by 12 · see citing works

Regulation of glucocorticoids by the central nervous system.

Cutolo, M., Buttgereit, F., & Straub, R. H. (2011) · PubMed · Cited by 11 · see citing works

Plasma corticosterone elevation inhibits the activation of nuclear factor kappa B (NFKB) in the Syrian hamster pineal gland

Ferreira, Z. S., Bothorel, B., Markus, R. P., & Simonneaux, V. (2011) · Stress · doi:10.3109/10253890.2011.627070 · Cited by 10 · see citing works

Psychosomatic and Biopsychosocial Medicine: Body-Mind Relationship, Its Roots, and Current Challenges

Grassi, L. G., Wise, T. N., Cockburn, D., Caruso, R., & Riba, M. (2018) · Integrating psychiatry and primary care · doi:10.1007/978-3-319-74736-1_2 · Cited by 10 · see citing works

Long‐term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta)

Rawashdeh, O., & Dubocovich, M. L. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12118 · Cited by 9 · see citing works

Long-Term Effects of the Periconception Period on Embryo Epigenetic Profile and Phenotype: The Role of Stress and How This Effect Is Mediated

Ord, J., Fazeli, A., & Watt, P. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-62414-3_7 · Cited by 9 · see citing works

Strain specific variation underlines the disparity in stress response of rats to calorie dense diets in the pathophysiology of obesity

Prasad, S. M. V. K., Muralidhar, M. N., Dinesh Yadav, D. M., Kondeti, S., & Kalashikam, R. R. (2020) · Steroids · doi:10.1016/j.steroids.2020.108653 · Cited by 8 · see citing works

Mathematical modeling of depressive disorders: Circadian driving, bistability and dynamical transitions

Cheng, X., D'Orsogna, M. R., & Chou, T. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.10.035 · Cited by 8 · see citing works

Seasonality of inflammation in the chicken: clock vs. melatonin control over the pro-inflammatory cytokine gene transcription

Turkowska, E., Adamska, I., Niedziółka, S. M., Majewski, P. M., & Skwarło‐Sońta, K. (2015) · Biological Rhythm Research · doi:10.1080/09291016.2015.1073486 · Cited by 7 · see citing works

Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides

Anderson, G., & Maes, M. H. J. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch13 · Cited by 7 · see citing works

Systemic administration of propranolol reduces bone resorption and inflammation in apical periodontitis of chronically stressed rats

Khoury, R. D., Minhoto, G. B., de Barros, P. P., Junqueira, J. C., Gagliardi, C. F., do Prado, R. F., & Valera, M. C. (2024) · International Endodontic Journal · doi:10.1111/iej.14118 · Cited by 6 · see citing works

Altered circadian rhythm: Possible trigger of familial Mediterranean fever attacks

Makay, B. B., & Ünsal, E. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.06.019 · Cited by 5 · see citing works

Short day length enhances physiological resilience of the immune system against 2-deoxy-d-glucose-induced metabolic stress in a tropical seasonal breeder Funambulus pennanti

Gupta, S., & Haldar, C. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.01.004 · Cited by 3 · see citing works

Impact of the time in an animal model of mood disorder

Sasso, E. M., Vieira, J. L., Dantas, G., de Souza, C. M., Levandovski, R. M., & Hidalgo, M. P. L. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.08.014 · Cited by 3 · see citing works

Regulação da produção hormonal da glândula pineal de ratos por moduladores do processo inflamatório.

Paulo, S. (2009) · Cited by 2 · see citing works

Effects of environmental and social stressors on biological rhythms

Sakakibara, H., Yasuda, M. T., & Shimoi, K. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.143 · Cited by 2 · see citing works

Biological Rhythms and Aging

Jagota, A., Kukkemane, K., & Thummadi, N. B. (2020) · Springer eBooks · doi:10.1007/978-981-32-9005-1_20 · Cited by 2 · see citing works

Modeling Circadian Rhythms in Inflammation

Scheff, J. D., Androulakis, I. P., Calvano, S. E., & Lowry, S. F. (2010) · IEEE International Conference on Bioinformatics and Bioengineering (BIBE) · doi:10.1109/bibe.2010.39 · Cited by 1 · see citing works

Acute stress disrupts temporal patterns of behavioral and biochemical parameters of rats

de Souza, A., Detanico, B. C., Medeiros, L. F., de Oliveira, C., Scarabelot, V. L., Cioato, S. G., Caumo, W., & Torres, I. L. D. S. (2017) · Biological Rhythm Research · doi:10.1080/09291016.2017.1386267 · Cited by 1 · see citing works

Hormones in Clock Regulation During Ageing

Jagota, A., & Thummadi, N. B. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_11 · Cited by 1 · see citing works

Regulação da atividade da glândula pineal por estimulação purinérgica.

Petrilli, C. L. (2012) · doi:10.11606/d.41.2012.tde-01052013-140517

Efeitos do diazepam sobre o crescimento do tumor ascítico de Ehrlich: envolvimento do Receptor Periférico para Benzodiazepínico (PBR) ou Proteína Translocadora (TSPO)

Sakai, M. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2009.tde-10112009-161606

Heart rate variability and rhythmic influences in human endotoxemia

Scheff, J. D. (2013) · doi:10.7282/t3571922

Desenvolvimento de biossensores para auxílio do diagnóstico do mal de Alzheimer, para quantificação rápida de melatonina e para determinação simples do traço genético de anemia falciforme

Brazaca, L. C. (2019) · doi:10.11606/t.76.2019.tde-08052019-142006

A mathematical model of HPA axis dynamics and impacts of alcohol consumption

Gergley, M., & Chellamuthu, V. (2026) · International Journal of Mathematics and Computer in Engineering · doi:10.2478/ijmce-2026-0006

The influence of altered light–dark cycles on circadian rhythms of blood biomarkers in Wistar rats

Anurkina, A. I., Areshidze, D. A., Kozlova, M. A., & Chernikov, V. P. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2650428

EFICÁCIA DA MELATONINA NO TRATAMENTO DA DOR MIOFASCIAL CRÔNICA FACIAL: ENSAIO CLÍNICO RANDOMIZADO, DUPLO-CEGO, CONTROLADO COM PLACEBO

Vidor, L. P. (2010) · Americanae (AECID Library)

The Immune-Pineal Axis: A Shuttle between Endocrine and Paracrine Melatonin Sources

Markus, R. P., Ferreira, Z. S., Fernandes, P. A. C. M., & Cecon, E. (2007) · NeuroImmunoModulation · doi:10.1159/000110635 · Cited by 161 · see citing works

Immune‐pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes

Markus, R. P., Fernandes, P. A. C. M., Kinker, G. S., Cruz‐Machado, S. D. S., & Marçola, M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14083 · Cited by 196 · see citing works

IMMUNE-PINEAL AXIS: A SHUTTLE BETWEEN ENDOCRINE AND PARACRINE MELATONIN PRODUCTION

Markus, R. P. (2009) · Sleep Science · doi:10.1055/s-0046-1820538

Role of the pineal gland in immunity

Maestroni, G. J. M., Conti, A., & Pierpaoli, W. (1986) · Journal of Neuroimmunology · doi:10.1016/0165-5728(86)90047-0 · Cited by 410 · see citing works

Effect of TNF‐α on the melatonin synthetic pathway in the rat pineal gland: basis for a ‘feedback’ of the immune response on circadian timing

Fernandes, P. A. C. M., Cecon, E., Markus, R. P., & Ferreira, Z. S. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00373.x · Cited by 111 · see citing works