Cited by 362Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPsychological Testing and Assessment

Validation of clinical diagnostic criteria for Alzheimer's disease

Morris, John C., McKeel, Daniel W., Fulling, Keith, Torack, Richard M., Berg, Leonard·1988·Annals of Neurology

Abstract

Clinical investigations of Alzheimer's disease (AD) have been limited by diagnostic inaccuracy. We employed explicit clinical inclusion and exclusion criteria to identify subjects with senile dementia of the Alzheimer type (SDAT). In a consecutive series of 26 postmortem examinations from this sample, AD was histologically verified in all subjects and was the primary dementing illness. Seventeen of the 26 SDAT subjects had been diagnosed when only mildly demented. Two control subjects were examined neuropathologically; AD was absent in both. We conclude that research clinical diagnostic criteria for SDAT, even in its mild stage, are valid.

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Crossref · 10.1002/ana.410240105

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Authors
Morris, J. C., McKeel, D. W., Fulling, K., Torack, R. M., & Berg, L.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Morris, John C.
Venue
Annals of Neurology
Publisher
Wiley
Published
1988-07
Volume
24
Issue
1
Pages
17-22
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2055629766
Cited by
362
References
31
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 2 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 7
FWCI
19.83
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG03991, AG 05681)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
Keywords
Alzheimer's disease, senile dementia of the Alzheimer type, clinical criteria, diagnostic accuracy, mild dementia, postmortem neuropathology, histopathological confirmation, underdiagnosis of dementia
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Infarction, Diagnosis, Differential, Female, Humans, Male, Neuropsychological Tests

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