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SNAP‐25 in Neuropsychiatric Disorders
Open accessAbstract
SNAP‐25 (synaptosomal‐associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP‐25 also modulates different voltage‐gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP‐25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.
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“However, these splicing changes affect transcripts encoding ion channels, neurotransmitter receptors, structural proteins and Ca2+ signalling molecules”
From The neurogenetics of alternative splicing (2016) · cites this paper as [137]
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“many of which are associated with seizure disorders in humans or mice, such as the GABAA receptor subunit Gabrg2, Grin1, the voltage-gated sodium channel Scn8a (which encodes NaV1.6), and synaptosomal-associated protein 25 (Snap25)133–137”
From The neurogenetics of alternative splicing (2016) · cites this paper as [137]
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Metadata
- Authors
- Corradini, I., Verderio, C., Sala, M., Wilson, M. C., & Matteoli, M.
- Affiliations
- University of Milan (IT)
- University of New Mexico Health Sciences Center (US)
- Corresponding author
- Matteoli, Michela
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 1152
- Issue
- 1
- Pages
- 93-99
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC2706123
- OpenAlex
- W2071613912
- Cited by
- 128
- References
- 63
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 3 · 2023: 18 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 11 · 2012: 8
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH 4-8989, R01MH048989)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- SNAP-25, SNARE complex, regulated exocytosis, neurotransmitter release, voltage-gated calcium channels, neuropsychiatric disorders, neurological disorders, genetic variants, mouse model, syntaxin, synaptobrevin
- MeSH terms
- Animals, Attention Deficit Disorder with Hyperactivity, Epilepsy, Humans, Nervous System Diseases, Schizophrenia, Synaptosomal-Associated Protein 25
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