Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Interplay between Cortical Spreading Depolarization and Seizures

Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,718 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

Hydrogen peroxide mediates amyloid β protein toxicity

Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works

Apoptosis in the nervous system

Yuan, J., & Yankner, B. A. (2000) · Nature · doi:10.1038/35037739 · Cited by 1,862 · see citing works

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works

PSD-95 Involvement in Maturation of Excitatory Synapses

El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

Husi, H., Ward, M. A., Choudhary, J. S., Blackstock, W. P., & Grant, S. G. N. (2000) · Nature Neuroscience · doi:10.1038/76615 · Cited by 1,194 · see citing works

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.

Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160 · see citing works

Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., & Klein, W. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834302100 · Cited by 1,061 · see citing works

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works

The neural basis of functional brain imaging signals

Attwell, D., & Iadecola, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02264-6 · Cited by 957 · see citing works

Mechanisms of action of docosahexaenoic acid in the nervous system

Salem, N., Litman, B., Kim, H., & Gawrisch, K. (2001) · Lipids · doi:10.1007/s11745-001-0805-6 · Cited by 919 · see citing works

Actin-based plasticity in dendritic spines

Matus, A. (2000) · Science · doi:10.1126/science.290.5492.754 · Cited by 815 · see citing works

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

Allanbutterfield, D., Castegna, A., Lauderback, C. M., & Drake, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00340-2 · Cited by 715 · see citing works

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., & Ashe, K. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01858.2002 · Cited by 714 · see citing works

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., & Gouras, G. K. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64463-x · Cited by 706 · see citing works

Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo

Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695 · see citing works

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

Datta, S. R., Katsov, A., Hu, L. S., Petros, A. M., Fesik, S. W., Yaffe, M. B., & Greenberg, M. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00012-2 · Cited by 663 · see citing works

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

IRIZARRY, M. C., MCNAMARA, M., FEDORCHAK, K., HSIAO, K., & HYMAN, B. T. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199709000-00002 · Cited by 649 · see citing works

Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment

Conquer, J. A., Tierney, M. C., Zecevic, J., Bettger, W. J., & Fisher, R. H. (2000) · Lipids · doi:10.1007/s11745-000-0646-3 · Cited by 523 · see citing works

Essential fatty acids and the brain: possible health implications

Youdim, K. A., Martin, A., & Joseph, J. A. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00013-7 · Cited by 517 · see citing works

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

Etminan, M., Gill, S., & Samii, A. (2003) · BMJ · doi:10.1136/bmj.327.7407.128 · Cited by 511 · see citing works

Protein oxidation in the brain in Alzheimer's disease

Aksenov, M. Y., Aksenova, M. V., Butterfield, D. A., Geddes, J. W., & Markesbery, W. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00580-7 · Cited by 503 · see citing works

Fish, meat, and risk of dementia: cohort study

Barberger‐Gateau, P. (2002) · BMJ · doi:10.1136/bmj.325.7370.932 · Cited by 486 · see citing works

Amyloid Precursor Protein, Presenilins, and α-Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer’s Disease

Suh, Y.-H., & Checler, F. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.469 · Cited by 467 · see citing works

Rapid turnover of actin in dendritic spines and its regulation by activity

Star, E. N., Kwiatkowski, D. J., & Murthy, V. N. (2002) · Nature Neuroscience · doi:10.1038/nn811 · Cited by 465 · see citing works

Intracellular accumulation of β-amyloid1–42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer’s disease

Nagele, R. G., D’Andrea, M. R., Anderson, W. J., & Wang, H.-Y. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00460-2 · Cited by 456 · see citing works

Behavioral Deficits Associated with Dietary Induction of Decreased Brain Docosahexaenoic Acid Concentration

Moriguchi, T., Greiner, R. S., & Salem, N. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752563.x · Cited by 421 · see citing works

Essential Fatty Acids and the Brain

Haag, M. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800308 · Cited by 421 · see citing works

α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity

Kihara, T., Shimohama, S., Sawada, H., Honda, K., Nakamizo, T., Shibasaki, H., Kume, T., & Akaike, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008035200 · Cited by 412 · see citing works

The role of polyunsaturated fatty acids in restoring the aging neuronal membrane

Yehuda, S., Rabinovitz, S., LCARASSO, R., & Mostofsky, D. I. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00074-x · Cited by 404 · see citing works

Rho proteins, mental retardation and the cellular basis of cognition

Ramakers, G. J. A. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02118-4 · Cited by 374 · see citing works

Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

Hashimoto, M., Hossain, S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J., & Shido, O. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00905.x · Cited by 364 · see citing works

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

Joseph, J. A., Arendash, G. W., Gordon, M. N., Diamond, D. M., Shukitt‐Hale, B., Morgan, D., & Denisova, N. A. (2003) · Nutritional Neuroscience · doi:10.1080/1028415031000111282 · Cited by 361 · see citing works

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

Schürmann, A., Mooney, A. F., Sanders, L. C., Sells, M. A., Wang, H., Reed, J. C., & Bokoch, G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.453-461.2000 · Cited by 355 · see citing works

The lipid composition of adult rat brain synaptosomal plasma membranes

Breckenridge, W. C. (1972) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(72)90012-1 · Cited by 351 · see citing works

The lipid composition of adult rat brain synaptosomal plasma membranes

Breckenridge, W. C., Gombos, G., & Morgan, I. G. (1972) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(72)90365-3 · Cited by 340 · see citing works

Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study

Tully, A.-M., Roche, H. M., Doyle, R., Fallon, C., Bruce, I., LAWLOR, B. A., Coakley, D., & Gibney, M. J. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002804 · Cited by 309 · see citing works

Spine Formation and Correlated Assembly of Presynaptic and Postsynaptic Molecules

Okabe, S., Miwa, A., & Okado, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06105.2001 · Cited by 291 · see citing works

Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways

Stein, T. D., & Johnson, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07380.2002 · Cited by 288 · see citing works

Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

Takashima, A., Noguchi, K., Michel, G., Mercken, M., Hoshi, M., Ishiguro, K., & Imahori, K. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12257-5 · Cited by 260 · see citing works

Synaptic lipid signaling

Bazan, N. G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300013-jlr200 · Cited by 247 · see citing works

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.

Yang, F., Sun, X., Beech, W. K., Teter, B., Wu, S. S. H., Sigel, J. J., Vinters, H. V., Frautschy, S. A., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 245 · see citing works

Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic Mice

Dickey, C. A., Loring, J. F., Montgomery, J., Gordon, M. N., Eastman, P. S., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05219.2003 · Cited by 242 · see citing works

Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases

Montine, K. S., Quinn, J. F., Zhang, J., Fessel, J. P., Roberts, L. J., Morrow, J. D., & Montine, T. J. (2003) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2003.10.010 · Cited by 242 · see citing works

Decrease and Structural Modifications of Phosphatidylethanolamine Plasmalogen in the Brain with Alzheimer Disease

Guan, Z., Wang, Y., Cairns, N. J., Lantos, P. L., Dallner, G., & Sindelar, P. J. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199907000-00008 · Cited by 236 · see citing works

Drebrin-Dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis

Takahashi, H., Sekino, Y., Tanaka, S., Mizui, T., Kishi, S., & Shirao, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06586.2003 · Cited by 233 · see citing works

Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms

Opazo, P., Watabe, A. M., Grant, S. G. N., & O'Dell, T. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03679.2003 · Cited by 215 · see citing works

Accelerated Plaque Accumulation, Associative Learning Deficits, and Up-regulation of α7 Nicotinic Receptor Protein in Transgenic Mice Co-expressing Mutant Human Presenilin 1 and Amyloid Precursor Proteins

Dineley, K. T., Xia, X., Bui, D., Sweatt, J. D., & Zheng, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200164200 · Cited by 212 · see citing works

The significance of environmental factors in the etiology of Alzheimer's disease

Grant, W. B., Campbell, A., Itzhaki, R. F., & Savory, J. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4308 · Cited by 208 · see citing works

Oxidative Dimer Formation Is the Critical Rate-Limiting Step for Parkinson's Disease α-Synuclein Fibrillogenesis

Krishnan, S., Chi, E. Y., Wood, S. J., Kendrick, B. S., Li, C., Garzon-Rodriguez, W., Wypych, J., Randolph, T. W., Narhi, L. O., Biere, A. L., et al. (2002) · Biochemistry · doi:10.1021/bi026528t · Cited by 202 · see citing works

Loss of Proteins Regulating Synaptic Plasticity in Normal Aging of the Human Brain and in Alzheimer Disease

Hatanpaa, K. J., Isaacs, K. R., Shirao, T., Brady, D. R., & Rapoport, S. I. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199906000-00008 · Cited by 200 · see citing works

Disappearance of actin‐binding protein, drebrin, from hippocampal synapses in alzheimer's disease

Harigaya, Y., Shoji, M., Shirao, T., & Hirai, S. (1996) · Journal of Neuroscience Research · doi:10.1002/jnr.490430111 · Cited by 198 · see citing works

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

Shim, K. S., & Lübec, G. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00210-0 · Cited by 186 · see citing works

n -3 Polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle

Taouis, M., Dagou, C., Ster, C., Durand, G., Pinault, M., & Delarue, J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00320.2001 · Cited by 181 · see citing works

Janus Kinase 2, an Early Target of α7 Nicotinic Acetylcholine Receptor-mediated Neuroprotection against Aβ-(1–42) Amyloid

Shaw, S., Bencherif, M., & Marrero, M. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204610200 · Cited by 172 · see citing works

ALZHEIMER'S DISEASE AND RELATED DISORDERS

Raskind, M. A., & Peskind, E. R. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70341-2 · Cited by 161 · see citing works

Oxidative Regulation of Fatty Acid-Induced Tau Polymerization

Gamblin, T. C., King, M. E., Kuret, J., Berry, R. W., & Binder, L. I. (2000) · Biochemistry · doi:10.1021/bi001876l · Cited by 151 · see citing works

Docosahexaenoic Acid Abundance in the Brain: A biodevice to Combat Oxidative Stress

Yavin, E., Brand, A., & Green, P. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290003159 · Cited by 147 · see citing works

Protective effects of docosahexaenoic acid in staurosporine‐induced apoptosis: involvement of phosphatidylinositol‐3 kinase pathway

Akbar, M. D., & Kim, H. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01015.x · Cited by 140 · see citing works

Low serum docosahexaenoic acid is a significant risk factor for alzheimer's dementia

Kyle, D. J., Schaefer, E. J., Patton, G. M., & Beiser, A. (1999) · Lipids · doi:10.1007/bf02562306 · Cited by 140 · see citing works

Methionine oxidation as a major cause of the functional impairment of oxidized actin

Dalle‐Donne, I., Rossi, R., Giustarini, D., Gagliano, N., Simplicio, P. D., Colombo, R., & Milzani, A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00799-2 · Cited by 137 · see citing works

The protein tyrosine kinase, fyn, in Alzheimerʼs disease pathology

Shirazi, S. K., & Wood, J. G. (1993) · Neuroreport · doi:10.1097/00001756-199304000-00024 · Cited by 136 · see citing works

Quantitative Decrease in Synaptophysin Message Expression and Increase in Cathepsin D Message Expression in Alzheimer Disease Neurons Containing Neurofibrillary Tangles

Callahan, L. M., Vaules, W. A., & Coleman, P. D. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199903000-00007 · Cited by 129 · see citing works

Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus

Favrelière, S. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00170-6 · Cited by 118 · see citing works

Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment

King, D. L., & Arendash, G. W. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03294-2 · Cited by 105 · see citing works

Alzheimer's Disease and Related Disorders

Harik, S. I. (1990) · Neurology · doi:10.1212/wnl.40.1.195-b · Cited by 85 · see citing works

Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines

Shirao, T., & Sekino, Y. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(01)00209-7 · Cited by 75 · see citing works

Cytoskeletal Links of Neuronal Acetylcholine Receptors Containing α7 Subunits

Shoop, R. D., Yamada, N., & Berg, D. K. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04021.2000 · Cited by 62 · see citing works

Insulin Insults May Spur Alzheimer's Disease

Taubes, G. (2003) · Science · doi:10.1126/science.301.5629.40 · Cited by 52 · see citing works

Phosphatidylinositol Kinase Is Reduced in Alzheimer's Disease

Jolles, J., Bothmer, J., Ittersum, M. M., & Ravid, R. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10981.x · Cited by 46 · see citing works

Reductions in brain phosphatidylinositol kinase activities in Alzheimer's disease.

Zubenko, G., Stiffler, J., Hughes, H. B., & Martinez, A. J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00073-0 · Cited by 45 · see citing works

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease

Liolitsa, D. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.3.261 · Cited by 45 · see citing works

Caspase‐cleaved actin (fractin) immunolabelling of Hirano bodies

Rossiter, J. P., Anderson, L. L., Yang, F., & Cole, G. M. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.00252.x · Cited by 42 · see citing works

Comparison of Two Quantitative Methods for the Evaluation of Neuronal Number in the Frontal Cortex in Alzheimer Disease

EVERALL, I. P., DeTeresa, R. M., Terry, R., & Masliah, E. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199711000-00004 · Cited by 37 · see citing works

Untitled work

Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336 · see citing works

Polyunsaturated fatty acids and their metabolites in brain function and disease

Bazinet, R. P., & Layé, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3820 · Cited by 1,613 · see citing works

Brain foods: The effects of nutrients on brain function.

Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372 · see citing works

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works

Distribution, interconversion, and dose response of n-3 fatty acids in humans.

Arterburn, L. M., Hall, E. B., & Oken, H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1467s · Cited by 1,162 · see citing works

Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production

Ratledge, C. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.017 · Cited by 1,125 · see citing works

MIND diet slows cognitive decline with aging

Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Barnes, L. L., Bennett, D. A., & Aggarwal, N. T. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.04.011 · Cited by 1,115 · see citing works

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

Lukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial

Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764 · see citing works

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764 · see citing works

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial

Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751 · see citing works

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 687 · see citing works

Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study

Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W. F., & Wolf, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1545 · Cited by 686 · see citing works

The Aging Brain

Yankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677 · see citing works

Essential Fatty Acids: Biochemistry, Physiology and Pathology

Das, U. N. (2006) · Biotechnology Journal · doi:10.1002/biot.200600012 · Cited by 650 · see citing works

Alpha-linolenic acid and its conversion to longer chain n−3 fatty acids: Benefits for human health and a role in maintaining tissue n−3 fatty acid levels

Barceló‐Coblijn, G., & Murphy, E. J. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.07.002 · Cited by 605 · see citing works

Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives

Harris, W. S., Miller, M., Tighe, A. P., Davidson, M. H., & Schaefer, E. J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.008 · Cited by 552 · see citing works

-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

Ma, Q.-L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1071-09.2009 · Cited by 536 · see citing works

Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, and neurodegeneration

Janssen, C. I. F., & Kiliaan, A. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.10.002 · Cited by 515 · see citing works

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

Julien, C., Tremblay, C., Émond, V., Lebbadi, M., Salem, N., Bennett, D. A., & Calon, F. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181922348 · Cited by 467 · see citing works

Modulation of inflammation in brain: A matter of fat

Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460 · see citing works

Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival

Akbar, M. D., Calderón, F. H., Wen, Z., & Kim, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502903102 · Cited by 466 · see citing works

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works

Fish Consumption and Cognitive Decline With Age in a Large Community Study

Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., & Wilson, R. S. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.noc50161 · Cited by 428 · see citing works

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

Yarza, R., Vela, S., Solas, M., & Ramírez, M. J. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00321 · Cited by 418 · see citing works

Docosahexaenoic acid promotes neurogenesis in vitro and in vivo

Kawakita, E., Hashimoto, M., & Shido, O. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.021 · Cited by 410 · see citing works

Docosahexaenoic Acid and Cognition throughout the Lifespan

Weiser, M., Butt, C., & Mohajeri, M. (2016) · Nutrients · doi:10.3390/nu8020099 · Cited by 400 · see citing works

Nutrition in Brain Development and Aging: Role of Essential Fatty Acids

Uauy, R. D., & Dangour, A. D. (2006) · Nutrition Reviews · doi:10.1301/nr.2006.may.s24-s33 · Cited by 417 · see citing works

Inhibitors of Brain Phospholipase A2 Activity: Their Neuropharmacological Effects and Therapeutic Importance for the Treatment of Neurologic Disorders

Farooqui, A. A., Ong, W., & Horrocks, L. A. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.7 · Cited by 368 · see citing works

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

Gubert, C., Kong, G., Renoir, T., & Hannan, A. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104621 · Cited by 372 · see citing works

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease

Hartman, R. E., Shah, A., Fagan, A. M., Schwetye, K. E., Parsadanian, M., Schulman, R. N., Finn, M. B., & Holtzman, D. M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.006 · Cited by 358 · see citing works

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors

Bazan, N. G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.005 · Cited by 353 · see citing works

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease

Maczurek, A. E., Häger, K., Kenklies, M., Sharman, M. J., Martins, R. N., Engel, J., Carlson, D. A., & Münch, G. W. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.04.015 · Cited by 350 · see citing works

Are all n-3 polyunsaturated fatty acids created equal?

Anderson, B. M., & David, W. L. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-33 · Cited by 335 · see citing works

Insulin-degrading Enzyme as a Downstream Target of Insulin Receptor Signaling cascade: Implications for Alzheimer's Disease Intervention

Zhao, L., Teter, B., Morihara, T., Lim, G. P., Ambegaokar, S. S., Ubeda, O. J., Frautschy, S. A., & Cole, G. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2860-04.2004 · Cited by 329 · see citing works

Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels

Green, K. N., Martínez‐Coria, H., Khashwji, H., Hall, E. B., Yurko‐Mauro, K., Ellis, L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0055-07.2007 · Cited by 326 · see citing works

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

Zhao, L., Ma, Q.-L., Calon, F., Harris-White, M. E., Yang, F., Lim, G. P., Morihara, T., Ubeda, O. J., Ambegaokar, S., Hansen, J. E., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1630 · Cited by 317 · see citing works

Fish, docosahexaenoic acid and Alzheimer’s disease

Cunnane, S. C., Plourde, M., Pifferi, F., Bégin, M. E., Féart, C., & Barberger‐Gateau, P. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.04.001 · Cited by 316 · see citing works

Neurological Benefits of Omega-3 Fatty Acids

Dyall, S. C., & Michael-Titus, A. T. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8036-z · Cited by 307 · see citing works

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases

Sun, G. Y., Simonyi, Á., Fritsche, K. L., Chuang, D. Y., Hannink, M., Gu, Z., Greenlief, C. M., Yao, J. K., Lee, J. C., & Beversdorf, D. Q. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.03.006 · Cited by 311 · see citing works

Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview

Mazza, M., Pomponi, M., Janiri, L., Bria, P., & Mazza, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.07.010 · Cited by 306 · see citing works

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

Knobloch, M., & Mansuy, I. M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8018-z · Cited by 296 · see citing works

Role of actin cytoskeleton in dendritic spine morphogenesis

Sekino, Y., Kojima, N., & Shirao, T. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.029 · Cited by 294 · see citing works

Fat Intake at Midlife and Risk of Dementia and Alzheimer’s Disease: A Population-Based Study

Laitinen, M. H., Ngandu, T., Rovio, S., Helkala, E.-L., Uusitalo, U. M., Viitanen, M. H., Nissinen, A. M., Tuomilehto, J., Soininen, H. S., & Kivipelto, M. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000093478 · Cited by 298 · see citing works

Diet and Alzheimer’s disease risk factors or prevention: the current evidence

Solfrizzi, V., Panza, F., Frisardi, V., Seripa, D., Logroscino, G., Imbimbo, B. P., & Pilotto, A. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.56 · Cited by 298 · see citing works

Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: Evidence from animal studies

Calon, F., & Cole, G. M. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.019 · Cited by 291 · see citing works

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Émond, V., Julien, P., & Calon, F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.022 · Cited by 288 · see citing works

A decade of modeling Alzheimer's disease in transgenic mice

MCGOWAN, E., ERIKSEN, J., & HUTTON, M. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.007 · Cited by 287 · see citing works

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

Oksman, M., Iivonen, H., Hőgyes, E., Amtul, Z., Penke, B., Leenders, I., Broersen, L. M., Lütjohann, D., Hartmann, T., & Tanila, H. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.013 · Cited by 287 · see citing works

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

Maezawa, I., Zimin, P. I., Wulff, H., & Jin, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135244 · Cited by 279 · see citing works

Phospholipase A₂-Generated Lipid Mediators in the Brain: The Good, the Bad, and the Ugly

Farooqui, A. A., & Horrocks, L. A. (2006) · The Neuroscientist · doi:10.1177/1073858405285923 · Cited by 273 · see citing works

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

Martín, M. V., Fabelo, N., Santpere, G., Puig, B., Marín, R., Ferrer, I., & Díaz, M. L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1242 · Cited by 269 · see citing works

DOCOSAHEXAENOIC ACID, FATTY ACID–INTERACTING PROTEINS, AND NEURONAL FUNCTION: Breastmilk and Fish Are Good for You

Marszalek, J. R., & Lodish, H. F. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120624 · Cited by 270 · see citing works

Omega-3 fatty acids and dementia

Cole, G. M., Ma, Q., & Frautschy, S. A. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.015 · Cited by 271 · see citing works

Neuroinflammation and Synaptic Loss

Rao, J. S., Kellom, M., Kim, H., Rapoport, S. I., & Reese, E. A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0708-2 · Cited by 262 · see citing works

Reduction in mitochondrial superoxide dismutase modulates Alzheimer’s disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice

Esposito, L., Raber, J., Kekonius, L., Yan, F., Yu, G.-Q., Bien-Ly, N., Puoliväli, J., Scearce-Levie, K., Masliah, E., & Mucke, L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0482-06.2006 · Cited by 254 · see citing works

Synaptic Changes in Alzheimer's Disease

Gylys, K. H., Fein, J. A., Yang, F., Wiley, D. J., Miller, C. A., & Cole, G. M. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63436-0 · Cited by 253 · see citing works

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., & Bazan, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015816 · Cited by 243 · see citing works

Dietary n‐3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease

Calon, F., Lim, G. P., Morihara, T., Yang, F., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04253.x · Cited by 244 · see citing works

Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection

Bazan, N. G. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32802b7030 · Cited by 244 · see citing works

Beneficial effects of dietary omega‐3 polyunsaturated fatty acid on toxin‐induced neuronal degeneration in an animal model of Parkinson's disease

Bousquet, M., Saint‐Pierre, M., Julien, C., Salem, N., Cicchetti, F., & Calon, F. (2007) · The FASEB Journal · doi:10.1096/fj.07-9677com · Cited by 232 · see citing works

Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β 42 by Human Microglia and Decrease Inflammatory Markers

Hjorth, E., Zhu, M., Toro, V. C., Vedin, I., Palmblad, J. E. W., Cederholm, T., Freund‐Levi, Y., Irving, G. F., Wahlund, L., Basun, H., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130131 · Cited by 228 · see citing works

Peroxisomal alterations in Alzheimer’s disease

Kou, J., Kovacs, G. G., Höftberger, R., Kulik, W., Brodde, A., Forss-Petter, S., Hönigschnabl, S., Gleiss, A., Brügger, B., Wanders, R., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0836-9 · Cited by 227 · see citing works

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

Lee, C.-C., Huang, C., & Hsu, K. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.003 · Cited by 227 · see citing works

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

Ouellet, M., Émond, V., Chen, C. T., Julien, C., Bourasset, F., Oddo, S., LaFerla, F. M., Bazinet, R. P., & Calon, F. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.04.018 · Cited by 227 · see citing works

Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions

Cole, G. M., Lim, G. P., Yang, F., Teter, B., Begum, A. N., Ma, Q., Harris‐White, M. E., & Frautschy, S. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.005 · Cited by 225 · see citing works

Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance

Su, H. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.003 · Cited by 222 · see citing works

Association of long-term adherence to the mind diet with cognitive function and cognitive decline in American women

Berendsen, A. M., Kang, J. H., Feskens, E. J. M., de Groot, C. P. G. M., Grodstein, F., & van de Rest, O. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0909-0 · Cited by 224 · see citing works

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

Grimm, M. O. W., Kuchenbecker, J., Grösgen, S., Burg, V. K., Hundsdörfer, B., Rothhaar, T. L., Frieß, P., de Wilde, M. C., Broersen, L. M., Penke, B., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.182329 · Cited by 221 · see citing works

Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

Astarita, G., Jung, K.-M., Berchtold, N. C., Nguyen, V. Q., Gillen, D. L., Head, E., Cotman, C. W., & Piomelli, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012538 · Cited by 218 · see citing works

Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice

Labrousse, V. F., Nadjar, A., Joffre, C., Costes, L., Aubert, A., Gregoire, S., Brétillon, L., & Layé, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036861 · Cited by 218 · see citing works

Nutrition and the Risk of Alzheimer's Disease

Hu, N., Yu, J., Tan, L., Wang, Y., Sun, L., & Tan, L. (2013) · BioMed Research International · doi:10.1155/2013/524820 · Cited by 212 · see citing works

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

Louneva, N., Cohen, J. W., Han, L., Talbot, K., Wilson, R. S., Bennett, D. A., Trojanowski, J. Q., & Arnold, S. E. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080434 · Cited by 207 · see citing works

Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk

Devore, E. E., Grodstein, F., van Rooij, F. J., Hofman, A., Rosner, B., Stampfer, M. J., Witteman, J. C., & Breteler, M. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27037 · Cited by 205 · see citing works

The emerging role of nutrition in Parkinson's disease

Seidl, S. E., Santiago, J. A., Bilyk, H. T., & Potashkin, J. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00036 · Cited by 209 · see citing works

Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex

Igarashi, M., Ma, K., Gao, F., Kim, H., Rapoport, S. I., & Rao, J. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101608 · Cited by 200 · see citing works

Role of the Blood–Brain Barrier in the Nutrition of the Central Nervous System

Campos‐Bedolla, P., Walter, F. R., Veszelka, S., & Deli, M. A. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.11.018 · Cited by 196 · see citing works

Effects of Omega-3 Polyunsaturated Fatty Acids on Brain Functions: A Systematic Review

Dighriri, I. M., Alsubaie, A. M., Hakami, F. N., Hamithi, D., Alshekh, M. M., Khobrani, F. A., Dalak, F. E., Hakami, A. A., Alsueaadi, E. H., Alsaawi, L. S., et al. (2022) · Cureus · doi:10.7759/cureus.30091 · Cited by 195 · see citing works

Oral supplementation with docosahexaenoic acid and uridine-5’-monophosphate increases dendritic spine density in adult gerbil hippocampus

Sakamoto, T., Cansev, M., & Wurtman, R. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.089 · Cited by 188 · see citing works

The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer’s Disease

Cole, G. M., & Frautschy, S. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.009 · Cited by 189 · see citing works

Relative Intake of Macronutrients Impacts Risk of Mild Cognitive Impairment or dementia

Roberts, R., Roberts, L. A., Geda, Y., Cha, R., Pankratz, V., O'Connor, H. M., Knopman, D., & Petersen, R. C. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120862 · Cited by 170 · see citing works

Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.M400486-JLR200

Lane, R., & Farlow, M. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400486-jlr200 · Cited by 184 · see citing works

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice

Arsenault, D., Julien, C., Tremblay, C., & Calon, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017397 · Cited by 177 · see citing works

Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease

Venigalla, M., Sonego, S., Gyengési, E., Sharman, M. J., & Münch, G. W. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.10.011 · Cited by 177 · see citing works

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Bhaskar, K., Miller, M., Chludzinski, A., Herrup, K., Zagorski, M., & Lamb, B. T. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-14 · Cited by 177 · see citing works

Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity

Pang, T. Y., & Hannan, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.029 · Cited by 173 · see citing works

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

Hu, S., Begum, A. N., Jones, M. R., Oh, M. S., Beech, W. K., Beech, B. H., Yang, F., Chen, P., Ubeda, O. J., Kim, P. C., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.10.007 · Cited by 175 · see citing works

Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease

Tosi, F., Sartori, F., Guarini, P., Olivieri, O., & Martinelli, N. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_7 · Cited by 173 · see citing works

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

Madore, C., Leyrolle, Q., Morel, L., Rossitto, M., Greenhalgh, A. D., Delpech, J.-C., Martinat, M., Bosch‐Bouju, C., Bourel, J., Rani, B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19861-z · Cited by 174 · see citing works

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

Hooijmans, C. R., van der Zee, C. E. E. M., Dederen, P. J. W. C., Brouwer, K. M., Reijmer, Y. D., Groen, T. V., Broersen, L. M., Lütjohann, D., Heerschap, A., & Kiliaan, A. J. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.002 · Cited by 171 · see citing works

Cholesterol as a risk factor for Alzheimer's disease - epidemiological evidence

Kivipelto, M., & Solomon, A. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00685.x · Cited by 165 · see citing works

Transfer of omega‐3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid‐rich omega‐3 fatty acid preparation in patients with A lzheimer's disease: the O meg AD study

Freund‐Levi, Y., Vedin, I., Cederholm, T., Basun, H., Irving, G. F., Eriksdotter, M., Hjorth, E., Schultzberg, M., Vessby, B., Wahlund, L., et al. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12166 · Cited by 165 · see citing works

Metabolism and functions of docosahexaenoic acid‐containing membrane glycerophospholipids

Hishikawa, D., Valentine, W. J., Iizuka‐Hishikawa, Y., Shindou, H., & Shimizu, T. (2017) · FEBS Letters · doi:10.1002/1873-3468.12825 · Cited by 166 · see citing works

Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer's Disease

Dumont, M., Kipiani, K., Yu, F., Wille, E. J., Katz, M., Calingasan, N. Y., Gouras, G. K., Lin, M. T. S., & Beal, M. F. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110209 · Cited by 161 · see citing works

Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

Quinn, J. F., Bussiere, J. R., Hammond, R., Montine, T. J., Henson, E., Jones, R. E., & Stackman, R. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.014 · Cited by 160 · see citing works

Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease

Axelsen, P. H., Komatsu, H., & Murray, I. V. J. (2011) · Physiology · doi:10.1152/physiol.00024.2010 · Cited by 158 · see citing works

Dietary fat types and 4‐year cognitive change in community‐dwelling older women

Okereke, O. I., ROSNER, B. A., Kim, D. H., Kang, J. H., Cook, N. R., Manson, J. E., Buring, J. E., Willett, W. C., & Grodstein, F. (2012) · Annals of Neurology · doi:10.1002/ana.23593 · Cited by 153 · see citing works

Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer

Serini, S., Piccioni, E., Merendino, N., & Calviello, G. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0298-2 · Cited by 157 · see citing works

The Effects of Long-Term Omega-3 Fatty Acid Supplementation on Cognition and Alzheimer's Pathology in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-Analysis

Hooijmans, C. R., Jong, P. C. M. P.-D., de Vries, R. B. M., & Ritskes-Hoitinga, M. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111217 · Cited by 156 · see citing works

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model, Neuron 43

Calon, F., Lim, G. P., Yang, F., Morihara, T., Ashe, H., Frautschy, S. A., & Cole, G. M. (2004)

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer’s disease mouse model. Neuron

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O. J., Triller, A., Salem, N., Ashe, K. H., Frautschy, S. A., et al. (2004)

Good fats prevent dendritic damage in mouse model of AD

Love, R. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00890-7 · Cited by 2 · see citing works

Dietary n‐3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease

Calon, F., Lim, G. P., Morihara, T., Yang, F., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04253.x · Cited by 244 · see citing works

The protective role of endogenous n-3 polyunsaturated fatty acids inTauAlzheimer’s disease mouse model

Fang, G., Shi, B., Wu, K., Chen, S., Gao, X., Xiao, S., Kang, J. X., Li, W., & Huang, R. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1533824 · Cited by 19 · see citing works