Cited by 175NF-κB Signaling PathwaysCancer, Hypoxia, and MetabolismSignaling Pathways in Disease

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The Role of NF‐κB in Hypoxia‐Induced Gene Expression

Taylor, Cormac T., Cummins, Eoin P.·2009·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2009.05024.x

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Abstract

Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen‐sensitive transcription factors including the hypoxia‐inducible factor (HIF) and nuclear factor‐kappaB (NF‐κB). Hypoxia‐dependent gene expression can have important physiologic or pathophysiologic consequences for an organism, depending upon the cause of the hypoxic insult. Consequently, this pathway represents an attractive therapeutic target in a number of disease states. While the mechanism linking hypoxia to the activation of HIF has been extensively studied, our understanding of how hypoxia activates NF‐κB is limited. Recent studies have demonstrated that similar oxygen‐sensing mechanisms are employed in conferring oxygen sensitivity to both HIF and NF‐κB−dependent gene expression. Furthermore, there is an extensive degree of cross‐talk occurring between NF‐κB and HIF. Investigations into mechanisms of hypoxic activation of HIF and NF‐κB and how these signaling pathways interact will uncover new therapeutic modalities in a diverse range of disease states where hypoxia is a feature of the microenvironment including cancer, vascular disease, and chronic inflammation.

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Authors: Taylor, C. T., & Cummins, E. P.
Affiliations: University College Dublin (IE)
Corresponding author: Taylor, Cormac T.
ORCID: Taylor, Cormac T.
Cummins, Eoin P.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2009-10
Volume: 1177
Issue: 1
Pages: 178-184
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2009.05024.x
OpenAlex: W2103214055
Cited by: 175
References: 35
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 13 · 2018: 11 · 2017: 10 · 2016: 15 · 2015: 15 · 2014: 17 · 2013: 16 · 2012: 15
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 14 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: NF-κB, hypoxia, hypoxia-inducible factor, oxygen sensing, transcriptional activation, gene expression regulation, therapeutic target, cancer, vascular disease, chronic inflammation, tumor microenvironment
MeSH terms: Animals, Hypoxia, Gene Expression Regulation, Humans, Models, Biological, NF-kappa B, Hypoxia-Inducible Factor 1

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The Role of NF‐κB in Hypoxia‐Induced Gene Expression

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