The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Flaxseed and Cardiovascular Risk
Abstract
Flaxseed has recently gained attention in the area of cardiovascular disease primarily because it is the richest known source of both alpha-linolenic acid (ALA) and the phytoestrogen, lignans, as well as being a good source of soluble fiber. Human studies have shown that flaxseed can modestly reduce serum total and low-density lipoprotein cholesterol concentrations, reduce postprandial glucose absorption, decrease some markers of inflammation, and raise serum levels of the omega-3 fatty acids, ALA and eicosapentaenoic acid. Data on the antiplatelet, antioxidant, and hypotensive effects of flaxseed, however, are inconclusive. More research is needed to define the role of this functional food in reducing cardiovascular risk.
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Cites
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707
Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review
Hu, F. B., Manson, J. E., & Willett, W. C. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719008 · Cited by 902
Singh, R. B., Dubnov, G., Niaz, M. A., Ghosh, S., Singh, R., Rastogi, S. S., Manor, O., Pella, D., & Berry, E. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11472-3 · Cited by 663
Thies, F., Miles, E. A., Nebe‐von‐Caron, G., Powell, J. R., Hurst, T. L., Newsholme, E. A., & Calder, P. C. (2001) · Lipids · doi:10.1007/s11745-001-0831-4 · Cited by 279 · cited 1×
“Another study found that 2 g of ALA from flaxseed oil did not change circulating cytokine levels or numbers of inflammatory cells in healthy adults.(58) There was, however, a reduction in soluble vascular cell adhesion molecule 1 and soluble E-selectin, both of which are markers of endothelial activation, in the flaxs…”
Vanharanta, M., Voutilainen, S., Lakka, T. A., van der Lee, M., Adlercreutz, H., & Salonen, J. T. (1999) · The Lancet · doi:10.1016/s0140-6736(99)05031-x · Cited by 246
Cited by
Ultrasound-assisted extraction of oil from flaxseed
Zhang, Z.-S., Wang, L.-J., Li, D., Jiao, S.-S., Chen, X. D., & Mao, Z.-H. (2008) · Separation and Purification Technology · doi:10.1016/j.seppur.2008.01.014 · Cited by 397
The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology
Yuan, Q., Xie, F., Huang, W., Hu, M., Yan, Q., Chen, Z., Zheng, Y., & Liu, L. (2022) · Phytotherapy Research · doi:10.1002/ptr.7295 · Cited by 285
Meta-analysis of the effects of flaxseed interventions on blood lipids
Pan, A., Yu, D., Demark-Wahnefried, W., Franco, O. H., & Lin, X. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27469 · Cited by 264
Ren, G.-Y., Chen, C.-Y., Chen, G.-C., Chen, W.-G., Pan, A., Pan, C.-W., Zhang, Y.-H., Qin, L.-Q., & Chen, L.-H. (2016) · Nutrients · doi:10.3390/nu8030136 · Cited by 88
Akrami, A., Nikaein, F., Babajafari, S., Faghih, S., & Yarmohammadi, H. (2018) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2017.11.004 · Cited by 85
Metadata
- Authors
- Bloedon, L. T., & Szapary, P. O.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01
- Volume
- 62
- Issue
- 1
- Pages
- 18-27
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2064962253
- Cited by
- 198
- References
- 5
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
