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Cited by 28Dementia and Cognitive Impairment ResearchCognitive Functions and MemoryCognitive Abilities and Testing

Measuring the impact of cognitive and psychosocial interventions in persons with mild cognitive impairment with a randomized single-blind controlled trial: rationale and design of the MEMO+ study

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Bier, Nathalie, Grenier, Sébastien, Brodeur, Catherine, Gauthier, Serge, Gilbert, Brigitte, Hudon, Carol, Lepage, Émilie, Ouellet, Marie-Christine +2 more·2015·International Psychogeriatrics
DOI 10.1017/s1041610214001902
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Abstract

BACKGROUND: Several studies have suggested that cognitive training is a potentially effective way to improve cognition and postpone cognitive decline in older adults with mild cognitive impairment (MCI). The MEMO+ study is a randomized, controlled, single-blind trial designed to test the efficacy, specificity, and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI. METHODS: One hundred and sixty-two participants with MCI will be recruited. They will be randomized into three groups: cognitive training, psychosocial intervention, and no-contact. Each intervention will last for eight weeks (one session per week) and a booster training session will be provided three months after the end of the intervention. Various proximal and distal outcomes will be measured at pre-intervention as well as at one week, three months, and six months post-training. Proximal outcomes include memory and psychological health measures. Distal outcomes focus on self-rated functioning in complex daily activities and strategies used in daily life to enhance function. Socio-demographic factors (age, gender, and education), general cognition, personality traits, engagement in activities, and self-efficacy will be used as moderators. Enrolment began in April 2012 and will be completed by December 2014. CONCLUSIONS: This study is likely to have a significant impact on the well-being of persons with MCI by contributing to the development of adapted and scientifically supported cognitive and psychosocial interventions.

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  • With regard to mood, well-being and quality of life, no therapeutic effects in MCI patients, neither at short-term (3 months) nor at long-term (24 months) follow-up, were detected in most studies, including four randomized controlled trials and one randomized non-controlled trial.

    “With regard to mood, well-being and quality of life no therapeutic effects in MCI patients, neither at short-term (3 months) nor at long-term (24 months) follow-up, were detected in most studies, including four randomized controlled trials [48–51, 54, 59, 60] and one randomized non-controlled trial [52, 53].”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [59]

  • Long-term follow-up assessments (6 or more months post-intervention) were described in 14 publications.

    “Long-term follow-up assessments (6 or more months post-intervention) were described in 14 publications [37, 39, 43, 48, 49, 51–53, 59, 60, 62, 63, 68, 69].”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [59]

  • A total of 10 research groups described psychoeducational interventions in individuals with MCI in addition to cognitive rehabilitation, cognitive training, mindfulness-based stress reduction, behavioral activation, or enriched by a recovery model approach.

    “A total of 10 research groups described psychoeducational interventions in addition to cognitive rehabilitation [38, 50], cognitive training [52, 53, 59, 60, 65], mindfulness-based stress reduction (MBSR) [46, 47, 57, 58], behavioral activation [44, 45, 48, 49, 51, 54], or enriched by a recovery model approach [67]”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [59]

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Authors
Bier, N., Grenier, S., Brodeur, C., Gauthier, S., Gilbert, B., Hudon, C., Lepage, É., Ouellet, M.-C., Viscogliosi, C., & Belleville, S.
Affiliations
  • Institut Universitaire de Gériatrie de Montréal (CA)
  • McGill University Health Centre (CA)
  • McGill University Research Centre for Studies in Aging (CA)
  • Institut Universitaire en Santé Mentale de Québec (CA)
  • Université Laval (CA)
  • Université de Sherbrooke (CA)
Corresponding author
Belleville, Sylvie
ORCID
Venue
International Psychogeriatrics
Publisher
Elsevier BV
Published
2015-03
Volume
27
Issue
3
Pages
511-525
ISSN
1041-6102 (ISSN-L)
DOI
10.1017/s1041610214001902
OpenAlex
W2037085959
Cited by
28
References
104
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2016: 9 · 2015: 3
FWCI
3.05
Type
journal article
Language
en
Open access
Licence
Locations
  • International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Canadian Institutes of Health Research
  • Fonds de Recherche du Québec - Santé
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
mild cognitive impairment, cognitive training, psychosocial interventions, cognitive decline prevention, older adults, memory, mental health, self-efficacy, personality traits, intervention moderators, booster training
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Canada, Cognition, Dementia, Education, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Research Design, Single-Blind Method, Self Efficacy, Cognitive Dysfunction, Patient Outcome Assessment

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