Circadian Clock Control of Liver Metabolic Functions

Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes &amp; Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works

A circadian gene expression atlas in mammals: Implications for biology and medicine

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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works

Extensive and divergent circadian gene expression in liver and heart

Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

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Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

Welsh, D. K., Takahashi, J. S., & Kay, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135919 · Cited by 1,216 · see citing works

Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126 · see citing works

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works

Physiological significance of a peripheral tissue circadian clock

Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science · doi:10.1126/science.1172156 · Cited by 958 · see citing works

Nuclear Receptor Expression Links the Circadian Clock to Metabolism

Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917 · see citing works

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

Leone, V., Gibbons, S. M., Martinez, K., Hutchison, A. L., Huang, E. Y., Cham, C. M., Pierre, J. F., Heneghan, A. F., Nadimpalli, A., Hubert, N., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.006 · Cited by 908 · see citing works

The Meter of Metabolism

Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · see citing works

Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock

Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844 · see citing works

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Solt, L. A., Wang, Y., Banerjee, S., Hughes, T., Kojetin, D. J., Lundåsen, T., Shin, Y., Liu, J., Cameron, M. D., Noël, R., et al. (2012) · Nature · doi:10.1038/nature11030 · Cited by 835 · see citing works

Circadian clocks in human red blood cells

O'Neill, J. S., & Reddy, A. B. (2011) · Nature · doi:10.1038/nature09702 · Cited by 830 · see citing works

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.

Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765 · see citing works

Pathogenesis of non-alcoholic fatty liver disease

Dowman, J. K., Tomlinson, J., & Newsome, P. N. (2009) · QJM · doi:10.1093/qjmed/hcp158 · Cited by 742 · see citing works

A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701 · see citing works

Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Peek, C. B., Affinati, A. H., Ramsey, K. M., Kuo, H.-Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., et al. (2013) · Science · doi:10.1126/science.1243417 · Cited by 658 · see citing works

System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658 · see citing works

Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism

Liu, C., Li, S., Liu, T., Borjigin, J., & Lin, J. D. (2007) · Nature · doi:10.1038/nature05767 · Cited by 643 · see citing works

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

Feldman, J. L., Baeza, J., & Denu, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.511261 · Cited by 637 · see citing works

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615 · see citing works

Crosstalk between components of circadian and metabolic cycles in mammals

Asher, G., & Schibler, U. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.006 · Cited by 601 · see citing works

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock

Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578 · see citing works

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567 · see citing works

Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs

Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560 · see citing works

Circadian rhythms persist without transcription in a eukaryote

O'Neill, J. S., Gerben Van Ooijen, A., Dixon, L. E., Troein, C., Corellou, F., Bouget, F., Reddy, A. B., & Millar, A. J. (2011) · Nature · doi:10.1038/nature09654 · Cited by 514 · see citing works

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification

Gachon, F., Fleury-Olela, F., Schaad, O., Descombes, P., & Schibler, U. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.015 · Cited by 511 · see citing works

Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint

Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 503 · see citing works

PER2 controls lipid metabolism by direct regulation of PPARγ

Grimaldi, B., Bellet, M. M., Katada, S., Astarita, G., Hirayama, J., Amin, R. H., Granneman, J. G., Piomelli, D., Leff, T., & Sassone-Corsi, P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.10.005 · Cited by 489 · see citing works

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

Martelot, G. L., Claudel, T., Gatfield, D., Schaad, O., Kornmann, B., Sasso, G. L., Moschetta, A., & Schibler, U. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000181 · Cited by 448 · see citing works

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis

So, A. Y.-L., Bernal, T. U., Pillsbury, M. L., Yamamoto, K. R., & Feldman, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909733106 · Cited by 431 · see citing works

Social jetlag, obesity and metabolic disorder: investigation in a cohort study

Parsons, M. J., Moffitt, T. E., Gregory, A. M., Goldman-Mellor, S., Nolan, P. M., Poulton, R., & Caspi, A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.201 · Cited by 426 · see citing works

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

Jacobi, D., Liu, S., Burkewitz, K., Kory, N., Knudsen, N. H., Alexander, R., Ünlütürk, U., Li, X., Kong, X., Hyde, A. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.006 · Cited by 411 · see citing works

Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410 · see citing works

In-Vivo Quantitative Proteomics Reveals a Key Contribution of Post-Transcriptional Mechanisms to the Circadian Regulation of Liver Metabolism

Robles, M. S., Cox, J., & Mann, M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004047 · Cited by 383 · see citing works

Coordination of the transcriptome and metabolome by the circadian clock

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Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U. (2010) · Cell · doi:10.1016/j.cell.2010.08.016 · Cited by 340 · see citing works

A Daily Rhythm in Glucose Tolerance

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Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

Mauvoisin, D., Wang, J., Jouffe, C., Martin, E., Atger, F., Waridel, P., Quadroni, M., Gachon, F., & Naef, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314066111 · Cited by 329 · see citing works

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.Preprint

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Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

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Gut clock: implication of circadian rhythms in the gastrointestinal tract.

Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2011) · PubMed · Cited by 286 · see citing works

Evidence for a circadian rhythm of insulin secretion

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Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillatorsPreprint

Saini, C., Morf, J., Stratmann, M., Gos, P., & Schibler, U. (2012) · Genes & Development · doi:10.1101/gad.183251.111 · Cited by 248 · see citing works

Circadian timing of metabolism in animal models and humans

Dibner, C., & Schibler, U. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12347 · Cited by 237 · see citing works

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factorPreprint

Reinke, H., Saini, C., Fleury-Olela, F., Dibner, C., Benjamin, I. J., & Schibler, U. (2008) · Genes & Development · doi:10.1101/gad.453808 · Cited by 228 · see citing works

(Re)inventing the Circadian Feedback Loop

Brown, S. A., Kowalska, E., & Dallmann, R. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.02.007 · Cited by 188 · see citing works

Identification of Rev-erbα as a physiological repressor of apoC-III gene transcription

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Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver

Zhang, Y.-K. J., Yeager, R. L., & Klaassen, C. D. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.024174 · Cited by 178 · see citing works

The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior

Ruiter, M., La Fleur, S. E., van Heijningen, C., van der Vliet, J., Kalsbeek, A., & Buijs, R. M. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1709 · Cited by 170 · see citing works

Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity

Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013) · Cell · doi:10.1016/j.cell.2012.12.027 · Cited by 160 · see citing works

Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age

Zwighaft, Z., Aviram, R., Shalev, M., Rousso-Noori, L., Kraut‐Cohen, J., Golik, M., Brandis, A. S., Reinke, H., Aharoni, A., Kahana, C., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.011 · Cited by 159 · see citing works

Klf15 orchestrates circadian nitrogen homeostasis

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Demonstration of a dawn phenomenon in normal human volunteers

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Demonstration of a Dawn Phenomenon in Normal Human Volunteers

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Krüppel-Like Factor KLF10 Is a Link between the Circadian Clock and Metabolism in Liver

Guillaumond, F., Gréchez‐Cassiau, A., Subramaniam, M., Brangolo, S., Maison-Peteri, B., Staels, B., Fiévet, C., Spelsberg, T. C., Delaunay, F., & Teboul, M. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01141-09 · Cited by 129 · see citing works

Autonomous and self-sustained circadian oscillators displayed in human islet cells

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Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

Han, S., Zhang, R., Jain, R., Shi, H., Zhang, L., Zhou, G., Sangwung, P., Tugal, D., Atkins, G. B., Prosdocimo, D. A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8231 · Cited by 102 · see citing works

Minireview: The Nuclear Hormone Receptor Family Round the Clock

Teboul, M., Guillaumond, F., Gréchez‐Cassiau, A., & Delaunay, F. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0521 · Cited by 96 · see citing works

Role of biological rhythms in gastrointestinal health and disease

Hoogerwerf, W. A. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9119-3 · Cited by 87 · see citing works

The emerging roles of lipids in circadian control

Adamovich, Y., Aviram, R., & Asher, G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.11.013 · Cited by 78 · see citing works

Regulation of bile acid synthesis in man. Presence of a diurnal rhythm.

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Regulation of Intestinal Lipid Absorption by Clock Genes

Hussain, M. M. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105322 · Cited by 28 · see citing works

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

Aron‐Wisnewsky, J., Vigliotti, C., Witjes, J. J., Le, P. T., Holleboom, A. G., Verheij, J., Nieuwdorp, M., & Clément, K. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0269-9 · Cited by 1,085 · see citing works

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Circadian regulation of glucose, lipid, and energy metabolism in humans

Poggiogalle, E., Jamshed, H., & Peterson, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.017 · Cited by 716 · see citing works

Crosstalk between metabolism and circadian clocks

Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598 · see citing works

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works

Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

Dallmann, R., Okyar, A., & Lévi, F. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.004 · Cited by 295 · see citing works

Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD

Mashek, D. G. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101115 · Cited by 233 · see citing works

Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview

Marchisello, S., Pino, A. D., Scicali, R., Urbano, F., Piro, S., Purrello, F., & Rabuazzo, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081948 · Cited by 194 · see citing works

Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease

Saran, A., Dave, S., & Zarrinpar, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.050 · Cited by 172 · see citing works

Circadian clocks in the digestive system

Segers, A., & Depoortere, I. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00401-5 · Cited by 160 · see citing works

Gut microbiota directs PPARγ‐driven reprogramming of the liver circadian clock by nutritional challenge

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Environmental Cycles, Melatonin, and Circadian Control of Stress Response in Fish

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Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization

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