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Cited by 23Circadian rhythm and melatoninLiver Disease Diagnosis and TreatmentLiver Disease and Transplantation

Circadian rhythms and the liver

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Costa, Rodolfo, Mangini, Chiara, Domenie, Esther D., Zarantonello, Lisa, Montagnese, Sara·2023·Liver International
DOI 10.1111/liv.15501
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Abstract

This narrative review briefly describes the mammalian circadian timing system, the specific features of the liver clock, also by comparison with other peripheral clocks, the role of the liver clock in the preparation of food intake, and its relationship with energy metabolism. It then goes on to provide a chronobiological perspective of the pathophysiology and management of several types of liver disease, with a particular focus on metabolic‐associated fatty liver disease (MAFLD), decompensated cirrhosis and liver transplantation. Finally, it provides some insight into the potential contribution of circadian principles and circadian hygiene practices in preventing MAFLD, improving the prognosis of advanced liver disease and modulating liver transplantation outcomes.

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  • Regulators of the circadian clock are highly associated with liver metabolism and are known to be regulated by MRTFs.

    “Regulators of the circadian clock are highly associated with liver metabolism and are known to be regulated by MRTFs [56, 57, 58].”

    From Mechanical stiffness orchestrates distinct regulation of <scp>MRTFs</scp> and <scp>YAP</scp> / <scp>TAZ</scp> transcriptional cofactors in hepatocytes (2026) · cites this paper as [58]

    Section 3, “The Liver Clock” (page not available), links circadian-clock activity to liver metabolism, including nutrient processing and rhythmic NAD+ synthesis. The passages do not say that MRTFs regulate circadian-clock regulators; a search for MRTFs and myocardin-related transcription factors found no support for that part of the claim. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Costa, R., Mangini, C., Domenie, E. D., Zarantonello, L., & Montagnese, S.
Affiliations
University of Padua (IT)
Corresponding author
Montagnese, Sara
ORCID
Venue
Liver International
Publisher
Wiley
Published
2023-01-11
Volume
43
Issue
3
Pages
534-545
ISSN
  • 0106-9543 (ISSN-L)
  • 1478-3223
  • 1478-3231
DOI
10.1111/liv.15501
OpenAlex
W4313277752
Cited by
23
References
15
Citations by year
2026: 5 · 2025: 9 · 2024: 7 · 2023: 2
FWCI
0.65
Type
journal article
Language
en
Open access
Licence
Locations
  • Liver International (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion, cc-by)
Funders
  • European Commission (765937)
  • Università degli Studi di Padova
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
circadian rhythm, liver clock, peripheral clocks, dietary intake, energy metabolism, metabolic-associated fatty liver disease, decompensated cirrhosis, liver transplantation, chronobiology, liver disease pathophysiology
MeSH terms
Animals, Circadian Rhythm, Humans, Liver, Liver Diseases, Mammals

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