Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin
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In mammalian cells, the level of the iron-storage protein ferritin (Ft) is tightly controlled by the iron-regulatory protein-1 (IRP-1) at the posttranscriptional level. This regulation prevents iron acting as a catalyst in reactions between reactive oxygen species and biomolecules. The ultraviolet A (UVA) radiation component of sunlight (320–400 nm) has been shown to be a source of oxidative stress to skin via generation of reactive oxygen species. We report here that the exposure of human primary skin fibroblasts, FEK4, to UVA radiation causes an immediate release of “free” iron in the cells via proteolysis of Ft. Within minutes of exposure to a range of doses of UVA at natural exposure levels, the binding activity of IRP-1, as well as Ft levels, decreases in a dose-dependent manner. This decrease coincides with a significant leakage of the lysosomal components into the cytosol. Stabilization of Ft molecules occurs only when cells are pretreated with lysosomal protease inhibitors after UVA treatment. We propose that the oxidative damage to lysosomes that leads to Ft degradation and the consequent rapid release of potentially harmful “free” iron to the cytosol might be a major factor in UVA-induced damage to the skin.
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UVA leads to release of iron from ferritin, thereby potentiating Fenton reactions.
“Interestingly, it was shown that UVA leads to the release of iron from ferritin, therefore potentiating emergence of Fenton reactions (107).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [107]
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- Authors
- Pourzand, C., Watkin, R. D., Brown, J. E., & Tyrrell, R. M.
- Affiliations
- University of Bath (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1999-06-08
- Volume
- 96
- Issue
- 12
- Pages
- 6751-6756
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21987
- OpenAlex
- W2066745245
- Cited by
- 176
- References
- 66
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 4
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- ultraviolet A radiation, ferritin, iron release, dermal fibroblasts, iron regulatory protein 1, lysosomal damage, oxidative stress, reactive oxygen species, skin damage
- MeSH terms
- Cells, Cultured, Ferritins, Fibroblasts, Humans, Iron, Iron-Sulfur Proteins, Radionuclide Imaging, Skin, Ultraviolet Rays, RNA-Binding Proteins, Iron-Regulatory Proteins, Iron Regulatory Protein 1
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