Endometriosis and ovarian cancer
Open accessAbstract
Endometriosis is the leading cause of morbidity among premenopausal women and the complex pathogenesis of this disease remains controversial despite extensive research. This disease represents one of the most common gynecological problems. It is generally believed that this disease is due primarily to retrograde menstruation or transplantation of shed endometrium. Based on overwhelming data, ovarian endometrioma is considered a neoplastic process, since most endometriosis-associated ovarian carcinoma occur in the presence of atypical ovarian endometriosis. A study comparing patients with typical epithelial ovarian cancer with endometriosis-associated ovarian cancer demonstrated that the patients with the latter disease strongly differ in both biological and histological characteristics. The prevelance of this disease is not completely established, but approximately 15 percent of women suffer from this disease. In addition, we know about the possible links between endometriosis and cancer for almost 100 years. Despite clear evidence revealing that endometriosis increases ovarian cancer risks, it is possible that it may not affect disease progression after the appearance of ovarian cancer. However, despite clear evidence revealing that endometriosis increases ovarian cancer risk, our knowledge of the risk factors is far from established. In our review, we focused on the most recent approaches including possible biomarkers and genetic approaches.
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Infertility and delayed menopause increase the risk, while hysterectomy, use of oral contraceptives, and tubal ligation decrease the risk and are common risk factors.
“Infertility and delayed menopause increase the risk, while hysterectomy, use of oral contraceptives, and tubal ligation decrease the risk and are common risk factors [12].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [12]
Disruption of redox metabolism may lead to the acquisition of cancer-specific metabolism in clear cell carcinoma.
“It has also been reported that endometriosis causes a disruption of redox metabolism, which may lead to the acquisition of cancer-specific metabolism in clear cell carcinoma [12].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [12]
Endometriosis causes a disruption of redox metabolism.
“It has also been reported that endometriosis causes a disruption of redox metabolism, which may lead to the acquisition of cancer-specific metabolism in clear cell carcinoma [12].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [12]
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“It has also been reported that endometriosis causes a disruption of redox metabolism, which may lead to the acquisition of cancer-specific metabolism in clear cell carcinoma [12].”
Background
- Authors
- Králíčková, M.
- Affiliations
- Charles University (CZ)
- Corresponding author
- Králíčková, Milena
- ORCID
- Králíčková, Milena
- Venue
- World Journal of Clinical Oncology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 5
- Issue
- 5
- Pages
- 800
- ISSN
- 2218-4333 (ISSN-L)
- PMC
- PMC4259943
- OpenAlex
- W2032878994
- Cited by
- 27
- References
- 66
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 3
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Clinical Oncology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, ovarian cancer, endometriosis-associated ovarian cancer, endometrioma, atypical endometriosis, retrograde menstruation, endometriosis pathogenesis, cancer risk factors, biomarkers, genetic susceptibility
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