Amphetamine-induced release of dopamine in primate prefrontal cortex and striatum: striking differences in magnitude and timecourse

Jedema, Hank P.; Narendran, Rajesh; Bradberry, Charles W.

doi:10.1111/jnc.12743

Cited by 30Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and Treatments

Amphetamine-induced release of dopamine in primate prefrontal cortex and striatum: striking differences in magnitude and timecourse

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Jedema, Hank P., Narendran, Rajesh, Bradberry, Charles W.·2014·Journal of Neurochemistry

DOI 10.1111/jnc.12743PMC PMC4126881

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Abstract

The psychostimulant amphetamine (AMPH) is frequently used to increase catecholamine levels in attention disorders and positron emission tomography imaging studies. Despite the fact that most radiotracers for positron emission tomography studies are characterized in non‐human primates (NHPs), data on regional differences of the effect of AMPH in NHPs are very limited. This study examined the impact of AMPH on extracellular dopamine (DA) levels in the medial prefrontal cortex and the caudate of NHPs using microdialysis. In addition to differences in magnitude, we observed striking differences in the temporal profile of extracellular DA levels between these regions that can likely be attributed to differences in the regulation of dopamine uptake and biosynthesis. The present data suggest that cortical DA levels may remain elevated longer than in the caudate which may contribute to the clinical profile of the actions of AMPH.image Using microdialysis probes implanted in the cortex and caudate region of non‐human primate brains, we observed in vivo differences in the magnitude and temporal profile of extracellular dopamine levels in response to intravenous amphetamine administration.

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Mechanisms of neurotransmitter release by amphetamines: A review
Sulzer, D. L., Sonders, M. S., Poulsen, N. W., & Galli, A. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.04.003 · Cited by 1,212 · see citing works
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154 · cited 2× · see citing works
“2005) and the species differences described above, studies in NHPs provide a premier opportunity for validation of PET displacement techniques by more invasive assessments of extracellular neurotransmitter levels as assessed by microdialysis (Dewey et al. 1993; Moghaddam et al. 1993; Saunders et al. 1994; Breier et al…”
Method
Imaging Synaptic Neurotransmission with <i>in Vivo</i> Binding Competition Techniques: A Critical Review
Laruelle, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00001 · Cited by 944 · see citing works
New Insights into the Mechanism of Action of Amphetamines
Fleckenstein, A. E., Volz, T. J., Riddle, E. L., Gibb, J. W., & Hanson, G. R. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105140 · Cited by 731 · see citing works
Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration
Solanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677 · see citing works
Attention‐Deficit‐Hyperactivity Disorder: An Update
Dopheide, J. A., & Pliszka, S. R. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.6.656 · Cited by 645 · see citing works
Dopamine Axon Varicosities in the Prelimbic Division of the Rat Prefrontal Cortex Exhibit Sparse Immunoreactivity for the Dopamine Transporter
Sesack, S. R., Hawrylak, V. A., Matus, C., Guido, M. A., & Levey, A. I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02697.1998 · Cited by 582 · see citing works
REGIONAL DIFFERENCES IN H3-NOREPINEPHRINE AND H3-DOPAMINE UPTAKE INTO RAT BRAIN HOMOGENATES
Snyder, S. H., & Coyle, J. T. (1969) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28163-0 · Cited by 430 · see citing works
Potential Adverse Effects of Amphetamine Treatment on Brain and Behavior: A Review
Arcos-Burgos, M., Jain, M., Acosta, M. T., Shively, S., Stanescu, H., Wallis, D., Domené, S., Velez, J. I., Karkera, J., Balog, J. Z., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.90 · Cited by 423 · see citing works
Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study
Garris, P., & Wightman, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00442.1994 · Cited by 413 · see citing works
Blockade of the Noradrenaline Carrier Increases Extracellular Dopamine Concentrations in the Prefrontal Cortex: Evidence that Dopamine Is Taken up In Vivo by Noradrenergic Terminals
Carboni, E., Tanda, G., Frau, R., & Chiara, G. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04599.x · Cited by 412 · see citing works
Quantitative Investigation of Connections of the Prefrontal Cortex in the Human and Macaque using Probabilistic Diffusion Tractography
Croxson, P. L., Johansen-Berg, H., Behrens, T. E. J., Robson, M. D., Pinsk, M. A., Gross, C. G., Richter, W., Richter, M. C., Kastner, S., & Rushworth, M. F. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1311-05.2005 · Cited by 410 · see citing works
Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism
Saunders, C., Ferrer, J. V., Shi, L., Chen, J., Merrill, G. A., Lamb, M. E., Leeb-Lundberg, L. M. F., Carvelli, L., Javitch, J. A., & Galli, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110035297 · Cited by 410 · see citing works
Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine
Kuczenski, R., Segal, D., Cho, A., & Melega, W. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01308.1995 · Cited by 376 · see citing works
Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization
Lewis, D. A., Melchitzky, D. S., Sesack, S. R., Whitehead, R. E., Auh, S., & Sampson, A. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1092 · Cited by 352 · see citing works
Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates
Brown, R. M., Crane, A. M., & Goldman, P. S. (1979) · Brain Research · doi:10.1016/0006-8993(79)90132-x · Cited by 330 · see citing works
Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation
WESENSTEN, N. J., KILLGORE, W. D. S., & BALKIN, T. J. (2005) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2005.00468.x · Cited by 306 · see citing works
Striatal binding of the PET ligand 11C‐raclopride is altered by drugs that modify synaptic dopamine levels
Dewey, S. L., Smith, G. S., Logan, J., Brodie, J. D., Fowler, J. S., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890130407 · Cited by 283 · see citing works
Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates
Laruelle, M. A., Iyer, R. N., Al‐Tikriti, M. S., Zea‐Ponce, Y., Malison, R. T., Zoghbi, S. S., Baldwin, R. M., Kung, H. F., Charney, D. S., Hoffer, P. B., et al. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199701)25:1 · Cited by 264 · see citing works
Self-citation
Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat
Benveniste, H., Drejer, J., Schousboe, A., & Diemer, N. H. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb00954.x · Cited by 255 · see citing works
Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress
Swanson, J., Baler, R. D., & Volkow, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.160 · Cited by 252 · see citing works
Regulation of Extracellular Dopamine by the Norepinephrine Transporter
Yamamoto, B. K., & Novotney, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010274.x · Cited by 218 · see citing works
Local Influence of Endogenous Norepinephrine on Extracellular Dopamine in Rat Medial Prefrontal Cortex
Gresch, P. J., Sved, A. F., Zigmond, M. J., & Finlay, J. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65010111.x · Cited by 208 · see citing works
A Closer Look at Amphetamine-Induced Reverse Transport and Trafficking of the Dopamine and Norepinephrine Transporters
Robertson, S. D., Matthies, H. J. G., & Galli, A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8053-4 · Cited by 206 · see citing works
Kinetic Modeling of [11C]Raclopride: Combined PET-Microdialysis Studies
Endres, C. J., Kolachana, B., Saunders, R., Su, T., Weinberger, D., Breier, A., Eckelman, W., & Carson, R. E. (1997) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1097/00004647-199709000-00002 · Cited by 198 · see citing works
Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: Comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity
Haber, S. N., Ryoo, H., Cox, C., & Lu, W. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903620308 · Cited by 188 · see citing works
Microdialysis of dopamine interpreted with quantitative model incorporating probe implantation trauma
Bungay, P. M., Newton‐Vinson, P., Isele, W., Garris, P. A., & Justice, J. B. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01904.x · Cited by 173 · see citing works
Autoreceptor Regulation of Dopamine Synthesis
Wolf, M. E., & Roth, R. H. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb32003.x · Cited by 162 · see citing works
Psychostimulants as cognitive enhancers: The prefrontal cortex, catecholamines, and attention-deficit/hyperactivity disorder
Berridge, C. W., & Devilbiss, D. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.023 · Cited by 160 · see citing works
In Vivo Assessment of Dopamine Uptake in Rat Medial Prefrontal Cortex: Comparison with Dorsal Striatum and Nucleus Accumbens
Cass, W. A., & Gerhardt, G. A. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65010201.x · Cited by 144 · see citing works
Effects of catecholamine uptake blockers in the caudate-putamen and subregions of the medial prefrontal cortex of the rat
Mazei‐Robison, M. S., Pluto, C. P., Kirkbride, B., & Pehek, E. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02542-8 · Cited by 143 · see citing works
Dopamine Neuronal Transport Kinetics and Effects of Amphetamine
Jones, S. R., Joseph, J. D., Barak, L. S., Caron, M. G., & Wightman, R. M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0732406.x · Cited by 141 · see citing works
Sustaining Executive Functions During Sleep Deprivation: A Comparison of Caffeine, Dextroamphetamine, and Modafinil
Killgore, W. D. S., Kahn-Greene, E. T., Grugle, N. L., Killgore, D. B., & Balkin, T. J. (2009) · Sleep · doi:10.1093/sleep/32.2.205 · Cited by 132 · see citing works
Positron emission tomography imaging of amphetamine‐induced dopamine release in the human cortex: A comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
Narendran, R., Frankle, W., Mason, N. S., Rabiner, E., Gunn, R., Searle, G. E., Vora, S., Litschge, M. Y., Kendro, S., Cooper, T. B., et al. (2009) · Synapse · doi:10.1002/syn.20628 · Cited by 131 · see citing works
Self-citation
Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness
Killgore, W. D. S., Rupp, T. L., Grugle, N. L., Reichardt, R. M., Lipizzi, E. L., & Balkin, T. J. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00654.x · Cited by 131 · see citing works
D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia
Buchsbaum, M. S., Christian, B. T., Lehrer, D. S., NARAYANAN, T., SHI, B., Mantil, J., Kemether, E. M., Oakes, T. R., & Mukherjee, J. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.03.042 · Cited by 124 · see citing works
Pharmacologic magnetic resonance imaging (phMRI): Imaging drug action in the brain
Jenkins, B. G. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.075 · Cited by 120 · see citing works
Acute and Chronic Dopamine Dynamics in a Nonhuman Primate Model of Recreational Cocaine Use
Bradberry, C. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-07109.2000 · Cited by 97 · see citing works
Self-citation
Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain
Canfield, D. R., Spealman, R. D., Kaufman, M. J., & Madras, B. K. (1990) · Synapse · doi:10.1002/syn.890060211 · Cited by 91 · see citing works
Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum
Moghaddam, B., Roth, R. H., & Bunney, B. S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90009-s · Cited by 87 · see citing works
Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates
Miocinovic, S., Zhang, J., Xu, W., Russo, G. S., Vitek, J. L., & McIntyre, C. C. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.12.007 · Cited by 86 · see citing works
Distribution of norepinephrine transporters in the non-human primate brain
Smith, H. R., Beveridge, T. J. R., & Porrino, L. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.033 · Cited by 79 · see citing works
Comparison of Effects of Haloperidol Administration on Amphetamine-Stimulated Dopamine Release in the Rat Medial Prefrontal Cortex and Dorsal Striatum
Pehek, E. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38101-7 · Cited by 70 · see citing works
In vivo assessment of basal and drug‐induced dopamine release in cortical and subcortical regions of the anesthetized primate
Moghaddam, B., Berridge, C. W., Goldman‐Rakic, P. S., Bunney, B. S., & Roth, R. H. (1993) · Synapse · doi:10.1002/syn.890130304 · Cited by 64 · see citing works
Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT
Kaufman, M. J., Spealman, R. D., & Madras, B. K. (1991) · Synapse · doi:10.1002/syn.890090304 · Cited by 60 · see citing works
Amphetamine Induces a Calcium/Calmodulin-Dependent Protein Kinase II-Dependent Reduction in Norepinephrine Transporter Surface Expression Linked to Changes in Syntaxin 1A/Transporter Complexes
Dipace, C., Sung, U., Binda, F., Blakely, R., & Galli, A. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026690 · Cited by 56 · see citing works
Regulation of the Human Norepinephrine Transporter by Cocaine and Amphetamine
Zhu, M., Shamburger, S., Li, J., & Ordway, G. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38993-1 · Cited by 48 · see citing works
[3H]GBR 12935 Binding to Dopamine Uptake Sites in the Human Brain
Keyser, J. D., Backer, J. D., Ebinger, G., et al. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb08530.x · Cited by 47 · see citing works
Human Methamphetamine Pharmacokinetics Simulated in the Rat: Single Daily Intravenous Administration Reveals Elements of Sensitization and Tolerance
Segal, D. S., & Kuczenski, R. T. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300865 · Cited by 46 · see citing works
Imaging dopamine transmission in the frontal cortex: a simultaneous microdiaysis and [11C]FLB 457 PET study
Narendran, R., Jedema, H., Lopresti, B., Mason, N., Gurnsey, K., Ruszkiewicz, J., Chen, C.-M., Deuitch, L., Frankle, W., & Bradberry, C. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.9 · Cited by 39 · see citing works
Self-citation
The Acute Impact of Ethanol on Cognitive Performance in Rhesus Macaques
Jedema, H. P., Carter, M. D., Dugan, B. P., Gurnsey, K., Olsen, A. S., & Bradberry, C. W. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq244 · Cited by 35 · see citing works
Self-citation
Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: An in vivo microdialysis study
Saunders, R. C., Kolachana, B. S., & Weinberger, D. (1994) · Experimental Brain Research · doi:10.1007/bf00229108 · Cited by 33 · see citing works
Disposition kinetics of d- and l-amphetamine following intravenous administration of racemic amphetamine to rats.
Hutchaleelaha, A., Sukbuntherng, J., Chow, H. ‐. S., & Mayersohn, M. (1994) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08390-4 · Cited by 33 · see citing works
Effects of tissue trauma on the characteristics of microdialysis zero-net-flux method sampling neurotransmitters
Chen, K. C. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.06.035 · Cited by 28 · see citing works
Applications of Microdialysis Methodology in Nonhuman Primates: Practice and Rationale
Bradberry, C. W. (2000) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v14.i2.30 · Cited by 18 · see citing works
Self-citation
Acute administration of amphetamine: differential regulation of dopamine synthesis in dopamine projection fields.
Tyler, C. B., & Galloway, M. P. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11076-8 · Cited by 16 · see citing works
Time-action and behavioral effects of amphetamine, ethanol, and acetylmethadol
Downs, D. A., & Braude, M. C. (1977) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(77)90093-4 · Cited by 13 · see citing works
Injections of an opioid antagonist into the locus coeruleus and periaqueductal gray but not the amygdala precipitates morphine withdrawal in the 7‐day‐old rat
Jones, K. L., & Barr, G. A. (2000) · Synapse · doi:10.1002/1098-2396(200102)39:2 · Cited by 11 · see citing works

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Authors: Jedema, H. P., Narendran, R., & Bradberry, C. W.
Affiliations: University of Pittsburgh (US)
Corresponding author: Jedema, Hank P.
ORCID: Jedema, Hank P.
Narendran, Rajesh
Bradberry, Charles W.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2014-05-19
Volume: 130
Issue: 4
Pages: 490-497
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/jnc.12743
PMC: PMC4126881
OpenAlex: W1994537263
Cited by: 30
References: 58
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1
FWCI: 1.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH
NIDA
VA (DA026472, DA025636, 1IO1BX000782)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: amphetamine, dopamine release, extracellular dopamine, medial prefrontal cortex, caudate nucleus, non-human primates, psychostimulants, dopamine uptake, dopamine synthesis, microdialysis
MeSH terms: Amphetamine, Animals, Caudate Nucleus, Dopamine, Dose-Response Relationship, Drug, Extracellular Space, Half-Life, Macaca mulatta, Male, Stereotaxic Techniques, Linear Models, Neostriatum, Prefrontal Cortex, Microdialysis, Dopamine Uptake Inhibitors

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Amphetamine-induced release of dopamine in primate prefrontal cortex and striatum: striking differences in magnitude and timecourse

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