Validation of clinical diagnostic criteria for Alzheimer's disease
Abstract
Clinical investigations of Alzheimer's disease (AD) have been limited by diagnostic inaccuracy. We employed explicit clinical inclusion and exclusion criteria to identify subjects with senile dementia of the Alzheimer type (SDAT). In a consecutive series of 26 postmortem examinations from this sample, AD was histologically verified in all subjects and was the primary dementing illness. Seventeen of the 26 SDAT subjects had been diagnosed when only mildly demented. Two control subjects were examined neuropathologically; AD was absent in both. We conclude that research clinical diagnostic criteria for SDAT, even in its mild stage, are valid.
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Clinicopathological analysis of dementia disorders in the elderly – An update
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Absence of cognitive impairment or decline in preclinical Alzheimer’s disease
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Self-citationClinical and Pathological Aspects of Parkinsonism in Alzheimer's Disease
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Incorrect Diagnosis of Alzheimer's Disease: A Clinicopathologic Study
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Dementia and response to pain in the elderly
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Self-citationFallacies in the pathological confirmation of the diagnosis of Alzheimer’s disease
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On the Preservation of Syntax in Alzheimer's Disease
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Leuko-Araiosis, Cerebral Atrophy, and Cerebral Perfusion in Normal Aging
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Auditory Dysfunction in Aging and Senile Dementia of the Alzheimer's Type
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Self-citationPotassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.
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Mild senile dementia of the Alzheimer type. 4. Evaluation of intervention
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Reliability of Clinical Nurse Specialists in the Staging of Dementia
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- Authors
- Morris, J. C., McKeel, D. W., Fulling, K., Torack, R. M., & Berg, L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Morris, John C.
- ORCID
- Morris, John C.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1988-07
- Volume
- 24
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2055629766
- Cited by
- 362
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 2 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 19.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG03991, AG 05681)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Keywords
- Alzheimer's disease, senile dementia of the Alzheimer type, clinical criteria, diagnostic accuracy, mild dementia, postmortem neuropathology, histopathological confirmation, underdiagnosis of dementia
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Infarction, Diagnosis, Differential, Female, Humans, Male, Neuropsychological Tests
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