Developing Robust, Sustainable, Implementation Systems Using Rigorous, Rapid and Relevant Science
Open accessAbstract
Background: Current approaches to medical science generally have not resulted in rapid, robust integration into feasible, sustainable real world healthcare programs and policies. Implementation science risks falling short of expectations if it aligns with historical norms. Fundamentally different scientific approaches are needed to accelerate such integration. Methods: We propose that the key goal of implementation science should be to study the development, spread and sustainability of broadly applicable and practical programs, treatments, guidelines, and policies that are contextually relevant and robust across diverse settings, delivery staff, and subgroups. We recommend key conceptual and methodological characteristics needed to accomplish these goals. Results: The methods to produce such advances should be rapid, rigorous, transparent, and contextually relevant. We recommend approaches that incorporate a systems perspective, investigate generalizability, are transparent, and employ practical measures and participatory approaches. Conclusions: To produce different outcomes, we need to think and act differently. Implications of such an implementation science approach include fundamental changes that should be relevant to Clinical Translational Science Award investigators, comparative effectiveness researchers, those interested in pragmatic trials, grant funders, and community partners. Clin Trans Sci 2012; Volume #: 1–8
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Experts have prioritized sustainability as an understudied area and identified it as one of the most significant translational research problems of our time.
“Recently, experts have prioritized sustainability as an understudied area (45), identifying it as “one of the most significant translational research problems of our time” (103, p. 2) and as a persistent challenge across a range of settings and service delivery sectors, and across health behaviors and outcomes.”
From The Sustainability of Evidence-Based Interventions and Practices in Public Health and Health Care (2018) · cites this paper as [45]
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- Authors
- Glasgow, R. E., & Chambers, D.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- Corresponding author
- Glasgow, Russell E.
- ORCID
- Glasgow, Russell E.
- Venue
- Clinical and Translational Science
- Publisher
- Wiley
- Published
- 2012-02
- Volume
- 5
- Issue
- 1
- Pages
- 48-55
- ISSN
- 1752-8054 (ISSN-L)
- 1752-8062
- PMC
- PMC5439908
- OpenAlex
- W1980568269
- Cited by
- 278
- References
- 42
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 18 · 2023: 17 · 2022: 30 · 2021: 41 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 14 · 2016: 12 · 2015: 23 · 2014: 14 · 2013: 15 · 2012: 7
- FWCI
- 33.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical and Translational Science (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Health Sciences › Health Professions › General Health Professions › Health Sciences Research and Education
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Keywords
- implementation science, generalizability, systems approach, participatory approach, translational research, pragmatic trials, comparative effectiveness research, research transparency
- MeSH terms
- Cooperative Behavior, Health Policy, Health Services Research, Humans, Organizational Objectives, Research Design, Research Support as Topic, Practice Guidelines as Topic, Community Networks, Evidence-Based Medicine, Translational Research, Biomedical, Comparative Effectiveness Research
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