Retinal Photodamage Mediated by All‐trans‐retinal†
Open accessAbstract
Accumulation of all‐trans‐retinal (all‐trans‐RAL), reactive vitamin A aldehyde, is one of the key factors in initiating retinal photodamage. This photodamage is characterized by progressive retinal cell death evoked by light exposure in both an acute and chronic fashion. Photoactivated rhodopsin releases all‐trans‐RAL, which is subsequently transported by ATP‐binding cassette transporter 4 and reduced to all‐trans‐retinol by all‐trans‐retinol dehydrogenases located in photoreceptor cells. Any interruptions in the clearing of all‐trans‐RAL in the photoreceptors can cause an accumulation of this reactive aldehyde and its toxic condensation products. This accumulation may result in the manifestation of retinal dystrophy including human retinal degenerative diseases such as Stargardt’s disease and age‐related macular degeneration. Herein, we discuss the mechanisms of all‐trans‐RAL clearance in photoreceptor cells by sequential enzymatic reactions, the visual (retinoid) cycle, and potential molecular pathways of retinal photodamage. We also review recent imaging technologies to monitor retinal health status as well as novel therapeutic strategies preventing all‐trans‐RAL‐associated retinal photodamage.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent studies of Abca4-/-Rdh8-/- double knockout mice indicate that all-trans-retinal itself may play a decisive role in light-induced photoreceptor degeneration.
“However, recent studies of Abca4–/–Rdh8–/– double knockout mice that closely recapitulate human retinal pathological conditions indicate that all-trans-retinal itself may play a decisive role in light-induced photoreceptor degeneration.318,320,531”
From Chemistry of the Retinoid (Visual) Cycle (2014) · cites this paper as [320]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
ABC Transporters: From Microorganisms to Man
Higgins, C. F. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.000435 · Cited by 3,985 · see citing works
Pegaptanib for neovascular age-related macular degeneration
Gragoudas, E. S., Adamis, A. P., Cunningham, E. T., Feinsod, M., & Guyer, D. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042760 · Cited by 2,337 · see citing works
Allikmets, R., Singh, N., Sun, H., Shroyer, N. F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-236 · Cited by 1,435 · see citing works
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle
Redmond., T. M., Yu, S., Lee, E., Bok, D., Hamasaki, D., Chen, N., Goletz, P., Ma, J.-X., Crouch, R. K., & Pfeifer, K. (1998) · Nature Genetics · doi:10.1038/3813 · Cited by 929 · see citing works
Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration
Allikmets, R. L., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A. P., Zabriskie, N. A., Li, Y., Hutchinson, A. A., et al. (1997) · Science · doi:10.1126/science.277.5333.1805 · Cited by 879 · see citing works
Human ATP-binding cassette (ABC) transporter family
Vasiliou, V., Vasiliou, K., & Nebert, D. W. (2008) · Human Genomics · doi:10.1186/1479-7364-3-3-281 · Cited by 779 · see citing works
Short-chain dehydrogenases/reductases (SDR): the 2002 update
Oppermann, U. C. T., Filling, C., Hult, M., Shafqat, N., Wu, X., Lindh, M., Shafqat, J., Nordling, E., Kallberg, Y., Persson, B., et al. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00164-3 · Cited by 633 · see citing works
Holz, F. G., Bindewald-Wittich, A., Fleckenstein, M., Dreyhaupt, J., Scholl, H. P. N., & Schmitz-Valckenberg, S. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.11.041 · Cited by 619 · see citing works
Sparrow, J. R., Nakanishi, K., & Parish, C. A. (2000) · PubMed · Cited by 566 · see citing works
Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes.
Weiter, J. J., Delori, F. C., Wing, G. L., & Fitch, K. A. (1986) · PubMed · Cited by 565 · see citing works
Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells.
Feeney-Burns, L., Hilderbrand, E. S., & Eldridge, S. (1984) · PubMed · Cited by 561 · see citing works
FUNDUS AUTOFLUORESCENCE IMAGING
Schmitz-Valckenberg, S., Holz, F. G., Bird, A. C., & Spaide, R. F. (2008) · Retina · doi:10.1097/iae.0b013e318164a907 · Cited by 538 · see citing works
Retinal age pigments generated by self-assembling lysosomotropic detergents
Eldred, G., & Lasky, M. R. (1993) · Nature · doi:10.1038/361724a0 · Cited by 489 · see citing works
Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.
Dorey, C. K., Wu, G., Ebenstein, D., Garsd, A., & Weiter, J. J. (1989) · PubMed · Cited by 488 · see citing works
Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects.
Delori, F. C., Goger, D. G., & Dorey, C. K. (2001) · PubMed · Cited by 424 · see citing works
Diseases Caused by Defects in the Visual Cycle: Retinoids as Potential Therapeutic Agents
Travis, G. H., Golczak, M., Moise, A. R., & Palczewski, K. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105225 · Cited by 419 · see citing works
Self-citationAAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness
Bennett, J., Ashtari, M., Wellman, J., Marshall, K. A., Cyckowski, L. L., Chung, D. C., McCague, S., Pierce, E. A., Chen, Y., Bennicelli, J. L., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002865 · Cited by 395 · see citing works
The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium.
Wing, G. L., Blanchard, G. C., & Weiter, J. J. (1978) · PubMed · Cited by 394 · see citing works
Batten, M. L., Imanishi, Y., Maeda, T., Tu, D. C., Moise, A. R., Bronson, D., Possin, D., Van Gelder, R. N., Baehr, W., & Palczewski, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312410200 · Cited by 368 · see citing works
Self-citationMcBee, J. K., Palczewski, K., Baehr, W., & Pepperberg, D. R. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00002-7 · Cited by 366 · cited 1× · see citing works
“phore from all-trans-RAL is essential for the renewal of lightsensitive visual pigments and determines photoreceptor survival in the vertebrate retina (4,5).”
BackgroundDrusen in Age-Related Macular Degeneration
Abdelsalam, A., Del Priore, L., & Zarbin, M. A. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00072-7 · Cited by 352 · see citing works
Rivera, A., White, K., Stöhr, H., Steiner, K., Hemmrich, N., Grimm, T., Jurklies, B., Lorenz, B., Scholl, H. P. N., Apfelstedt-Sylla, E., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/303090 · Cited by 340 · see citing works
Baylor, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.560 · Cited by 337 · see citing works
Mutations in the ABCA4 (ABCR) Gene Are the Major Cause of Autosomal Recessive Cone-Rod Dystrophy
Maugeri, A., Klevering, B. J., Rohrschneider, K., Blankenagel, A., Brunner, H. G., Deutman, A. F., Hoyng, C. B., & Cremers, F. P. M. (2000) · The American Journal of Human Genetics · doi:10.1086/303079 · Cited by 329 · see citing works
A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.
Sparrow, J. R., Parish, C. A., Hashimoto, M., & Nakanishi, K. (1999) · PubMed · Cited by 312 · see citing works
The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily
Illing, M., Molday, L. L., & Molday, R. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10303 · Cited by 304 · see citing works
Retinopathy in Mice Induced by Disrupted All-trans-retinal Clearance
Maeda, A., Maeda, T., Golczak, M., & Palczewski, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804505200 · Cited by 300 · see citing works
Self-citationChemistry and Biology of Vision
Palczewski, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.301150 · Cited by 289 · see citing works
Grimm, C., Wenzel, A., Hafezi, F., Yu, S., Redmond, T. M., & Remé, C. E. (2000) · Nature Genetics · doi:10.1038/75614 · Cited by 283 · see citing works
Fleckenstein, M., Issa, P. C., Helb, H. –., Schmitz-Valckenberg, S., Finger, R. P., Scholl, H. P. N., Loeffler, K. U., & Holz, F. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1967 · Cited by 283 · see citing works
Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.
Holz, F. G., Schütt, F., Kopitz, J., Eldred, G. E., Kruse, F. E., Völcker, H. E., & Cantz, M. (1999) · PubMed · Cited by 280 · see citing works
ABCR expression in foveal cone photoreceptors and its role in Stargardt macular dystrophy
Molday, L. L., Rabin, A. R., & Molday, R. S. (2000) · Nature Genetics · doi:10.1038/77004 · Cited by 269 · see citing works
Liu, J., Itagaki, Y., Ben-Shabat, S., Nakanishi, K., & Sparrow, J. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910191199 · Cited by 255 · see citing works
Histopathology of Best's Macular Dystrophy
Weingeist, T. A., Kobrin, J. L., & Watzke, R. C. (1982) · Archives of Ophthalmology · doi:10.1001/archopht.1982.01030040086016 · Cited by 249 · see citing works
Involvement of All-trans-retinal in Acute Light-induced Retinopathy of Mice
Maeda, A., Maeda, T., Golczak, M., Chou, S., Desai, A., Hoppel, C. L., Matsuyama, S., & Palczewski, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900322200 · Cited by 248 · see citing works
Self-citationIn vivo measurement of lipofuscin in Stargardt's disease--Fundus flavimaculatus.
Delori, F. C., Staurenghi, G., Arend, O., Dorey, C. K., Goger, D. G., & Weiter, J. J. (1995) · PubMed · Cited by 245 · see citing works
Papermaster, D. S., Schneider, B., Zorn, M., & Kraehenbühl, J. P. (1978) · The Journal of Cell Biology · doi:10.1083/jcb.78.2.415 · Cited by 237 · see citing works
Macular degeneration: recent advances and therapeutic opportunities
Rattner, A., & Nathans, J. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2007 · Cited by 230 · see citing works
Chen, Y., Okano, K., Maeda, T., Chauhan, V., Golczak, M., Maeda, A., & Palczewski, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.315432 · Cited by 229 · see citing works
Self-citationRadu, R. A., Mata, N. L., Nusinowitz, S., Liu, X., Sieving, P. A., & Travis, G. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737855100 · Cited by 227 · see citing works
Radu, R. A., Han, Y., Bui, T. V., Nusinowitz, S., Bok, D., Lichter, J. B., Widder, K., Travis, G. H., & Mata, N. L. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0820 · Cited by 225 · see citing works
Structure and function of ABC transporters: the ATP switch provides flexible control
Linton, K. J., & Higgins, C. F. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0126-x · Cited by 221 · see citing works
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography
Nickell, S., Park, P. S.-H., Baumeister, W., & Palczewski, K. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612010 · Cited by 209 · see citing works
Rattner, A., Smallwood, P. M., & Nathans, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11034 · Cited by 207 · see citing works
Photoreceptor Signaling: Supporting Vision across a Wide Range of Light Intensities
Arshavsky, V. Y., & Burns, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.305243 · Cited by 204 · see citing works
PHOTOPHYSICAL STUDIES ON HUMAN RETINAL LIPOFUSCIN
Gaillard, E. R., Atherton, S. J., Eldred, G. E., & Dillon, J. P. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb02343.x · Cited by 203 · see citing works
Biochemical defects in ABCR protein variants associated with human retinopathies
Sun, H., Smallwood, P. M., & Nathans, J. (2000) · Nature Genetics · doi:10.1038/79994 · Cited by 203 · see citing works
Fundus Autofluorescence and Progression of Age-related Macular Degeneration
Schmitz-Valckenberg, S., Fleckenstein, M., Scholl, H. P. N., & Holz, F. G. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.10.004 · Cited by 203 · see citing works
Tsybovsky, Y., Molday, R. S., & Palczewski, K. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-5635-4_8 · Cited by 200 · see citing works
Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells
Davies, S., Elliott, M. H., Floor, E., Truscott, T. G., Zaręba, M., Sarna, T., Shamsi, F. A., & Boulton, M. E. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00582-2 · Cited by 198 · see citing works
Light‐induced Damage to the Retina: Role of Rhodopsin Chromophore Revisited
Różanowska, M., & Sarna, T. (2005) · Photochemistry and Photobiology · doi:10.1562/2004-11-13-ir-371 · Cited by 183 · see citing works
Key enzymes of the retinoid (visual) cycle in vertebrate retina
Kiser, P. D., Golczak, M., Maeda, A., & Palczewski, K. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.03.005 · Cited by 177 · see citing works
Self-citationRod Outer Segment Retinol Dehydrogenase: Substrate Specificity and Role in Phototransduction
Palczewski, K., Jäger, S., Buczyłko, J., Crouch, R. K., Bredberg, D. L., Hofmann, K. P., Asson–Batres, M. A., & Saari, J. C. (1994) · Biochemistry · doi:10.1021/bi00250a027 · Cited by 173 · see citing works
Retinol dehydrogenases (RDHs) in the visual cycle
Parker, R. O., & Crouch, R. K. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.08.013 · Cited by 173 · see citing works
Retinal Pigment Epithelium Lipofuscin Proteomics
Ng, K.-P., Gugiu, B., Renganathan, K., Davies, M. W., Gu, X., Crabb, J. S., Kim, S. R., Różanowska, M. B., Bonilha, V. L., Rayborn, M. E., et al. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700525-mcp200 · Cited by 162 · see citing works
Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo
Maeda, A., Maeda, T., Imanishi, Y., Kuksa, V., Alekseev, A., Bronson, J. D., Zhang, H., Zhu, L., Sun, W., Saperstein, D. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501757200 · Cited by 159 · see citing works
Self-citationRadu, R. A., Hu, J., Yuan, Q., Welch, D. L., Makshanoff, J., Lloyd, M., McMullen, S., Travis, G. H., & Bok, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.191866 · Cited by 157 · see citing works
Vives-Bauza, C., Anand, M., Shirazi, A. K., Magrane, J., Gao, J., Vollmer-Snarr, H. R., Manfredi, G., & Finnemann, S. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800706200 · Cited by 155 · see citing works
Sieving, P. A., Chaudhry, P. S., Kondo, M., Provenzano, M. J., Wu, D. M., Carlson, T. J., Bush, R. A., & Thompson, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1835 · Cited by 152 · see citing works
Light and inherited retinal degeneration
Paskowitz, D. M. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.097436 · Cited by 151 · see citing works
A Comparison of Fundus Autofluorescence and Retinal Structure in Patients with Stargardt Disease
Gomes, N. L., Greenstein, V. C., Carlson, J. N., Tsang, S. H., Smith, R. T., Carr, R. E., Hood, D. C., & Chang, S. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2657 · Cited by 148 · see citing works
Feeney-Burns, L., & Ge, E. (1983) · PubMed · Cited by 143 · see citing works
The formation of autofluorescent granules in cultured human RPE.
Boulton, M. E., McKechnie, N. M., Breda, J., Bayly, M., & Marshall, J. (1989) · PubMed · Cited by 143 · see citing works
Primary amines protect against retinal degeneration in mouse models of retinopathies
Maeda, A., Golczak, M., Chen, Y., Okano, K., Kohno, H., Shiose, S., Ishikawa, K., Harte, W., Palczewska, G., Maeda, T., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.759 · Cited by 135 · see citing works
Self-citationGolczak, M., Kuksa, V., Maeda, T., Moise, A. R., & Palczewski, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503318102 · Cited by 124 · see citing works
Self-citationRetinol Dehydrogenase (RDH12) Protects Photoreceptors from Light-induced Degeneration in Mice
Maeda, A., Maeda, T., Imanishi, Y., Sun, W., Jastrzębska, B., Hatala, D. A., Winkens, H. J., Hofmann, K. P., Janssen, J. J. M., Baehr, W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608375200 · Cited by 121 · see citing works
Self-citationRetinoids for treatment of retinal diseases
Palczewski, K. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.03.001 · Cited by 111 · see citing works
Autosomal-dominant Fundus Flavimaculatus
Lopez, P. F., Maumenee, I. H., de la Cruz, Z. C., & Green, W. R. (1990) · Ophthalmology · doi:10.1016/s0161-6420(90)32508-3 · Cited by 110 · see citing works
Fundus autofluorescence and the bisretinoids of retina
Sparrow, J. R., Wu, Y., Nagasaki, T., Yoon, K. D., Yamamoto, K., & Zhou, J. (2010) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00207k · Cited by 106 · see citing works
Schmitz-Valckenberg, S., Fleckenstein, M., Göbel, A. P., Hohman, T. C., & Holz, F. G. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5619 · Cited by 106 · see citing works
Imaging retinal mosaics in the living eye
Rossi, E. A., Chung, M. E., Dubra, A., Hunter, J. J., Merigan, W. H., & Williams, D. R. (2011) · Eye · doi:10.1038/eye.2010.221 · Cited by 104 · see citing works
Natural History of Phenotypic Changes in Stargardt Macular Dystrophy
Walia, S., & Fishman, G. A. (2009) · Ophthalmic Genetics · doi:10.1080/13816810802695550 · Cited by 104 · see citing works
Molday, R. S. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9118-6 · Cited by 101 · see citing works
The ATP-binding cassette family: a structural perspective
Kos, V. N., & Ford, R. C. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0064-9 · Cited by 100 · see citing works
Sun, H., & Nathans, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010152200 · Cited by 93 · see citing works
Requirement for an Enzymatic Visual Cycle in Drosophila
Wang, X., Wang, T., Jiao, Y., Lintig, J. V., & Montell, C. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.022 · Cited by 90 · see citing works
Palczewska, G., Maeda, T., Imanishi, Y., Sun, W., Chen, Y., Williams, D. R., Piston, D. W., Maeda, A., & Palczewski, K. (2010) · Nature Medicine · doi:10.1038/nm.2260 · Cited by 88 · see citing works
Self-citationRabb, M. F., Tso, M. O. M., & Fishman, G. A. (1986) · Ophthalmology · doi:10.1016/s0161-6420(86)33547-4 · Cited by 79 · see citing works
Maeda, A., Maeda, T., Golczak, M., Imanishi, Y., Leahy, P. S., Kubota, R., & Palczewski, K. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026823 · Cited by 79 · see citing works
Self-citationSchmitz-Valckenberg, S., Fleckenstein, M., Göbel, A. P., et al. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2008.04.006 · Cited by 68 · see citing works
Weleber, R. G. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090180050033 · Cited by 65 · see citing works
Shiose, S., Chen, Y., Okano, K., Roy, S., Kohno, H., Tang, J. C. O., Pearlman, E. M., Maeda, T., Palczewski, K., & Maeda, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228551 · Cited by 64 · see citing works
Self-citationTawa, P., Tam, J. P., Cassady, R., et al. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400769 · Cited by 60 · see citing works
EIdred, G. E. (1993) · Nature · doi:10.1038/364396a0 · Cited by 58 · see citing works
Rdh12 activity and effects on retinoid processing in the murine retina
Chrispell, J. D., Feathers, K. L., Kane, M. A., Kim, C. Y., Brooks, M., Khanna, R., Kurth, I., Hübner, C. A., Gal, A., Mears, A. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020966 · Cited by 56 · see citing works
Lipofuscin and Autofluorescence Metrics in Progressive STGD
Smith, R. T., Gomes, N. L., Barile, G. R., Busuioc, M., Lee, N., & Laine, A. F. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2448 · Cited by 56 · see citing works
Quantification of Peripapillary Sparing and Macular Involvement in Stargardt Disease (STGD1)
Burke, T. R., Rhee, D. W., Smith, R. T., Tsang, S. H., Allikmets, R. L., Chang, S., Lazow, M., Hood, D. C., & Greenstein, V. C. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7693 · Cited by 53 · see citing works
Sparrow, J. R., Kim, S. R., Cuervo, A. M., & Bandhyopadhyayand, U. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-74904-4_46 · Cited by 52 · see citing works
Spatial localization of A2E in the retinal pigment epithelium
Grey, A. C., Crouch, R. K., Koutalos, Y., Schey, K. L., & Ablonczy, Z. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-7020 · Cited by 52 · see citing works
Gollapalli, D. R., & Rando, R. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401936101 · Cited by 49 · see citing works
Two-photon excited autofluorescence imaging of human retinal pigment epithelial cells
Han, M., Bindewald-Wittich, A., Holz, F. G., Giese, G., Niemz, M. H., Snyder, S., Sun, H., Yu, J., Agopov, M., Schiazza, O. L., et al. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2171649 · Cited by 42 · see citing works
Posttranslational Modifications of the Photoreceptor-Specific ABC Transporter ABCA4
Tsybovsky, Y., Wang, B., Quazi, F., Molday, R. S., & Palczewski, K. (2011) · Biochemistry · doi:10.1021/bi200774w · Cited by 39 · see citing works
Lochner, J. E., Badwey, J. A., Horn, W., & Karnovsky, M. L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7673 · Cited by 34 · see citing works
The specificity of alcohol dehydrogenase with cis‐retinoids
Martras, S., Álvarez, R., Martínez, S. E., Torres, D., Gallego, O., Duester, G., Farrés, J., de Lera, Á. R., & Parés, X. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04058.x · Cited by 25 · see citing works
Compositional studies of human RPE lipofuscin: mechanisms of molecular modifications
Murdaugh, L. S., Mandal, S., Dill, A. E., Dillon, J. P., Simon, J. D., & Gaillard, E. R. (2010) · Journal of Mass Spectrometry · doi:10.1002/jms.1865 · Cited by 25 · see citing works
Gene therapy: light is finally in the tunnel
Cao, H., Molday, R. S., & Hu, J. (2011) · Protein & Cell · doi:10.1007/s13238-011-1126-y · Cited by 23 · see citing works
Properties of rat retina alcohol dehydrogenase
Parés, X., Julià, P., & Farrés, J. (1985) · Alcohol · doi:10.1016/0741-8329(85)90013-8 · Cited by 22 · see citing works
Redmond, T. M., Weber, C. H., Poliakov, E., Yu, S., & Gentleman, S. (2007) · PubMed · Cited by 21 · see citing works
Yasukawa, T., Wiedemann, P., Hoffmann, S. R. K., Kacza, J., Eichler, W., Wang, Y., Nishiwaki, A., Seeger, J., & Ogura, Y. (2007) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-007-0571-z · Cited by 20 · see citing works
Davis, J. L., Olsen, T. W., Stewart, M., & Sternberg, P. (2011) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2011.07.004 · Cited by 17 · see citing works
UNIDENTIFIED FACTORS REQUIRED BY LACTOBACILLUS CASEI
Daniel, L. J., Peeler, H. T., Norris, L. C., et al. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57036-8 · Cited by 9 · see citing works
Allikmets, R. L. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-186-4_5 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chemistry of the Retinoid (Visual) Cycle
Kiser, P. D., Golczak, M., & Palczewski, K. (2014) · Chemical Reviews · doi:10.1021/cr400107q · Cited by 353 · see citing works
Self-citationVicente-Tejedor, J., Marchena, M., Ramírez, L., García-Ayuso, D., Gómez-Vicente, V., Sánchez-Ramos, C., de la Villa, P., & Germain, F. (2018) · PLOS ONE · doi:10.1371/journal.pone.0194218 · Cited by 90 · see citing works
Maeda, T., Dong, Z., Jin, H., Sawada, O., Gao, S., Utkhede, D., Monk, W., Palczewska, G., & Palczewski, K. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.12-11152 · Cited by 41 · see citing works
Self-citation
- Authors
- Maeda, T., Golczak, M., & Maeda, A.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Maeda, Akiko
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2012-04-24
- Volume
- 88
- Issue
- 6
- Pages
- 1309-1319
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- PMC
- PMC3424387
- OpenAlex
- W2022410686
- Cited by
- 92
- References
- 102
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 3 · 2023: 16 · 2022: 6 · 2021: 2 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Research to Prevent Blindness
- Case Western Reserve University (P30 EY11373, EY11373)
- Ohio Lions Eye Research Foundation
- National Institutes of Health (EY-11373)
- National Eye Institute (R01EY022658, EY021126, K08EY019880, EY019880, EY009339, K08EY019031, R24EY021126, EY019031, P30EY011373, R01EY009339)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- all-trans-retinal, photoreceptors, rhodopsin, visual cycle, retinal degeneration, Stargardt disease, age-related macular degeneration, retinal imaging, photoprotection
- MeSH terms
- Animals, Humans, Light, Retina, Retinal Degeneration, Retinaldehyde
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
