Relationship Between β-Cell Mass and Fasting Blood Glucose Concentration in Humans

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011 · see citing works

U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease

U.K. Prospective Diabetes Study Group (1995) · Diabetes · doi:10.2337/diab.44.11.1249 · Cited by 1,923 · see citing works

Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Buchanan, T. A., Xiang, A. H., Peters, R. K., Kjos, S. L., Marroquin, A., Goico, J., Ochoa, C., Tan, S., Berkowitz, K., Hodis, H. N., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2796 · Cited by 1,339 · see citing works

U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group

(1995) · Diabetes · doi:10.2337/diabetes.44.11.1249 · Cited by 796 · see citing works

Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

Klöppel, G., Löhr, M., Habich, K., Oberholzer, M., & Heitz, P. (1985) · Survey and Synthesis of Pathology Research · doi:10.1159/000156969 · Cited by 645 · see citing works

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

Yoon, K., Ko, S., Cho, J., Lee, J. M., Ahn, Y., Song, K. H., Yoo, S. J., Kang, M. I., Cha, B. Y., Lee, K. W., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020735 · Cited by 645 · see citing works

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

Donath, M. Y., & Halban, P. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1336-4 · Cited by 427 · see citing works

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C., Scorrano, L., Dalgaard, L. T., St‐Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19774 · Cited by 401 · see citing works

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319774 · Cited by 401 · see citing works

Pancreatic Islets from Type 2 Diabetic Patients Have Functional Defects and Increased Apoptosis That Are Ameliorated by Metformin

Marchetti, P., Guerra, S. D., Marselli, L., Lupi, R., Masini, M., Pollera, M., Bugliani, M., Boggi, U., Vistoli, F., Mosca, F., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0150 · Cited by 335 · see citing works

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

Matschinsky, F. M., Gläser, B., & Magnuson, M. A. (1998) · Diabetes · doi:10.2337/diabetes.47.3.307 · Cited by 334 · see citing works

Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat)

Butler, A. E., Jang, J., Gurlo, T., Carty, M. D., Soeller, W. C., & Butler, P. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1509 · Cited by 267 · see citing works

Hyperglycemia and Insulin Resistance: Possible Mechanisms

Tomás, E., Lin, Y., Dagher, Z., Saha, A. K., Luo, Z., Ido, Y., & Ruderman, N. B. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04262.x · Cited by 176 · see citing works

Pioglitazone and Sodium Salicylate Protect Human β-Cells against Apoptosis and Impaired Function Induced by Glucose and Interleukin-1β

Zeender, E., Maedler, K., Bosco, D., Berney, T., Donath, M. Y., & Halban, P. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0446 · Cited by 103 · see citing works

Induction of β-Cell Rest by a Kir6.2/SUR1-Selective KATP-Channel Opener Preserves β-Cell Insulin Stores and Insulin Secretion in Human Islets Cultured at High (11 mM) Glucose

Ritzel, R. A., Hansen, J. B., Veldhuis, J. D., & Butler, P. C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031120 · Cited by 74 · see citing works

Glucagon-like peptide 1 (GLP-1) in the treatment of diabetes

Nauck, M. A. (2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-826175 · Cited by 72 · see citing works

β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

Meier, J. J., Butler, A. E., Saisho, Y., Monchamp, T., Galasso, R., Bhushan, A., Rizza, R. A., & Butler, P. C. (2008) · Diabetes · doi:10.2337/db07-1369 · Cited by 683 · see citing works

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

Haataja, L., Gurlo, T., Huang, C. J., & Butler, P. C. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0037 · Cited by 612 · see citing works

Defining and Characterizing the Progression of Type 2 Diabetes

Fonseca, V. A. (2009) · Diabetes Care · doi:10.2337/dc09-s301 · Cited by 573 · see citing works

Expansion of β-cell mass in response to pregnancy

Rieck, S., & Kaestner, K. H. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.11.001 · Cited by 358 · see citing works

The replication of β cells in normal physiology, in disease and for therapy

Butler, P. C., Meier, J. J., Butler, A. E., & Bhushan, A. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0647 · Cited by 268 · see citing works

β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes

Saisho, Y. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i1.109 · Cited by 263 · see citing works

Relationship between β‐cell mass and diabetes onset

Matveyenko, A. V., & Butler, P. C. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00939.x · Cited by 249 · see citing works

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

Cnop, M., Hughes, S. J., Igoillo‐Esteve, M., Hoppa, M. B., Sayyed, F., van de Laar, L., Gunter, J. H., de Koning, E. J. P., Walls, G. V., Gray, D. W. G., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1562-x · Cited by 240 · see citing works

Diabetes mellitus—advances and challenges in human β-cell proliferation

Wang, P., Fiaschi‐Taesch, N., Vasavada, R. C., Scott, D. K., Garcı́a-Ocaña, A., & Stewart, A. F. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.9 · Cited by 204 · see citing works

Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice

Suarez‐Pinzon, W. L., Power, R. F., Yan, Y., Wasserfall, C. H., Atkinson, M. A., & Rabinovitch, A. (2008) · Diabetes · doi:10.2337/db08-0688 · Cited by 182 · see citing works

Lean diabetes mellitus: An emerging entity in the era of obesity

George, A. M., Jacob, A. G., & Fogelfeld, L. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.613 · Cited by 177 · see citing works

Partial pancreatectomy in adult humans does not provoke β-cell regeneration

Menge, B. A., Tannapfel, A., Belyaev, O., Drescher, R., Müller, C., Uhl, W., Schmidt, W. E., & Meier, J. J. (2008) · Diabetes · doi:10.2337/db07-1294 · Cited by 173 · see citing works

Functional Assessment of Pancreatic β-Cell Area in Humans

Meier, J. J., Menge, B. A., Breuer, T. G. K., Müller, C., Tannapfel, A., Uhl, W. H., Schmidt, W. E., & Schrader, H. (2009) · Diabetes · doi:10.2337/db08-1611 · Cited by 164 · see citing works

Minireview: Meeting the Demand for Insulin: Molecular Mechanisms of Adaptive Postnatal ß-Cell Mass Expansion

Sachdeva, M. M., & Stoffers, D. A. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0400 · Cited by 155 · see citing works

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

Hanley, S. C., Austin, E. B., Assouline-Thomas, B., Kapeluto, J., Blaichman, J. I., Moosavi, M., Petropavlovskaia, M., & Rosenberg, L. C. (2010) · Endocrinology · doi:10.1210/en.2009-1277 · Cited by 155 · see citing works

Beta cell mass in diabetes: a realistic therapeutic target?

Meier, J. J. (2008) · Diabetologia · doi:10.1007/s00125-008-0936-9 · Cited by 155 · see citing works

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Cohrs, C. M., Panzer, J. K., Drotar, D. M., Enos, S. J., Kipke, N., Chen, C., Bozsak, R., Schöniger, E., Ehehalt, F., Distler, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.033 · Cited by 154 · see citing works

β-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes

Matveyenko, A. V., & Butler, P. C. (2006) · Diabetes · doi:10.2337/db05-1672 · Cited by 142 · see citing works

Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

Meier, J. J., Breuer, T. G. K., Bonadonna, R. C., Tannapfel, A., Uhl, W. H., Schmidt, W. E., Schrader, H., & Menge, B. (2012) · Diabetologia · doi:10.1007/s00125-012-2466-8 · Cited by 144 · see citing works

Non-invasive quantification of the beta cell mass by SPECT with 111In-labelled exendin

Brom, M., der Weg, W. W.-V., Joosten, L., Frielink, C., Bouckenooghe, T., Rijken, P. F. J. W., Andralojc, K. M., Göke, B., de Jong, M., Eizirik, D. L., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3166-3 · Cited by 139 · see citing works

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

Annes, J. P., Kenty, J. H.-R., Lam, K., Carolan, P. J., Utz, K., Hollister‐Lock, J., Arvanites, A. C., Rubin, L. L., Weir, G. C., & Melton, D. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201149109 · Cited by 137 · see citing works

Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis

Butler, A. E., Galasso, R., Meier, J. J., Basu, R., Rizza, R. A., & Butler, P. C. (2007) · Diabetologia · doi:10.1007/s00125-007-0794-x · Cited by 137 · see citing works

Pancreatic β-Cell Proliferation in Obesity

Linnemann, A. K., Baan, M., & Davis, D. B. (2014) · Advances in Nutrition · doi:10.3945/an.113.005488 · Cited by 132 · see citing works

β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

Costes, S., Langen, R., Gurlo, T., Matveyenko, A. V., & Butler, P. C. (2013) · Diabetes · doi:10.2337/db12-1326 · Cited by 121 · see citing works

Mathematical models of diabetes progression.

Gaetano, A. D., Hardy, T., Beck, B. H. L., Abu-Raddad, E., Palumbo, P., Bue-Valleskey, J., & Porksen, N. (2008) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.90444.2008 · Cited by 111 · see citing works

Visualizing pancreatic β-cell mass with [11C]DTBZ

Simpson, N. R., Souza, F., Witkowski, P., Maffei, A., Raffo, A. J., Herron, A. J., Kilbourn, M. R., Jurewicz, A., Herold, K. C., Liu, E., et al. (2006) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2006.07.002 · Cited by 117 · see citing works

The effects of glucagon‐like peptide‐1 on the beta cell

Vilsbøll, T. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01073.x · Cited by 115 · see citing works

Impaired islet turnover in human donor pancreata with aging

Reers, C., Erbel, S., Esposito, I., Schmied, B., Büchler, M. W., Nawroth, P. P., & Ritzel, R. A. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0596 · Cited by 113 · see citing works

β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation

Butler, A. E., Dhawan, S., Hoang, J. D., Cory, M., Zeng, K., Fritsch, H., Meier, J. J., Rizza, R. A., & Butler, P. C. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3566 · Cited by 109 · see citing works

Targeting β-Cell Mass in Type 2 Diabetes: Promise and Limitations of New Drugs Based on Incretins

Salehi, M., Aulinger, B. A., & D’Alessio, D. A. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0031 · Cited by 106 · see citing works

Reduced Pancreatic Volume and β-Cell Area in Patients With Chronic Pancreatitis

Schrader, H., Menge, B. A., Schneider, S., Belyaev, O., Tannapfel, A., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.083 · Cited by 108 · see citing works

Pancreatic Volumetric Assessment as a Predictor of New-Onset Diabetes Following Distal Pancreatectomy

Shirakawa, S., Matsumoto, I., Toyama, H., Shinzeki, M., Ajiki, T., Fukumoto, T., & Ku, Y. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-2039-7 · Cited by 100 · see citing works

Longevity of human islet α ‐ and β ‐cells

Cnop, M., Igoillo‐Esteve, M., Hughes, S. J., Walker, J. N., Cnop, I., & Clark, A. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01443.x · Cited by 97 · see citing works

FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation

Davis, D. B., Lavine, J. A., Suhonen, J. I., Krautkramer, K. A., Rabaglia, M. E., Sperger, J. M., Fernandez, L. A., Yandell, B. S., Keller, M. P., Wang, I., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0082 · Cited by 90 · see citing works

Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation

Kim, W., Lao, Q., Shin, Y., Carlson, O. D., Lee, E. K., Gorospe, M., Kulkarni, R., & Egan, J. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002519 · Cited by 90 · see citing works

Non-obese patients with type 2 diabetes and prediabetic subjects: distinct phenotypes requiring special diabetes treatment and (or) prevention?

Vaag, A., & Lund, S. S. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-100 · Cited by 89 · see citing works

Metabolic consequences of a 50% partial pancreatectomy in humans

Menge, B., Schrader, H., Breuer, T. G. K., Dabrowski, Y., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2008) · Diabetologia · doi:10.1007/s00125-008-1219-1 · Cited by 86 · see citing works

Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas

Saisho, Y., Harris, P. E., Butler, A. E., Galasso, R., Gurlo, T., Rizza, R. A., & Butler, P. C. (2008) · Journal of Molecular Histology · doi:10.1007/s10735-008-9195-9 · Cited by 85 · see citing works

Glucolipotoxicity and beta cells in type 2 diabetes mellitus: Target for durable therapy?

van Raalte, D. H., & Diamant, M. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(11)70012-2 · Cited by 83 · see citing works

Glucolipotoxicity in Pancreatic β-Cells

Kim, J.-W., & Yoon, K.-H. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.5.444 · Cited by 82 · see citing works

What is type 2 diabetes?

Smushkin, G., & Vella, A. V. (2010) · Medicine · doi:10.1016/j.mpmed.2010.08.008 · Cited by 80 · see citing works

Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18

Pascoe, J. L., Hollern, D. A., Stamateris, R. E., Abbasi, M., Romano, L. C., Zou, B., O'Donnell, C. P., Garcı́a-Ocaña, A., & Alonso, L. C. (2012) · Diabetes · doi:10.2337/db11-0991 · Cited by 72 · see citing works

Cholecystokinin Is Up-Regulated in Obese Mouse Islets and Expands β-Cell Mass by Increasing β-Cell Survival

Lavine, J. A., Raess, P. W., Stapleton, D. S., Rabaglia, M. E., Suhonen, J. I., Schueler, K. L., Koltes, J. E., Dawson, J., Yandell, B. S., Samuelson, L. C., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0233 · Cited by 70 · see citing works

CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition

Abdolazimi, Y., Zhao, Z., Lee, S., Xu, H., Allegretti, P. A., Horton, T. M., Yeh, B. T., Moeller, H. P., Nichols, R. J., McCutcheon, D., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00083 · Cited by 68 · see citing works

A dominant role for glucose in β cell compensation of insulin resistance

Weir, G. C., & Bonner‐Weir, S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30862 · Cited by 70 · see citing works

β‐cell mass in people with type 2 diabetes

Cho, J., Kim, J., Shin, J., Shin, J., & Yoon, K. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00072.x · Cited by 69 · see citing works

ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice

Shoemaker, R., Yiannikouris, F. B., Thatcher, S. E., & Cassis, L. A. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00054.2015 · Cited by 69 · see citing works

Posttransplant Diabetes Mellitus After Pancreas Transplantation

Dean, P. G., Kudva, Y. C., Larson, T. S., Kremers, W. K., & Stegall, M. D. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02018.x · Cited by 67 · see citing works

Cyclin D2 Is Essential for the Compensatory β-Cell Hyperplastic Response to Insulin Resistance in Rodents

Georgia, S. K., Hinault, C., Kawamori, D., Hu, J., Meyer, J., Kanji, M., Bhushan, A., & Kulkarni, R. N. (2010) · Diabetes · doi:10.2337/db09-0838 · Cited by 67 · see citing works

Combination Therapy with Glucagon-Like Peptide-1 and Gastrin Induces β-Cell Neogenesis from Pancreatic Duct Cells in Human Islets Transplanted in Immunodeficient Diabetic Mice

Suarez‐Pinzon, W. L., Lakey, J. R. T., & Rabinovitch, A. (2008) · Cell Transplantation · doi:10.3727/096368908786092775 · Cited by 65 · see citing works

Risk of Glucose Intolerance and Diabetes in Hemipancreatectomized Donors Selected for Normal Preoperative Glucose Metabolism

Kumar, A. F., Gruessner, R. W. G., & Seaquist, E. R. (2008) · Diabetes Care · doi:10.2337/dc07-2453 · Cited by 62 · see citing works

Targeting pancreatic β cells for diabetes treatment

Jain, C., Ansarullah, M., Bilekova, S., & Lickert, H. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00618-5 · Cited by 65 · see citing works

Gastrointestinal hormones and the regulation of β‐cell mass

Lavine, J. A., & Attie, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05802.x · Cited by 61 · see citing works

Goals of Treatment for Type 2 Diabetes

Marchetti, P., Lupi, R., Guerra, S. D., Bugliani, M., D’Aleo, V., Occhipinti, M., Boggi, U., Marselli, L., & Masini, M. (2009) · Diabetes Care · doi:10.2337/dc09-s306 · Cited by 61 · see citing works

Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model

Omar, B. A., Vikman, J., Winzell, M. S., Voss, U., Ekblad, E., Foley, J. E., & Åhrén, B. (2013) · Diabetologia · doi:10.1007/s00125-013-2927-8 · Cited by 60 · see citing works

Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic β-cell line, MIN6

Sawada, F., Inoguchi, T., Tsubouchi, H., Sasaki, S., Fujii, M., Maeda, Y., Morinaga, H., Nomura, M., Kobayashi, K., & Takayanagi, R. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.038 · Cited by 60 · see citing works

Interventions to Preserve Beta-Cell Function in the Management and Prevention of Type 2 Diabetes

Page, K. A., & Reisman, T. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0363-2 · Cited by 60 · see citing works

Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys

Kavanagh, K., Zhang, L., & Wagner, J. D. (2008) · Cell Stress and Chaperones · doi:10.1007/s12192-008-0084-7 · Cited by 58 · see citing works

Pathways governing development of stem cell‐derived pancreatic β cells: lessons from embryogenesis

Al‐Khawaga, S., Memon, B., Butler, A. E., Taheri, S., Abou‐Samra, A., & Abdelalim, E. M. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12349 · Cited by 58 · see citing works

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

Ardestani, A. D., & Maedler, K. (2016) · Diabetologia · doi:10.1007/s00125-016-3892-9 · Cited by 57 · see citing works

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice

Hinault, C., Kawamori, D., Liew, C. W., Maier, B., Hu, J., Keller, S. R., Mirmira, R. G., Scrable, H. J., & Kulkarni, R. (2011) · Diabetes · doi:10.2337/db09-1379 · Cited by 56 · see citing works

Human Beta Cell Regenerative Drug Therapy for Diabetes: Past Achievements and Future Challenges

Wang, P., Karaköse, E., Choleva, L., Kumar, K., DeVita, R. J., Garcı́a-Ocaña, A., & Stewart, A. F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.671946 · Cited by 53 · see citing works

Effects of Obesity and Diabetes on α- and β-Cell Mass in Surgically Resected Human Pancreas

Inaishi, J., Saisho, Y., Sato, S., Kou, K., Murakami, R., Watanabe, Y., Kitago, M., Kitagawa, Y., Yamada, T., & Itoh, H. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1374 · Cited by 53 · see citing works

Protective Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor against Increased β Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes

Shirakawa, J., Amo, K., Ohminami, H., Orime, K., Togashi, Y., Ito, Y., Tajima, K., Koganei, M., Sasaki, H., Takeda, E., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217216 · Cited by 53 · see citing works

(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives

Baeyens, L., Lemper, M., Staels, W., Groef, S. D., Leu, N. D., Heremans, Y., German, M. S., & Heimberg, H. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2016 · Cited by 50 · see citing works

Insulin secretion and insulin-producing tumors

Guettier, J., & Görden, P. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.83 · Cited by 47 · see citing works

Determinants of glucose control in patients with chronic pancreatitis

Schrader, H., Menge, B., Zeidler, C., Ritter, P. R., Tannapfel, A., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1705-0 · Cited by 45 · see citing works

A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations

Sathananthan, A., Man, C. D., Zinsmeister, A. R., Camilleri, M., Rodeheffer, R. J., TOFFOLO, G. M., Cobelli, C., Rizza, R. A., & Vella, A. V. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04159.x · Cited by 43 · see citing works

Differential Development of Glucose Intolerance and Pancreatic Islet Adaptation in Multiple Diet Induced Obesity Models

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Santos, J. L., Yévenes, I., Cataldo, L. R., Morales, M., Galgani, J., Arancibia, C., Vega, J., Olmos, P., Flores, M., Valderas, J., et al. (2015) · Journal of physiology and biochemistry · doi:10.1007/s13105-015-0458-0 · Cited by 34 · see citing works

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Saisho, Y., Butler, A. E., Manesso, E., Galasso, R., Zhang, L., Gurlo, T., TOFFOLO, G. M., Cobelli, C., Kavanagh, K., Wagner, J. D., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1552-z · Cited by 33 · see citing works

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Fujita, Y., Kozawa, J., Iwahashi, H., Yoneda, S., Uno, S., Yoshikawa, A., Okita, K., Eguchi, H., Nagano, H., Imagawa, A., et al. (2015) · Endocrine Journal · doi:10.1507/endocrj.ej14-0456 · Cited by 30 · see citing works

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Zhao, Z., Low, Y., Armstrong, N., Kenty, J. H.-R., Sun, S. A., Arvanites, A. C., Hollister‐Lock, J., Shah, N. H., Weir, G. C., & Annes, J. P. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1120 · Cited by 30 · see citing works

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Augstein, P., & Salzsieder, E. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-448-3_12 · Cited by 30 · see citing works

Pharmacotherapy of Diabetes: New Developments

Mogensen, C. E. (2007) · Springer eBooks · doi:10.1007/978-0-387-69737-6 · Cited by 30 · see citing works

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Zheng, C., Zhou, W., Wang, T., You, P., Zhao, Y., Yang, Y., Wang, X., Luo, J., Chen, Y., Liu, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134051 · Cited by 29 · see citing works

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Li, Z., Zhou, Z., Huang, G., Hu, F., Xiang, Y., & He, L.-N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076172 · Cited by 29 · see citing works

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Saisho, Y. (2018) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530318666180821161825 · Cited by 27 · see citing works

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Docherty, F. M., & Sussel, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073306 · Cited by 28 · see citing works

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Vetere, A., & Wagner, B. K. (2012) · International Journal of Endocrinology · doi:10.1155/2012/925143 · Cited by 27 · see citing works

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Vinet, L., Lamprianou, S., Babič, A., Lange, N., Thorel, F., Herrera, P. L., Montet, X., & Meda, P. (2014) · Diabetologia · doi:10.1007/s00125-014-3442-2 · Cited by 27 · see citing works

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Gaetano, A. D., & Hardy, T. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222833 · Cited by 29 · see citing works

Birth and Death of Human β-Cells in Pancreases from Cadaver Donors, Autopsies, Surgical Specimens, and Islets Transplanted into Mice

Caballero, F., Siniakowicz, K., Hollister‐Lock, J., Duran, L., Katsuta, H., Yamada, T., Lei, J., Deng, S., Westermark, G. T., Markmann, J. F., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x659916 · Cited by 27 · see citing works

Therapeutic approaches based on beta-cell mass preservation and/or regeneration

Robert, A. R. (2009) · Frontiers in bioscience · doi:10.2741/3345 · Cited by 26 · see citing works

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Montanya, E. (2014) · Diabetes · doi:10.2337/db13-1843 · Cited by 25 · see citing works

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Flatt, A. J., Greenbaum, C. J., Shaw, J., & Rickels, M. R. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14572 · Cited by 25 · see citing works

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Iqbal, A., Zhou, K., Kashyap, S. R., & Lansang, M. C. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab697 · Cited by 24 · see citing works

Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells

Lee, S., Hao, E., Levine, F., & Itkin‐Ansari, P. (2011) · Islets · doi:10.4161/isl.3.6.17923 · Cited by 24 · see citing works

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization

Allegretti, P. A., Horton, T. M., Abdolazimi, Y., Moeller, H. P., Yeh, B. T., Caffet, M., Michel, G., Smith, M. A., & Annes, J. P. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.115193 · Cited by 24 · see citing works

Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes

Pang, Bao, Yu-qian, Wang, Chen, LU, L., Jun-xi, Jia, J., Weiping, Xiang, ■., et al. (2008) · 中华医学杂志：英文版

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税所, 芳., 山田, 健., 佐藤, 誠., 稲石, 淳., 村上, 理., & 北郷, 実. (2017) · Institutional Repositories DataBase (IRDB)

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