MEMO+: Efficacy, Durability and Effect of Cognitive Training and Psychosocial Intervention in Individuals with Mild Cognitive Impairment
Open accessAbstract
Background/Objectives: There is no consensus on the efficacy of cognitive training in persons with mild cognitive impairment ( MCI ) because of the paucity of well‐designed randomized controlled trials. The objective was to assess the effect of memory training on the cognitive functioning of persons with MCI and its durability and to evaluate whether this effect generalizes to daily life and whether positive effects could be obtained from psychosocial intervention. Design: Single‐blind randomized controlled trial. Setting: Research centers of the Institut Universitaire de Gériatrie de Montréal and Institut Universitaire en Santé Mentale de Québec. Participants: Older adults meeting criteria for amnestic MCI (N = 145). Intervention: Participants were randomized to cognitive training, a psychosocial intervention, or a no‐contact control condition. Interventions were provided in small groups in eight 2‐hour sessions. Measurement: Outcome measures were immediate and delayed composite performance memory scores, psychological health (depression, anxiety, well‐being), and generalization effects of the intervention (strategy use in everyday life, difficulties in complex activities of daily living, memory complaints). Testing was administered before training and immediately, 3 months, and 6 months after training. Results: Participants in the cognitive training condition improved on the delayed composite memory score and on strategy use in everyday life. Improvement was maintained at the 3‐ and 6‐month follow‐up assessments. Participants in the psychosocial and no‐contact conditions did not show any significant improvement. Conclusion: Cognitive training improves the memory of persons with amnestic MCI . The effect persists over a 6‐month period, and learned strategies are used in everyday life. Cognitive training is a valid way to promote cognition in MCI .
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With regard to mood, well-being and quality of life, no therapeutic effects in MCI patients, neither at short-term (3 months) nor at long-term (24 months) follow-up, were detected in most studies, including four randomized controlled trials and one randomized non-controlled trial.
“With regard to mood, well-being and quality of life no therapeutic effects in MCI patients, neither at short-term (3 months) nor at long-term (24 months) follow-up, were detected in most studies, including four randomized controlled trials [48–51, 54, 59, 60] and one randomized non-controlled trial [52, 53].”
From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [60]
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Experimental — accuracy not yet measuredLong-term follow-up assessments (6 or more months post-intervention) were described in 14 publications.
“Long-term follow-up assessments (6 or more months post-intervention) were described in 14 publications [37, 39, 43, 48, 49, 51–53, 59, 60, 62, 63, 68, 69].”
From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [60]
A total of 10 research groups described psychoeducational interventions in individuals with MCI in addition to cognitive rehabilitation, cognitive training, mindfulness-based stress reduction, behavioral activation, or enriched by a recovery model approach.
“A total of 10 research groups described psychoeducational interventions in addition to cognitive rehabilitation [38, 50], cognitive training [52, 53, 59, 60, 65], mindfulness-based stress reduction (MBSR) [46, 47, 57, 58], behavioral activation [44, 45, 48, 49, 51, 54], or enriched by a recovery model approach [67]”
From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [60]
Cognitive training improved the use of strategies in daily life in individuals with MCI.
“cognitive training improved the use of strategies in daily life”
From Evaluation of a Novel Psychological Intervention Tailored for Patients With Early Cognitive Impairment (PIPCI): Study Protocol of a Randomized Controlled Trial (2020) · cites this paper as Belleville et al., 2018
Neither cognitive training nor CBT improved patient mood or well-being in individuals with MCI.
“neither cognitive training nor CBT improved patient mood or well-being”
From Evaluation of a Novel Psychological Intervention Tailored for Patients With Early Cognitive Impairment (PIPCI): Study Protocol of a Randomized Controlled Trial (2020) · cites this paper as Belleville et al., 2018
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Self-citation
- Authors
- Belleville, S., Hudon, C., Bier, N., Brodeur, C., Gilbert, B., Grenier, S., Ouellet, M., Viscogliosi, C., & Gauthier, S.
- Affiliations
- Institut Universitaire de Gériatrie de Montréal (CA)
- Université Laval (CA)
- Université de Sherbrooke (CA)
- McGill University Research Centre for Studies in Aging (CA)
- Corresponding author
- Belleville, Sylvie
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2018-01-04
- Volume
- 66
- Issue
- 4
- Pages
- 655-663
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2782530605
- Cited by
- 109
- References
- 45
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 11 · 2023: 7 · 2022: 16 · 2021: 19 · 2020: 20 · 2019: 12 · 2018: 2
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the American Geriatrics Society (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes for Health Research (MOP115086)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- mild cognitive impairment, amnestic MCI, cognitive training, memory training, psychosocial interventions, memory strategies, activities of daily living, memory impairment, anxiety and depression, psychological well-being, older adults, treatment durability
- MeSH terms
- Activities of Daily Living, Aged, Female, Humans, Male, Neuropsychological Tests, Quebec, Time Factors, Cognitive Behavioral Therapy, Single-Blind Method, Cognitive Dysfunction
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