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Contributions of the ventromedial prefrontal cortex to goal-directed action selection

O’Doherty, John P.·2011·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2011.06290.x

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Abstract

In this article, it will be argued that one of the key contributions of the ventromedial prefrontal cortex (vmPFC) to goal-directed action selection lies both in retrieving the value of goals that are the putative outcomes of the decision process and in establishing a relative preference ranking for these goals by taking into account the value of each of the different goals under consideration in a given decision-making scenario. These goal-value signals are then suggested to be used as an input into the on-line computation of action values mediated by brain regions outside of the vmPFC, such as parts of the parietal cortex, supplementary motor cortex, and dorsal striatum. Collectively, these areas can be considered to be constituent elements of a multistage decision process whereby the values of different goals must first be represented and ranked before the value of different courses of action available for the pursuit of those goals can be computed.

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Authors: O’Doherty, J. P.
Affiliations: California Institute of Technology (US)
Corresponding author: O’Doherty, John P.
ORCID: O’Doherty, John P.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2011-12
Volume: 1239
Issue: 1
Pages: 118-129
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2011.06290.x
OpenAlex: W1766116129
Cited by: 225
References: 60
Citations by year: 2026: 8 · 2025: 13 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 13 · 2020: 41 · 2019: 8 · 2018: 13 · 2017: 16 · 2016: 15 · 2015: 22 · 2014: 17 · 2013: 17 · 2012: 10
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: ventromedial prefrontal cortex, decision-making, dorsal striatum, supplementary motor area, parietal cortex, multi-stage decision making
MeSH terms: Animals, Behavior, Animal, Brain Mapping, Corpus Striatum, Decision Making, Frontal Lobe, Goals, Humans, Models, Psychological, Motor Cortex, Neurons, Parietal Lobe, Physiology, Comparative, Reward, Social Behavior, Social Values

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Contributions of the ventromedial prefrontal cortex to goal-directed action selection

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