Effects of plasmalogens on systemic lipopolysaccharide‐induced glial activation and β‐amyloid accumulation in adult mice
Abstract
Neuroinflammation essentially involves an activation of glial cells as the cause/effect of neurodegenerative diseases such as Alzheimer's disease (AD). Plasmalogens (Pls) are glycerophospholipids constituting cellular membranes and play significant roles in membrane fluidity and cellular processes like vesicular fusion and signal transduction. Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 250 μg/kg) for 7 days resulted in the morphological changes and increase in number of Iba-1(+) microglia showing neuroinflammation in the adult mouse hippocampus. The LPS-induced activation of glial cells was significantly attenuated by i.p. pretreatment with Pls dissolved in corn oil. In addition, systemic injection of LPS induced Aβ(1-16) (+) neurons in the hippocampus were also abolished by application of Pls. Finally, contents of Pls in the hippocampus decreased after LPS injection, and the reduction was suppressed by administration of Pls. These findings suggest an antiamyloidogenic effect of Pls, implicating a possible therapeutic application of Pls against AD.
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Plasmalogens suppress microglia activation after systemic LPS injection in mice.
“This concept is also supported by the finding that plasmalogens suppress microglia activation after systemic injection of lipopolysaccharides (LPS) in mice [221,222].”
From Peroxisomes in brain development and function (2016) · cites this paper as [222]
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Self-citation
- Authors
- Katafuchi, T., Ifuku, M., Mawatari, S., Noda, M., Miake, K., Sugiyama, M., & Fujino, T.
- Affiliations
- Kyushu University (JP)
- Institute of Rheological Functions of Food (JP)
- Marudai FOOD Co., Ltd. (Japan) (JP)
- Corresponding author
- Katafuchi, Toshihiko
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2012-07
- Volume
- 1262
- Issue
- 1
- Pages
- 85-92
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2155109894
- Cited by
- 68
- References
- 53
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 5 · 2020: 9 · 2019: 6 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22590084)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- plasmalogens, lipopolysaccharide, neuroinflammation, glial activation, microglia, amyloid-beta deposition, Alzheimer's disease, hippocampus, Iba1, glycerophospholipids, membrane fluidity, neuroprotection
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Hippocampus, Lipopolysaccharides, Male, Mice, Inbred C57BL, Neuroglia, Plasmalogens, Amyloid beta-Peptides, Prefrontal Cortex, Microglia, Neuroprotective Agents, Mice, CA1 Region, Hippocampal
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