Human skin gene expression doesn't correlate with protein expression? Unless both parameters are quantified
Abstract
Summary: Many cosmetic companies utilize in vitro gene array studies to display significant stimulation or inhibition of various human skin biomarkers to validate in vivo actions that are reported to enhance dermal health. This follows the central dogma of DNA‐to‐RNA results in protein expression; however, gene and protein expressions do not usually correlate. Unless both gene and protein expressions are quantified which require further investigational time and investment. Where data are available, this short commentary displays the in vitro comparison of four human skin biomarkers for the gene and protein expressions of the stimulation of collagen type I and elastin and the inhibition of matrix metalloproteinases 1 and 3, when equol was tested. The results demonstrate a good correspondence between gene and protein expressions for the human skin biomarkers tested.
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Equol is the only cosmetic ingredient where in vitro gene expression biomarkers have been shown to correspond to protein expression levels, validating that gene activation results in a parallel change in gene product or protein levels.
“equol is the only cosmetic ingredient, where in vitro gene expression biomarkers have been shown to correspond to protein expression levels validating that gene activation results in a parallel change in gene product or protein levels [86].”
Cites
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“Notably, one journal report demonstrated that the RNA and protein expressions of a particular gene did not correlate in single cells.(3) Another major study suggested that a gene-specific RNA-to-protein (RTP) conversion rate has been introduced to enhance the predictability of protein copy numbers from RNA levels.”
BackgroundRepeated, long-distance migrations by a philopatric predator targeting highly contrasting ecosystems
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Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325 · see citing works
Self-citationGopaul, R., Knaggs, H. E., & Lephart, E. D. (2012) · BioFactors · doi:10.1002/biof.191 · Cited by 72 · see citing works
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Lephart, E. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061193 · Cited by 50 · see citing works
Self-citationLephart, E. (2018) · Cosmetics · doi:10.3390/cosmetics5010016 · Cited by 42 · see citing works
Self-citation
- Authors
- Lephart, E. D.
- Affiliations
- Brigham Young University (US)
- Corresponding author
- Lephart, Edwin D.
- ORCID
- Lephart, Edwin D.
- Venue
- Journal of Cosmetic Dermatology
- Publisher
- Wiley
- Published
- 2017-05-25
- Volume
- 17
- Issue
- 2
- Pages
- 244-245
- ISSN
- 1473-2130 (ISSN-L)
- 1473-2165
- OpenAlex
- W2618282259
- Cited by
- 6
- References
- 6
- Citations by year
- 2023: 1 · 2021: 1 · 2018: 3 · 2017: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cosmetic Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- gene expression, protein expression, type I collagen, elastin, MMP-1, matrix metalloproteinase-3, equol, cosmetic ingredients
- MeSH terms
- Elastin, Humans, Skin, Transcription, Genetic, Protein Biosynthesis, Matrix Metalloproteinase 3, Matrix Metalloproteinase 1, Collagen Type I, Phytoestrogens, Equol
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