Plasmalogens and Alzheimer’s disease: A review
Open accessAbstract
Growing evidence suggests that ethanolamine plasmalogens (PlsEtns), a subtype of phospholipids, have a close association with Alzheimer's disease (AD). Decreased levels of PlsEtns have been commonly found in AD patients, and were correlated with cognition deficit and severity of disease. Limited studies showed positive therapeutic outcomes with plasmalogens interventions in AD subjects and in rodents. The potential mechanisms underlying the beneficial effects of PlsEtns on AD may be related to the reduction of γ-secretase activity, an enzyme that catalyzes the synthesis of β-amyloid (Aβ), a hallmark of AD. Emerging in vitro evidence also showed that PlsEtns prevented neuronal cell death by enhancing phosphorylation of AKT and ERK signaling through the activation of orphan G-protein coupled receptor (GPCR) proteins. In addition, PlsEtns have been found to suppress the death of primary mouse hippocampal neuronal cells through the inhibition of caspase-9 and caspase-3 cleavages. Further in-depth investigations are required to determine the signature molecular species of PlsEtns associated with AD, hence their potential role as biomarkers. Clinical intervention with plasmalogens is still in its infancy but may have the potential to be explored for a novel therapeutic approach to correct AD pathology and neural function.
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Decreased levels of ethanolamine plasmalogens (PlsEtns) correlate with the severity of AD.
“Decreased levels of ethanolamine plasmalogens (PlsEtns) have been found to correlate with the severity of AD.”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [146]
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- Authors
- Su, X. Q., Wang, J., & Sinclair, A. J.
- Affiliations
- Victoria University (AU)
- University of Mississippi Medical Center (US)
- Deakin University (AU)
- Corresponding author
- Su, Xiao Q.
- Venue
- Lipids in Health and Disease
- Published
- 2019-04-16
- Volume
- 18
- Issue
- 1
- Pages
- 100-100
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC6466717
- OpenAlex
- W2946079822
- Cited by
- 172
- References
- 71
- Citations by year
- 2026: 23 · 2025: 19 · 2024: 24 · 2023: 26 · 2022: 32 · 2021: 27 · 2020: 17 · 2019: 4
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion, cc-by)
- Own your potential (DEAKIN) (submittedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Victoria University
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- plasmalogens, ethanolamine plasmalogen, Alzheimer's disease, phospholipids, gamma-secretase, amyloid-beta, Akt signaling, ERK signaling, orphan G protein-coupled receptor, caspase-9, caspase-3, neuronal cell death, hippocampal neurons, biomarkers
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Gene Expression Regulation, Humans, Neurons, Plasmalogens, Severity of Illness Index, Signal Transduction, Biomarkers, Amyloid beta-Peptides, Cell Death, Receptors, G-Protein-Coupled, Extracellular Signal-Regulated MAP Kinases, Proto-Oncogene Proteins c-akt, Amyloid Precursor Protein Secretases, Cognitive Dysfunction
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