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Comparison of the effects of flaxseed oil and sunflower seed oil consumption on serum glucose, lipid profile, blood pressure, and lipid peroxidation in patients with metabolic syndrome

Akrami, Atefeh, Nikaein, Farzad, Babajafari, Siavash, Faghih, Shiva, Yarmohammadi, Hassan·2018·Journal of Clinical Lipidology
DOI 10.1016/j.jacl.2017.11.004
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Abstract

Background Metabolic syndrome (MetSyn) increases the risk of type II diabetes and morbidity and mortality due to cardiovascular diseases. Flaxseed oil (FO), as a functional food, is one of the major vegetal sources of essential omega-3 fatty acids.Objective This study aimed to compare the effects of consumption of FO and sunflower seed oil (SO) on lipid peroxidation and other symptoms of MetSyn.Methods This randomized controlled interventional trial was conducted on 60 volunteers aged 30 to 60 years who were diagnosed with MetSyn in Shiraz, Iran. The participants who fulfilled the inclusion criteria were randomly assigned to SO (n = 30, receiving 25 mL/d SO) and FO (n = 30, receiving 25 ml/d FO) groups using block randomization. The diets were identical for all the participants. Blood pressure (BP), serum lipid, fasting blood sugar, and malondialdehyde were measured at baseline and at the end of week 7.Result The results showed no significant difference between the 2 groups regarding blood lipid levels and fasting blood sugar at the end of the study. However, significant reductions in total cholesterol, low-density lipoprotein cholesterol (5.6% in FO and 10.8% in SO), and triglyceride levels were seen within each group after treatment with FO and SO (P < .05). Nonetheless, between-group changes were significant (<0.05) for systolic BP (mean [±standard deviation {SD}] changes were -14.0 ± 22.41 in the FO group [P = .004] and 0.92 ± 8.70 in the SO group [P = .594]) and diastolic BP (mean [±SD] changes were -4.26 ± 7.44 in the FO group [P = .007] and 1.30 ± 6.91 in the SO group [P = .344]), but marginally significant (P = .053) for malondialdehyde level (mean [±SD] changes were -1.29 ± 1.48 in the FO group [P < .001] and -0.52 ± 1.34 in the SO group [P = .52]). A significant decrease in weight was also found in both groups. However, waist circumference decreased significantly only in the FO group at the end of the study (P < .05).Conclusion Our results indicated that dietary FO could be effective in amelioration of some symptoms of MetSyn and decrease BP and lipid peroxidation.

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Authors
Akrami, A., Nikaein, F., Babajafari, S., Faghih, S., & Yarmohammadi, H.
Affiliations
Shiraz University of Medical Sciences (IR)
Corresponding author
Babajafari, Siavash
ORCID
Venue
Journal of Clinical Lipidology
Publisher
Elsevier BV
Published
2018-01
Volume
12
Issue
1
Pages
70-77
ISSN
  • 1876-4789 (ISSN-L)
  • 1933-2874
DOI
10.1016/j.jacl.2017.11.004
OpenAlex
W2768831597
Cited by
85
References
36
Citations by year
2026: 3 · 2025: 8 · 2024: 8 · 2023: 15 · 2022: 11 · 2021: 19 · 2020: 8 · 2019: 8 · 2018: 5
FWCI
4.77
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of clinical lipidology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Shiraz University of Medical Sciences (7420)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords
metabolic syndrome, linseed oil, sunflower oil, omega-3 fatty acids, lipid peroxidation, malondialdehyde, serum lipids, LDL cholesterol, triglycerides, blood pressure, fasting blood glucose, weight loss, waist circumference, dietary intervention, functional foods, cardiovascular risk factors, type 2 diabetes risk, HDL cholesterol, HDL2
MeSH terms
Sunflower Oil, Adult, Blood Glucose, Blood Pressure, Diet, Female, Humans, Linseed Oil, Cholesterol, HDL, Cholesterol, LDL, Male, Malondialdehyde, Gas Chromatography-Mass Spectrometry, Middle Aged, Triglycerides, Lipid Peroxidation, Metabolic Syndrome, Waist Circumference

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