The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The Role of NF‐κB in Hypoxia‐Induced Gene Expression
Abstract
Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen‐sensitive transcription factors including the hypoxia‐inducible factor (HIF) and nuclear factor‐kappaB (NF‐κB). Hypoxia‐dependent gene expression can have important physiologic or pathophysiologic consequences for an organism, depending upon the cause of the hypoxic insult. Consequently, this pathway represents an attractive therapeutic target in a number of disease states. While the mechanism linking hypoxia to the activation of HIF has been extensively studied, our understanding of how hypoxia activates NF‐κB is limited. Recent studies have demonstrated that similar oxygen‐sensing mechanisms are employed in conferring oxygen sensitivity to both HIF and NF‐κB−dependent gene expression. Furthermore, there is an extensive degree of cross‐talk occurring between NF‐κB and HIF. Investigations into mechanisms of hypoxic activation of HIF and NF‐κB and how these signaling pathways interact will uncover new therapeutic modalities in a diverse range of disease states where hypoxia is a feature of the microenvironment including cancer, vascular disease, and chronic inflammation.
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“hypoxia activates the NF-kB pathway through p65 and p50 stabilization and nuclear translocation that induces transcription of many genes [54].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [54]
Citations
Cites
Shared Principles in NF-κB Signaling
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Nuclear factor-κB in cancer development and progression
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ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,507
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
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NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 970
Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity
Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040624 · Cited by 891
Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602235103 · Cited by 788
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Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis
Rath, E., Moschetta, A., & Haller, D. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0021-x · Cited by 313
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
Kvietys, P. R., & Granger, D. N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.002 · Cited by 319
Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells
Colwell, N. A., Larion, M., Giles, A. J., Seldomridge, A. N., Sizdahkhani, S., Gilbert, M. R., & Park, D. M. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now258 · Cited by 293
Broekgaarden, M., Weijer, R., van Gulik, T. M., Hamblin, M. R., & Heger, M. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9588-7 · Cited by 266
Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
Strowitzki, M. J., Cummins, E. P., & Taylor, C. T. (2019) · Cells · doi:10.3390/cells8050384 · Cited by 257
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Metadata
- Authors
- Taylor, C. T., & Cummins, E. P.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Taylor, Cormac T.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2009-10
- Volume
- 1177
- Issue
- 1
- Pages
- 178-184
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2103214055
- Cited by
- 175
- References
- 35
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 13 · 2018: 11 · 2017: 10 · 2016: 15 · 2015: 15 · 2014: 17 · 2013: 16 · 2012: 15
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB, hypoxia, hypoxia-inducible factor, oxygen sensing, transcriptional activation, gene expression regulation, therapeutic target, cancer, vascular disease, chronic inflammation, tumor microenvironment
- MeSH terms
- Animals, Hypoxia, Gene Expression Regulation, Humans, Models, Biological, NF-kappa B, Hypoxia-Inducible Factor 1
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