Cited by 116Advanced Drug Delivery SystemsOlfactory and Sensory Function StudiesInhalation and Respiratory Drug Delivery

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Intranasal delivery of insulin via the olfactory nerve pathway

Renner, Dan B, Svitak, Aleta L, Gallus, Nathan J, Ericson, Marna E, Frey, William H, Hanson, Leah R·2012·Journal of Pharmacy and Pharmacology

DOI 10.1111/j.2042-7158.2012.01555.x

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Abstract

Objectives: Intranasal delivery has been shown to target peptide therapeutics to the central nervous system (CNS) of animal models and induce specific neurological responses. In an investigation into the pathways by which intranasal administration delivers insulin to the CNS, this study has focused on the direct delivery of insulin from the olfactory mucosa to the olfactory bulbs via the olfactory nerve pathway. Methods: Nasal and olfactory tissues of mice were imaged with fluorescent and electron microscopy 30 min following intranasal administration. Key findings: Macroscopic analysis confirmed delivery to the anterior regions of the olfactory bulbs. Confocal microscopy captured delivery along the olfactory nerve bundles exiting the nasal mucosa, traversing the cribriform plate and entering the bulbs. With electron microscopy, insulin was found within cells of the olfactory nerve layer and glomerular layer of the olfactory bulbs. Conclusions: These results demonstrated that intranasal administration of labelled insulin targeted the CNS through the olfactory nerve pathway in mice.

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“Many studies demonstrated that induction of insulin through the intracerebroventricular route improves spatial memory function by acting directly at the hippocampal site [120].”
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Self-citation
Intranasal Insulin for the Treatment of Persistent Post‐COVID‐19 Olfactory Dysfunction
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Experimental Approach to Alzheimer’s Disease with Emphasis on Insulin Resistance in the Brain
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Applications of Polymeric Nanoparticle in Nose to Brain Drug Delivery
Sunena, S., Kumar, S., Sulekha, S., Tomar, D., Kumar, D., & Kishore, V. (2023) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2023.00988 · Cited by 6
Von der Nase ins Gehirn
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Low-Intensity Ultrasound Facilitation of Intranasal Drug Delivery to Olfactory Bulb and Trigeminal Nerves
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Potential Application of Intranasal Insulin Delivery for Treatment of Intracerebral Hemorrhage: A Review of The Literature
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Outcome and Safety of Insulin in the Management of Smell Loss: A Systematic Review
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“6,8 In this review, 2 studies have tested the intranasal insulin effect on patients suffering from anosmia.”
Diagnostic and theranostic intranasal nanointerventions for brain diseases
Upadhaya, P. G., Pulakkat, S., & Patravale, V. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00013-8 · Cited by 4
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Intranasal vs. Device-Assisted Drug Delivery: Advantages and Limitations for the Delivery of Biopharmaceuticals to the CNS
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Nose
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Focused Ultrasound Enhanced Intranasal Delivery of Neurotrophic Factors Exhibit Neurorestorative Effects in Parkinson's Disease Mouse Model
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Maternal Insulin Sensitivity and Fetal Brain Activity
Schleger, F., Linder, K., Fritsche, A., & Preissl, H. T. (2017) · Springer eBooks · doi:10.1007/978-3-319-60289-9_6 · Cited by 2

Authors: Renner, D. B., Svitak, A. L., Gallus, N. J., Ericson, M. E., Frey, W. H., & Hanson, L. R.
Affiliations: Regions Hospital (US)
Corresponding author: Renner, Dan B
ORCID: Ericson, Marna E
Frey, William H
Hanson, Leah R
Venue: Journal of Pharmacy and Pharmacology
Publisher: Oxford University Press (OUP)
Published: 2012-12-01
Volume: 64
Issue: 12
Pages: 1709-1714
ISSN: 0022-3573 (ISSN-L)
2042-7158
DOI: 10.1111/j.2042-7158.2012.01555.x
OpenAlex: W1612293997
Cited by: 116
References: 24
Citations by year: 2026: 5 · 2025: 6 · 2024: 11 · 2023: 14 · 2022: 7 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 1
FWCI: 4.55
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Pharmacy and Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: olfactory bulb, olfactory epithelium, central nervous system targeting, peptide therapeutics, cribriform plate, glomerular layer, intranasal drug delivery
MeSH terms: Administration, Intranasal, Animals, Central Nervous System, Ethmoid Bone, Insulin, Male, Mice, Inbred C57BL, Microscopy, Nasal Mucosa, Olfactory Bulb, Olfactory Nerve, Olfactory Pathways, Mice

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Intranasal delivery of insulin via the olfactory nerve pathway

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