The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Implantation of bone marrow‐derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon
Open accessAbstract
Summary: Reasons for performing study: Mesenchymal stem (progenitor; stromal) cell (MSC) therapy has gained popularity for the treatment of equine tendon injuries but without reports of long‐term follow‐up. Objectives: To evaluate the safety and reinjury rate of racehorses after intralesional MSC injection in a large study of naturally occurring superficial digital flexor tendinopathy and to compare these data with those published for other treatments. Methods: Safety was assessed clinically, ultrasonographically, scintigraphically and histologically in a cohort of treated cases: 141 client‐owned treated racehorses followed‐up for a minimum of 2 years after return to full work. Reinjury percentages were compared to 2 published studies of other treatments with similar selection criteria and follow‐up. The number of race starts, discipline, age, number of MSCs injected and interval between injury and treatment were analysed. Results: There were no adverse effects of the treatment with no aberrant tissue on histological examination. The reinjury percentage of all racehorses with follow‐up (n = 113) undergoing MSC treatment was 27.4%, with the rate for flat (n = 8) and National Hunt (n = 105) racehorses being 50 and 25.7%, respectively. This was significantly less than published for National Hunt racehorses treated in other ways. No relationship between outcome and age, discipline, number of MSCs injected or injury to implantation interval was found. Conclusions: Whilst recognising the limitations of historical controls, this study has shown that MPC implantation is safe and appears to reduce the reinjury rate after superficial digital flexor tendinopathy, especially in National Hunt racehorses. Potential relevance: This study has provided evidence for the long‐term efficacy of MSC treatment for tendinopathy in racehorses and provides support for translation to human tendon injuries.
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Cites
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,485
Bi, Y., Ehirchiou, D., Kilts, T. M., Inkson, C. A., Embree, M. C., Sonoyama, W., Li, L., Leet, A. I., Seo, B.-M., Zhang, L., et al. (2007) · Nature Medicine · doi:10.1038/nm1630 · Cited by 1,486
Use of mesenchymal stem cells in a collagen matrix for achilles tendon repair
Young, R. G., Butler, D. L., Weber, W., Caplan, A. I., Gordon, S. L., & Fink, D. J. (1998) · Journal of Orthopaedic Research · doi:10.1002/jor.1100160403 · Cited by 791
Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon
Awad, H. A., Butler, D. L., Boivin, G. P., Smith, F. N. L., Malaviya, P., Huibregtse, B., & Caplan, A. I. (1999) · Tissue Engineering · doi:10.1089/ten.1999.5.267 · Cited by 543
Im, G.-I., Shin, Y.-W., & Lee, K.-B. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.05.005 · Cited by 543
Repair of patellar tendon injuries using a cell–collagen composite
Awad, H. A., Boivin, G. P., Dressler, M. R., Smith, F. N. L., Young, R. G., & Butler, D. L. (2003) · Journal of Orthopaedic Research · doi:10.1016/s0736-0266(02)00163-8 · Cited by 396
Butler, D. L., Juncosa‐Melvin, N., Boivin, G. P., Galloway, M. T., Shearn, J. T., Gooch, C., & Awad, H. (2008) · Journal of Orthopaedic Research · doi:10.1002/jor.20456 · Cited by 378
Nixon, A. J., Dahlgren, L. A., Haupt, J. L., Yeager, A. E., & Ward, D. L. (2008) · American Journal of Veterinary Research · doi:10.2460/ajvr.69.7.928 · Cited by 285
Schnabel, L. V., Lynch, M. E., van der Meulen, M. C. H., Yeager, A. E., Kornatowski, M. A., & Nixon, A. J. (2009) · Journal of Orthopaedic Research · doi:10.1002/jor.20887 · Cited by 264
DYSON, S. J. (2004) · Equine Veterinary Journal · doi:10.2746/0425164044868422 · Cited by 254
Metadata
- Authors
- GODWIN, E. E., YOUNG, N. J., DUDHIA, J., BEAMISH, I. C., & SMITH, R. K. W.
- Venue
- Equine Veterinary Journal
- Publisher
- Wiley
- Published
- 2011-05-26
- Volume
- 44
- Issue
- 1
- Pages
- 25-32
- ISSN
- 0425-1644 (ISSN-L)
- 2042-3306
- OpenAlex
- W1486827600
- Cited by
- 410
- References
- 39
- FWCI
- 40.67
- Type
- journal article
- Language
- en
- Open access
- green
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- GODWIN, E. E., YOUNG, N. J., DUDHIA, J., BEAMISH, I. C., & SMITH, R. K. W. (2012). Implantation of bone marrow‐derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon. Equine Veterinary Journal. https://doi.org/10.1111/j.2042-3306.2011.00363.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
