The impact of abuse and mood on bowel symptoms and health‐related quality of life in irritable bowel syndrome (IBS)

Kanuri, N.; Cassell, B.; Bruce, S. E.; White, K. S.; Gott, B. M.; Gyawali, C. P.; Sayuk, G. S.

doi:10.1111/nmo.12848

Cited by 59Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsInfant Health and Development

The impact of abuse and mood on bowel symptoms and health‐related quality of life in irritable bowel syndrome (IBS)

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Kanuri, N., Cassell, B., Bruce, S. E., White, K. S., Gott, B. M., Gyawali, C. P., Sayuk, G. S.·2016·Neurogastroenterology & Motility

DOI 10.1111/nmo.12848PMC PMC5042818

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Abstract

Background: Irritable bowel syndrome (IBS) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in IBS. While abuse relates to mood disorders (depression and anxiety) also common in IBS, the influence of abuse on gastrointestinal (GI) symptoms and health‐related quality of life (HRQOL) and its independence from psychological symptom comorbidity has not been studied. Methods: Consecutive GI outpatients completed the ROME III Research Diagnostic Questionnaire and questionnaires on trauma (Life‐Stress Questionnaire), mood (Beck Depression/Anxiety Inventories), somatic symptoms (PHQ‐12), and HRQOL (SF‐36). Current GI symptom severity and bother were assessed using 10‐cm Visual Analog Scales. Key Results: 272 ROME‐defined IBS (47.6 ± 0.9 years, 81% female) and 246 non‐FGID (51.6 ± 1.0 years, 65% female) subjects participated. IBS patients reported greater rates of physical, sexual, and emotional abuse (p < 0.006 each), and higher depression, anxiety, and somatic symptoms (p < 0.001). Greater bowel symptom bother (7.4 ± 0.2 vs 6.7 ± 0.2, p = 0.040), severity (7.7 ± 0.2 vs 6.5 ± 0.2, p < 0.001), recent symptomatic days (9.8 ± 0.4 vs 8.5 ± 0.3, p = 0.02), and poorer HRQOL (40.9 ± 2.3 vs 55.5 ± 1.7, p < 0.001) were noted in IBS with abuse. Abuse effects were additive, with greater IBS symptom severity and poorer HRQOL noted in cases with multiple forms of abuse. Mediation analyses suggested that abuse effects on GI symptoms and HRQOL were partially mediated by mood. Conclusions & Inferences: Abuse experiences common among IBS sufferers are associated with reports of greater GI symptoms and poorer HRQOL, particularly in those with multiple forms of abuse; this relationship may be partially mediated by concomitant mood disturbances.

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Authors: Kanuri, N., Cassell, B., Bruce, S. E., White, K. S., Gott, B. M., Gyawali, C. P., & Sayuk, G. S.
Affiliations: Washington University in St. Louis (US)
University of Missouri–St. Louis (US)
Corresponding author: Sayuk, G. S.
ORCID: Cassell, B.
Bruce, S. E.
White, K. S.
Gyawali, C. P.
Sayuk, G. S.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2016-05-05
Volume: 28
Issue: 10
Pages: 1508-1517
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/nmo.12848
PMC: PMC5042818
OpenAlex: W2346853306
Cited by: 59
References: 60
Citations by year: 2026: 2 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 1
FWCI: 7.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (K23 DK84113)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords: irritable bowel syndrome, childhood abuse, physical abuse, sexual abuse, emotional abuse, depression, anxiety, health-related quality of life, bowel symptoms, gastrointestinal symptoms, mood disorders, somatic symptoms
MeSH terms: Physical Abuse, Adult, Affect, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Sex Offenses, Stress, Psychological, Cohort Studies, Irritable Bowel Syndrome

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The impact of abuse and mood on bowel symptoms and health‐related quality of life in irritable bowel syndrome (IBS)

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