Impaired insulin action in the human brain: causes and metabolic consequences

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works

Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities

Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works

Impact of Informing Overweight Individuals about the Role of Genetics in Obesity: An Online Experimental Study

Lippa, N. C., & Sanderson, S. C. (2013) · Human Heredity · doi:10.1159/000353712 · Cited by 6,093 · see citing works

Use and Abuse of HOMA Modeling

Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114 · see citing works

A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531 · see citing works

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760 · see citing works

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728 · see citing works

Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina, C., Meyre, D., Gallina, S., Durand, E., Körner, A., Jacobson, P., Carlsson, L. M. S., Kieß, W., Vatin, V., Lecœur, C., et al. (2007) · Nature Genetics · doi:10.1038/ng2048 · Cited by 1,620 · see citing works

Sniffing neuropeptides: A transnasal approach to the human brain

Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works

Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: A study of discordant sibships

Dabelea, D., Hanson, R. L., Lindsay, R. S., Pettitt, D. J., Imperatore, G., Gabir, M. M., Roumain, J., Bennett, P. H., & Knowler, W. C. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2208 · Cited by 1,277 · see citing works

A frameshift mutation in MC4R associated with dominantly inherited human obesity

Yeo, G. S. H., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G., & O'Rahilly, S. (1998) · Nature Genetics · doi:10.1038/2404 · Cited by 1,159 · see citing works

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116 · see citing works

A frameshift mutation in human MC4R is associated with a dominant form of obesity

Vaisse, C., Clément, K., Guy-grand, B., & Froguel, P. (1998) · Nature Genetics · doi:10.1038/2407 · Cited by 1,091 · see citing works

Hypothalamic insulin signaling is required for inhibition of glucose production

Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904 · see citing works

The many faces of insulin-like peptide signalling in the brain

Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872 · see citing works

Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748 · see citing works

Endocannabinoid control of food intake and energy balance

Marzo, V. D., & Matias, I. (2005) · Nature Neuroscience · doi:10.1038/nn1457 · Cited by 746 · see citing works

Intranasal insulin improves memory in humans

Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H. L., Born, J., & Kern, W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.04.003 · Cited by 699 · see citing works

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.004 · Cited by 695 · see citing works

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Kleinridders, A., Ferris, H. A., Cai, W., & Kahn, C. R. (2014) · Diabetes · doi:10.2337/db14-0568 · Cited by 688 · see citing works

Leptin Regulates Striatal Regions and Human Eating Behavior

Farooqi, I. S., Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S., & Fletcher, P. C. (2007) · Science · doi:10.1126/science.1144599 · Cited by 622 · see citing works

Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype

Reger, M. A., Watson, G. S., Frey, W. H., Baker, L. D., Cholerton, B., Keeling, M. L., Belongia, D., Fishel, M. A., Plymate, S. R., Schellenberg, G. D., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.016 · Cited by 621 · see citing works

Identification of insulin in rat brain.

Havránková, J., Schmechel, D. E., Roth, J., & Brownstein, M. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.11.5737 · Cited by 607 · see citing works

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype

Craft, S., Peskind, E., Schwartz, M. W., Schellenberg, G. D., Raskind, M., & Porte, D. (1998) · Neurology · doi:10.1212/wnl.50.1.164 · Cited by 560 · see citing works

The source of cerebral insulin

Banks, W. A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.040 · Cited by 489 · see citing works

Memory formation and long-term retention in humans and animals: Convergence towards a transformation account of hippocampal–neocortical interactions

Winocur, G., Moscovitch, M., & Bontempi, B. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.04.016 · Cited by 486 · see citing works

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Freiherr, J., Hallschmid, M., Frey, W. H., Brünner, Y. F., Chapman, C. D., Hölscher, C., Craft, S., Felice, F. G. D., & Benedict, C. (2013) · CNS Drugs · doi:10.1007/s40263-013-0076-8 · Cited by 470 · see citing works

Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia

Claxton, A., Baker, L. D., Hanson, A., Trittschuh, E. H., Cholerton, B., Morgan, A., Callaghan, M., Arbuckle, M., Behl, C., & Craft, S. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-141791 · Cited by 467 · see citing works

Brain metabolic dysfunction at the core of Alzheimer's disease

de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 462 · see citing works

SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

Ferrannini, E., & Solini, A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.243 · Cited by 459 · see citing works

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

Williams, K. W., & Elmquist, J. K. (2012) · Nature Neuroscience · doi:10.1038/nn.3217 · Cited by 421 · see citing works

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

Hill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413 · see citing works

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

Łabuzek, K., Suchy, D., Gabryel, B., Bielecka, A., Liber, S., & Okopień, B. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70357-1 · Cited by 404 · see citing works

Human Blood—Brain Barrier Insulin Receptor

Pardridge, W. M., Eisenberg, J., & Yang, J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07167.x · Cited by 399 · see citing works

A brain-liver circuit regulates glucose homeostasis

Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392 · see citing works

Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways

Page, K. A., Chan, O., Arora, J., Belfort-DeAguiar, R., Dzuira, J., Roehmholdt, B., Cline, G. W., Naik, S., Sinha, R., Constable, R. T., et al. (2013) · JAMA · doi:10.1001/jama.2012.116975 · Cited by 379 · see citing works

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

Vogt, M. C., Paeger, L., Heß, S., Steculorum, S. M., Awazawa, M., Hampel, B., Neupert, S., Nicholls, H. T., Mauer, J., Hausen, A. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.008 · Cited by 358 · see citing works

Insulin Regulation of Lipolysis in Nondiabetic and IDDM Subjects

Jensen, M. D., Caruso, M., Heiling, V. J., & Miles, J. M. (1989) · Diabetes · doi:10.2337/diab.38.12.1595 · Cited by 331 · see citing works

Toll-like receptors: linking inflammation to metabolism

Könner, A. C., & Brüning, J. C. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 327 · see citing works

Insulin and the Blood-Brain Barrier

Woods, S. C., Seeley, R. J., Baskin, D. G., & Schwartz, M. W. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033455323 · Cited by 321 · see citing works

Cooperation between brain and islet in glucose homeostasis and diabetes

Schwartz, M. W., Seeley, R. J., Tschöp, M. H., Woods, S. C., Morton, G. J., Myers, M. G., & D’Alessio, D. A. (2013) · Nature · doi:10.1038/nature12709 · Cited by 315 · see citing works

Improving influence of insulin on cognitive functions in humans

Kern, W., Peters, A., Fruehwald-Schultes, B., Deininger, E., Born, J., & Fehm, H. L. (2001) · Neuroendocrinology · doi:10.1159/000054694 · Cited by 308 · see citing works

Selective Insulin and Leptin Resistance in Metabolic Disorders

Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 304 · see citing works

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301193 · Cited by 302 · see citing works

Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin

Benedict, C., Kern, W., Schultes, B., Born, J., & Hallschmid, M. (2008) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2007-2606 · Cited by 296 · see citing works

The Role of Insulin in Human Brain Glucose Metabolism

Bingham, E., Hopkins, D., Smith, D., Pernet, A., Hallett, W. A., Reed, L. J., Marsden, P. K., & Amiel, S. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3384 · Cited by 293 · see citing works

Effect of a diabetic environment in utero on predisposition to type 2 diabetes

Sobngwi, E., Boudou, P., Mauvais‐Jarvis, F., Leblanc, H., Velho, G., Vexiau, P., Porcher, R., Hadjadj, S., Pratley, R. E., Tataranni, P. A., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13505-2 · Cited by 285 · see citing works

Intranasal Insulin Reduces Body Fat in Men but not in Women

Hallschmid, M., Benedict, C., Schultes, B., Fehm, H.-L., Born, J., & Kern, W. (2004) · Diabetes · doi:10.2337/diabetes.53.11.3024 · Cited by 281 · see citing works

Altered hypothalamic function in response to glucose ingestion in obese humans.

Matsuda, M., Liu, Y., Mahankali, S., Pu, Y., Mahankali, A., Wang, J., DeFronzo, R., Fox, P. T., & Gao, J.-H. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1801 · Cited by 276 · see citing works

The obese brain: Association of body mass index and insulin sensitivity with resting state network functional connectivity

Kullmann, S., Heni, M., Veit, R., Ketterer, C., Schick, F., Häring, H., Fritsche, A., & Preissl, H. T. (2011) · Human Brain Mapping · doi:10.1002/hbm.21268 · Cited by 273 · see citing works

Central insulin action regulates peripheral glucose and fat metabolism in mice

Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 270 · see citing works

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

Scherer, T., O’Hare, J., Diggs‐Andrews, K. A., Schweiger, M., Cheng, B., Lindtner, C., Zieliński, E., Vempati, P., Su, K., Dighe, S. V., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.008 · Cited by 262 · see citing works

Cerebrospinal Fluid Insulin Levels Increase During Intravenous Insulin Infusions in Man*

Wallum, B. J., Taborsky, G. J., Porte, D., Figlewicz, D. P., Jacobson, L., Beard, J. C., Ward, W. K., & Dorsa, D. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-190 · Cited by 254 · see citing works

Receptors for Insulin-like Growth Factors I and II: Autoradiographic Localization in Rat Brain and Comparison to Receptors for Insulin*

Lesniak, M. A., Hill, J. M., Kieß, W., Rojeski, M., Pert, C. B., & Roth, J. (1988) · Endocrinology · doi:10.1210/endo-123-4-2089 · Cited by 252 · see citing works

Relationship of Serum Adiponectin and Leptin Concentrations with Body Fat Distribution in Humans

Staiger, H., Tschritter, O., Machann, J., Thamer, C., Fritsche, A., Maerker, E., Schick, F., Häring, H., & Stümvoll, M. (2003) · Obesity Research · doi:10.1038/oby.2003.48 · Cited by 250 · see citing works

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

Yarchoan, M. M., & Arnold, S. E. (2014) · Diabetes · doi:10.2337/db14-0287 · Cited by 228 · see citing works

The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study

Tschritter, O., Preissl, H., Hennige, A. M., Stumvoll, M., Porubska, K., Frost, R., Marx, H., Klösel, B., Lutzenberger, W., Birbaumer, N., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604404103 · Cited by 223 · see citing works

Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

Novak, V., Milberg, W., Hao, Y., Munshi, M. N., Novák, P., Galica, A. M., Manor, B., Roberson, P. K., Craft, S., & Abduljalil, A. (2013) · Diabetes Care · doi:10.2337/dc13-1672 · Cited by 207 · see citing works

Insulin Regulates Brain Function, but How Does It Get There?

Gray, S. M., Meijer, R. I., & Barrett, E. J. (2014) · Diabetes · doi:10.2337/db14-0340 · Cited by 206 · see citing works

Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity

Jastreboff, A. M., Sinha, R., Lacadie, C., Small, D. M., Sherwin, R. S., & Potenza, M. N. (2013) · Diabetes Care · doi:10.2337/dc12-1112 · Cited by 204 · see citing works

Untitled work

Anthony (2006) · doi:10.2337/db06-0376 · Cited by 195 · see citing works

Associations between Postprandial Insulin and Blood Glucose Responses, Appetite Sensations and Energy Intake in Normal Weight and Overweight Individuals: A Meta-Analysis of Test Meal Studies

Flint, A., Gregersen, N. T., Gluud, L. L., Møller, B. K., Raben, A., Tetens, I., Verdich, C., & Astrup, A. (2007) · British Journal of Nutrition · doi:10.1017/s000711450768297x · Cited by 192 · see citing works

Central nervous system effects of intranasally administered insulin during euglycemia in men.

Kern, W., Jan Born, A., Schreiber, H., & Fehm, H. (1999) · Diabetes · doi:10.2337/diabetes.48.3.557 · Cited by 192 · see citing works

CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age

Vogt, M. C., & Brüning, J. C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.004 · Cited by 188 · see citing works

The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans

Seaquist, E. R., Damberg, G., Tkáč, I., & Rolf Gruetter, A. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2203 · Cited by 185 · see citing works

Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women

Hallschmid, M., Higgs, S., Thienel, M., Ott, V., & Lehnert, H. (2012) · Diabetes · doi:10.2337/db11-1390 · Cited by 181 · see citing works

Variation in the FTO Gene Influences Food Intake but not Energy Expenditure

Haupt, A., Thamer, C., Staiger, H., Tschritter, O., Kirchhoff, K., Machicao, F. E., Häring, H.-U., Stefan, N., & Fritsche, A. (2008) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0028-1087176 · Cited by 176 · see citing works

Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes

Zhang, H., Hao, Y., Manor, B., Novak, P., Milberg, W., Zhang, J., Fang, J., & Novak, V. (2015) · Diabetes · doi:10.2337/db14-1000 · Cited by 176 · see citing works

Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults

Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H.-U., Fritsche, A., & Preissl, H. (2015) · Diabetes Care · doi:10.2337/dc14-2319 · Cited by 175 · see citing works

Leçons de physiologie expérimentale appliquée à la médecine, faites au Collège de France,

Bernard, C. (1855) · doi:10.5962/bhl.title.1818 · Cited by 174 · see citing works

A (3H)2-Deoxyglucose Method for Comparing Rates of Glucose Metabolism and Insulin Responses Among Rat Tissues In Vivo: Validation of the Model and the Absence of an Insulin Effect on Brain

Hom, F., Goodner, C. J., & Berrie, M. A. (1984) · Diabetes · doi:10.2337/diab.33.2.141 · Cited by 170 · see citing works

Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men

Heni, M., Wagner, R., Kullmann, S., Veit, R., Mat Husin, H., Linder, K., Benkendorff, C., Peter, A., Stefan, N., Häring, H.-U., et al. (2014) · Diabetes · doi:10.2337/db14-0477 · Cited by 167 · see citing works

Obese men respond to cognitive but not to catabolic brain insulin signaling

Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803722 · Cited by 165 · see citing works

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

Jauch‐Chara, K., Friedrich, A., Rezmer, M., Melchert, U. H., Scholand-Engler, H. G., Hallschmid, M., & Oltmanns, K. M. (2012) · Diabetes · doi:10.2337/db12-0025 · Cited by 164 · see citing works

Functional MRI of human hypothalamic responses following glucose ingestion

Smeets, P. A. M., de Graaf, C., Stafleu, A., van Osch, M. J. P., & van der Grond, J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.073 · Cited by 160 · see citing works

Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans

Heni, M., Schöpfer, P., Peter, A., Sartorius, T., Fritsche, A., Synofzik, M., Häring, H.-U., Maetzler, W., & Hennige, A. M. (2014) · Acta Diabetologica · doi:10.1007/s00592-013-0546-y · Cited by 158 · see citing works

Insulin and Alzheimer's Disease: Untangling the Web

Craft, S., Cholerton, B., & Baker, L. D. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129042 · Cited by 157 · see citing works

Insulin Modulates Food-Related Activity in the Central Nervous System

Guthoff, M., Grichisch, Y., Canova, C., Tschritter, O., Veit, R., Hallschmid, M., Häring, H., Preissl, H. T., Hennige, A. M., & Fritsche, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1677 · Cited by 157 · see citing works

Low cerebrospinal fluid insulin levels in obese humans

Kern, W., Benedict, C., Schultes, B., Plohr, F., Moser, A., Jan Born, A., Fehm, H. L., & Hallschmid, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0409-y · Cited by 143 · see citing works

Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

Ott, V., Benedict, C., Schultes, B., Born, J., & Hallschmid, M. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01490.x · Cited by 139 · see citing works

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

Benedict, C., Brede, S., Schiöth, H. B., Lehnert, H., Schultes, B., Born, J., & Hallschmid, M. (2011) · Diabetes · doi:10.2337/db10-0329 · Cited by 129 · see citing works

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

Hirvonen, J., Virtanen, K. A., Nummenmaa, L., Hannukainen, J. C., Honka, M., Bucci, M., Nesterov, S. V., Parkkola, R. K., Rinne, J. O., Iozzo, P., et al. (2011) · Diabetes · doi:10.2337/db10-0940 · Cited by 128 · see citing works

Intranasal delivery of insulin via the olfactory nerve pathway

Renner, D. B., Svitak, A. L., Gallus, N. J., Ericson, M. E., Frey, W. H., & Hanson, L. R. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01555.x · Cited by 116 · see citing works

Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans

Tschritter, O., Preissl, H. T., Yokoyama, Y., Machicao, F. E., Häring, H., & Fritsche, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0839-1 · Cited by 114 · see citing works

Insulin resistance and AD—extending the translational path

Craft, S. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.112 · Cited by 113 · see citing works

(Still) longing for food: Insulin reactivity modulates response to food pictures

Kroemer, N. B., Krebs, L., Kobiella, A., Grimm, O., Vollstädt‐Klein, S., Wolfensteller, U., Kling, R., Bidlingmaier, M., Zimmermann, U. S., & Smolka, M. N. (2012) · Human Brain Mapping · doi:10.1002/hbm.22071 · Cited by 112 · see citing works

Intranasal Insulin Modulates Intrinsic Reward and Prefrontal Circuitry of the Human Brain in Lean Women

Kullmann, S., Frank, S., Heni, M., Ketterer, C., Veit, R., Häring, H.-U., Fritsche, A., & Preissl, H. (2013) · Neuroendocrinology · doi:10.1159/000341406 · Cited by 110 · see citing works

Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

Heni, M., Kullmann, S., Ketterer, C., Guthoff, M., Linder, K., Wagner, R. J., Stingl, K. T., Veit, R., Staiger, H., Häring, H., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2528-y · Cited by 109 · see citing works

Hypothalamic alterations in fetuses of high fat diet-fed obese female rats

Gupta, A., Srinivasan, M., Thamadilok, S., & Patel, M. S. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0429 · Cited by 109 · see citing works

Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta‐analysis

Pontiroli, A. E., Miele, L., & Morabito, A. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01433.x · Cited by 108 · see citing works

Intranasal Insulin Suppresses Endogenous Glucose Production in Humans Compared With Placebo in the Presence of Similar Venous Insulin Concentrations

Dash, S., Xiao, C., Morgantini, C., Koulajian, K., & Lewis, G. F. (2015) · Diabetes · doi:10.2337/db14-0685 · Cited by 108 · see citing works

Activation of KATP channels suppresses glucose production in humans

Kishore, P., Boucai, L., Zhang, K., Li, W., Koppaka, S., Kehlenbrink, S., Schiwek, A., Esterson, Y. B., Mehta, D., Bursheh, S. S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58035 · Cited by 107 · see citing works

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

Filippi, B., Yang, C. S., Tang, C., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.005 · Cited by 105 · see citing works

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

Sartorius, T., Peter, A., Heni, M., Maetzler, W., Fritsche, A., Häring, H., & Hennige, A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126804 · Cited by 103 · see citing works

Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus

Fekete, C., Singru, P. S., Sanchez, E., Sarkar, S., Christoffolete, M. A., Riberio, R. S., Rand, W. M., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2006) · Endocrinology · doi:10.1210/en.2005-0956 · Cited by 97 · see citing works

Tissue selectivity of insulin detemir action in vivo

Hennige, A. M., Sartorius, T., Tschritter, O., Preissl, H. T., Fritsche, A., Ruth, P., & Häring, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0192-9 · Cited by 93 · see citing works

Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?

Hallschmid, M., & Schultes, B. (2009) · Diabetologia · doi:10.1007/s00125-009-1501-x · Cited by 90 · see citing works

Intranasal insulin attenuates the hypothalamic–pituitary–adrenal axis response to psychosocial stress

Bohringer, A., Schwabe, L., Richter, S., & Schachinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.002 · Cited by 89 · see citing works

Insulin and Hippocampus Activation in Response to Images of High‐Calorie Food in Normal Weight and Obese Adolescents

Wallner-Liebmann, S., Koschutnig, K., Reishofer, G., Sorantin, E., Blaschitz, B., Kruschitz, R., Unterrainer, H., Gasser, R., Freytag, F., Bauer-Denk, C., et al. (2010) · Obesity · doi:10.1038/oby.2010.26 · Cited by 87 · see citing works

Insulin Action in the Human Brain: Evidence from Neuroimaging Studies

Kullmann, S., Heni, M., Fritsche, A., & Preissl, H. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12254 · Cited by 83 · see citing works

Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans

Gancheva, S., Koliaki, C., Bierwagen, A., Nowotny, P., Heni, M., Fritsche, A., Häring, H.-U., Szendroedi, J., & Roden, M. (2015) · Diabetes · doi:10.2337/db14-0892 · Cited by 81 · see citing works

Glucose Ingestion Fails to Inhibit Hypothalamic Neuronal Activity in Patients With Type 2 Diabetes

Vidarsdóttir, S., Smeets, P. A. M., Eichelsheim, D. L., van Osch, M. J. P., Viergever, M. A., Romijn, J. A., van der Grond, J., & Pijl, H. (2007) · Diabetes · doi:10.2337/db07-0193 · Cited by 79 · see citing works

Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults

Heni, M., Kullmann, S., Ketterer, C., Guthoff, M., Bayer, M., Staiger, H., Machicao, F. E., Häring, H., Preissl, H. T., Veit, R., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22223 · Cited by 77 · see citing works

Role of Non-Neuronal Cells in Body Weight and Appetite Control

Argente-Arizón, P., Freire‐Regatillo, A., Argente, J., & Chowen, J. A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00042 · Cited by 68 · see citing works

High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention

Tschritter, O., Preissl, H. T., Hennige, A. M., Sartorius, T., Štingl, K., Heni, M., Ketterer, C., Stefan, N., Machann, J., Schleicher, E., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2309-z · Cited by 63 · see citing works

Leptin Therapy in a Congenital Leptin-Deficient Patient Leads to Acute and Long-Term Changes in Homeostatic, Reward, and Food-Related Brain Areas

Frank, S., Heni, M., Moß, A., von Schnurbein, J., Fritsche, A., Häring, H., Farooqi, I. S., Preissl, H. T., & Wabitsch, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2713 · Cited by 62 · see citing works

Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese

Tuulari, J. J., Karlsson, H. K., Hirvonen, J., Hannukainen, J. C., Bucci, M., Helmiö, M., Ovaska, J. T., Soinio, M., Salminen, P. T. P., Savisto, N., et al. (2013) · Diabetes · doi:10.2337/db12-1460 · Cited by 62 · see citing works

Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects

Hallschmid, M., Jauch-Chara, K., Korn, O., Mölle, M., Rasch, B., Born, J., Schultes, B., & Kern, W. (2010) · Diabetes · doi:10.2337/db09-1493 · Cited by 61 · see citing works

Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism

Scherer, T., & Buettner, C. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9190-4 · Cited by 60 · see citing works

The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects

Guthoff, M., Stingl, K. T., Tschritter, O., Vidaković, M. R., Heni, M., Štingl, K., Hallschmid, M., Häring, H., Fritsche, A., Preissl, H. T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019482 · Cited by 59 · see citing works

Intranasal Insulin Suppresses Systemic but Not Subcutaneous Lipolysis in Healthy Humans

Iwen, K. A., Scherer, T., Heni, M., Sayk, F., Wellnitz, T., Machleidt, F., Preissl, H., Häring, H.-U., Fritsche, A., Lehnert, H., et al. (2014) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2013-3169 · Cited by 59 · see citing works

Intranasal Insulin Reduces Olfactory Sensitivity in Normosmic Humans

Brünner, Y. F., Benedict, C., & Freiherr, J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2061 · Cited by 59 · see citing works

Evidence against a Physiologic Role for Acute Changes in CNS Insulin Action in the Rapid Regulation of Hepatic Glucose Production

Ramnanan, C. J., Edgerton, D. S., & Cherrington, A. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.006 · Cited by 56 · see citing works

Central insulin signaling modulates hypothalamus–pituitary–adrenal axis responsiveness

Chong, A. C. N., Vogt, M. C., Hill, A. S., Brüning, J. C., & Zeltser, L. M. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.12.001 · Cited by 55 · see citing works

Effect of the Pattern of Elevated Free Fatty Acids on Insulin Sensitivity and Insulin Secretion in Healthy Humans

Stefan, N., Wahl, H. G., Fritsche, A., Häring, H.-U., & Stümvoll, M. (2001) · Hormone and Metabolic Research · doi:10.1055/s-2001-16231 · Cited by 55 · see citing works

Cerebrocortical Beta Activity in Overweight Humans Responds to Insulin Detemir

Tschritter, O., Hennige, A. M., Preissl, H. T., Porubská, K., Schäfer, S., Lutzenberger, W., Machicao, F. E., Birbaumer, N., Fritsche, A., & Häring, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001196 · Cited by 53 · see citing works

Insulin sensitivity of the human brain

Ketterer, C., Tschritter, O., Preissl, H. T., Heni, M., Häring, H., & Fritsche, A. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(11)70013-4 · Cited by 52 · see citing works

Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects

Ketterer, C., Heni, M., Thamer, C., Herzberg-Schäfer, S. A., Häring, H., & Fritsche, A. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.251 · Cited by 51 · see citing works

Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity

Linder, K., Schleger, F., Ketterer, C., Fritsche, L., Kiefer‐Schmidt, I., Hennige, A. M., Häring, H., Preissl, H. T., & Fritsche, A. (2014) · Diabetologia · doi:10.1007/s00125-014-3217-9 · Cited by 51 · see citing works

Transcortical Direct Current Potential Shift Reflects Immediate Signaling of Systemic Insulin to the Human Brain

Hallschmid, M., Schultes, B., Marshall, L., Mölle, M., Kern, W., Bredthauer, J., Fehm, H. L., & Jan Born, A. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2202 · Cited by 50 · see citing works

Reversal of Diet-Induced Obesity Increases Insulin Transport into Cerebrospinal Fluid and Restores Sensitivity to the Anorexic Action of Central Insulin in Male Rats

Begg, D. P., Mul, J. D., Liu, M., Reedy, B. M., D’Alessio, D. A., Seeley, R. J., & Woods, S. C. (2013) · Endocrinology · doi:10.1210/en.2012-1929 · Cited by 49 · see citing works

Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids

Krogmann, A., Staiger, K., Haas, C., Gommer, N., Peter, A., Heni, M., Machicao, F. E., Häring, H., & Staiger, H. (2010) · Microvascular Research · doi:10.1016/j.mvr.2010.11.008 · Cited by 48 · see citing works

Insulin Affects the Neuronal Response in the Medial Temporal Lobe in Humans

Rotte, M., Baerecke, C., Pottag, G., Klose, S., Kanneberg, E., Heinze, H., & Lehnert, H. (2005) · Neuroendocrinology · doi:10.1159/000084874 · Cited by 48 · see citing works

Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex

Heni, M., Kullmann, S., Veit, R., Ketterer, C., Frank, S., Machicao, F. E., Staiger, H., Häring, H., Preissl, H. T., & Fritsche, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.11.009 · Cited by 47 · see citing works

A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review

Frier, B. M., Russell-Jones, D. L., & Heise, T. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12106 · Cited by 46 · see citing works

Anorexigenic Effects of GLP-1 and Its Analogues

Gallwitz, B. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-24716-3_8 · Cited by 45 · see citing works

Mapping glucose-mediated gut-to-brain signalling pathways in humans

Little, T. J., McKie, S., Jones, R. B., D’Amato, M., Smith, C. P., Kiss, O., Thompson, D. G., & McLaughlin, J. T. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.03.059 · Cited by 45 · see citing works

Insulin's effect on the liver: "Direct or indirect?" continues to be the question

Girard, J. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27743 · Cited by 45 · see citing works

The Insulin Effect on Cerebrocortical Theta Activity Is Associated with Serum Concentrations of Saturated Nonesterified Fatty Acids

Tschritter, O., Preissl, H., Hennige, A. M., Sartorius, T., Grichisch, Y., Stefan, N., Guthoff, M., Düsing, S., Machann, J., Schleicher, E., et al. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2009-0469 · Cited by 42 · see citing works

Estimating insulin sensitivity and beta cell function: perspectives from the modern pandemics of obesity and type 2 diabetes

Nolan, J. J., & Færch, K. (2012) · Diabetologia · doi:10.1007/s00125-012-2684-0 · Cited by 42 · see citing works

Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity

Hennige, A. M., Sartorius, T., Lutz, S. Z., Tschritter, O., Preissl, H., Hopp, S., Fritsche, A., Rammensee, H.-G., Ruth, P., & Häring, H.-U. (2009) · Diabetologia · doi:10.1007/s00125-009-1522-5 · Cited by 41 · see citing works

Insulin Modulation of Magnetoencephalographic Resting State Dynamics in Lean and Obese Subjects

Stingl, K. T., Kullmann, S., Guthoff, M., Heni, M., Fritsche, A., & Preissl, H. T. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00157 · Cited by 41 · see citing works

Toll‐like receptors 2 and 4 impair insulin‐mediated brain activity by interleukin‐6 and osteopontin and alter sleep architecture

Sartorius, T., Lutz, S. Z., Hoene, M., Waak, J., Peter, A., Weigert, C., Rammensee, H., Kahle, P. J., Häring, H., & Hennige, A. M. (2012) · The FASEB Journal · doi:10.1096/fj.11-191023 · Cited by 39 · see citing works

Gut-brain mechanisms controlling glucose homeostasis

Scarlett, J. M., & Schwartz, M. W. (2015) · F1000Prime Reports · doi:10.12703/p7-12 · Cited by 38 · see citing works

Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings

Benedict, C., Dodt, C., Hallschmid, M., Lepiorz, M., Fehm, H. L., Jan Born, A., & Kern, W. (2005) · Metabolism · doi:10.1016/j.metabol.2005.04.026 · Cited by 38 · see citing works

Long-Term Stabilization Effects of Leptin on Brain Functions in a Leptin-Deficient Patient

Frank, S., Heni, M., Moß, A., von Schnurbein, J., Farooqi, I. S., Häring, H., Fritsche, A., Preissl, H. T., & Wabitsch, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065893 · Cited by 37 · see citing works

Central Nervous Insulin Administration Does Not Potentiate the Acute Glucoregulatory Impact of Concurrent Mild Hyperinsulinemia

Ott, V., Lehnert, H., Staub, J., Wönne, K., Jan Born, A., & Hallschmid, M. (2014) · Diabetes · doi:10.2337/db14-0931 · Cited by 35 · see citing works

Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease

Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35 · see citing works

Unconditioned and conditioned effects of intranasally administered insulin vs placebo in healthy men: a randomised controlled trial

Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2011) · Diabetologia · doi:10.1007/s00125-011-2111-y · Cited by 33 · see citing works

An Obesity Risk SNP (rs17782313) near theMC4RGene Is Associated with Cerebrocortical Insulin Resistance in Humans

Tschritter, O., Haupt, A., Preissl, H. T., Ketterer, C., Hennige, A. M., Sartorius, T., Machicao, F. E., Fritsche, A., & Häring, H. (2011) · Journal of Obesity · doi:10.1155/2011/283153 · Cited by 33 · see citing works

Short-Term Caloric Restriction Normalizes Hypothalamic Neuronal Responsiveness to Glucose Ingestion in Patients With Type 2 Diabetes

Teeuwisse, W. M., Widya, R. L., Paulides, M., Lamb, H. J., Smit, J. W. A., Roos, A., van Buchem, M. A., Pijl, H., & van der Grond, J. (2012) · Diabetes · doi:10.2337/db11-1835 · Cited by 33 · see citing works

Polymorphism rs3123554 in CNR2 reveals gender‐specific effects on body weight and affects loss of body weight and cerebral insulin action

Ketterer, C., Heni, M., Stingl, K. T., Tschritter, O., Linder, K., Wagner, R. J., Machicao, F. E., Häring, H., Preissl, H. T., Staiger, H., et al. (2013) · Obesity · doi:10.1002/oby.20573 · Cited by 31 · see citing works

Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin

Begg, D. P., May-Zhang, A. A., Mul, J. D., Liu, M., D’Alessio, D. A., Seeley, R. J., & Woods, S. C. (2015) · Diabetes · doi:10.2337/db14-1364 · Cited by 31 · see citing works

Effect of Insulin on the Brain Activity Obtained during Visual and Memory Tasks in Healthy Human Subjects

Benedict, L. E., Nelson, C. A., Schunk, E., Sullwold, K., & Seaquist, E. R. (2006) · Neuroendocrinology · doi:10.1159/000093338 · Cited by 29 · see citing works

Cerebrospinal fluid insulin during non-neurological surgery

Bromander, S., Anckarsäter, R., Åhrén, B., Kristiansson, M., Blennow, K., Holmäng, A. B., Zetterberg, H., Anckarsäter, H. S., & Wass, C. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0456-x · Cited by 29 · see citing works

Insulin Reduces the BOLD Response but is without Effect on the VEP during Presentation of a Visual Task in Humans

Seaquist, E. R., Chen, W., Benedict, L. E., Uǧurbil, K., Kwag, J.-H., Zhu, X., & Nelson, C. A. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600316 · Cited by 28 · see citing works

Insulin effects on beta and theta activity in the human brain are differentially affected by ageing

Tschritter, O., Hennige, A. M., Preissl, H. T., Grichisch, Y., Kirchhoff, K., Kantartzis, K., Machicao, F. E., Fritsche, A., & Häring, H. (2008) · Diabetologia · doi:10.1007/s00125-008-1187-5 · Cited by 27 · see citing works

Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice

Coomans, C. P., Biermasz, N. R., Geerling, J. J., Guigas, B., Rensen, P. C. N., Havekes, L. M., & Romijn, J. A. (2011) · Diabetes · doi:10.2337/db10-1100 · Cited by 26 · see citing works

Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice

Coomans, C. P., Geerling, J. J., Guigas, B., van den Hoek, A. M., Parlevliet, E. T., Ouwens, D. M., Pijl, H., Voshol, P. J., Rensen, P. C. N., Havekes, L. M., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m015396 · Cited by 23 · see citing works

Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity

Sartorius, T., Heni, M., Tschritter, O., Preissl, H. T., Hopp, S., Fritsche, A., Lievertz, P.-S., Gertler, A., Berthou, F., Taouis, M., et al. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000339060 · Cited by 21 · see citing works

Risk of postprandial insulin resistance: The liver/vagus rapport

Macedo, M. P., Sousa‐Lima, I., Gaspar, J. M., Afonso, R. A., Patarrão, R. S., Kim, Y., & Ribeiro, R. T. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9281-5 · Cited by 20 · see citing works

Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?

Edgerton, D. S., & Cherrington, A. D. (2015) · Diabetes · doi:10.2337/db14-1666 · Cited by 17 · see citing works

Response to Comment on Heni et al. Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men. Diabetes 2014;63:4083–4088

Heni, M., Wagner, R. J., Kullmann, S., Preissl, H. T., & Fritsche, A. (2015) · Diabetes · doi:10.2337/db15-0209 · Cited by 8 · see citing works

The role of dietary cholesterol in the regulation of postprandial apolipoprotein B48 levels in diabetes.

Lövestam-Adrian (1997) · Research Portal (Queen's University Belfast) · doi:10.1002/(sici)1096-9136(199712)14:12 · Cited by 4 · see citing works

Processing of food-relevant visual stimuli measured by magnetoencephalography and its modulation by insulin

Porubská, K., Tschritter, O., Fritsche, A., Häring, H.-U., Birbaumer, N., & Preissl, H. T. (2007) · International Congress Series · doi:10.1016/j.ics.2007.01.010 · Cited by 2 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

Kellar, D., & Craft, S. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30231-3 · Cited by 832 · see citing works

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

Timper, K., & Brüning, J. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.026609 · Cited by 802 · see citing works

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 632 · see citing works

The impact of insulin resistance on the kidney and vasculature

Artunç, F., Schleicher, E. D., Weigert, C., Fritsche, A., Stefan, N., & Häring, H. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.145 · Cited by 474 · see citing works

Insulin Signaling and Heart Failure

Riehle, C., & Abel, E. D. (2016) · Circulation Research · doi:10.1161/circresaha.116.306206 · Cited by 415 · see citing works

The Prefrontal Cortex and Obesity: A Health Neuroscience Perspective

Lowe, C. J., Reichelt, A. C., & Hall, P. A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.005 · Cited by 295 · see citing works

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works

Insulin Resistance and Oxidative Stress in the Brain: What’s New?

Maciejczyk, M., Żebrowska, E., & Chabowski, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040874 · Cited by 262 · see citing works

Weight loss is associated with improvements in cognitive function among overweight and obese people: a systematic review and meta-analysis

Veronese, N., Facchini, S., Stubbs, B., Luchini, C., Solmi, M., Manzato, E., Sergi, G., Maggi, S., Cosco, T., & Fontana, L. (2017) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.017 · Cited by 251 · see citing works

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

Mullins, R. J., Diehl, T. C., Chia, C. W., & Kapogiannis, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00118 · Cited by 217 · see citing works

Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia

Lima, J. E. B. F., Moreira, N. C. S., & Sakamoto-Hojo, E. T. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2021.503437 · Cited by 203 · see citing works

Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder

Mellon, S. H., Gautam, A., Hammamieh, R., Jett, M., & Wolkowitz, O. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.007 · Cited by 184 · see citing works

How Does Exercise Reduce the Rate of Age-Associated Cognitive Decline? A Review of Potential Mechanisms

Kennedy, G., Hardman, R. J., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160665 · Cited by 187 · see citing works

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

Chow, H.-M., Shi, M., Cheng, A., Gao, Y., Chen, G., Song, X., So, R. W. L., Zhang, J., & Herrup, K. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0505-1 · Cited by 171 · see citing works

The Complex Interactions Between Obesity, Metabolism and the Brain

Uranga, R. M., & Keller, J. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00513 · Cited by 166 · see citing works

The blood–brain barrier as an endocrine tissue

Banks, W. A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0213-7 · Cited by 164 · see citing works

Review: Traumatic brain injury and hyperglycemia, a potentially modifiable risk factor

Shi, J., Dong, B., Mao, Y., Guan, W., Cao, J., Zhu, R., & Wang, S. (2016) · Oncotarget · doi:10.18632/oncotarget.11958 · Cited by 164 · see citing works

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression

Hancock, M., Meyer, R. C., Mistry, M., Khetani, R. S., Wagschal, A., Shin, T., Sui, S. J. H., Näär, A. M., & Flanagan, J. G. (2019) · Cell · doi:10.1016/j.cell.2019.02.030 · Cited by 159 · see citing works

Distribution of insulin in trigeminal nerve and brain after intranasal administration

Lochhead, J. J., Kellohen, K. L., Ronaldson, P. T., & Davis, T. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-39191-5 · Cited by 146 · see citing works

Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease

Kang, S., Lee, Y., & Lee, J. E. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.3.479 · Cited by 143 · see citing works

Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions

Li, G., Hu, Y., Zhang, W., Wang, J., Ji, W., Manza, P., Volkow, N. D., Zhang, Y., & Wang, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02025-y · Cited by 135 · see citing works

Brain insulin sensitivity is linked to adiposity and body fat distribution

Kullmann, S., Valenta, V., Wagner, R., Tschritter, O., Machann, J., Häring, H.-U., Preissl, H., Fritsche, A., & Heni, M. (2020) · Nature Communications · doi:10.1038/s41467-020-15686-y · Cited by 134 · see citing works

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

Pivovarova‐Ramich, O., Höhn, A., Grune, T., Pfeiffer, A. F. H., & Rudovich, N. N. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1197416 · Cited by 132 · see citing works

Insulin resistance and clinical outcomes after acute ischemic stroke

Ago, T., Matsuo, R., Hata, J., Wakisaka, Y., Kuroda, J., Kitazono, T., Kamouchi, M., & On behalf of the Fukuoka Stroke Registry Investigators (2018) · Neurology · doi:10.1212/wnl.0000000000005358 · Cited by 129 · see citing works

Resting-state functional connectivity of the human hypothalamus

Kullmann, S., Heni, M., Linder, K., Zipfel, S., Häring, H., Veit, R., Fritsche, A., & Preissl, H. T. (2014) · Human Brain Mapping · doi:10.1002/hbm.22607 · Cited by 123 · see citing works

Molecular mechanisms underlying hyperglycemia associated cognitive decline

Gupta, M., Pandey, S., Rumman, M., Singh, B., & Mahdi, A. A. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.12.006 · Cited by 122 · see citing works

Insulin resistance in Alzheimer's disease

Diehl, T. C., Mullins, R. J., & Kapogiannis, D. (2016) · Translational research · doi:10.1016/j.trsl.2016.12.005 · Cited by 119 · see citing works

The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics

Di Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. A. (2017) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2016.6759 · Cited by 114 · see citing works

Hypothalamic and Striatal Insulin Action Suppresses Endogenous Glucose Production and May Stimulate Glucose Uptake During Hyperinsulinemia in Lean but Not in Overweight Men

Heni, M., Wagner, R., Kullmann, S., Gancheva, S., Roden, M., Peter, A., Stefan, N., Preissl, H., Häring, H.-U., & Fritsche, A. (2017) · Diabetes · doi:10.2337/db16-1380 · Cited by 115 · see citing works

The Relevance of Insulin Action in the Dopaminergic System

Fiory, F., Perruolo, G., Cimmino, I., Cabaro, S., Pignalosa, F. C., Miele, C., Bèguinot, F., Formisano, P., & Oriente, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00868 · Cited by 114 · see citing works

Central insulin modulates food valuation via mesolimbic pathways

Tiedemann, L. J., Schmid, S. M., Hettel, J., Giesen, K., Francke, P., Büchel, C., & Brassen, S. (2017) · Nature Communications · doi:10.1038/ncomms16052 · Cited by 113 · see citing works

Cerebrovascular insulin receptors are defective in Alzheimer’s disease

Leclerc, M., Bourassa, P., Tremblay, C., Caron, V., Sugère, C., Émond, V., Bennett, D. A., & Calon, F. (2022) · Brain · doi:10.1093/brain/awac309 · Cited by 110 · see citing works

Safety of intranasal human insulin: A review

Schmid, V., Kullmann, S., Gfrörer, W., Hund, V., Hallschmid, M., Lipp, H., Häring, H., Preissl, H., Fritsche, A., & Heni, M. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13279 · Cited by 110 · see citing works

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

Busquets, O., Ettcheto, M., Pallàs, M., Beas‐Zárate, C., Verdaguer, E., Auladell, C., Folch, J., & Camins, A. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.11.002 · Cited by 104 · see citing works

Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis

Chen, W., Balland, É., & Cowley, M. A. (2017) · Neuroendocrinology · doi:10.1159/000455865 · Cited by 99 · see citing works

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H., Fritsche, A., & Preissl, H. T. (2017) · Scientific Reports · doi:10.1038/s41598-017-01907-w · Cited by 92 · see citing works

Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models?

García-Serrano, A. M., & Duarte, J. M. N. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00229 · Cited by 94 · see citing works

Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese

Kullmann, S., Goj, T., Veit, R., Fritsche, L., Wagner, L., Schneeweiß, P., Hoene, M., Hoffmann, C., Machann, J., Niess, A. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.161498 · Cited by 93 · see citing works

Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia

Kim, O. Y., & Song, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122356 · Cited by 96 · see citing works

Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high‐fat diet

Xu, J., Gao, H. Y., Zhang, L., Rong, S., Yang, W. Q., Ma, C., Chen, M., Huang, Q., Deng, Q., & Huang, F. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12584 · Cited by 93 · see citing works

Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway

Fangfang, Li, H., Qin, T., Li, M., & Ma, S. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9921-z · Cited by 88 · see citing works

Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults

Duvivier, B. M. F. M., Schaper, N. C., Koster, A., van Kan, L., Peters, H. P. F., Adam, J. J., Giesbrecht, T., Moonen‐Kornips, E., Hulsbosch, M. M., Willems, P. J. B., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00353 · Cited by 89 · see citing works

Reorganization of brain connectivity in obesity

Geha, P., Cecchi, G., Constable, R. T., Abdallah, C. G., & Small, D. M. (2016) · Human Brain Mapping · doi:10.1002/hbm.23462 · Cited by 83 · see citing works

Insulin sensitivity predicts cognitive decline in individuals with prediabetes

Willmann, C., Brockmann, K., Wagner, R. J., Kullmann, S., Preissl, H. T., Schnauder, G., Maetzler, W., Gasser, T., Berg, D., Eschweiler, G. W., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001741 · Cited by 83 · see citing works

Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults

Hoscheidt, S. M., Starks, E. J., Oh, J. M., Zetterberg, H., Blennow, K., Krause, R. A., Gleason, C. E., Puglielli, L., Atwood, C., Carlsson, C. M., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160110 · Cited by 82 · see citing works

Cerebral cortex: a target and source of insulin?

Csajbók, É., & Tamás, G. (2016) · Diabetologia · doi:10.1007/s00125-016-3996-2 · Cited by 78 · see citing works

Dose-Dependent Effects of Intranasal Insulin on Resting-State Brain Activity

Kullmann, S., Veit, R., Peter, A., Pohmann, R., Scheffler, K., Häring, H.-U., Fritsche, A., Preissl, H., & Heni, M. (2018) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2017-01976 · Cited by 78 · see citing works

Lymnaea stagnalis as model for translational neuroscience research: From pond to bench

Rivi, V., Benatti, C., Colliva, C., Radighieri, G., Brunello, N., Tascedda, F., & Blom, J. M. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.020 · Cited by 77 · see citing works

Insulin action in the brain: Roles in energy and glucose homeostasis

Dodd, G. T., & Tiganis, T. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12513 · Cited by 75 · see citing works

High-Fat-Diet-Induced Deficits in Dopamine Terminal Function Are Reversed by Restoring Insulin Signaling

Fordahl, S. C., & Jones, S. R. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00308 · Cited by 76 · see citing works

Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders

Shan, C., Ghosh, A., Guo, X., Wang, S., Hou, Y., Li, S., & Liu, J. (2019) · Molecular Brain · doi:10.1186/s13041-019-0444-5 · Cited by 75 · see citing works

Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction

Fu, Z., Wu, J., Nesil, T., Li, M. D., Aylor, K. W., & Liu, Z. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2016 · Cited by 74 · see citing works

Insulin and Its Key Role for Mitochondrial Function/Dysfunction and Quality Control: A Shared Link between Dysmetabolism and Neurodegeneration

Galizzi, G., & Carlo, M. D. (2022) · Biology · doi:10.3390/biology11060943 · Cited by 76 · see citing works

Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging

Wingrove, J., Swedrowska, M., Scherließ, R., Parry, M., Ramjeeawon, M., Taylor, D., Gauthier, G., Brown, L., Amiel, S., Zelaya, F., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.032 · Cited by 67 · see citing works

Deciphering Brain Insulin Receptor and Insulin‐Like Growth Factor 1 Receptor Signalling

Kleinridders, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12433 · Cited by 65 · see citing works

Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases

Sousa, L., Guarda, M., Meneses, M. J., Macedo, M. P., & Miranda, H. V. (2021) · The Journal of Pathology · doi:10.1002/path.5777 · Cited by 63 · see citing works

Body–Brain Connections: The Effects of Obesity and Behavioral Interventions on Neurocognitive Aging

Stillman, C. M., Weinstein, A. M., Marsland, A. L., Gianaros, P. J., & Erickson, K. I. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00115 · Cited by 65 · see citing works

Migraine, Brain Glucose Metabolism and the “Neuroenergetic” Hypothesis: A Scoping Review

Moro, L. D., Rota, E., Pirovano, E., & Rainero, I. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.02.006 · Cited by 64 · see citing works

Brain insulin, insulin‐like growth factor 1 and glucagon‐like peptide 1 signalling in Alzheimer’s disease

Ferreira, S. T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12959 · Cited by 59 · see citing works

Effects of Diabetes Mellitus-Related Dysglycemia on the Functions of Blood–Brain Barrier and the Risk of Dementia

Wątroba, M., Grabowska, A. D., & Szukiewicz, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210069 · Cited by 60 · see citing works

Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions

Jin, M., & Cai, S. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00969-9 · Cited by 59 · see citing works

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

Shpakov, A. O., Zorina, I. I., & Derkach, K. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043278 · Cited by 57 · see citing works

Design and development of chitosan-insulin-transfersomes (Transfersulin) as effective intranasal nanovesicles for the treatment of Alzheimer’s disease: In vitro, in vivo, and ex vivo evaluations

Nojoki, F., Ebrahimi-Hosseinzadeh, B., Hatamian-Zarmi, A., Khodagholi, F., & Khezri, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113450 · Cited by 55 · see citing works

Modulation of midbrain neurocircuitry by intranasal insulin

Edwin Thanarajah, S., Iglesias, S., Kuzmanovic, B., Rigoux, L., Stephan, K. E., Brüning, J. C., & Tittgemeyer, M. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.050 · Cited by 55 · see citing works

Novel phenotypes of prediabetes?

Häring, H. (2016) · Diabetologia · doi:10.1007/s00125-016-4015-3 · Cited by 53 · see citing works

Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice

Kim, B.-H., Kelschenbach, J., Borjabad, A., Hadas, E., He, H., Potash, M. J., Nedelcovych, M. T., Rais, R., Haughey, N. J., McArthur, J. C., et al. (2019) · AIDS · doi:10.1097/qad.0000000000002150 · Cited by 51 · see citing works

Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients With Type 2 Diabetes

Zhang, Z., Zhang, B., Wang, X., Zhang, X., Yang, Q. X., Zhao, Q., Lu, J., Bi, Y., & Zhu, D. (2018) · Diabetes · doi:10.2337/db17-1274 · Cited by 50 · see citing works

Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

Hummel, J., Benkendorff, C., Fritsche, L., Prystupa, K., Vosseler, A., Gancheva, S., Trenkamp, S., Birkenfeld, A. L., Preissl, H., Roden, M., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00869-w · Cited by 48 · see citing works

Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism

Osada, T., Suzuki, R., Ogawa, A., Tanaka, M., Hori, M., Aoki, S., Tamura, Y., Watada, H., Kawamori, R., & Konishi, S. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.08.056 · Cited by 48 · see citing works

Metabolomic and glycomic findings in posttraumatic stress disorder

Konjevod, M., Tudor, L., Štrac, D. Š., Erjavec, G. N., Barbas, C., Žarković, N., Perković, M. N., Uzun, S., Kozumplik, O., Lauc, G., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.07.014 · Cited by 47 · see citing works

The role of mitochondrial reactive oxygen species in insulin resistance

Ayer, A., Fazakerley, D. J., James, D. E., & Stocker, R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.007 · Cited by 47 · see citing works

Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity

Heni, M., Kullmann, S., Ahlqvist, E., Wagner, R. J., Machicao, F. E., Staiger, H., Häring, H.-U., Almgren, P., Groop, L., Small, D. M., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4095-0 · Cited by 46 · see citing works

Investigating obesity‐associated brain inflammation using quantitative water content mapping

Kullmann, S., Abbas, Z., Machann, J., Shah, N. J., Scheffler, K., Birkenfeld, A. L., Häring, H., Fritsche, A., Heni, M., & Preissl, H. T. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12907 · Cited by 46 · see citing works

Leptin Signaling in the Arcuate Nucleus Reduces Insulin’s Capacity to Suppress Hepatic Glucose Production in Obese Mice

Balland, E., Chen, W., Dodd, G. T., Conductier, G., Coppari, R., Tiganis, T., & Cowley, M. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.061 · Cited by 44 · see citing works

The Role of Thyroid Dysfunction in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Salehipour, A., Dolatshahi, M., Haghshomar, M., & Amin, J. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.20 · Cited by 43 · see citing works

Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives

Ding, B., Zhu, Z., Guo, C., Li, J., Gan, Y., & Yu, M. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.02.019 · Cited by 43 · see citing works

P21-activated kinase 2 (PAK2) regulates glucose uptake and insulin sensitivity in neuronal cells

Varshney, P., & Dey, C. S. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.03.035 · Cited by 42 · see citing works

GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans

Hanßen, R., Kretschmer, A. C., Rigoux, L., Albus, K., Thanarajah, S. E., Sitnikow, T., Melzer, C., Cornely, O. A., Brüning, J. C., & Tittgemeyer, M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101163 · Cited by 40 · see citing works

HMGB1 signaling pathway in diabetes-related dementia: Blood-brain barrier breakdown, brain insulin resistance, and Aβ accumulation

Jeong, J., Lee, D. H., & Song, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112933 · Cited by 39 · see citing works

Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity

Schriever, S. C., Kabra, D. G., Pfuhlmann, K., Baumann, P., Baumgart, E. V., Nagler, J., Seebacher, F., Harrison, L. P., Irmler, M., Kullmann, S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136363 · Cited by 38 · see citing works

Effects of Intranasal Insulin Administration on Cerebral Blood Flow and Cognitive Performance in Adults: A Systematic Review of Randomized, Placebo-Controlled Intervention Studies

Nijssen, K. M. R., Mensink, R. P., & Joris, P. J. (2022) · Neuroendocrinology · doi:10.1159/000526717 · Cited by 37 · see citing works

Outcomes and clinical implications of intranasal insulin administration to the central nervous system

Santiago, J. C. P., & Hallschmid, M. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.007 · Cited by 36 · see citing works

Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1

Nieuwenhuis, S., Okkersen, K., Widomska, J., Blom, P., Hoen, P. A. C. ’., van Engelen, B. G. M., & Glennon, J. C. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01229 · Cited by 36 · see citing works

Insulin Action in the Hypothalamus Increases Second-Phase Insulin Secretion in Humans

Heni, M., Wagner, R., Willmann, C., Jaghutriz, B. A., Vosseler, A., Kübler, C., Hund, V., Scheffler, K., Peter, A., Häring, H.-U., et al. (2020) · Neuroendocrinology · doi:10.1159/000504551 · Cited by 36 · see citing works

Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis

Bakker, W., Imbernón, M., Salinas, C. G., Chao, D. H. M., Hassouna, R., Morel, C., Martin, C., Leger, C., Denis, R., Castel, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111698 · Cited by 35 · see citing works

Iron and Targeted Iron Therapy in Alzheimer’s Disease

Wang, J., Fu, J., Zhao, Y., Liu, Q., Yan, X., & Su, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216353 · Cited by 35 · see citing works

The Role of Insulin Resistance and Protein O-GlcNAcylation in Neurodegeneration

Ansari, S. A., & Emerald, B. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00473 · Cited by 35 · see citing works

Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice

Bell, G. A., & Fadool, D. A. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.02.044 · Cited by 34 · see citing works

Objectively measured physical activity and cognitive function in urban‐dwelling older adults

Umegaki, H., Makino, T., Uemura, K., Shimada, H., Cheng, X. W., & Kuzuya, M. (2018) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13284 · Cited by 33 · see citing works

Insulin signalling in hypothalamic neurones

Belsham, D. D., & Dalvi, P. S. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12919 · Cited by 33 · see citing works

Neuronal Food Reward Activity in Patients With Type 2 Diabetes With Improved Glycemic Control After Bariatric Surgery

Frank, S., Heinze, J. M., Fritsche, A., Linder, K., von Feilitzsch, M., Königsrainer, A., Häring, H., Veit, R., & Preissl, H. T. (2016) · Diabetes Care · doi:10.2337/dc16-0094 · Cited by 32 · see citing works

Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition

Smith, P. J. (2019) · Brain Plasticity · doi:10.3233/bpl-190083 · Cited by 32 · see citing works

Sex-Specific Associations of Testosterone With Metabolic Traits

Lutz, S. Z., Wagner, R. J., Fritsche, L., Peter, A., Rettig, I., Willmann, C., Fehlert, E., Martus, P., Todenhöfer, T., Stefan, N., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00090 · Cited by 31 · see citing works

Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans

Kullmann, S., Fritsche, A., Wagner, R. J., Schwab, S., Häring, H., Preissl, H. T., & Heni, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.036 · Cited by 31 · see citing works

Neuroanatomical changes in white and grey matter after sleeve gastrectomy

Michaud, A., Dadar, M., Pelletier, M., Zeighami, Y., García‐García, I., Iceta, S., Yau, Y. H. C., Nadeau, M., Marceau, S., Biertho, L. D., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116696 · Cited by 31 · see citing works

Association between thyroid function and Alzheimer's disease: A systematic review

Figueroa, P. B. S., Ferreira, A. F. F., Britto, L. R., Doussoulin, A. P., & Torrão, A. D. S. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00760-1 · Cited by 28 · see citing works

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice

Balland, É., Chen, W., Tiganis, T., & Cowley, M. A. (2019) · Neuroendocrinology · doi:10.1159/000500201 · Cited by 29 · see citing works

Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men

Ritze, Y., Kern, W., Ebner, E.-M., Jahn, S., Benedict, C., & Hallschmid, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00663 · Cited by 28 · see citing works

Non-Invasive Techniques of Nose to Brain Delivery Using Nanoparticulate Carriers: Hopes and Hurdles

Butola, M., & Nainwal, N. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02946-z · Cited by 28 · see citing works

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 632 · see citing works

Insulin sensitivity of the human brain

Ketterer, C., Tschritter, O., Preissl, H. T., Heni, M., Häring, H., & Fritsche, A. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(11)70013-4 · Cited by 52 · see citing works

Untitled work

Anthony (2006) · doi:10.2337/db06-0376 · Cited by 195 · see citing works

The insulin resistant brain: impact on whole-body metabolism and body fat distribution

Heni, M. (2024) · Diabetologia · doi:10.1007/s00125-024-06104-9 · Cited by 73 · see citing works

Is Insulin Action in the Brain Clinically Relevant?

Filippi, B., Mighiu, P. I., & Lam, T. K. T. (2012) · Diabetes · doi:10.2337/db12-0048 · Cited by 17 · see citing works